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Synaptic Vesicles Studied By Small Angle X Ray Scattering
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Book Synopsis Synaptic Vesicles Studied by Small-angle X-ray Scattering by : Simon Castorph
Download or read book Synaptic Vesicles Studied by Small-angle X-ray Scattering written by Simon Castorph and published by Universitätsverlag Göttingen. This book was released on 2012 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The heterogeneous structure of synaptic vesicles isolated from rat brain is investigated considering solution small-angle x-ray scattering data in combination with data obtained by cryogenic electron microscopy, dynamic light scattering and biochemical analysis. Overall low resolution structural models of the entire functional synaptic vesicle are proposed, elucidating details on the density profile of the membrane, including contributions from the lipids and the proteins, as well as addressing the average conformation and overall lateral organization of proteins in micro-domains on the average synaptic vesicle under quasi-physiological conditions. Entropic contributions to free energy due to possible protein cluster formation and disintegration on the synaptic vesicle are investigated. Further, cell free fusion systems are characterized employing dynamic light scattering and applicability of small-angle x-ray scattering is considered for investigating membrane fusion processes."--Open Textbook Library.
Book Synopsis Synaptic Vesicles Studied by Small-angle X-ray Scattering by : Simon Johannes Castorph
Download or read book Synaptic Vesicles Studied by Small-angle X-ray Scattering written by Simon Johannes Castorph and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synaptic vesicles studied by small-angle x-ray scattering by : Simon Castorph
Download or read book Synaptic vesicles studied by small-angle x-ray scattering written by Simon Castorph and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The heterogeneous structure of synaptic vesicles isolated from rat brain is investigated considering solution small-angle x-ray scattering data in combination with data obtained by cryogenic electron microscopy, dynamic light scattering and biochemical analysis. Overall low resolution structural models of the entire functional synaptic vesicle are proposed, elucidating details on the density profi le of the membrane, including contributions from the lipids and the proteins, as well as addressing the average conformation and overall lateral organization of proteins in micro-domains on the average synaptic vesicle under quasi-physiological conditions. Entropic contributions to free energy due to possible protein cluster formation and disintegration on the synaptic vesicle are investigated. Further, cell free fusion systems are characterized employing dynamic light scattering and applicability of small-angle x-ray scattering is considered for investigating membrane fusion processes.
Book Synopsis Vesicle Adhesion, Fusion, and Neurotransmitter Uptake Studied by Small-Angle X-ray Scattering by : Karlo Komorowski
Download or read book Vesicle Adhesion, Fusion, and Neurotransmitter Uptake Studied by Small-Angle X-ray Scattering written by Karlo Komorowski and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Synaptic neurotransmission is a highly complex and crucial process in the communication between neuronal cells, and is thus directly related to the complex functions of the neural system, including information processing in the brain, sensory reactions, and learning. The last decades have considerably shaped our current understanding of the underlying processes in synaptic neurotransmission on the molecular level, and up to the level of the entire synapse. X-ray crystallography and more recently also cryo-electron microscopy have provided the structural basis to elucidate the function of ma...
Book Synopsis Characterization of Biological Membranes by : Mu-Ping Nieh
Download or read book Characterization of Biological Membranes written by Mu-Ping Nieh and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-07-22 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of membranes has become of high importance in the fields of biology, pharmaceutical chemistry and medicine, since much of what happens in a cell or in a virus involves biological membranes. The current book is an excellent introduction to the area, which explains how modern analytical methods can be applied to study biological membranes and membrane proteins and the bioprocesses they are involved to.
Book Synopsis Stalk Structures in Lipid Bilayer Fusion Studied by X-ray Diffraction by : Sebastian Aeffner
Download or read book Stalk Structures in Lipid Bilayer Fusion Studied by X-ray Diffraction written by Sebastian Aeffner and published by Universitätsverlag Göttingen. This book was released on 2012 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fusion of two biological membranes is an important step in many processes on the cellular and sub-cellular level. Understanding the involved interplay of different lipid species, a specialized protein machinery and water on length scales of few nanometers poses a significant challenge to current structural biology. Among several complementary approaches, one strategy is to study the structural rearrangements of the lipid matrix. As the initial step, lipid bilayers must be forced into close contact to form a non-bilayer intermediate termed a stalk. This has been the subject of numerous theoretical studies and simulations, but experimental data on stalks are largely lacking. Currently, the only way to obtain structural information at the required sub-nanometer resolution is x-ray diffraction on the recently discovered stalk phaseʺ formed by certain lipids. We apply this method to elucidate the effect of lipid composition on stalk geometry and the repulsive forces between lipid bilayers prior to stalk formation. An approach based on differential geometry of electron density isosurfaces is introduced to analyze the curvatures and bending energies of the lipid monolayers. For the first time, this connects experiment-based structures of stalks and the associated bending and hydration energies. In addition, this thesis aims to provide a self-contained introduction to the required background in x-ray diffraction on lipid mesophases and electron density reconstruction.
