Synthesis Of Peptides And Peptidomimetics

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Synthesis of Peptides and Peptidomimetics

Author : Murray Goodman
Publisher : Thieme Medical Publishers
ISBN 13 : 9781588903136
Total Pages : 785 pages
Book Rating : 4.9/5 (31 download)

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Book Synopsis Synthesis of Peptides and Peptidomimetics by : Murray Goodman

Download or read book Synthesis of Peptides and Peptidomimetics written by Murray Goodman and published by Thieme Medical Publishers. This book was released on 2004 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now over 100 years since the first report of peptide synthesis by Emil Fischer in 1899. Houben-Weyl Synthesis of Peptides and Peptidomimetics, published in the English language, will reflect the current changes of this important discipline, which is at the center of modern chemistry and biology. The four-volume set, edited by the internationally renowned peptide chemists Professors Murray Goodman, Arthur Felix, Luis Moroder, and Claudio Toniolo will comprise a critical selection of synthetic methods in a consistent style. Synthesis of Peptides and Peptidomimetics is an indispensable resource for every synthetic chemist. For full information on the complete Houben-Weyl series, please visit the Houben-Weyl Homepage.

Peptidomimetics in Organic and Medicinal Chemistry

Author : Antonio Guarna
Publisher : John Wiley & Sons
ISBN 13 : 1119950600
Total Pages : 334 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Peptidomimetics in Organic and Medicinal Chemistry by : Antonio Guarna

Download or read book Peptidomimetics in Organic and Medicinal Chemistry written by Antonio Guarna and published by John Wiley & Sons. This book was released on 2014-04-07 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Peptidomimetics in Organic and Medicinal Chemistry

Author : Antonio Guarna
Publisher : John Wiley & Sons
ISBN 13 : 1118683145
Total Pages : 334 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Peptidomimetics in Organic and Medicinal Chemistry by : Antonio Guarna

Download or read book Peptidomimetics in Organic and Medicinal Chemistry written by Antonio Guarna and published by John Wiley & Sons. This book was released on 2014-03-14 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Principles of Peptide Synthesis

Author : Miklos Bodanszky
Publisher : Springer Science & Business Media
ISBN 13 : 3642780563
Total Pages : 335 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Principles of Peptide Synthesis by : Miklos Bodanszky

Download or read book Principles of Peptide Synthesis written by Miklos Bodanszky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Peptide Synthesis is a very successful book by one of the pioneers of contemporary bioorganic synthesis. Its first edition proved a valuable source that is kept close to the work bench for frequent consulting. Any researcher planning the formation of the peptide bond, be it for the synthesis of a peptide chain or a cyclic peptide, benefits from the author's experience. The concise and critical treatment of the steps involved: protection, activation and bond formation require careful planning to avoid racemization and undesired side reactions. The second edition has been completely revised and updated. New procedures that have been developed since the first edition was published and that did not fit into the original are added in a separate chapter. This separation of old and new make it possible to assess new ideas and discern novel trends.

Peptide Applications in Biomedicine, Biotechnology and Bioengineering

Author : Sotirios Koutsopoulos
Publisher : Woodhead Publishing
ISBN 13 : 0081007426
Total Pages : 655 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Peptide Applications in Biomedicine, Biotechnology and Bioengineering by : Sotirios Koutsopoulos

Download or read book Peptide Applications in Biomedicine, Biotechnology and Bioengineering written by Sotirios Koutsopoulos and published by Woodhead Publishing. This book was released on 2017-11-16 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides

Volume E 22: Synthesis of Peptides and Peptidomimetics Part A

Author : Murray Goodman
Publisher : Thieme Chemistry
ISBN 13 : 9783131401342
Total Pages : 0 pages
Book Rating : 4.4/5 (13 download)

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Book Synopsis Volume E 22: Synthesis of Peptides and Peptidomimetics Part A by : Murray Goodman

Download or read book Volume E 22: Synthesis of Peptides and Peptidomimetics Part A written by Murray Goodman and published by Thieme Chemistry. This book was released on 2004-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now over 100 years since the first report of peptide synthesis by Emil Fischer in 1899. Houben-Weyl Synthesis of Peptides and Peptidomimetics, published in the English language, will reflect the current changes of this important discipline, which is at the center of modern chemistry and biology. The four-volume set, edited by the internationally renowned peptide chemists Professors Murray Goodman, Arthur Felix, Luis Moroder, and Claudio Toniolo will comprise a critical selection of synthetic methods in a consistent style. Synthesis of Peptides and Peptidomimetics is an indispensable resource for every synthetic chemist. For full information on the complete Houben-Weyl series, please visit the Houben-Weyl Homepage

Chemical Epigenetics

Author : Antonello Mai
Publisher : Springer Nature
ISBN 13 : 3030429822
Total Pages : 569 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Chemical Epigenetics by : Antonello Mai

Download or read book Chemical Epigenetics written by Antonello Mai and published by Springer Nature. This book was released on 2020-03-31 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.

