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Author : Petra Jeannette Maria van Gurp
Publisher :
ISBN 13 : 9789090223124
Total Pages : 168 pages
Book Rating : 4.2/5 (231 download)
Download or read book Sympathetic Nervous System Activity and Diabetes Mellitus written by Petra Jeannette Maria van Gurp and published by . This book was released on 2007 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Aristidis Veves
Publisher : Springer Science & Business Media
ISBN 13 : 1597453110
Total Pages : 520 pages
Book Rating : 4.5/5 (974 download)
Download or read book Diabetic Neuropathy written by Aristidis Veves and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this updated edition, leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. The contributors focus on the practical aspects of diabetic neuropathy and describe in detail the treatments that are currently available or expected to become available in the near future. They also include concise discussions of the pathogenesis of diabetic neuropathy.
Author : Aaron I. Vinik
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128079967
Total Pages : 43 pages
Book Rating : 4.1/5 (28 download)
Download or read book Autonomic Nervous System written by Aaron I. Vinik and published by Elsevier Inc. Chapters. This book was released on 2013-11-11 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autonomic neuropathy, once considered to be the Cinderella of diabetes complications, has come of age. The autonomic nervous system innervates the entire human body, and is involved in the regulation of every single organ in the body. Thus, perturbations in autonomic function account for everything from abnormalities in pupillary function to gastroparesis, intestinal dysmotility, diabetic diarrhea, genitourinary dysfunction, amongst others. “Know autonomic function and one knows the whole of medicine!” It is now becoming apparent that before the advent of severe pathological damage to the autonomic nervous system there may be an imbalance between the two major arms, namely the sympathetic and parasympathetic nerve fibers that innervate the heart and blood vessels, resulting in abnormalities in heart rate control and vascular dynamics. Cardiac autonomic neuropathy (CAN) has been linked to resting tachycardia, postural hypotension, orthostatic bradycardia and orthostatic tachycardia (POTTS), exercise intolerance, decreased hypoxia-induced respiratory drive, loss of baroreceptor sensitivity, enhanced intraoperative or perioperative cardiovascular lability, increased incidence of asymptomatic ischemia, myocardial infarction, and decreased rate of survival after myocardial infarction and congestive heart failure. Autonomic dysfunction can affect daily activities of individuals with diabetes and may invoke potentially life-threatening outcomes. Intensification of glycemic control in the presence of autonomic dysfunction (more so if combined with peripheral neuropathy) increases the likelihood of sudden death and is a caveat for aggressive glycemic control. Advances in technology, built on decades of research and clinical testing, now make it possible to objectively identify early stages of CAN with the use of careful measurement of time and frequency domain analyses of autonomic function. Fifteen studies using different end points report prevalence rates of 1% to 90%. CAN may be present at diagnosis, and prevalence increases with age, duration of diabetes, obesity, smoking, and poor glycemic control. CAN also cosegregates with distal symmetric polyneuropathy, microangiopathy, and macroangiopathy. It now appears that autonomic imbalance may precede the development of the inflammatory cascade in type 2 diabetes and there is a role for central loss of dopaminergic restraint on sympathetic overactivity. Restoration of dopaminergic tone suppresses the sympathetic dominance and reduces cardiovascular events and mortality by close to 50%. Cinderella’s slipper can now be worn!
Author : Philip E. Cryer
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128079975
Total Pages : 35 pages
Book Rating : 4.1/5 (28 download)
Download or read book Autonomic Nervous System written by Philip E. Cryer and published by Elsevier Inc. Chapters. This book was released on 2013-11-11 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent antecedent hypoglycemia, as well as sleep or prior exercise, causes both defective glucose counterregulation (by attenuating the adrenomedullary epinephrine response, in the setting of absent insulin and glucagon responses) and hypoglycemia unawareness (by attenuating the sympathoadrenal, largely the sympathetic neural, response) and thus a vicious cycle of recurrent hypoglycemia. Albeit with different time courses, the pathophysiology of defense against hypoglycemia – no decrease in therapeutic insulin, no increase in glucagon and an attenuated increase in sympathoadrenal activity – is the same in type 1 diabetes and advanced type 2 diabetes. Hypoglycemia unawareness is reversible by 2–3 weeks of scrupulous avoidance of hypoglycemia in most affected patients. The pathophysiology of HAAF in diabetes explains why the incidence of hypoglycemia increases as patients approach the absolute endogenous insulin deficient end of the disease, provides a comprehensive set of risk factors including those indicative of HAAF, and leads logically to the practice of hypoglycemia risk factor reduction. Because of the risk of hypoglycemic mortality, presumably from cardiac arrhythmias, glycemic goals in diabetes should be individualized, based in part on the risk of hypoglycemia. By practicing hypoglycemia risk reduction – addressing the issue, applying the principles of aggressive glycemic therapy and considering both the conventional risk factors and those indicative of HAAF – it is possible to both improve glycemic control and reduce the risk of hypoglycemia in many patients with diabetes.
Author : Francesco Amenta
Publisher : CRC Press
ISBN 13 : 9780849369810
Total Pages : 392 pages
Book Rating : 4.3/5 (698 download)
Download or read book Aging of the Autonomic Nervous System written by Francesco Amenta and published by CRC Press. This book was released on 1993-06-16 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging of the Autonomic Nervous System is the first book devoted to the aging of the autonomic nervous system. The book presents the most recent findings on topics such as general aspects of the autonomic nervous system, main neurotransmitter systems, age-dependent changes of neuroeffector mechanisms in target organs, and therapeutic perspectives. It also provides a comprehensive analysis of the possible consequences of these findings. Aging of the Autonomic Nervous System will be a useful volume for gerontologists and neuroscientists.
Author : Sultana Ferdousi
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book Type 2 Diabetes Mellitus written by Sultana Ferdousi and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 2 Diabetes Mellitus is associated with both macro- and microvascular complications. One among the latter, is cardiovascular autonomic neuropathy (CAN). CAN is attributed to cardiac arrhythmias and sudden death. Underlying pathogenesis of cardiac autonomic neuropathy is chronic hyperglycemia induced oxidative stress causing neuronal necrosis, apoptosis and death, leading to the sympathetic and parasympathetic nerve dysfunction. The balance between sympathetic and parasympathetic nervous system is reflected by heart rate variability (HRV). HRV describes ,Äúthe variations of both instantaneous heart rate and R-R intervals which in turn reflects the cardiac autonomic nervous control,Äù. HRV measured at rest is a marker of autonomic nerve function status. Thus, HRV test is recommended to diagnose diabetic CAN. Time domain parameters predominantly reflect overall autonomic activity and parasympathetic nervous system (PNS) modulations. Frequency domain parameters either reflect, sympathetic nervous system (SNS) activity, PNS activity, or the balance between the two activities. Nonlinear HRV indices marks PNS influences, SNS influences and sympatho-vagal balance. Almost all these HRV parameters are remarkably reduced in T2DM due to cardiac autonomic dysfunction. HRV is an important simple and noninvasive diagnostic tool to detect CAN.
Author : Jean-Pierre Felber
Publisher : Wiley
ISBN 13 : 9780471927655
Total Pages : 312 pages
Book Rating : 4.9/5 (276 download)
Download or read book From Obesity to Diabetes written by Jean-Pierre Felber and published by Wiley. This book was released on 1992-12-14 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces a metabolic approach to the effects of obesity on glucose metabolism. Highlights the frequent progressive development of impaired glucose tolerance and diabetes. Demonstrates continuity in both cross-over and longitudinal studies. The reversibility of the phenomena, as well as prevention and therapy, are also presented in relation to physiopathological observations. Cites epidemiological studies which relate the progressive occurrence of diabetes to obesity in populations where the lifestyle has changed with richer food and decreased exercise.
Author : Samy I. McFarlane
Publisher : Springer Science & Business Media
ISBN 13 : 1603273573
Total Pages : 196 pages
Book Rating : 4.6/5 (32 download)
Download or read book Diabetes and Hypertension written by Samy I. McFarlane and published by Springer Science & Business Media. This book was released on 2012-10-19 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
Author : Michitoshi Inoue
Publisher : Springer Science & Business Media
ISBN 13 : 4431683674
Total Pages : 330 pages
Book Rating : 4.4/5 (316 download)
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Author : Michal Javorka
Publisher : Nova Biomedical Books
ISBN 13 : 9781608767885
Total Pages : 0 pages
Book Rating : 4.7/5 (678 download)
Download or read book Cardiovascular Signals in Diabetes Mellitus written by Michal Javorka and published by Nova Biomedical Books. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early detection of sub-clinical autonomic dysfunction is of vital importance in patients with diabetes mellitus (DM) for the prevention of subsequent serious adverse consequences. Reduction in heart rate variability (HRV) is now regarded as the earliest indicator of cardiovascular dysregulation in DM. HRV has traditionally been quantified using linear measures, which describe the magnitude of RR interval oscillations, but are insufficient to characterise complex heart rate dynamics. While HRV is mostly mediated by parasympathetic nervous system, beat-to-beat blood pressure recordings may provide information regarding sympathetic activity. A variety of novel measures has been developed to quantify non-linear features of cardiovascular signals, providing information on the complexity of the dynamical system involved in the genesis of these short-term fluctuations. In this book, it is demonstrated that novel non-linear methods are often more sensitive to autonomic dysregulation than linear methods and therefore may improve the diagnostic power of cardiovascular variability analysis for cardiovascular autonomic neuropathy in DM. Our data indicate that cardiovascular dysregulation progresses in relatively short time frames, depending on the history of DM. Further, its progression appears to be associated with glycemic control. Different methods of cardiovascular variability analysis can provide mutually independent information and therefore should be used simultaneously for a comprehensive analysis of autonomic dysfunction to identify patients at risk for autonomic neuropathy.
