Subversion Of Innate Immunity By Blastomyces Dermatitidis

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Subversion of Innate Immunity by Blastomyces Dermatitidis

Author :
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 (888 download)

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Book Synopsis Subversion of Innate Immunity by Blastomyces Dermatitidis by :

Download or read book Subversion of Innate Immunity by Blastomyces Dermatitidis written by and published by . This book was released on 2014 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the innate immune response to the dimorphic fungus, Blastomyces dermatitidis, is very limited. Blastomycosis is a challenging disease from a clinical perspective due to the long incubation time and difficulty in diagnosis. B. dermatitidis is widely believed to be an extracellular pathogen. We found that pulmonary instillation of spores (the infectious particle) leads to rapid and efficient internalization within leukocytes, particularly alveolar macrophages. The harsh intracellular environment of alveolar macrophages is normally fatal to microorganisms. However, using live imaging we found that B. dermatitidis is able to survive this attack, transition from spores to the pathogenic yeast form, and replicate within alveolar macrophages. We found that depleting alveolar macrophages curtailed infection and delayed phase transition. Additionally, spores cultured in vitro converted to yeast faster in the presence of macrophages than in medium alone. This research reveals B. dermatitidis as facultative intracellular pathogen of alveolar macrophages able to respond to host factors to establish disease. B. dermatitidis also subverts the innate immune response through the production of the aminopeptidase DppIV. Gene silencing in B. dermatitidis revealed that DppIV is essential for virulence, and acts in part by blunting recruitment of Ly6ChiCCR2+ inflammatory monocytes to the lung, and their differentiation into TipDCs as well as impairing activation of neutrophils and killing of yeast mediated by these cells and macrophages. Mammalian DppIV regulates the immune response through cleavage and inactivation of cytokines and chemokines. B. dermatitidis likewise dampens innate immunity by producing DppIV. This serves as an example of a pathogen exploiting molecular mimicry. Collectively, this work identifies early mechanisms of pathogenesis through innate immune evasion and alteration by B. dermatitidis.

The Immune Response

Author : Tak W. Mak
Publisher : Academic Press
ISBN 13 : 0080534481
Total Pages : 1217 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Immune Response by : Tak W. Mak

Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. - Current and thorough 30 chapter reference reviewed by luminaries in the field - Unique 'single voice' ensures consistency of definitions and concepts - Comprehensive and elegant illustrations bring key concepts to life - Provides historical context to allow fuller understanding of key issues - Introductory chapters 1-4 serve as an 'Immunology Primer' before topics are discussed in more detail

Metabolic Interaction in Infection

Author : Ricardo Silvestre
Publisher : Springer
ISBN 13 : 3319749323
Total Pages : 478 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Metabolic Interaction in Infection by : Ricardo Silvestre

Download or read book Metabolic Interaction in Infection written by Ricardo Silvestre and published by Springer. This book was released on 2018-04-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.

The Rasputin Effect: When Commensals and Symbionts Become Parasitic

Author : Christon J. Hurst
Publisher : Springer
ISBN 13 : 3319281704
Total Pages : 364 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis The Rasputin Effect: When Commensals and Symbionts Become Parasitic by : Christon J. Hurst

Download or read book The Rasputin Effect: When Commensals and Symbionts Become Parasitic written by Christon J. Hurst and published by Springer. This book was released on 2016-07-05 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on those instances when benign and even beneficial relationships between microbes and their hosts opportunistically change and become detrimental toward the host. It examines the triggering events which can factor into these changes, such as reduction in the host’s capacity for mounting an effective defensive response due to nutritional deprivation, coinfections and seemingly subtle environmental influences like the amounts of sunlight, temperature, and either water or air quality. The effects of environmental changes can be compounded when they necessitate a physical relocation of species, in turn changing the probability of encounter between microbe and host. The change also can result when pathogens, including virus species, either have modified the opportunist or attacked the host’s protective natural microflora. The authors discuss these opportunistic interactions and assess their outcomes in both aquatic as well as terrestrial ecosystems, highlighting the impact on plant, invertebrate and vertebrate hosts.

Desk Encyclopedia of Microbiology

Author : Moselio Schaechter
Publisher : Academic Press
ISBN 13 : 0080961282
Total Pages : 1277 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Desk Encyclopedia of Microbiology by : Moselio Schaechter

Download or read book Desk Encyclopedia of Microbiology written by Moselio Schaechter and published by Academic Press. This book was released on 2010-04-19 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Desk Encyclopedia of Microbiology, Second Edition is a single-volume comprehensive guide to microbiology for the advanced reader. Derived from the six volume e-only Encyclopedia of Microbiology, Third Edition, it bridges the gap between introductory texts and specialized reviews. Covering topics ranging from the basic science of microbiology to the current "hot" topics in the field, it will be invaluable for obtaining background information on a broad range of microbiological topics, preparing lectures and preparing grant applications and reports. - The most comprehensive single-volume source providing an overview of microbiology to non-specialists - Bridges the gap between introductory texts and specialized reviews - Provides concise and general overviews of important topics within the field making it a helpful resource when preparing for lectures, writing reports, or drafting grant applications

