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Synthesis Of Biodegradable Polymer Micro And Nanoparticles For Controlled Drug Delivery By Multiplexed Electrosprays
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Book Synopsis Synthesis of Biodegradable Polymer Micro- and Nanoparticles for Controlled Drug Delivery by Multiplexed Electrosprays by : Begoña Almería
Download or read book Synthesis of Biodegradable Polymer Micro- and Nanoparticles for Controlled Drug Delivery by Multiplexed Electrosprays written by Begoña Almería and published by . This book was released on 2012 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polymers for Controlled Drug Delivery by : Peter J. Tarcha
Download or read book Polymers for Controlled Drug Delivery written by Peter J. Tarcha and published by CRC Press. This book was released on 1990-11-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
Book Synopsis Polymers for Controlled Drug Delivery by : Peter J. Tarcha
Download or read book Polymers for Controlled Drug Delivery written by Peter J. Tarcha and published by CRC Press. This book was released on 2023-06-14 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
Book Synopsis Polymers in Drug Delivery by : Ijeoma F. Uchegbu
Download or read book Polymers in Drug Delivery written by Ijeoma F. Uchegbu and published by CRC Press. This book was released on 2006-05-19 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera
Book Synopsis Polymer Nanoparticles for Nanomedicines by : Christine Vauthier
Download or read book Polymer Nanoparticles for Nanomedicines written by Christine Vauthier and published by Springer. This book was released on 2017-01-07 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.
Book Synopsis Achieving Long-term Controlled Drug Delivery by Using Biodegradable Polymeric Nanoparticles by : Avinash Budhian
Download or read book Achieving Long-term Controlled Drug Delivery by Using Biodegradable Polymeric Nanoparticles written by Avinash Budhian and published by . This book was released on 2006 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Polyester Drug Delivery Systems by : M. N. V. Ravi Kumar
Download or read book Handbook of Polyester Drug Delivery Systems written by M. N. V. Ravi Kumar and published by CRC Press. This book was released on 2017-03-27 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the quest for innovative drug delivery systems attempting to meet the unmet needs in pharmaceutical space, research has taken a much more complicated path that poses a significant challenge for translation. Despite the progress made with novel materials, polyesters still remain at the helm of drug delivery technologies. This book provides a single source of reference of polyester drug delivery systems that covers a broad spectrum of materials design, manufacturing techniques, and applications.
Book Synopsis Biodegradable Polyesters by : Stoyko Fakirov
Download or read book Biodegradable Polyesters written by Stoyko Fakirov and published by John Wiley & Sons. This book was released on 2015-03-04 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collating otherwise hard-to-get and recently acquired knowledge in one work, this is a comprehensive reference on the synthesis, properties, characterization, and applications of this eco-friendly class of plastics. A group of internationally renowned researchers offer their first-hand experience and knowledge, dealing exclusively with those biodegradable polyesters that have become increasingly important over the past two decades due to environmental concerns on the one hand and newly-devised applications in the biomedical field on the other. The result is an unparalleled overview for the industrial chemist and materials scientist, as well as for developers and researchers in industry and academia alike.
Book Synopsis Biodegradable Polymer-Drug Conjugates for Anticancer Drug Delivery by : Yun Yu
Download or read book Biodegradable Polymer-Drug Conjugates for Anticancer Drug Delivery written by Yun Yu and published by . This book was released on 2013 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer-drug conjugate, also known as macromolecular prodrug, is a type of polymeric nanomedicine in which drugs are covalently bonded to polymers. This dissertation focuses on the development of four types of novel biodegradable polymer-drug conjugates for anticancer drug delivery. A novel biodegradable brush polymer-drug conjugate (BPDC) with paclitaxel (PTXL) as the divalent agent to bridge between the degradable polylactide (PLA)-based backbone and hydrophilic poly(ethylene glycol) (PEG) side chains, was prepared by the copper-catalyzed azide-alkyne cycloaddition reaction of alkyne-functionalized polylactide (PLA) with azide-functionalized PTXL-PEG conjugate. After multi-step synthesis of alkyne-functionalized lactide monomer, the alkyne-functionalized PLA was prepared by ring-opening polymerization (ROP) of the functional lactide with L-lactide. The azide-functionalized PTXL-PEG conjugate was also prepared by multi-step organic synthesis. The well-controlled chemical structures of the BPDC and its precursors were verified by proton nuclear magnetic resonance (1H NMR) and gel permeation chromatography (GPC) characterizations. Dynamic light scattering (DLS) analysis indicated that BPDC molecules assembled in water to form nanoparticles with sizes of 8-40 nm. Multiple hydrolysis reactions under the experimental conditions were observed, which resulted in the release of PTXL moieties and the cleavage of PLA-based backbone. To improve the drug release profile of the above BPDC, another biodegradable BPDC was synthesized through azide-alkyne click reaction of alkyne-functionalized polylactide (PLA) with azide-functionalized paclitaxel (PTXL) and poly(ethylene glycol) (PEG). Well-controlled structures of the resulting BPDC and its precursors were verified by 1H NMR and GPC characterizations. Both DLS analysis and transmission electron microscopy (TEM) imaging indicated that the BPDC had a nanoscopic size around 10-30 nm. Drug release behavior of BPDC was monitored by high performance liquid chromatography (HPLC) indicating 50 % of drug moiety was effectively released within 24 h. The significant hydrolytic degradability of the PLA backbone of the BPDC was confirmed by GPC analysis of its incubated solution. As illustrated by cytotoxicity and cell uptake study, BPDC exhibited high therapeutic efficacy toward MCF-7 cancer cells. To further demonstrate the versatility of such BPDC template, a novel brush polymer-drug conjugate (BPDC) consisting of biodegradable scaffold and pH-responsive drug conjugation was prepared. The biodegradable scaffold, PLA-graft-aldehyde/PEG (PLA-g-ALD/PEG), was synthesized via copper-catalyzed azide-alkyne click reaction. Then BPDC was obtained by conjugating doxorubicin (DOX) with the scaffold through acid-liable Schiff base linkages. Well-controlled structures of the resulting BPDC and its precursors were verified by 1H NMR and GPC characterizations. As revealed by DLS and TEM, the BPDC had well-defined nanostructure with size of 10-30 nm. Due to the Schiff base conjugation linkage in BPDC, acid-liable drug release behavior of the NPs was observed. Both cytotoxicity and cell internalization study of BPDC in MCF-7 breast cancer cells indicated its great potential application as an anticancer nanomedicine. Finally, biodegradable nanoparticles (NPs) mainly consisting of hydrophobic polymer-drug conjugate, PLA-g-DOX, were prepared for anticancer drug delivery via nanoprecipitation. PLA-g-DOX conjugate was synthesized by azide-alkyne click reaction to transform alkyne-functioanlized PLA into PLA-g-aldehyde (PLA-g-ALD), followed by DOX conjugation to form acid-sensitive Schiff base linkage between drug moieties and polymer scaffold.^PLA-g-DOX was further used to prepare NPs with precisely controlled drug loading by nanoprecipitaiton in the presence of a PEGylated surfactant. The effects of organic solvent, PLA-g-DOX concentration and PLA-g-DOX/surfactant mass ratio on size and size distribution of NPs were systematically examined based on DLS and TEM analysis. Due to the Schiff base conjugation linkage in PLA-g-DOX, acid-liable drug release behavior of the NPs was observed. Cytotoxicity and cell uptake studies of the NPs towards MCF-7 breast cancer cells indicated their promising potential applications as anti-cancer nanomedicines.
Book Synopsis Size-tuneable Biodegradable Polymeric Nanoparticles for Controlled Drug Delivery by : Arrandeep Singh Basra
Download or read book Size-tuneable Biodegradable Polymeric Nanoparticles for Controlled Drug Delivery written by Arrandeep Singh Basra and published by . This book was released on 2015 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Inorganic-biodegradable Polymer Composite Microspheres for Controlled Delivery of a DNA Prime-protein Boost Vaccine by :
Download or read book Synthesis of Inorganic-biodegradable Polymer Composite Microspheres for Controlled Delivery of a DNA Prime-protein Boost Vaccine written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biodegradable Polymer Micro- and Nanoparticles as Protein Delivery Systems by : Cuifang Cai
Download or read book Biodegradable Polymer Micro- and Nanoparticles as Protein Delivery Systems written by Cuifang Cai and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Processing and Characterization of Polymer Microparticles for Controlled Drug Delivery Systems by : Aravind Chakrapani
Download or read book Processing and Characterization of Polymer Microparticles for Controlled Drug Delivery Systems written by Aravind Chakrapani and published by . This book was released on 2006 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: We report a novel soft lithography based technique to fabricate non-spherical biodegradable polymeric microparticles of different sizes and shapes as drug delivery systems. Geometrical control over the shape and size of these microparticles renders them different aerodynamic and fluidic dynamic properties when compared to conventional spherical microparticles and may prove to be beneficial in certain drug delivery strategies, such as pulmonary and intravenous routes. The surface morphology of the particles was studied using a scanning electron microscope and size distribution of the particles was determined using a Coulter counter. The process is reproducible and millions of uniform biodegradable particles of various sizes and shapes with dimensions ranging from 2-30 um have been fabricated and were collected by a simple vacuum filtration apparatus. In addition, we demonstrated encapsulation of a model drug (FITC), and FITC distributions within the particles were studied by confocal microscopy. Particle size is a critical parameter for several aspects of controlled drug delivery including control of drug-release kinetics, passive targeting to specific cell or tissue types, biodistribution upon administration and available routes of administration. In conclusion, the uniform, biodegradable polymeric microparticles produced have potential to be used in a variety of drug delivery applications and polymer-based microfabrication technology holds promise to produce sophisticated, multi-functional drug delivery devices.
Book Synopsis Development of Novel Multilayered Particles for Drug Delivery and Cell Isolation Applications by : Bhanuprasanth Koppolu
Download or read book Development of Novel Multilayered Particles for Drug Delivery and Cell Isolation Applications written by Bhanuprasanth Koppolu and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this work is to develop multilayered nanoparticles for drug delivery and cell isolation applications. These particles principally consist of three layers; biodegradable polymer, thermo sensitive polymer and magnetic materials. For drug delivery, multilayered nanoparticles (MLNP) consisting of a magnetic core and two encompassing shells made up of temperature sensitive polymer, poly (Nisopropylacrylamide) (PNIPAAm), and biodegradable polymer, poly(D, L lactide-coglycolide) (PLGA), were developed for targeted and controlled drug delivery. The PNIPAAm layer was immobilized onto magnetic nanoparticles (MNPs) via a silane coupling agent, Vinyltrimethoxysilane (VTMS), and free radical polymerization. These particles were then encapsulated with PLGA using a double emulsion solvent evaporation method with poly (vinyl alcohol) (PVA) as a surfactant. Transmission electron microscopy (TEM) confirmed that multilayered particles were obtained with PNIPAAm magnetic nanoparticles embedded within the PLGA shell. Factorial design analysis of the results showed that the particles size was inversely proportional to surfactant PVA concentrations and sonication powers while it was directly proportional to PLGA concentrations. PVA concentrations were the most important factor affecting the particle size, while PLGA was the least important factor. The drug release results demonstrated that these multilayer particles produced an initial burst release and a subsequent sustained release of both drugs loaded in the core and shell of MLNP. For cell isolation, Multi Layered Microparticles (MLMP) with a biodegradable polymeric core and two shells made up of MNPs and PNIPAAm-AH were synthesized. PLGA microspheres loaded with protein were prepared by using a double emulsion method. Magnetic nanoparticles functionalized with silane and silane amide were conjugated onto the surface of the PLGA microspheres by covalently bonding. PNIPAAm-AH copolymer was then immobilized onto the magnetic nanoparticles layer using a coupled silane agent and free radical polymerization of the NIPPAAm and Allylamine (AH) monomers. Scanning electron microscopy (SEM) showed that multilayered particles of size 50 to 100 [mu]m were obtained. The polymeric composition of particles was also confirmed by FTIR spectrum. Differential scanning calorimetric (DSC) analysis determined that the polymer had a lower critical solution temperature (LCST) of 34.9C. Conjugation studies showed that the particles could further be conjugated with antibodies. The protein release results demonstrated that these multilayer particles produced an initial burst release and a subsequent sustained release of proteins. The shell release profile was affected by the changes of temperature where as the core release was affected by the core degradation, shell hydrophilicity, and protein diffusion through the shell. These results show that the particles can be used for impulsive release of differentiating factors followed by slow release of cell enrichment factors. Cell adhesion studies showed that the PNIPAAm-AH surface of the particles supports cell adhesion. Also, cell extraction studies showed that MLMPs can be used to extract cells from a suspension and the isolation process has no significant effect on cell viability.
Book Synopsis Immunopotentiators in Modern Vaccines by : Virgil Schijns
Download or read book Immunopotentiators in Modern Vaccines written by Virgil Schijns and published by Academic Press. This book was released on 2016-11-02 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful. - Provides contributions from leading international authorities in the field - Features immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune system - Lists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator - Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines
Book Synopsis Handbook of Encapsulation and Controlled Release by : Munmaya Mishra
Download or read book Handbook of Encapsulation and Controlled Release written by Munmaya Mishra and published by CRC Press. This book was released on 2015-12-01 with total page 1516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of encapsulation, especially microencapsulation, is a rapidly growing area of research and product development. The Handbook of Encapsulation and Controlled Release covers the entire field, presenting the fundamental processes involved and exploring how to use those processes for different applications in industry. Written at a level comp
Book Synopsis Generating and Sustaining Stable Autoantigen-specific CD4 and CD8 Regulatory T Cells in Lupus by : Syamal Kumar Datta
Download or read book Generating and Sustaining Stable Autoantigen-specific CD4 and CD8 Regulatory T Cells in Lupus written by Syamal Kumar Datta and published by Frontiers Media SA. This book was released on 2022-08-19 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:
