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Synthesis And Characterization Of An Aromatic Polyanydride And Imide Containing Copolymers
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Book Synopsis Synthesis and Characterization of an Aromatic Polyanydride and Imide-containing Copolymers by : Christi R. Bedell
Download or read book Synthesis and Characterization of an Aromatic Polyanydride and Imide-containing Copolymers written by Christi R. Bedell and published by . This book was released on 1998 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Synthesis and Characterization of Polyanhydrides by : Brandon Michael Vogel
Download or read book The Synthesis and Characterization of Polyanhydrides written by Brandon Michael Vogel and published by . This book was released on 2004 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis is divided into four sections, all related to polyanhydride synthesis and characterization: first, the synthesis and characterization of polyethylene glycol containing aromatic polyanhydrides, second, the microwave polymerization of polyanhydrides, third the parallel synthesis and high-throughput dissolution screening, and finally preliminary investigations into the parallel investigation of blend phase behavior of a ternary polyanhydride blend. Oligomers of ethylene glycols were used to selectively modify the hydrophobicity of an aromatic polyanhydride. Aromatic diacids were synthesized from chlorinated triethylene and pentaethylene glycols and hydroxy benzoic acid. The diacids were acetylated with acetic anhydride to produce homopolymers of polyanhydrides for the stabilization of proteins and drugs. The glycol containing polyanhydrides were characterized by NMR, GPC, DSC and dissolution testing. The release characteristics of the new polyanhydrides were evaluated with a hydrophilic (Acid Orange) and hydrophobic dye (Rhodamine B Base) and the release mechanisms were investigated. Microwave radiation was used to explore the high throughput synthesis of polyanhydrides for materials library characterization. Aliphatic diacids were acetylated in situ for two minutes in a closed reaction vessel before removal of excess acetic anhydride and subsequent polymerization, all in the microwave. Reaction conditions such as acetic anhydride equivalents, duration of microwave exposure and comparision to conventional polycondensation were explored. Microwave polymerization times of 6 to 8 minutes yielded optimum number average molecular weights in contrast to conventional polycondensation, which took between 1.5 to 2 hours under high vacuum. A strategy was developed to synthesize copolymers of polyanhydrides using photolithographically generated microwells. The copolymers were characterized by NMR and spectroscopic FTIR as well as by parallel dissolution of a model dye from 25 copolymers using image analysis. Moreover, preliminary work was conducted on optical methods to investigate the phase behavior of a ternary blend of polyanhydrides in a parallel fashion. In conclusion, this thesis explored the synthesis and characterization of various polyanhydride-based homopolymers and copolymers by conventional as high-throughput techniques for controlled drug delivery applications.
Book Synopsis Preparation and Properties of Imide/pyrrone Copolymers by : Vernon Lee Bell
Download or read book Preparation and Properties of Imide/pyrrone Copolymers written by Vernon Lee Bell and published by . This book was released on 1969 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two series of copolymers containing imidazopyrrolone (Pyrrone) and imide groups were prepared by solution polymerization. The mechanical properties of thin films of the copolymers were measured and the films showed a general increase in the tangent modulus and a decrease in elongation with increasing Pyrrone content. The copolymers were more resistant to degradation by strong acids and bases than the corresponding polyimide. The thermal stabilities of the copolymers in air improved with increasing imide content, while the thermal stabilities in a vacuum improved with increasing pyrrone content. These copolymers represent a way to utilize the useful properties of each class of homopolymers.
Book Synopsis Synthesis and Characterization of Soluble, Melt-processible Aromatic Poly(amide-imides) by : Venkateshwaran N. Sekharipuram
Download or read book Synthesis and Characterization of Soluble, Melt-processible Aromatic Poly(amide-imides) written by Venkateshwaran N. Sekharipuram and published by . This book was released on 1994 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Polyanhydrides for Controlled Drug Delivery by : Brandon Michael Vogel
Download or read book Synthesis of Polyanhydrides for Controlled Drug Delivery written by Brandon Michael Vogel and published by . This book was released on 2003 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis is divided into three sections, all related to polyanhydride synthesis: first, attempts at the synthesis of polyanhydride-polyanhydride block copolymers, second, synthesis and characterization of polyethylene glycol containing aromatic polyanhydrides, and third, microwave polymerization of polyanhydrides. A strategy was developed to produce block copolymers of polyanhydrides using a hydroxyamide linker for the controlled release of proteins and higher molecular weight drugs. Block copolymers offer more control over micro structure than random copolymers, which allows for improved controlled release of proteins. The condensation polymerization of anhydrides typically yields random copolymers, therefore making the synthesis of block copolymers difficult. Methods of block copolymer synthesis explored consisted of end-functionalizing a short polyanhydride chain with hydroxylamine and ring opening polymerization through a macro-initiator. A discussion of the various methods explored is presented. Adding ethylene glycol segments to the monomers allows one to tailor the hydrophobicity of the polyanhydride, which in turn dictates the solubility of molecules within the polymer matrix and degradation rate of the polymer. Aromatic diacids were synthesized from chlorinated triethylene and pentaethylene glycols and hydroxy benzoic acid. The diacids were acetylated with acetic anhydride to produce homopolymers of polyanhydrides for the stabilization of proteins and drugs. The glycol containing polyanhydrides were characterized by NMR, GPC, DSC and dissolution testing. The release characteristics of the new polyanhydrides were evaluated with a hydrophilic (Acid Orange) and hydrophobic dye (Rhodamine B Base) and the release mechanisms were investigated. Microwave radiation was used to explore the high throughput synthesis of polyanhydrides for materials library characterization. Aliphatic diacids were acetylated in situ for two minutes in a closed reaction vessel before removal of excess acetic anhydride and subsequent polymerization, all in the microwave. Reaction conditions such as acetic anhydride equivalents, duration of microwave exposure and comparison to conventional polycondensation were explored. Microwave polymerization times of 6 to 8 minutes yielded optimum number average molecular weights in contrast to conventional polycondensation, which took between 1.5 to 2 hours under high vacuum. In conclusion, this thesis explored the synthesis and characterization of various polyanhydride-based homopolymers and copolymers by conventional as well as microwave techniques for controlled drug delivery applications.
Book Synopsis Synthesis and Characterization of Aromatic Substituted Polyactides by : Tara Simmons
Download or read book Synthesis and Characterization of Aromatic Substituted Polyactides written by Tara Simmons and published by . This book was released on 2000 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Characterization of Poly(imide-g-nylon 6) Copolymers as Novel Molecular Composites by : Yeong-Cheng Lee
Download or read book Synthesis and Characterization of Poly(imide-g-nylon 6) Copolymers as Novel Molecular Composites written by Yeong-Cheng Lee and published by . This book was released on 1996 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