Immunology and Evolution of Infectious Disease

Author : Steven A. Frank
Publisher : Princeton University Press
ISBN 13 : 9780691095950
Total Pages : 364 pages
Book Rating : 4.0/5 (959 download)

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Book Synopsis Immunology and Evolution of Infectious Disease by : Steven A. Frank

Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description

Clinical and Basic Immunodermatology

Author : Anthony Gaspari
Publisher : Springer Science & Business Media
ISBN 13 : 1848001657
Total Pages : 812 pages
Book Rating : 4.8/5 (48 download)

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Book Synopsis Clinical and Basic Immunodermatology by : Anthony Gaspari

Download or read book Clinical and Basic Immunodermatology written by Anthony Gaspari and published by Springer Science & Business Media. This book was released on 2008-11-05 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.

Microbes

Author : Prakash S. Bisen
Publisher : John Wiley & Sons
ISBN 13 : 1118311892
Total Pages : 731 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Microbes by : Prakash S. Bisen

Download or read book Microbes written by Prakash S. Bisen and published by John Wiley & Sons. This book was released on 2012-06-22 with total page 731 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible introduction to the world of microbes—from basic microbe biology through industrial applications Microbes affect our lives in a variety of ways—playing an important role in our health, food, agriculture, and environment. While some microbes are beneficial, others are pathogenic or opportunistic. Microbes: Concepts and Applications describes basic microbe biology and identification and shows not only how they operate in the subfields of medicine, biotechnology, environmental science, bioengineering, agriculture, and food science, but how they can be harnessed as a resource. It provides readers with a solid grasp of etiologic agents, pathogenic processes, epidemiology, and the role of microbes as therapeutic agents. Placing a major emphasis on omics technology, the book covers recent developments in the arena of microbes and discusses their role in industry and agriculture, as well as in related fields such as immunology, cell biology, and molecular biology. It offers complete discussions of the major bacterial, viral, fungal, and parasitic pathogens; includes information on emerging infectious diseases, antibiotic resistance, and bioterrorism; and talks about the future challenges in microbiology. The most complete treatment of microbial biology available, Microbes features eye-opening chapters on: Human and Microbial World Gene Technology: Application and Techniques Molecular Diagnostic and Medical Microbiology Identification and Classification of Microbes Diversity of Microorganisms Microbes in Agriculture Microbes as a Tool for Industry and Research Complete with charts and figures, this book is an invaluable textbook for university teachers, students, researchers, and people everywhere who care about microorganisms.

Pathogen Genomics

Author : Karen Joy Shaw
Publisher : Springer Science & Business Media
ISBN 13 : 1592591728
Total Pages : 513 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Pathogen Genomics by : Karen Joy Shaw

Download or read book Pathogen Genomics written by Karen Joy Shaw and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to the prevention, diagnosis, and treatment. The authors' cross-disciplinary approach, with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa, reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA micoarrays and the impact of genome sequencing comparisons on the discovery and choices of novel drug targets. The result is a better understanding how genomic information can reveal the fundamentals of microbial pathogenesis and how organisms interact with their host environment.

Combating Fungal Infections

Author : Iqbal Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 364212173X
Total Pages : 549 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Combating Fungal Infections by : Iqbal Ahmad

Download or read book Combating Fungal Infections written by Iqbal Ahmad and published by Springer Science & Business Media. This book was released on 2010-08-03 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

Author : John E. Bennett
Publisher : Elsevier Health Sciences
ISBN 13 : 1437720609
Total Pages : 4306 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book by : John E. Bennett

Download or read book Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book written by John E. Bennett and published by Elsevier Health Sciences. This book was released on 2009-10-19 with total page 4306 pages. Available in PDF, EPUB and Kindle. Book excerpt: After thirty years, PPID is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th Edition helps you identify and treat whatever infectious disease you see. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome. Benefit from fresh perspectives and global insights from an expanded team of international contributors. Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult. Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information. Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention. Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.

Parasitoids

Author : H. Charles J. Godfray
Publisher : Princeton University Press
ISBN 13 : 069120702X
Total Pages : 484 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Parasitoids by : H. Charles J. Godfray

Download or read book Parasitoids written by H. Charles J. Godfray and published by Princeton University Press. This book was released on 2019-12-31 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parasitoids lay their eggs on or in the bodies of other species of insect, and the parasitoid larvae develop by feeding on the host, causing its eventual death. Known for a long time to applied biologists for their importance in regulating the population densities of economic pests, parasitoids have recently proven to be valuable tools in testing many aspects of evolutionary theory. This book synthesizes the work of both schools of parasitoid biology and asks how a consideration of evolutionary biology can help us understand the behavior, ecology, and diversity of the approximately one to two million species of parasitoid found on earth. After a general introduction to parasitoid natural history and taxonomy, the first part of the book treats the different components of the reproductive strategy of parasitoids: searching for a host, host selection, clutch size, and the sex ratio. Subsequent chapters discuss pathogens and non-Mendelian genetic elements that affect sexual reproduction; evolutionary aspects of the physiological interactions between parasitoid and host; mating strategies; life history theory and community ecology. A special effort is made to discuss the theoretical background to the subject, but without the use of mathematics.