Book Synopsis Handbook of Lipid Membranes by : Cyrus R. Safinya
Download or read book Handbook of Lipid Membranes written by Cyrus R. Safinya and published by CRC Press. This book was released on 2021-09-14 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a unique overview of lipid membrane fundamentals and applications. The fascinating world of lipids that harbor and govern so many biological functionalities are discussed within the context of membrane structures, interactions, and shape evolution. Beyond the fundamentals in lipid science, this handbook focuses on how scientists are building bioinspired biomimetic systems for applications in medicine, cosmetics, and nanotechnology. Key Features: Includes experimental and theoretical overviews on the role of lipids, with or without associated biomolecules, as structural components imparting distinct membrane shapes and intermembrane interactions Covers the mechanisms of lipid-membrane curvature, by peptide and protein binding, and the roles of signalling lipids and the cytoskeleton in plasma membrane shape evolution Covers advanced X-ray and force measurement techniques Discusses applications in biomedicine, cosmetics, and nanotechnology, including lipid vectors in nucleic acid, drug delivery in dermal applications, and lipid-based sensors and artificial biointerfaces Covers artificial membranes from block copolymers, synthetic copolypeptides, and recombinant proteins Includes an exciting section that explores the role of lipids in the origin of life in hydrothermal conditions This book is a highly informative companion for professionals in biophysics, biochemistry, physical chemistry, and material and pharmaceutical sciences and bioengineering.
Book Synopsis Issues in Biophysics and Geophysics Research and Application: 2011 Edition by :
Download or read book Issues in Biophysics and Geophysics Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Biophysics and Geophysics Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biophysics and Geophysics Research and Application. The editors have built Issues in Biophysics and Geophysics Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biophysics and Geophysics Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biophysics and Geophysics Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis X-Ray Diffraction by : Oliver H. Seeck
Download or read book X-Ray Diffraction written by Oliver H. Seeck and published by CRC Press. This book was released on 2015-02-10 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-resolution x-ray diffraction and scattering is a key tool for structure analysis not only in bulk materials but also at surfaces and buried interfaces from the sub-nanometer range to micrometers. This book offers an overview of diffraction and scattering methods currently available at modern synchrotron sources and illustrates bulk and interface investigations of solid and liquid matter with up-to-date research examples. It presents important characteristics of the sources, experimental set-up, and new detector developments. The book also considers future exploitation of x-ray free electron lasers for diffraction applications.
Book Synopsis Introduction to Proteins by : Amit Kessel
Download or read book Introduction to Proteins written by Amit Kessel and published by CRC Press. This book was released on 2018-03-22 with total page 985 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels. The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercises, and References. New features in the thoroughly-updated second edition include: A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale description of biochemical and biophysical methods for studying proteins, including fully accessible internet-based resources, such as databases and algorithms Animations of protein dynamics and conformational changes, accessible via embedded QR codes Additional features Extensive discussion of the energetics of protein folding, stability and interactions A comprehensive view of membrane proteins, with emphasis on structure-function relationship Coverage of intrinsically unstructured proteins, providing a complete, realistic view of the proteome and its underlying functions Exploration of industrial applications of protein engineering and rational drug design Each chapter includes a Summary, Exercies, and References Approximately 300 color images Downloadable solutions manual available at www.crcpress.com For more information, including all presentations, tables, animations, and exercises, as well as a complete teaching course on proteins' structure and function, please visit the author's website. Praise for the first edition "This book captures, in a very accessible way, a growing body of literature on the structure, function and motion of proteins. This is a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers, and instructors involved in structural biology or biophysics courses or in research on protein structure-function relationships." --David Sheehan, ChemBioChem, 2011 "Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. This is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper-level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, 2012
Book Synopsis Biomembrane Vesicles: Scientific, Clinical and Technological Considerations by :
