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Studies Towards The Total Synthesis Of Merrilactone A
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Book Synopsis Studies Towards the Total Synthesis of Merrilactone A by : Jone Iriondo-Alberdi
Download or read book Studies Towards the Total Synthesis of Merrilactone A written by Jone Iriondo-Alberdi and published by . This book was released on 2007 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Merrilactone A by : Karsten Meyer
Download or read book Studies Towards the Total Synthesis of Merrilactone A written by Karsten Meyer and published by . This book was released on 2009 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Formal Total Synthesis of (±)-Merrilactone A and Studies Towards Anislactones A by : Naim Nazef
Download or read book Formal Total Synthesis of (±)-Merrilactone A and Studies Towards Anislactones A written by Naim Nazef and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Merrilactone A (1) and the epimeric anislactones A (2) and B (3) are sesquiterpene natural products that were first isolated from the dried pericarps of Illicium merrillianum (Fukuyama in 2000) and Illicium anisatum (Kouno in 1990), respectively. Merrilactone A (1) was identified as a potent nonpeptidal neurotrophic factor that strongly promotes neurite outgrowth in the culture of foetal rat cortical neurons and is a potential small molecule lead for the treatment of neurodegenerative disorders. Merrilactone A (1) together with 2 and 3, are highly complex cage-like structures that have established themselves as challenging and attractive targets in natural product synthesis. Presented in this research is a regiodivergent approach to both sets of natural products via the first known application of the defining transformation, an intramolecular tandem cyano-aldol cyclisation. We demonstrated an efficient route to the cyano-aldol product 303, which acted as the common intermediate to either natural product by orthogonal lactonisation sequences. This culminated in the successful synthesis of known intermediate 320, which represents the formal total synthesis of 1, and advanced tetracyclic intermediate 309, that is the full carbon skeleton of 2 and 3.
Book Synopsis Asymmetric Synthesis of Merrilactone A ; Studies Toward the Total Synthesis of Pinnamine by : Zhaoyang Meng
Download or read book Asymmetric Synthesis of Merrilactone A ; Studies Toward the Total Synthesis of Pinnamine written by Zhaoyang Meng and published by . This book was released on 2006 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of (±)-Merrilactone A and (±)-Anislactone A. by : Lei Shi
Download or read book Total Synthesis of (±)-Merrilactone A and (±)-Anislactone A. written by Lei Shi and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Merrilactone A (1) was isolated in only 0.004% yield from the methanol extracts of the pericarps of Illicium merrillianum. Structural elucidation of Merrilactone A revealed a compact, cage-like pentacyclic architecture of high molecular complexity, featuring seven stereocentres, five of which as contiguous fully substituted carbon atoms, two [gamma]-lactones and a central oxetane ring. Merrilactone A also exhibits an important neurotrophic activity, significantly promoting neurite outgrowth in the primary cultures of foetal rat cortical neurons at very low concentrations. Structurally, merrilactone A is related to anislactones A and B, a pair of epimeric sesquiterpene dilactones discovered ten years earlier by Kouno and co-workers from the related Illicium anisatum plant. Fukuyama has shown that anislactone B can be converted into merrilactone A using a simple three step sequence, suggesting that the anislactones may be biogenetic precursors to merrilactone A. Described in this thesis are our research efforts directed towards developing a conceptually novel synthetic route enabling regiodivergent total synthesis of both anislactone A / B and merrilactone A. Our synthetic route (around 22 steps) features several key reactions, which include a [2+2] photo-cycloaddition reaction, Tiffeneau-Demjanov ring expansion and titanium(III) mediated radical cyclization.
Book Synopsis Total Synthesis of (±)-Merrilactone A and (±)-Anislactone A by : Lei Shi (Ph.D.)
