Superantigens

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Superantigens

Author : Bernhard Fleischer
Publisher : Springer Science & Business Media
ISBN 13 : 3642509983
Total Pages : 144 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Superantigens by : Bernhard Fleischer

Download or read book Superantigens written by Bernhard Fleischer and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.

Streptococcal Superantigens

Author : Anshu Babbar
Publisher : Springer
ISBN 13 : 3319224557
Total Pages : 51 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Streptococcal Superantigens by : Anshu Babbar

Download or read book Streptococcal Superantigens written by Anshu Babbar and published by Springer. This book was released on 2015-07-24 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides ample knowledge and better understanding of Streptococcus pyogenes and their superantigens. Many illustrations make this a highly informative book. This book elucidates briefly Streptococcus pyogenes as a strict human pathogen possessing an array of virulence factors. These help in evading host immune responses such as by the activation of non-specific T-cell subpopulations by producing superantigens. This book mainly focuses on streptococcal superantigens and explains how they are different from conventional antigens. Moreover, it elaborates those diseases in which superantigens are actively involved. Useful aspects of superantigens and different therapeutic interventions to eradicate superantigens induced diseased are also discussed.

Viral Superantigens

Author : Kyuhei Tomonari
Publisher : CRC Press
ISBN 13 : 9780849376887
Total Pages : 284 pages
Book Rating : 4.3/5 (768 download)

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Book Synopsis Viral Superantigens by : Kyuhei Tomonari

Download or read book Viral Superantigens written by Kyuhei Tomonari and published by CRC Press. This book was released on 1997-05-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of viral superantigens in 1991, immunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral superantigens. Viral Superantigens presents a complete review of this new area of study. Edited by a leading researcher and authored by a distinguished team of contributors, this comprehensive analysis covers every aspect of viral superantigens and related subjects, including critical topics such as effects on the T cell repertoire and viral superantigen-mediated diseases. Immunologists and virologists, clinical practitioners, and graduate students will find this book an invaluable resource to encourage further advances in research.

Superantigens

Author : Leung
Publisher : CRC Press
ISBN 13 : 9780824798130
Total Pages : 626 pages
Book Rating : 4.7/5 (981 download)

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Book Synopsis Superantigens by : Leung

Download or read book Superantigens written by Leung and published by CRC Press. This book was released on 1997-02-20 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases. Discusses diseases beyond Toxic Shock Syndrome, such as autoimmune and inflammatory skin conditions, as well as the role of superantigens in other infectious diseases. Illustrated with molecular structures of superantigens.

Superantigens and Superallergens

Author : Gianni Marone
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805582668
Total Pages : 259 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Superantigens and Superallergens by : Gianni Marone

Download or read book Superantigens and Superallergens written by Gianni Marone and published by Karger Medical and Scientific Publishers. This book was released on 2007-01-01 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Superantigens constitute a growing family of bacterial and viral proteins that share the capacity of inducing massive activation of the immune system. This volume contains contributions from leaders in the field of classical T cell superantigens and sheds light on relevant B cell superantigens at the molecular and biochemical levels. This is the first volume to put together basic and clinical aspects of the classical T cell superantigens, B cell superantigens and superallergens. It will therefore be indispensable reading to basic and clinical immunologists, microbiologists, virologists and specialists in allergic and immune disorders.

Superantigens

Author : Brigitte T. Huber
Publisher : CSHL Press
ISBN 13 : 9780879693985
Total Pages : 198 pages
Book Rating : 4.6/5 (939 download)

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Book Synopsis Superantigens by : Brigitte T. Huber

Download or read book Superantigens written by Brigitte T. Huber and published by CSHL Press. This book was released on 1993 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Superantigens are microbial products that defy the conventional notion of lymphocyte activation to produce an unusually vigorous, genetically unrestricted response among many subsets of antigen-specific T cells. Bacterial toxins and certain viral gene products behave as superantigens, deleting T cells in vivo and stimulating their proliferation in vitro. These observations raise many fascinating questions about the nature of T-cell activation and microbial pathogenesis. This volume is an up-to-date, wide-ranging examination of the function and significance of superantigens in virology, biochemistry, and cell and stuctural biology as well as immunology. The book will interest graduate students and postdoctoral fellows in a wide range of biomedical sciences.

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Superantigen Protocols

Author : Teresa Krakauer
Publisher : Springer Science & Business Media
ISBN 13 : 1592593674
Total Pages : 259 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Superantigen Protocols by : Teresa Krakauer

Download or read book Superantigen Protocols written by Teresa Krakauer and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading researchers in the biological, chemical, and physical investigation of superantigens describe in step-by-step detail their best experimental techniques to assess the physical characteristics and biological effects of superantigens. Their protocols range from those for investigating the interactions of superantigens with cellular receptors to those for the analysis of their immunological and biological effects, including methods for using BIOcore to determine binding kinetics and establishing various lymphocyte cell culture systems. There are also accounts of such methods as the RNase protection assay, cytokine ELISA, FACS analysis, and cytokine production at the single cell level..

The Comprehensive Sourcebook of Bacterial Protein Toxins

Author : Joseph E. Alouf
Publisher : Elsevier
ISBN 13 : 0080456987
Total Pages : 1072 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis The Comprehensive Sourcebook of Bacterial Protein Toxins by : Joseph E. Alouf

Download or read book The Comprehensive Sourcebook of Bacterial Protein Toxins written by Joseph E. Alouf and published by Elsevier. This book was released on 2005-12-20 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Fusion Protein Technologies for Biopharmaceuticals

Author : Stefan R. Schmidt
Publisher : John Wiley & Sons
ISBN 13 : 1118354583
Total Pages : 995 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Fusion Protein Technologies for Biopharmaceuticals by : Stefan R. Schmidt

Download or read book Fusion Protein Technologies for Biopharmaceuticals written by Stefan R. Schmidt and published by John Wiley & Sons. This book was released on 2013-01-28 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.