Download or read book Biomembrane Vesicles: Scientific, Clinical and Technological Considerations written by and published by Academic Press. This book was released on 2020-11-19 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations, Part 1 Volume 32 in the Advances in Biomembranes and Lipid Self-Assembly series, highlights new advances in the field, with this release presenting chapters written by an international board of authors. Topics in this new release include Amyloid ß-peptide interaction with GM1 containing model membrane, The Human EV Membranome, Protocol for isolation of Microvesicles form blood plasma, Urinary Extracellular Vesicles: Single patient analysis for clinical applications, Treatment of chronic wounds with platelet and extracellular vesicles enriched plasma, Liposome loading and imaging, Standardization and reproducibility in EV research: the support of a Quality management system, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Biomembranes and Lipid Self-Assembly series Updated release includes the latest information on the Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations
Book Synopsis Lipid-Protein Mesophases and Cell Organelle Ultrastructure in Health and Disease by : Yuru Deng
Download or read book Lipid-Protein Mesophases and Cell Organelle Ultrastructure in Health and Disease written by Yuru Deng and published by Frontiers Media SA. This book was released on 2021-11-29 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biological Soft Matter by : Corinne Nardin
Download or read book Biological Soft Matter written by Corinne Nardin and published by John Wiley & Sons. This book was released on 2021-03-18 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore a comprehensive, one-stop reference on biological soft matter written and edited by leading voices in the field Biological Soft Matter: Fundamentals, Properties and Applications delivers a unique and indispensable compilation of up-to-date knowledge and material on biological soft matter. The book presents a thorough overview about biological soft matter, beginning with different substance classes, including proteins, nucleic acids, lipids, and polysaccharides. It goes on to describe a variety of superstructures and aggregated and how they are formed by self-assembly processes like protein folding or crystallization. The distinguished editors have included materials with a special emphasis on macromolecular assembly, including how it applies to lipid membranes, DNA condensation, and DNA fibrillization. Biological Soft Matter is a crucial resource for anyone working in the field, compiling information about all important substance classes and their respective roles in forming superstructures. The book is ideal for beginners and experts alike and makes the perfect guide for chemists, physicists, and life scientists with an interest in the area. Readers will also benefit from the inclusion of: An introduction to DNA nano-engineering and DNA-driven nanoparticle assembly Explorations of polysaccharides and glycoproteins, engineered biopolymers, and engineered hydrogels Discussions of macromolecular assemblies, including liquid membranes and small molecule inhibitors for amyloid aggregation A treatment of inorganic nanomaterials as promoters and inhibitors of amyloid fibril formation An examination of a wide variety of natural and artificial polymers Perfect for materials scientists, biochemists, polymer chemists, and protein chemists, Biological Soft Matter: Fundamentals, Properties and Applications will also earn a place in the libraries of biophysicists and physical chemists seeking a one-stop reference summarizing the rapidly evolving topic of biological soft matter.
Book Synopsis Cellular Nanomachines by : Bhanu P. Jena
Download or read book Cellular Nanomachines written by Bhanu P. Jena and published by Springer Nature. This book was released on 2020-04-29 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them. The major focus of this book is the “porosome” nanomachine, the universal secretory portal in cells. This is an ideal book for students, researchers, and professionals in the fields of nanoscience and nanotechnology.
Book Synopsis Proteins—Advances in Research and Application: 2012 Edition by :
Download or read book Proteins—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 3385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Proteins. The editors have built Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Comprehensive Biophysics written by and published by Academic Press. This book was released on 2012-04-12 with total page 3533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource
Book Synopsis Introduction to Condensed Matter Chemistry by : Jihong Yu
Download or read book Introduction to Condensed Matter Chemistry written by Jihong Yu and published by Elsevier. This book was released on 2024-06-10 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Condensed Matter Chemistry offers a general view of chemistry from the perspective of condensed matter chemistry, analyzing and contrasting chemical reactions in a more realistic setting than traditional thinking. Readers will also find discussions on the goals and major scientific questions in condensed matter chemistry and the molecular engineering of functional condensed matter. Processes and products of chemical reactions should not be determined solely by the structure and composition of these basic species but also by the complex and possibly multilevel structured physical and chemical environment, together referred to as their condensed state. Relevant matters in condensed state should be the main bodies of chemical reactions, which is applicable not only to solids and liquids but also to gas molecules as reactions among gas molecules can take place only in the presence of catalysts in specific condensed states or after their state transition under extreme reaction conditions. This book provides new insights on the liquid state chemistry, definitions, aspects, and interactions, summarizing fundamentals of main chemical reactions from a new perspective. Helps to establish the new field of Condensed Matter Chemistry Highlights the molecular engineering of functional condensed matter Focuses on both liquid and solid state chemistry