Textbook of Oral Medicine

Author : Anil Govindrao Ghom
Publisher : JP Medical Ltd
ISBN 13 : 9351523039
Total Pages : 1144 pages
Book Rating : 4.3/5 (515 download)

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Book Synopsis Textbook of Oral Medicine by : Anil Govindrao Ghom

Download or read book Textbook of Oral Medicine written by Anil Govindrao Ghom and published by JP Medical Ltd. This book was released on 2014-09-30 with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition presenting latest advances in oral medicine. Includes multiple choice questions for revision and a free book called Basic Oral Radiology (9789351523215). Previous edition published in 2008.

Allergy Frontiers:Classification and Pathomechanisms

Author : Ruby Pawankar
Publisher : Springer Science & Business Media
ISBN 13 : 4431883150
Total Pages : 608 pages
Book Rating : 4.4/5 (318 download)

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Book Synopsis Allergy Frontiers:Classification and Pathomechanisms by : Ruby Pawankar

Download or read book Allergy Frontiers:Classification and Pathomechanisms written by Ruby Pawankar and published by Springer Science & Business Media. This book was released on 2009-03-13 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: When I entered the field of allergy in the early 1970s, the standard textbook was a few hundred pages, and the specialty was so compact that texts were often authored entirely by a single individual and were never larger than one volume. Compare this with Allergy Frontiers: Epigenetics, Allergens, and Risk Factors, the present s- volume text with well over 150 contributors from throughout the world. This book captures the explosive growth of our specialty since the single-author textbooks referred to above. The unprecedented format of this work lies in its meticulous attention to detail yet comprehensive scope. For example, great detail is seen in manuscripts dealing with topics such as “Exosomes, naturally occurring minimal antigen presenting units” and “Neuropeptide S receptor 1 (NPSR1), an asthma susceptibility gene.” The scope is exemplified by the unique approach to disease entities normally dealt with in a single chapter in most texts. For example, anaphylaxis, a topic u- ally confined to one chapter in most textbooks, is given five chapters in Allergy Frontiers. This approach allows the text to employ multiple contributors for a single topic, giving the reader the advantage of being introduced to more than one vi- point regarding a single disease.

Healing is Voltage

Author : Jerry Tennant
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781453649169
Total Pages : 0 pages
Book Rating : 4.6/5 (491 download)

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Book Synopsis Healing is Voltage by : Jerry Tennant

Download or read book Healing is Voltage written by Jerry Tennant and published by Createspace Independent Publishing Platform. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book tells how to measure the voltages of each organ, how to insert new electrons and how to figure out why voltage dropped in the first place."--Page 4 of cover.

Proceedings of the National Academy of Sciences of the United States of America

Author : National Academy of Sciences (U.S.).
Publisher :
ISBN 13 :
Total Pages : 980 pages
Book Rating : 4.:/5 (891 download)

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Book Synopsis Proceedings of the National Academy of Sciences of the United States of America by : National Academy of Sciences (U.S.).

Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.). and published by . This book was released on 2007 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemistry, Biochemistry, and Biology of 1-3 Beta Glucans and Related Polysaccharides

Author : Antony Bacic
Publisher : Academic Press
ISBN 13 : 0080920543
Total Pages : 713 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Chemistry, Biochemistry, and Biology of 1-3 Beta Glucans and Related Polysaccharides by : Antony Bacic

Download or read book Chemistry, Biochemistry, and Biology of 1-3 Beta Glucans and Related Polysaccharides written by Antony Bacic and published by Academic Press. This book was released on 2009-07-07 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry, Biochemistry, and Biology of 1-3 Beta Glucans and Related Polysaccharides presents a comprehensive, systematic and authoritative survey of information about a family of chemically related, but functionally diverse, naturally occurring polysaccharides--the (1-3)-glucans. International contributors describe the chemical and physicochemical properties of these glucans and their derivatives and the molecular biological and structural aspects of the enzymes involved in their formation and breakdown. A detailed analysis of their physiological roles in the various biological situations in which they are found will be provided. Additionally, evolutionary relationships among the family of these glucans will be described. - Topics of medical relevance include detailing the glucans' interactions with the immune system and research for cancer therapy applications - Web resource links allow scientists to explore additional beta glucan research - Separate indexes divided into Species and Subject for enhanced searchability