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Author : Weijian Zhang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)
Download or read book Synthesis of Nucleoside Analogues with a Modified Methylene-sugar written by Weijian Zhang and published by . This book was released on 1992 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Weijian Zhang
Publisher :
ISBN 13 :
Total Pages : 204 pages
Book Rating : 4.:/5 (89 download)
Download or read book Synthesis of Nucleoside Analogues with a Modified Methyene-sugar written by Weijian Zhang and published by . This book was released on 1992 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pedro Merino
Publisher : John Wiley & Sons
ISBN 13 : 1118498100
Total Pages : 859 pages
Book Rating : 4.1/5 (184 download)
Download or read book Chemical Synthesis of Nucleoside Analogues written by Pedro Merino and published by John Wiley & Sons. This book was released on 2013-02-12 with total page 859 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
Author : Lea Pickering
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (911 download)
Download or read book The Synthesis of Nucleoside Analogues with Modified Heterocyclic Sugars written by Lea Pickering and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : JEFFREY STANLEY PUDLO
Publisher :
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.:/5 (687 download)
Download or read book THE SYNTHESIS OF 3'-SUGAR-MODIFIED NUCLEOSIDE ANALOGS RELATED TO OXETANOCIN. written by JEFFREY STANLEY PUDLO and published by . This book was released on 1991 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1,5-O-benzoyl-3-deoxy-3-(benzyloxy)methyl-$ \alpha $,$\beta $-D-ribofuranose. These compounds could then be condensed with a series of aglycones.
Author :
Publisher :
ISBN 13 :
Total Pages : 902 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Piet Herdewijn
Publisher : John Wiley & Sons
ISBN 13 : 3527623124
Total Pages : 684 pages
Book Rating : 4.5/5 (276 download)
Download or read book Modified Nucleosides written by Piet Herdewijn and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.
Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608051986
Total Pages : 594 pages
Book Rating : 4.6/5 (8 download)
Download or read book Advances in Organic Synthesis written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2011-01-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating agents. It brings t"
Author :
Publisher : Elsevier
ISBN 13 : 0128032014
Total Pages : 4609 pages
Book Rating : 4.1/5 (28 download)
Download or read book Comprehensive Medicinal Chemistry III written by and published by Elsevier. This book was released on 2017-06-03 with total page 4609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Author : Michael A. Lieberman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 197512149X
Total Pages : 448 pages
Book Rating : 4.9/5 (751 download)
Download or read book BRS Biochemistry, Molecular Biology, and Genetics written by Michael A. Lieberman and published by Lippincott Williams & Wilkins. This book was released on 2019-01-09 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Practical, approachable, and perfect for today’s busy medical students and practitioners, BRS Biochemistry, Molecular Biology, and Genetics, Seventh Edition helps ensure excellence in class exams and on the USMLE Step 1. The popular Board Review Series outline format keeps content succinct and accessible for the most efficient review, accompanied by bolded key terms, detailed figures, quick-reference tables, and other aids that highlight important concepts and reinforce understanding. This revised edition is updated to reflect the latest perspectives in biochemistry, molecular biology, and genetics, with a clinical emphasis essential to success in practice. New Clinical Correlation boxes detail the real-world application of chapter concepts, and updated USMLE-style questions with answers test retention and enhance preparation for board exams and beyond.
