Synthesis And Anticancer Activity Of Water Soluble Porphyrin

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Synthesis and Anticancer Activity of Water Soluble Porphyrin

Author : Aaron David Lammer
Publisher :
ISBN 13 :
Total Pages : 46 pages
Book Rating : 4.:/5 (944 download)

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Book Synopsis Synthesis and Anticancer Activity of Water Soluble Porphyrin by : Aaron David Lammer

Download or read book Synthesis and Anticancer Activity of Water Soluble Porphyrin written by Aaron David Lammer and published by . This book was released on 2015 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: As resistance to traditional chemotherapies increases, there is a concurrent need for novel therapies. Much work has been devoted the development of gold(III) treatments, however much of this work has been hampered by the propensity of gold(III) to reduce to gold(I) under physiological conditions. Porphyrins have previously been used to stabilize reactive metals, due to being a strongly chelating multi-dentate ligand. Although this stabilization is offset by poor solubility in aqueous or physiological conditions. Synthesis of porphyrins with multiple hydroxyl substituents has greatly increased the aqueous solubility of the ligand, and any metals chelated to it. By combining this water soluble porphyrin with gold(III) was have synthesized novel gold(III) complex. In this work we report the synthesis and anticancer activity of this gold(III) complex.

Synthesis of a Novel Water-soluble Porphyrin Derivative for Use as a Potential Phototherapeutic Cancer Treatment

Author : Joseph Earl Bradshaw
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis Synthesis of a Novel Water-soluble Porphyrin Derivative for Use as a Potential Phototherapeutic Cancer Treatment by : Joseph Earl Bradshaw

Download or read book Synthesis of a Novel Water-soluble Porphyrin Derivative for Use as a Potential Phototherapeutic Cancer Treatment written by Joseph Earl Bradshaw and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic therapy (PDT) agents are light-activated materials used for localized disease treatment. Porphyrins are classic representations of photosensitive agents. Identified by their large, planar molecular structure, porphyrins are centrally composed of four pyrrole rings. Through this project, the starting material, H2TPPC, a tetra-carboxylic acid porphyrin, was first synthesized and later modified through the addition of the amine, morpholin-2-ylmethanol. This multi-step synthesis resulted in the highly water-soluble porphyrin product H2TPP-MorphMeOH. Following this synthesis, the compound was purified using liquid chromatography, and then structurally identified and classified using infrared (IR), nuclear magnetic resonance (NMR), and UV-Vis spectroscopies. Lastly, to determine its utility as a potential PDT agent, the cytotoxicity of H2TPP-MorphMeOH was determined using an MTT assay on MDA-MB-231 triple negative breast cancer cells comparing exposure and absence of white light.

Synthesis, Characterisation and Biological Activities of a Water-soluble C60-porphyrin Dyad

Author : Wallace Wing Ho Wong
Publisher :
ISBN 13 :
Total Pages : 186 pages
Book Rating : 4.:/5 (223 download)

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Book Synopsis Synthesis, Characterisation and Biological Activities of a Water-soluble C60-porphyrin Dyad by : Wallace Wing Ho Wong

Download or read book Synthesis, Characterisation and Biological Activities of a Water-soluble C60-porphyrin Dyad written by Wallace Wing Ho Wong and published by . This book was released on 2001 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Developing a New Water-soluble Porphyrin as a Potential Photodynamic Cancer Therapy Agent

Author : Catherine Shirley
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis Developing a New Water-soluble Porphyrin as a Potential Photodynamic Cancer Therapy Agent by : Catherine Shirley

Download or read book Developing a New Water-soluble Porphyrin as a Potential Photodynamic Cancer Therapy Agent written by Catherine Shirley and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic cancer therapy (PDT) is a type of treatment involving the use of light in conjunction with a photosensitive agent- a chemical or series of chemicals designed for activation when exposed to light. This research project investigated the synthesis and identification of the novel photosensitive agent, H2TPP-Pro-OH. To create the water-soluble porphyrin, (S)-(+)-prolinol was added to the tetra-carboxyl porphyrin, H2TPPC, to form the final H2TPP-Pro-OH product. This compound was then purified using syringe filtration and column chromatography, and subsequently characterized using infrared (IR), nuclear magnetic resonance (NMR), and UV-vis spectroscopies. Finally, the utility of the material as a PDT agent was determined by examining the cytotoxicity of the H2TPP-Pro-OH product was determined using MTT assay on MDA-MB-231 triple negative breast cancer cells comparing dark and light exposure.

Bericht über den Gründungskonvent des Kapitels des Kgl. Sächs. Mil. St.-Heinrichsordens in Bamberg

Author :
Publisher :
ISBN 13 :
Total Pages : 40 pages
Book Rating : 4.:/5 (634 download)

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Book Synopsis Bericht über den Gründungskonvent des Kapitels des Kgl. Sächs. Mil. St.-Heinrichsordens in Bamberg by :

Download or read book Bericht über den Gründungskonvent des Kapitels des Kgl. Sächs. Mil. St.-Heinrichsordens in Bamberg written by and published by . This book was released on 1960 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis and Characterization of a Water Soluble "picket Fence" Porphyrin

Download Synthesis and Characterization of a Water Soluble

Author : James Randolph Peacey
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Synthesis and Characterization of a Water Soluble "picket Fence" Porphyrin by : James Randolph Peacey

Download or read book Synthesis and Characterization of a Water Soluble "picket Fence" Porphyrin written by James Randolph Peacey and published by . This book was released on 1983 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis of Water-soluble Porphyrin-dendron Conjugates for Targeted Photodynamic Therapy

Author : Francesca Bryden
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Synthesis of Water-soluble Porphyrin-dendron Conjugates for Targeted Photodynamic Therapy by : Francesca Bryden

Download or read book Synthesis of Water-soluble Porphyrin-dendron Conjugates for Targeted Photodynamic Therapy written by Francesca Bryden and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Synthesis of a Water Soluble Porphyrin and the Mechanism of the Formation of Its Zinc Complex in Aqueous Solution

Author : Thomas Peter Stein
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis The Synthesis of a Water Soluble Porphyrin and the Mechanism of the Formation of Its Zinc Complex in Aqueous Solution by : Thomas Peter Stein

Download or read book The Synthesis of a Water Soluble Porphyrin and the Mechanism of the Formation of Its Zinc Complex in Aqueous Solution written by Thomas Peter Stein and published by . This book was released on 1967 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis, Characterisation and Biological Activities of Singly and Doubly Linked Water-soluble Porphyrin-fulleropyrrolidine Dyads

Download Synthesis, Characterisation and Biological Activities of Singly and Doubly Linked Water-soluble Porphyrin-fulleropyrrolidine Dyads PDF Online Free

Author : Devashish Sengupta
Publisher :
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.:/5 (225 download)

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Book Synopsis Synthesis, Characterisation and Biological Activities of Singly and Doubly Linked Water-soluble Porphyrin-fulleropyrrolidine Dyads by : Devashish Sengupta

Download or read book Synthesis, Characterisation and Biological Activities of Singly and Doubly Linked Water-soluble Porphyrin-fulleropyrrolidine Dyads written by Devashish Sengupta and published by . This book was released on 2006 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis of Unsymmetrical Core-modified Porphyrins

Author :
Publisher :
ISBN 13 :
Total Pages : 41 pages
Book Rating : 4.:/5 (664 download)

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Book Synopsis Synthesis of Unsymmetrical Core-modified Porphyrins by :

Download or read book Synthesis of Unsymmetrical Core-modified Porphyrins written by and published by . This book was released on 2005 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water-soluble core-modified porphyrins have been designed as photosensitizers for the use in Photodynamic Therapy, a cancer treatment regime introduced over 100 years ago. These photosensitizers are recognized by the substitution in the porphyrin chromophore with different chalcogens, providing longer wavelengths. Substitutions at the meso - positions of the chromophore, however, have shown to correlate to the solubility of the molecule. Dicarboxylic and monocarboxylic acid derivatives have been reported as potent photosensitizers, where the dicarboxylic acid has been furthered investigated with varying substituents located at the other meso - positions. These studies showed that the symmetrical dicarboxylic acid molecules were prone to aggregate in polar solvents, believed to lead to low cellular uptake or a false positive activity result in the tumor cells. The following chapters will discuss background work leading to the design and synthesis of unsymmetrical core-modified porphyrins as photosensitizers. The major impetus in the design of these compounds is to examine (1) whether the unsymmetrical structures would have a positive effect on the aggregation issues observed with the dicarboxylic acid derivatives, and (2) whether increasing the log P values would affect the cellular uptake significantly. The major isomer of 20(4- tert -butylphenyl)-5,10-diphenyl-15-(4-methoxy)phenyl-21,23-dithiaporphyrin was successfully isolated and identified as the cis -isomer by X-ray crystallography.

Developing a New Water-soluble Porphyrin as a Potential Phtodynamic Cancer Therapy Agent

Author : Catherine Shirley
Publisher :
ISBN 13 :
Total Pages : 58 pages
Book Rating : 4.:/5 (119 download)

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Book Synopsis Developing a New Water-soluble Porphyrin as a Potential Phtodynamic Cancer Therapy Agent by : Catherine Shirley

Download or read book Developing a New Water-soluble Porphyrin as a Potential Phtodynamic Cancer Therapy Agent written by Catherine Shirley and published by . This book was released on 2020 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Photosensitizers in Medicine, Environment, and Security

Author : Tebello Nyokong
Publisher : Springer Science & Business Media
ISBN 13 : 9048138728
Total Pages : 672 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Photosensitizers in Medicine, Environment, and Security by : Tebello Nyokong

Download or read book Photosensitizers in Medicine, Environment, and Security written by Tebello Nyokong and published by Springer Science & Business Media. This book was released on 2012-01-02 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the synthesis of photosensitizers, the main emphasis being on the new methods of synthesis such as microwave, sonochemistry and the use of ionic liquids. It also addresses the photochemistry and photophysics of the photosensitizers alone and in combination with nanoparticles, the use of the photosensitizers in environmental control, safety and medicine. It discusses the common structures of the photosensitizers which are beneficial to these applications.

Porphyrin Science by Women (in 3 Volumes)

Author : Fabienne Dumoulin
Publisher : World Scientific Publishing Company
ISBN 13 : 9789811223549
Total Pages : 0 pages
Book Rating : 4.2/5 (235 download)

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Book Synopsis Porphyrin Science by Women (in 3 Volumes) by : Fabienne Dumoulin

Download or read book Porphyrin Science by Women (in 3 Volumes) written by Fabienne Dumoulin and published by World Scientific Publishing Company. This book was released on 2021-01-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a reprint three volume set with a thematic organization of the articles of the four Women in Porphyrin Science special issues published in the Journal of Porphyrins and Phthalocyanines in 2019. All the articles were carefully arranged by the volume editors and Karl Kadish, the Journal of Porphyrins and Phthalocyanines Editor-in-Chief, in order to provide a comprehensive coverage of each topic. Volume 1 covers the biomedical aspects, applications and uses of BODIPY's, porphyrins, phthalocyanines and related derivatives, mainly for photodynamic therapy. Volume 2 covers the synthesis, characteristics and properties of these compounds, while Volume 3 is on topics related to materials, sensors, energy and catalysis. These state-of-the-art articles are contributed by women. This book will strongly contribute to the visibility of women in the field of porphyrin science.

Photophysics and Nanophysics in Therapeutics

Author : Nilesh M. Mahajan
Publisher : Elsevier
ISBN 13 : 0323885683
Total Pages : 478 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Photophysics and Nanophysics in Therapeutics by : Nilesh M. Mahajan

Download or read book Photophysics and Nanophysics in Therapeutics written by Nilesh M. Mahajan and published by Elsevier. This book was released on 2022-04-29 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photophysics and Nanophysics in Therapeutics explores the latest advances and applications of phototherapy and nanotherapy, covering the application of light, radiation, and nanotechnology in therapeutics, along with the fundamental principles of physics in these areas. Consisting of two parts, the book first features a range of chapters covering phototherapeutics, from the fundamentals of photodynamic therapy (PDT) to applications such as cancer treatment and advances in radiotherapy, applied physics in cancer radiotherapy treatment, and the role of carbon ion beam therapy. Other sections cover nanotherapeutics, potential applications and challenges, and nanotherapy for drug delivery to the brain. Final chapters delve into nanotechnology in the diagnosis and treatment of cancers, the role of nanocarriers for HIV treatment, nanoparticles for rheumatoid arthritis treatment, peptide functionalized nanomaterials as microbial sensors, and theranostic nanoagents. Evaluates the latest developments in the fields of phototherapy and nanotherapy Investigates the fundamental physics behind these technologies Explores therapeutic applications across a range of diseases, such as skin disorders, cancer, and neurological conditions Includes case studies that illustrate research in practice Considers challenges and future perspectives

Encapsulation Technologies for Active Food Ingredients and Food Processing

Author : N.J. Zuidam
Publisher : Springer Science & Business Media
ISBN 13 : 1441910085
Total Pages : 402 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Encapsulation Technologies for Active Food Ingredients and Food Processing by : N.J. Zuidam

Download or read book Encapsulation Technologies for Active Food Ingredients and Food Processing written by N.J. Zuidam and published by Springer Science & Business Media. This book was released on 2009-10-30 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consumers prefer food products that are tasty, healthy, and convenient. Encapsulation is an important way to meet these demands by delivering food ingredients at the right time and right place. For example, encapsulates may allow flavor retention, mask bad tasting or bad smelling components, stabilize food ingredients, and increase their bioavailability. Encapsulation may also be used to immobilize cells or enzymes in the production of food materials or products, such as fermentation or metabolite production. This book provides a detailed overview of the encapsulation technologies available for use in food products, food processing, and food production. The book aims to inform those who work in academia or R&D about both the delivery of food compounds via encapsulation and food processing using immobilized cells or enzymes. The structure of the book is according to the use of encapsulates for a specific application. Emphasis is placed on strategy, since encapsulation technologies may change. Most chapters include application possibilities of the encapsulation technologies in specific food products or processes. The first part of the book reviews general technologies, food-grade materials, and characterization methods for encapsulates. The second part discusses encapsulates of active ingredients (e.g., aroma, fish oil, minerals, vitamins, peptides, proteins, probiotics) for specific food applications. The last part describes immobilization technologies of cells and enzymes for use within food fermentation processes (e.g., beer, wine, dairy, meat), and food production (e.g., sugar conversion, production of organic acids or amino acids, hydrolysis of triglycerides). Edited by two leading experts in the field, Encapsulation Technologies for Food Active Ingredients and Food Processing will be a valuable reference source for those working in the academia or food industry. The editors work in both industry or academia, and they have brought together in this book contributions from both fields.

The Golden Future in Medicinal Chemistry: Perspectives and Resources from Old and New Gold-Based Drug Candidates

Author : Alessandro Pratesi
Publisher : Frontiers Media SA
ISBN 13 : 2889667510
Total Pages : 84 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis The Golden Future in Medicinal Chemistry: Perspectives and Resources from Old and New Gold-Based Drug Candidates by : Alessandro Pratesi

Download or read book The Golden Future in Medicinal Chemistry: Perspectives and Resources from Old and New Gold-Based Drug Candidates written by Alessandro Pratesi and published by Frontiers Media SA. This book was released on 2021-05-10 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Melanoma

Author : Guy Huynh Thien Duc
Publisher : BoD – Books on Demand
ISBN 13 : 9535109618
Total Pages : 734 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Melanoma by : Guy Huynh Thien Duc

Download or read book Melanoma written by Guy Huynh Thien Duc and published by BoD – Books on Demand. This book was released on 2013-01-30 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Book "Melanoma - From Early Detection To Treatment" is aiming to present data and knowledge from most experienced experts in the field. The book covers main topics from the fundamental aspects to multiple approaches in the disease treatment as well as related features. It offers a global view concerning one of the most frequent types of cancer to which a substantial high proportion of people worldwide is confronted at some time point in life.