Author : Douglas W. Zochodne
Publisher : Elsevier
ISBN 13 : 9780444534804
Total Pages : 0 pages
Book Rating : 4.5/5 (348 download)
Download or read book Diabetes and the Nervous System written by Douglas W. Zochodne and published by Elsevier. This book was released on 2014-12-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson's disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system.
Author : Philip Cryer
Publisher : American Diabetes Association
ISBN 13 : 1580406491
Total Pages : 194 pages
Book Rating : 4.5/5 (84 download)
Download or read book Hypoglycemia in Diabetes written by Philip Cryer and published by American Diabetes Association. This book was released on 2016-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen.
Author : Anca Pantea Stoian
Publisher : BoD – Books on Demand
ISBN 13 : 1838819037
Total Pages : 442 pages
Book Rating : 4.8/5 (388 download)
Download or read book Type 2 Diabetes written by Anca Pantea Stoian and published by BoD – Books on Demand. This book was released on 2021-09-22 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is a metabolic disease characterized by chronic high blood glucose levels. Of the various types of diabetes, type 2 diabetes is increasing in prevalence due to obesity, aging, sedentarism, and other factors. This book presents a novel approach to preventing and treating type 2 diabetes. Chapters cover such topics as diagnosis, pathogenesis, management, lifestyle and nutritional intervention, and systems to support early diagnosis and prevention of prediabetes.
Author : Douglas W Zochodne
Publisher : Elsevier
ISBN 13 : 0444635416
Total Pages : 634 pages
Book Rating : 4.4/5 (446 download)
Download or read book Diabetes and the Nervous System written by Douglas W Zochodne and published by Elsevier. This book was released on 2014-11-05 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson's disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system. - Offers a unique emphasis on the neurological manifestations of diabetes - Provides thorough coverage of the clinical, experimental, mechanistic, therapeutic, peripheral, and central aspects of diabetic neuropathy - Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Author : John Barton Furness
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Enteric Nervous System written by John Barton Furness and published by . This book was released on 1987 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Examination of Altered Sympathetic Nervous Function in Obesity and Diabetes Mellitus Using [carbon-11]meta-hydroxyephedrine PDF Online Free](https://books.google.com/books/content/images/frontcover/INe2zwEACAAJ?fife=w200-h370)
Author : James Thackeray
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)
Download or read book Examination of Altered Sympathetic Nervous Function in Obesity and Diabetes Mellitus Using [carbon-11]meta-hydroxyephedrine written by James Thackeray and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abnormal sympathetic nervous system (SNS) signaling is a synergistic complication of obesity, diabetes mellitus, and congestive heart failure. In vivo biodistribution studies in rats using [11C] meta-hydroxyephedrine ([11C]HED) were performed in obese, lean, type I and type II diabetic animals to delineate deviations in sympathetic nervous integrity at the uptake-1 site (NET-1) as compared to healthy controls. Specific, blockable tracer accumulation was observed in myocardium, lung, brown adipose tissue and pancreas. Obese animals exhibit a time-dependent elevation in uptake-1 specific myocardial [11C]HED retention and time-independent depressed tracer accumulation in brown adipose tissue as compared to lean animals. Type II diabetic rats show a time- and hyperglycaemia-dependent reduction of myocardial tracer uptake and a time- and glycaemia-independent increase in brown adipose tissue uptake-1 specific [11C]HED retention. Positron emission tomography using [11C]HED may prove useful in examining alterations in SNS signaling before, during, and subsequent to therapy for obesity and/or DM.
Author : E. I. Sokolov
Publisher : VSP
ISBN 13 : 9789067642125
Total Pages : 338 pages
Book Rating : 4.6/5 (421 download)
Download or read book Obesity and Diabetes Mellitus written by E. I. Sokolov and published by VSP. This book was released on 1997-04 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the result of the study of metabolic and hormonal disorders in patients suffering obesity and diabetes mellitus, focusing on mechanisms of formation of atherosclerotic changes in the myocardium and vessels in diabetes mellitus patient.