Stereochemical Considerations for the Synthesis of Peptides and Peptidomimetics

Author : Todd Theodore Romoff
Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Stereochemical Considerations for the Synthesis of Peptides and Peptidomimetics by : Todd Theodore Romoff

Download or read book Stereochemical Considerations for the Synthesis of Peptides and Peptidomimetics written by Todd Theodore Romoff and published by . This book was released on 1996 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Peptides

Author : Norbert Sewald
Publisher : John Wiley & Sons
ISBN 13 : 3527802657
Total Pages : 771 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Peptides by : Norbert Sewald

Download or read book Peptides written by Norbert Sewald and published by John Wiley & Sons. This book was released on 2015-11-19 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: Der "Sewald/Jakubke" ist und bleibt das einzige moderne, auf dem neuesten wissenschaftlichen Stand gehaltene fortgeschrittene Lehrbuch der Peptid-Biochemie! Auch für diese zweite, um ein Viertel erweitere Auflage haben die Autoren Hunderte von Publikationen gelesen und zu einem informativen und vollständigen Überblick über das Fachgebiet zusammengefasst. Nach einer Einführung in die Grundlagen der Peptidstruktur und -synthese werden die wichtigsten Familien biologisch aktiver Peptide systematisch abgehandelt. Mit interdisziplinärem Anspruch werden dann wichtige Anwendungen aus der Biotechnologie, Pharmazie und Biomedizin besprochen. Selbstverständlich werden auch Themen der Spitzenforschung berücksichtigt, zum Beispiel Pseudopeptide, Peptidmimetika und Aspekte der kombinatorischen Synthese. -- Neu in dieser Auflage sind Fragen und Übungsaufgaben, die das Nacharbeiten von Vorlesungen oder das Selbststudium erleichtern.

Advances in Amino Acid Mimetics and Peptidomimetics

Author : A. Abell
Publisher : Elsevier
ISBN 13 : 0080552625
Total Pages : 321 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Advances in Amino Acid Mimetics and Peptidomimetics by : A. Abell

Download or read book Advances in Amino Acid Mimetics and Peptidomimetics written by A. Abell and published by Elsevier. This book was released on 1997-11-19 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptidomimetics are compounds which mimic the biological activity of peptides while offering the advantages of increased bioavailability, biostability, bioefficiency, and bioselectivity against the natural biological target of the parent peptide. Examples of peptidomimetics have been isolated as natural products, synthesized as libraries from novel subunits, and designed on the basis of X-ray crystallographic studies and through an intricate knowledge of the biological mode of action of natural peptides. They offer challenging synthetic targets and are increasingly important medicinal agents and biological probes. As a consequence, peptidomimetics embrace much of what is modern medicinal and organic chemistry. This volume highlights some recent and exciting developments in the area.

Synthesis of peptides and peptidomimetics

Author :
Publisher :
ISBN 13 : 9781588900708
Total Pages : 0 pages
Book Rating : 4.9/5 (7 download)

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Book Synopsis Synthesis of peptides and peptidomimetics by :

Download or read book Synthesis of peptides and peptidomimetics written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis of Peptides and Peptidomimetics

Author : Arthur Felix
Publisher :
ISBN 13 : 9783132196049
Total Pages : pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Synthesis of Peptides and Peptidomimetics by : Arthur Felix

Download or read book Synthesis of Peptides and Peptidomimetics written by Arthur Felix and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis

Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527641572
Total Pages : 541 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis by :

Download or read book Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis written by and published by John Wiley & Sons. This book was released on 2011-06-03 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Peptide and Peptidomimetic Therapeutics

Author : Nir Qvit
Publisher : Academic Press
ISBN 13 : 0128204478
Total Pages : 792 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Peptide and Peptidomimetic Therapeutics by : Nir Qvit

Download or read book Peptide and Peptidomimetic Therapeutics written by Nir Qvit and published by Academic Press. This book was released on 2022-09-22 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development

Principles of Peptide Synthesis

Author : M. Bodanszky
Publisher : Springer Science & Business Media
ISBN 13 : 3642967639
Total Pages : 320 pages
Book Rating : 4.6/5 (429 download)

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Book Synopsis Principles of Peptide Synthesis by : M. Bodanszky

Download or read book Principles of Peptide Synthesis written by M. Bodanszky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on some experimental project that requires the construction of peptide chains. Not less useful are the monographs which were compiled to aid the adept practitioner and to provide him with references to the growing literature of a very active field. Is there any need for a new book on peptide synthesis? Should we add a new volume to an already impressive and certainly useful series? The answer is not obvious. The author has already participated in two similar en deavors. The first edition! of "Peptide Synthesis", with M. A. Ondetti as coauthor, was meant to serve as an introduction for the beginner. It was rather well received by researchers who joined the field of peptide chemistry and were looking for initiation. While working on the 2 second edition with Drs. Klausner and Ondetti, we became painfully aware of the impossibility of the task.

Synthesis of Peptides and Peptidomimetics

Author :
Publisher :
ISBN 13 : 9781588900241
Total Pages : 0 pages
Book Rating : 4.9/5 (2 download)

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Book Synopsis Synthesis of Peptides and Peptidomimetics by :

Download or read book Synthesis of Peptides and Peptidomimetics written by and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Side Reactions in Peptide Synthesis

Author : Yi Yang
Publisher : Academic Press
ISBN 13 : 0128011815
Total Pages : 378 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Side Reactions in Peptide Synthesis by : Yi Yang

Download or read book Side Reactions in Peptide Synthesis written by Yi Yang and published by Academic Press. This book was released on 2015-09-01 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration