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Synthesis Approaches To Indolizidine Alkaloids
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Book Synopsis Synthesis Approaches to Indolizidine Alkaloids by :
Download or read book Synthesis Approaches to Indolizidine Alkaloids written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Novel Approach to the Synthesis of Indolizidine Alkaloids Utilizing 1-acyldihydropyridines by : Young Chan Myoung
Download or read book A Novel Approach to the Synthesis of Indolizidine Alkaloids Utilizing 1-acyldihydropyridines written by Young Chan Myoung and published by . This book was released on 1988 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Reactions and Synthetic Strategies Toward Indolizidine Alkaloids and Pallavicinia Diterpenes by : Alison Rae Hardin Narayan
Download or read book New Reactions and Synthetic Strategies Toward Indolizidine Alkaloids and Pallavicinia Diterpenes written by Alison Rae Hardin Narayan and published by . This book was released on 2011 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract New Reactions and Synthetic Strategies toward Indolizidine Alkaloids and Pallavicinia Diterpenes by Alison Rae Hardin Narayan Doctor of Philosophy in Chemistry University of California, Berkeley Professor Richmond Sarpong, Chair Strategies toward indolizidine alkaloids and pallavicinia diterpenes have been established. The first six chapters of this thesis are devoted to the development and execution of approaches toward N-fused bicycles and their application to the synthesis of indolizidine alkaloids. The final chapter details efforts toward the synthesis of pallavicinin and related diterpenes. An overview of the indolizidine alkaloids is provided, including the major structural distinctions of the subclasses of these alkaloids as well as their known biological activity. This sets the stage for a discussion of our synthetic approach toward this class of natural products, aiming to build these molecules from indolizine and indolizinone precursors. Several methods were developed to rapidly access indolizines and indolizinones. Specifically, the platinum-catalyzed cycloisomerization of propargylic esters to 2,3-disubstituted indolizines was realized. The nuances of the effect of the substrate's electronic properties on the reaction pathway were studied and this knowledge was utilized to develop a reaction selective for the formation of 2,3-disubstituted indolizines over the 1,3-disubstituted products. Subsequently, a metal-free version of a previously established metal-catalyzed cyclization was identified for the formation of 1,3-disubstituted indolizines and indolizinones. With methods in place to form substituted indolizines and indolizinones, these bicycles were employed in the synthesis of indolizidine alkaloids. First, indolizine precursors were used to accomplish a five-step total synthesis of indolizidine 209D and a formal synthesis of securinine. Next, the innate reactivity of indolizinones was explored and applied to the synthesis of tricyclic marine alkaloids. From indolizinone building blocks, two routes were established to the tricyclic cylindricine core. The first approach toward the cylindricines featured a ring-opening/ring-closing metathesis to assemble the cis-6,6-ring fusion conserved throughout this family of natural products. The second approach toward the cylindricines employed a ring-contractive cyclization to form a tricyclic indolizinone, which served as a common intermediate to both the cylindricine and the closely related lepadiformine alkaloids. The ring-contractive cyclization approach led to the synthesis of the cylindricine core in eight steps. Additionally, progress toward lepadiformine C from an intermediate accessed in the cylindricine synthesis has been achieved. Finally, a strategy toward pallavicinin and related diterpenes has been tested. The approach features a gold-catalyzed cyclization to construct the [3.2.1]bicycle of pallavicinin and an Eschenmoser-Claisen rearrangement to form a key carbon-carbon bond. This strategy has been successful for the formation of the 8,9-epi, epi-pallavicinin tetracycle.
Book Synopsis Synthetic Approaches to Indolizidine and Pyrrolizidine Alkaloids by : Jerel Jay Shapiro
Download or read book Synthetic Approaches to Indolizidine and Pyrrolizidine Alkaloids written by Jerel Jay Shapiro and published by . This book was released on 1981 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Novel Approach to the Synthesis of Polyhydroxylated Indolizidine Alkaloids by : Elizabeth Farrant
Download or read book A Novel Approach to the Synthesis of Polyhydroxylated Indolizidine Alkaloids written by Elizabeth Farrant and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Routes to Indolizidine Alkaloids by : James D. Cuthbertson
Download or read book New Routes to Indolizidine Alkaloids written by James D. Cuthbertson and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The plant family Elaeocarpaceae has been the source of a plethora of structurally related alkaloids isolated over the last 50 years. This Thesis describes our synthetic approaches to (-)-grandisine B I, a bioactive indolizidine alkaloid isolated from Elaocarpus grandis in 2005. An overview of alkaloids isolated from the family Elaeocarpaceae is provided and preliminary studies into the synthesis of grandisine B I are described (Chapters 1 and 2). Novel routes to bicyclic lactams II and isoquinuclidinone frameworks III have been developed using aqueous ammonia in a one-pot amination/cyclisation sequence (Chapters 3 and 4). The scope of the developed methodology was initially demonstrated with a concise synthesis of the alkaloid (-)-mearsine V. A biomimetic synthesis of (±)-grandisine B I, using the alkaloid grandisine D IV as a synthetic precursor, is then described in Chapter 5. The development of a formic acid mediated alkyne/acetal cyclisation for the synthesis of heterocyclic scaffolds is also reported. The scope and limitations of the methodology are discussed and applications of the methodology in the synthesis of (-)-grandisine B I and structurally related Elaeocarpus alkaloids are described (Chapter 6).
Book Synopsis Synthesis of Indolizidine Alkaloids Via the Intramolecular Acylnitroso Diels-Alder Reaction by : Duane R. Romer
Download or read book Synthesis of Indolizidine Alkaloids Via the Intramolecular Acylnitroso Diels-Alder Reaction written by Duane R. Romer and published by . This book was released on 1990 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Synthetic Approaches to Indolizidine and Pyrrolidine Alkaloids by : Brendon Scott Gourlay
Download or read book New Synthetic Approaches to Indolizidine and Pyrrolidine Alkaloids written by Brendon Scott Gourlay and published by . This book was released on 2010 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Methods for the Synthesis of Polyhydroxylated Pyrrolizidine and Indolizidine Alkaloids /cJamie Louise Brubaker by : Jamie Louise Brubaker
Download or read book Development of Methods for the Synthesis of Polyhydroxylated Pyrrolizidine and Indolizidine Alkaloids /cJamie Louise Brubaker written by Jamie Louise Brubaker and published by . This book was released on 2000 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Approaches to Polyhydroxy Indolizidine Alkaloids by : Tiberiu Simandan
Download or read book Synthetic Approaches to Polyhydroxy Indolizidine Alkaloids written by Tiberiu Simandan and published by . This book was released on 1995 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Routes to Indolizidine Alkaloids by : James David Cuthbertson
Download or read book New Routes to Indolizidine Alkaloids written by James David Cuthbertson and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Bioactive Indolizidine Alkaloids by : Angela S. J. Nelson
Download or read book Synthesis of Bioactive Indolizidine Alkaloids written by Angela S. J. Nelson and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis INTRAMOLECULAR CYCLOADDITIONS OF AZIDES WITH OLEFINS: SYNTHETIC APPROACHES TO PYRROLIZIDINE AND INDOLIZIDINE ALKALOIDS. by : JOHN PATRICK WILLIAMS
Download or read book INTRAMOLECULAR CYCLOADDITIONS OF AZIDES WITH OLEFINS: SYNTHETIC APPROACHES TO PYRROLIZIDINE AND INDOLIZIDINE ALKALOIDS. written by JOHN PATRICK WILLIAMS and published by . This book was released on 1991 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: followed by treatment with phenylsulfenyl chloride.
Book Synopsis Synthetic Approaches to the Duocarmycins and Amphibian Indolizidine Alkaloids by : Christiaan Wynand Van der Westhuyzen
Download or read book Synthetic Approaches to the Duocarmycins and Amphibian Indolizidine Alkaloids written by Christiaan Wynand Van der Westhuyzen and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Synthesis of Hydroxylated Indolizidine Alkaloids by : Yves St-Denis
Download or read book Studies Toward the Synthesis of Hydroxylated Indolizidine Alkaloids written by Yves St-Denis and published by . This book was released on 1991 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Finally, the regioselective and stereoselective introduction of hydroxyl groups into the pyrrolidine ring system was studied in order to prepare mono- and di-hydroxylated pyrrolidines for the synthesis of the aforementioned natural products." --
Book Synopsis Models for the Diastereoselective Synthesis of Indolizidine Alkaloids by : Rui Werner Macedo Krause
Download or read book Models for the Diastereoselective Synthesis of Indolizidine Alkaloids written by Rui Werner Macedo Krause and published by . This book was released on 2004 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Remote Dianions in the Synthesis of Indolizidine Alkaloids by : Diana Lee Conway Green
Download or read book Remote Dianions in the Synthesis of Indolizidine Alkaloids written by Diana Lee Conway Green and published by . This book was released on 1992 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: