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Synthese Et Caracterisation De Complexes De Gdiii Pour Limagerie Medicale Par Resonance Magnetique
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Book Synopsis Synthèse et caractérisation de complexes de GD(III) pour l'imagerie médicale par résonance magnétique by : Laurent Québatte
Download or read book Synthèse et caractérisation de complexes de GD(III) pour l'imagerie médicale par résonance magnétique written by Laurent Québatte and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthèse et caractérisation de sondes bimodales pour l'IRM et l'imagerie optique by : Fabien Caillé
Download or read book Synthèse et caractérisation de sondes bimodales pour l'IRM et l'imagerie optique written by Fabien Caillé and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'Imagerie par Résonance Magnétique (IRM) offre une excellente résolution à l'échelle macroscopique alors que l'imagerie optique lui est parfaitement complémentaire car elle dispose d'une haute résolution à l'échelle microscopique ainsi que d'une forte sensibilité. Les complexes de gadolinium(III) ont déjà prouvé leur efficacité en tant qu'agents de contraste IRM et d'autres lanthanides luminescents émettant dans le proche infrarouge conviennent pour l'imagerie optique. Des complexes de lanthanides bishydratés à motif pyridine montrant des résultats très prometteurs pour les deux types d'imagerie ont été développés précédemment au laboratoire. Afin d'améliorer leurs propriétés optiques, des ligands à motifs isoquinoléines ont été synthétisés. Leurs complexes de lanthanides montrent des propriétés magnétiques prometteuses et des constantes thermodynamiques qui démontrent leur faible toxicité in vitro. La longueur d'onde d'excitation et les rendements quantiques des complexes d'Yb3+ et de Nd3+ ont été augmentés pour permettre d'obtenir des images de luminescence et d'envisager des applications in vivo.Afin d'améliorer davantage ces propriétés optiques, la synthèse de ligands à motif 2-azaanthraquinone a été entreprise mais l'instabilité chimique de ces molécules n'a pas permis d'isoler les ligands désirés.Cette approche bimodale a été appliquée à la conception de sondes sensibles au zinc. La synthèse de complexes de Gd3+ à motifs pyridines adaptés permet une detection relaxométrique qualitative et sélective de ce cation. Cependant, l'absence de variation du nombre d'hydratation ne permet pas la détection par luminescence. De légères modifications chimiques sur les ligands devraient permettre d'atteindre cet objectif.
Book Synopsis Développement de nouveaux agents de contraste pour l'IRM à base de [beta]- et [alpha]-cyclodextrines régio-fonctionnalisées par des ligands pyridino-carboxylate et -phosphonate by : Celia Sappei
Download or read book Développement de nouveaux agents de contraste pour l'IRM à base de [beta]- et [alpha]-cyclodextrines régio-fonctionnalisées par des ligands pyridino-carboxylate et -phosphonate written by Celia Sappei and published by . This book was released on 2018 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'Imagerie par Résonance Magnétique est une technique d'imagerie possédant une des plus hautes résolutions d'images, utilisée pour le diagnostic clinique et en recherche. Cependant cette technique souffre d'une faible sensibilité intrinsèque due au faible contraste naturel entre les différents tissus. Pour pallier à cette limitation, des agents de contraste, principalement des complexes de Gd(III), sont actuellement utilisés et continus d'être développés. Ce projet de thèse s'inscrit dans la volonté de concevoir de nouveaux agents de contrastes plus efficaces et plus stables en utilisant la [beta]- et l'[alpha]-cyclodextrines (CD) comme plateforme capables d'intégrer trois ou quatre fonctions pyridine-carboxylates ou pyridine-phosphonates, connues pour leur pouvoir chélatant du Gd(III). La première partie des travaux concerne les aménagements fonctionnels des CDs afin de pouvoir les fonctionnaliser régiosélectivement avec des bras chélatants du Gd(III) de types pyridino-carboxylate et pyridino-phosphonate. La deuxième partie traite de la caractérisation physico-chimique des nouveaux systèmes complexes Gd-ligands synthétisés (Gd-L[alpha] et Gd-L[beta]). Les principales propriétés caractérisant les agents de contraste ont été mesurées. Ainsi, de très bonne relaxivités ont été obtenue (25 mM-1s-1
Book Synopsis Complexes d'ions Lanthanide(III) dérivés de ligands à motifs polyaminocarboxylique by : Isabelle Nasso
Download or read book Complexes d'ions Lanthanide(III) dérivés de ligands à motifs polyaminocarboxylique written by Isabelle Nasso and published by . This book was released on 2006 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'intérêt des complexes organiques de gadolinium(III) comme agents de contraste en Imagerie par Résonance Magnétique (IRM) n'est plus à démontrer. D'autre part, la longue durée de vie de luminescence de certains complexes de lanthanides (Eu(III) et Tb(III)) peut être exploitée dans de nombreux domaines (biologie, diagnostic médical, microscopie, imagerie de fluorescence). Dans ce contexte et en tenant compte des paramètres requis pour ces deux applications, nous avons conçu et synthétisé des ligands bivalents, c'est-à-dire des ligands dont le complexe de Gd(III) est actif en IRM et dont les complexes Eu(III) et Tb(III) sont luminescents. Ces ligands hepta ou octadentés présentent une structure acyclique ou macrocyclique et intégrant un chromophore dérivé de la pyridine.L'étude des propriétés de luminescence des complexes Eu3+ et Tb3+ révèle pour certains des rendements quantiques particulièrement élevés (jusqu'à 49%) et des durées de vie de luminescence supérieures à 0,56 ms. Les propriétés relaxométriques (relaxivité, temps d'échange de la molécule d'eau) de certains de nos complexes de gadolinium(III) sont comparables à celles du Gd-DTPA, le composé utilisé en clinique.
Book Synopsis Synthèse de nouveaux agents de contraste pour de l'imagerie par résonance magnétique (IRM) by : Goeffroy Sir
Download or read book Synthèse de nouveaux agents de contraste pour de l'imagerie par résonance magnétique (IRM) written by Goeffroy Sir and published by . This book was released on 2005 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Contrast Agents for MRI by : Valérie C Pierre
Download or read book Contrast Agents for MRI written by Valérie C Pierre and published by Royal Society of Chemistry. This book was released on 2017-11-09 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a practical reference guide for designing and performing experiments, this book focuses on the five most common classes of contrast agents for MRI namely gadolinium complexes, chemical exchange saturation transfer agents, iron oxide nanoparticles, manganese complexes and fluorine contrast agents. It describes how to characterize and evaluate them and for each class, a description of the theory behind their mechanisms is discussed briefly to orient the new reader. Detailed subchapters discuss the different physical chemistry methods used to characterize them in terms of their efficacy, safety and in vivo behavior. Important consideration is also given to the different physical properties that affect the performance of the contrast agents. The editors and contributors are at the forefront of research in the field of MRI contrast agents and this unique, cutting edge book is a timely addition to the literature in this area.
Book Synopsis MRI Contrast Agents by : Sophie Laurent
Download or read book MRI Contrast Agents written by Sophie Laurent and published by Springer. This book was released on 2016-11-03 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc.
Book Synopsis Nanotheranostics For Personalized Medicine by : Patrick Couvreur
Download or read book Nanotheranostics For Personalized Medicine written by Patrick Couvreur and published by World Scientific. This book was released on 2016-02-22 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome.Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine.This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field.
Book Synopsis Iron Oxide Nanoparticles for Biomedical Applications by : Sophie Laurent
Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine.
Book Synopsis Magnetic Nanoparticles in Human Health and Medicine by : Costica Caizer
Download or read book Magnetic Nanoparticles in Human Health and Medicine written by Costica Caizer and published by John Wiley & Sons. This book was released on 2021-09-08 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.
Book Synopsis Field-cycling NMR Relaxometry by : Rainer Kimmich
Download or read book Field-cycling NMR Relaxometry written by Rainer Kimmich and published by Royal Society of Chemistry. This book was released on 2018-10-11 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Field-cycling NMR relaxometry is evolving into a methodology of widespread interest with recent technological developments resulting in powerful and versatile commercial instruments. Polymers, liquid crystals, biomaterials, porous media, tissue, cement and many other materials of practical importance can be studied using this technique. This book summarises the expertise of leading scientists in the area and the editor is well placed, after four decades of working in this field, to ensure a broad ranging and high quality title. Starting with an overview of the basic principles of the technique and the scope of its use, the content then develops to look at theory, instrumentation, practical limitations and applications in different systems. Newcomers to the field will find this book invaluable for successful use of the technique. Researchers already in academic and industrial settings, interested in molecular dynamics and magnetic resonance, will discover an important addition to the literature.
Book Synopsis Clinical Applications of Magnetic Nanoparticles by : Nguyen TK Thanh
Download or read book Clinical Applications of Magnetic Nanoparticles written by Nguyen TK Thanh and published by CRC Press. This book was released on 2018-02-06 with total page 1137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.
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