All Around the Nose

Author : Cemal Cingi
Publisher : Springer Nature
ISBN 13 : 3030212173
Total Pages : 896 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis All Around the Nose by : Cemal Cingi

Download or read book All Around the Nose written by Cemal Cingi and published by Springer Nature. This book was released on 2019-11-05 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to provide all the information required for a sound understanding of diseases of the nose and paranasal sinuses and the surgical techniques used in their management. After an opening section on basic science, clinical and radiological assessment is explained and individual chapters focus on conditions ranging from infectious diseases, allergic rhinitis, and nasal polyposis to trauma, malignancies, and skin diseases. A wide variety of surgical techniques are then described with the aid of high-quality illustrations, covering nasal airway procedures and surgical approaches to the paranasal sinuses, including diverse endoscopic and image-guided procedures, nasal reconstruction, and endonasal and external rhinoplasty. The book is a collaborative project between the new generation of Turkish specialists and well-known experts from across the world. It will be of value for ENT doctors in all countries, as well as for students and trainees and those working in ENT-related fields such as maxillo-facial surgery, pediatrics, allergology, neurology, infectious diseases, and neurosurgery.

Kuby Immunology

Author : Thomas J. Kindt
Publisher : Macmillan
ISBN 13 : 9781429202114
Total Pages : 700 pages
Book Rating : 4.2/5 (21 download)

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Book Synopsis Kuby Immunology by : Thomas J. Kindt

Download or read book Kuby Immunology written by Thomas J. Kindt and published by Macmillan. This book was released on 2007 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally authored by the award winning author Janis Kuby, "Immunology" remains the best selling textbook for the undergraduate course. The first and only true textbook written by professors who teach the undergraduate course, it presents the most current concepts in an experimental context with clinical advances highlighted in boxes, supported by the kind of helpful pedagogical tools that other books do not provide.

Adverse Effects of Vaccines

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309214351
Total Pages : 894 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Adverse Effects of Vaccines by : Institute of Medicine

Download or read book Adverse Effects of Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 2012-04-26 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Immunology

Author : Richard Coico
Publisher : John Wiley & Sons
ISBN 13 : 1118396898
Total Pages : 432 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Immunology by : Richard Coico

Download or read book Immunology written by Richard Coico and published by John Wiley & Sons. This book was released on 2015-01-28 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology: A Short Course, 7th Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs. This new edition of Immunology: A Short Course: • Has been fully revised and updated, with a brand new art program to help reinforce learning • Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area • Highlights important therapeutic successes resulting from targeted antibody therapies • Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications

Bacterial Superantigens

Author : Jacques Thibodeau
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Bacterial Superantigens by : Jacques Thibodeau

Download or read book Bacterial Superantigens written by Jacques Thibodeau and published by . This book was released on 1995 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the field of superantigens (SAgs) has boomed in recent years, the function of these proteins in bacterial infection remains elusive. This volume begins with a brief introduction, followed by 15 chapters. Among the topics are structural studies of streptococcal pyrogenic exotoxin superantigens; Yersinia infection--the virulence determinants and SAgs they produce; structural features of T cell receptor recognition of SAgs; the pathophysiology of bacterial SAgs in vivo; and antibody targeted SAgs in experimental tumor therapy. Annotation copyright by Book News, Inc., Portland, OR

Skin Microbiome Handbook

Author : Nava Dayan
Publisher : John Wiley & Sons
ISBN 13 : 1119592232
Total Pages : 432 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Skin Microbiome Handbook by : Nava Dayan

Download or read book Skin Microbiome Handbook written by Nava Dayan and published by John Wiley & Sons. This book was released on 2020-09-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive detailed summary of current status on skin microbiome research in health and disease as well as key regulatory and legal aspects. In the past decade, interest and technology have greatly advanced to unravel the nature and effect of skin microbiome on our health. Diseases such as atopic dermatitis and acne are at the forefront of this research, but also other conditions such as skin cancer are under investigation. In addition, mapping of the skin microbiome has gone from basic to more detailed with attempts to correlate it to various ages, ethnicities and genders. In parallel to mapping it, a great deal of research is dedicated to understanding its functionality and communication (and hence effect) on human cells. The Skin Microbiome Handbook is a summary of current status of knowledge, research tools and approaches in skin microbiome, in health and disease. It contains the following categories: healthy skin microbiome and oral-skin interaction; skin microbiome observational research; skin microbiome in disequilibrium and disease; skin's innate immunity; testing and study design; regulatory and legal aspects for skin microbiome related products. The 18 chapters of the book are written by carefully selected leaders in the academia and industry exhibiting extensive experience and understanding in the areas of interest.

Encyclopedic Reference of Immunotoxicology

Author : Hans-Werner Vohr
Publisher : Springer
ISBN 13 : 9783540441724
Total Pages : 0 pages
Book Rating : 4.4/5 (417 download)

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Book Synopsis Encyclopedic Reference of Immunotoxicology by : Hans-Werner Vohr

Download or read book Encyclopedic Reference of Immunotoxicology written by Hans-Werner Vohr and published by Springer. This book was released on 2005-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors – including many of the world’s top specialists – have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans. The single A–Z format of both types of entry makes this reference book very easy to use. The Encyclopedic Reference of Immunotoxicology is intended to be a comprehensive work of reference which will provide easy access to relevant information in the fast-growing field of Immunotoxicology.