Summary Report On The Evaluation Of Short Term Tests For Carcinogens Collaborative Study On In Vitro Tests

Author : J Ashby (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Download or read book Evaluation of Short Term Tests for Carcinogens, Volume 1; Report of the International Programme on Chemical Safety's Collaborative Study on in Vivo Assays written by J Ashby (Ed) and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The IPCS in vivo collaborative study, overview and conclusions; The statistical analysis of in vivo genotoxicity data, case studies of the rat hepatocyte UDS and mouse bone marrow micronucleus assays; Benzo(a)pyrene and pyrene; 2-Acetylaminofluorene and 4-acetylaminofluorene; Summary report on the performance of sister chromatid exchange, micronucleus, and chromosome aberration tests in rodent bone marrow cells; Summary report on the performance of the in vivo mammalian cell cytogenetics chromosome aberrations, metaphase analysis assays; Evaluation of chromosomal aberrations in bone marrow of male IC3F1 mice; Analysis of chromosomal aberrations in bone marrow cells of C57BL/6 mice treated with benzo(a)pyrene, pyrene, 2-acetylaminofluorene, and 4-acetylaminofluorene; Induction of chromosomal aberrations in BALB/c mouse bone marrow cells; Metaphase analysis test results in male ICR Swiss mice; A study of the ability of benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene to damage bone marrow cell chromosomes in five inbred strains of mice; Induction of chromosomal aberrations in bone marrow cells and ascites tumor cells of mice by 2-acetylaminofluorene, 4-acetylaminofluorene and benzo(a)pyrene; A comparative analysis of the induction of chromosomal aberrations in the bone marrow cells of B6C3F1 mice; An in vivo cytogenetic test in bone marrow cells of the Alderley Park Wistar derived rat; Mutagenic activity of four compounds in chromosomal aberration assay using Chinese hamster bone marrow cells; Examination of metaphase chromosomes obtained from the bone marrow of Chinese hamsters (Cricetulus griseus); Summary report on the performance of the in vivo micronucleus assays; Bone marrow micronucleus tests on NMRI mice; Bone marrow micronucleus induction in HPBBL mice; Micronuclei induction in mouse bone marrow cells with benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene; Micronucleus test results for two carcinogen/noncarcinogen chemical pairs in male ICR Swiss mice; The micronucleus test in mutagen sensitive MS/Ae mice; The micronucleus test in strain C57BL/6J mice; Micronucleus test on benzo(a)pyrene and pyrene performed in NMRI mice; Micronucleus test in bone marrow cells of CBA male mice; Induction of micronuclei in BALB/c mouse bone marrow cells; Induction of micronuclei in polychromatic erythrocytes in bone marrow of adult IC3F1, hybrid male mice; Tests on two pairs of structural analogues in the mouse in vivo micronucleus assay; The clastogenic activity of benzo(a)pyrene, pyrene, 2-acetylaminofluorene and 4-acetylaminofluorene in the mouse bone marrow micronucleus test; Bone marrow micronucleus test in Swiss male mice; Micronucleus incidences induced in bone marrow erythrocytes of pregnant NMRI mice and in liver derived erythrocytes of their foetuses; Detection of micronucleated polychromatic erythrocytes in bone marrow of male mice; The peripheral blood erythrocyte micronucleus assay in weanling and foetal Swiss mice; Micronucleus test in bone marrow of rats exposed to 2-acetylaminofluorene or 4-acetylaminofluorene; Micronucleus test in the Alderley Park Wistar derived albino rat; Summary report on the performance of the in vivo sister chromatid exchange assays; A comparative analysis of the induction of sister chromatid exchanges in the bone marrow cells of B6C3F1 mice; Analysis of sister chromatid exchange in C57BL/6 mouse bone marrow cells following in vivo exposure to carcinogen/noncarcinogen chemical pairs; Detection of sister chromatid exchanges in bone marrow of male mice; In vivo sister chromatid exchanges in mouse bone marrow, test of four compounds in male and female CD-1 mice; Tests with Swiss albino mice to detect the induction of sister chromatid exchanges in bone marrow cells; Sister chromatid exchange induction in bone marrow cells of Swiss mice; In vivo sister chromatid exchange evaluation in Sprague Dawley rats; Analysis of sister chromatid exchange in C57B1/6 mouse peripheral blood lymphocytess following in vivo exposure to carcinogen/noncarcinogen pairs; Discrimination of structurally similar carcinogen/noncarcinogen analogues by analysis of sister chromatid exchange in vivo in bone marrow and intestinal epithelium of Chinese hamster; Introduction, liver specific assays; Summary report of liver specific short term tests; Summary report on the performance of the liver initiation and promotion assays; Early cytomorphological and cytochemical changes induced in liver by single large doses of 2-acetylaminofluorene and 4-acetylaminofluorene; Liver initiation assay, the rat liver foci bioassay of carcinogens and noncarcinogens; Ability of the test chemicals to initiate gamma glutamyltranspeptidase positive foci in female rats; In vivo promotion assay of four compounds on enhancement of the development of gamma glutamyl transpeptidase positive liver cell foci in male F344 rats; A liver cell transplantation assay for promoting activity in rats; Summary report on the performance of the in vivo DNA repair assays; A comparison of the response of carcinogen/noncarcinogen pairs in the rat and mouse hepatocyte DNA repair assays in vivo and in vitro; Activity of 2-acetylaminofluorene and 4-acetylaminofluorene in an in vitro and an in vivo/in vitro assay for unscheduled DNA synthesis in the rat liver; An evaluation of the ability of benzo(a)pyrene, pyrene, 2- and 4-acetylaminofluorene to induce unscheduled DNA synthesis and cell proliferation in the livers of male rats and mice treated in vivo; Unscheduled DNA synthesis in rat liver after in vivo treatment with 2-acetylaminofluorene or 4-acetylaminofluorene; Induction of unscheduled DNA synthesis and DNA replication in rat hepatocytes following in vivo administration of 2-actylaminofluorene and 4-acetylaminofluorene; Testing of 2-acetylaminofluorene and 4-acetylaminofluorene in the in vivo/in vitro rat hepatocyte/DNA repair assay and investigation of lactational exposure of neonatal rats to 2-acetylaminofluorene; In vivo-in vitro assay for quantifying hepatic DNA repair and S phase in F344 rats; Inactivity of benzo(a)pyrene in a weanling rat liver, unscheduled DNA synthesis assay; Summary report on the performance of cytogenetic assays in rat hepatic cells; Chromosome studies in hepatic cells from rats exposed to genotoxic chemicals; Micronucleus test with rat hepatocytes to detect induction of clastogenic damage; Summary report of the measurement of DNA strand breaks; DNA strand break induction in Fischer 344 rat hepatocytes as assessed by the alkaline elution assay; DNA strand breakage monitored by alkaline elution in the livers of male Wistar derived rats administered carcinogenic/noncarcinogenic analogues; Alkaline elution of rat liver DNA for benzo(a)pyrene, pyrene 2-acetylaminofluorene, and 4-acetylaminofluorene; Use of the fluorometric analysis of DNA unwinding (FADU) assay to detect DNA strand breaks in the liver of CD-1 mice exposed to carcinogens and a repair inhibitor.