Author : A. Varvoglis
Publisher : Academic Press
ISBN 13 : 0080534368
Total Pages : 245 pages
Book Rating : 4.0/5 (85 download)
Download or read book Hypervalent Iodine in Organic Synthesis written by A. Varvoglis and published by Academic Press. This book was released on 1996-11-14 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fascinating chemistry of the many kinds of organic compounds of hypervalent iodine. Each chapter deals with a particular iodine compound or families of compounds which have been used as reagents in a plethora of useful transformations. These include assorted oxidation, such as with the precious Dess-Martin reagent as well as with a wide range of further reactions. Prominent features of hypervalent iodine reagents derived from iodobenzene are: ready availability, operational simplicity, mild reaction conditions, and high efficiency. They are environmentally safe and can be recycled. New species may be easily prepared by introducing substituents in the benzene ring or changing the ligand attached to iodine. Their combination with other reagents broadens considerably their synthetic potential. Today, no synthetic chemist can afford to ignore the valuable hypervalentiodine reagents. Features up-to-date coverage of a wide range of topics Includes many tables featuring a diversity of reactivity, and a comprehensive index Acts as a comprehensive, up-to-date reference on all aspects of hypervalent iodine chemistry Contains a section on unusual efficiency of hypervalent iodine reactions
Author : Peter Goekjian
Publisher : Academic Press
ISBN 13 : 012803789X
Total Pages : 796 pages
Book Rating : 4.1/5 (28 download)
Download or read book C-Furanosides written by Peter Goekjian and published by Academic Press. This book was released on 2017-11-30 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon. While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems. Provides a comprehensive review of the growing literature in C-furanosides Enables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished cases Explores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models
Author : Naoki Sugimoto
Publisher : Springer Nature
ISBN 13 : 9811997764
Total Pages : 2847 pages
Book Rating : 4.8/5 (119 download)
Download or read book Handbook of Chemical Biology of Nucleic Acids written by Naoki Sugimoto and published by Springer Nature. This book was released on 2023-07-29 with total page 2847 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.
Author :
Publisher : Academic Press
ISBN 13 : 0080562841
Total Pages : 559 pages
Book Rating : 4.0/5 (85 download)
Download or read book Advances in Carbohydrate Chemistry and Biochemistry written by and published by Academic Press. This book was released on 1971-05-14 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Carbohydrate Chemistry and Biochemistry
Author : Stefan Jurga
Publisher : Springer
ISBN 13 : 3319341758
Total Pages : 456 pages
Book Rating : 4.3/5 (193 download)
Download or read book Modified Nucleic Acids in Biology and Medicine written by Stefan Jurga and published by Springer. This book was released on 2016-07-29 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Author : Robert A. Meyers
Publisher : John Wiley & Sons
ISBN 13 : 352768719X
Total Pages : 1100 pages
Book Rating : 4.5/5 (276 download)
Download or read book Translational Medicine written by Robert A. Meyers and published by John Wiley & Sons. This book was released on 2018-03-02 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.
Author : Serge L. Beaucage
Publisher : Current Protocols
ISBN 13 : 9780471246626
Total Pages : pages
Book Rating : 4.2/5 (466 download)
Download or read book Current Protocols in Nucleic Acid Chemistry written by Serge L. Beaucage and published by Current Protocols. This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Good methods must be reliable, well-tested, and honed to minimize the time and expense required to achieve the desired results. CPNC provides a continuously growing and evolving set of protocols that allows researchers to benefit from the experience of other researchers around the world. The core manual provides a comprehensive set of protocols that have been compiled, revised, and streamlined over the last 6 years. Quarterly updates provide new protocols in emerging areas of research as well as continued advances and new applications for fundamental methods. The book is designed to grow and change with the field of nucleic acid chemistry. Fundamental nucleoside chemistry methods include sugar-base condensation, phosphorylation, and nucleoside protection. Methods for oligonucleotide synthesis include H-phosphonate and phosphoramidite approaches, solid-phase and solution-phase synthesis, large-scale synthesis, synthesis for modified and unmodified oligonucleotides, conjugation of oligonucleotides, synthesis without base protection, and synthesis on microarrays. More specialized synthetic methods include synthesis of biologically active nucleosides and prodrugs. Purification and characterization methods are detailed. Advanced methods include biophysical analysis, combinatorial methods, and nanotechnology. Each protocol includes rationale for choosing appropriate methods, step-by-step procedures, complete recipes, anticipated results, characterization data, and troubleshooting, as well as background and recommended reading. The level of procedural detail is far beyond that found in the research literature, and tips and comments from authors are geared towards ensuring reliable duplication in the laboratory.