Download or read book Total Synthesis of (±)-Merrilactone A and (±)-Anislactone A written by Lei Shi (Ph.D.) and published by . This book was released on 2011 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. by : Sanil Sreekumar
Download or read book Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. written by Sanil Sreekumar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents our studies towards the first total synthesis of the novel anti- HIV agent lancifodilactone G, which has a highly unusual aliphatic enol. The first chapter provides a survey of architecturally diverse nortriterpenoids that were isolated from the Schisandraceae family. A proposed biosynthetic pathway for lancifodilactone G and closely related natural products provides a rationale for the formation of the consecutive 7/8/5 fused carbo cycles that are unique to Schisandra nortriterpenoids. Chapter 1 goes on to outline the reported strategies to access the core of lancifodilactone G and concludes with a retrosynthetic analysis proposed by the Evans group, which includes a biosynthetically inspired single-pot polycyclisation reaction. Chapter 2 describes the highly stereocontrolled synthesis of the eastern fragment (F-G rings) using transition metal-mediated Pauson-Khand reaction. This chapter also reviews the metal-mediated diastereoselective Pauson-Khand reaction directed by the stereogenic centre at C2, with the ample illustration to total synthesis. Attempted strategies for the assembly of the bicyclic cyclopentanone motif via a dienyl Pauson-Khand reaction of silicon- and oxygen- tethered diene-enes are presented. The failure of these strategies at different stages of the synthesis resulted in the exploration of a classical Pauson-Khand approach, which successfully furnished the eastern fragment. Finally, a second-generation synthesis is described which provided the fully functionalised eastern fragment with improved efficiency and overall yield. Chapter 3 discusses the successful synthesis of the western fragment (B-C rings) using a diastereoselective [4+3] cycloaddition strategy. Attempted strategies for the synthesis of the key 2,3-disubstituted furan derivative are presented, which was achieved via a hetero Pauson- Khand reaction. This chapter includes a brief account of the classical [4+3] cycloaddition reactions of furans using an in situ generated oxyallyl cation and also employing vinyl carbenoids in the metal-catalysed version. The review also highlights the application of the [4+ 3] cycloaddition reaction in the expeditious assembly of functionalised 7-membered rings that occur in a number of important biologically active natural products. The third chapter goes on to describe the application of these cycloaddition reactions in the synthesis of the fully functionalised western fragment of Lancifodilactone G. Chapter 4 describes a model study aimed at expediting the synthesis of the western fragment using a rhodium-catalysed allylic substitution reaction. A brief mechanistic discussion on unique aspects of the allylic alkylation reaction is illustrated. Chapter 4 concludes by outlining the coupling strategy for eastern and western fragments and the end game studies for the completion of the synthesis of lancifodilactone G.
Book Synopsis Part A. Studies Directed Towards the Total Synthesis of (±) A-23187 ; Part B. Formal Total Synthesis of (±) A-23187 by : Eric L. Williams
Download or read book Part A. Studies Directed Towards the Total Synthesis of (±) A-23187 ; Part B. Formal Total Synthesis of (±) A-23187 written by Eric L. Williams and published by . This book was released on 1980 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Asymmetric Total Synthesis of (-)-merrilactone A by : Takaaki Sato
Download or read book Asymmetric Total Synthesis of (-)-merrilactone A written by Takaaki Sato and published by . This book was released on 2006 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies towards the total synthesis of FR182877 by : Frederick Woolf Goldberg
Download or read book Studies towards the total synthesis of FR182877 written by Frederick Woolf Goldberg and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Madeirolide A. by : Adam Christopher Loy Yip
Download or read book Studies Towards the Total Synthesis of Madeirolide A. written by Adam Christopher Loy Yip and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of (±)-Maoecrystal V by : Jianxian Gong
Download or read book Total Synthesis of (±)-Maoecrystal V written by Jianxian Gong and published by Springer. This book was released on 2014-07-08 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
Book Synopsis Studies Towards the Total Synthesis of the Epothilones A and B. by : Jane Elaine Fletcher
Download or read book Studies Towards the Total Synthesis of the Epothilones A and B. written by Jane Elaine Fletcher and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Lasionectrin and Synthetic Studies Towards Pestaloxazine A by : Vincent Poral
Download or read book Total Synthesis of Lasionectrin and Synthetic Studies Towards Pestaloxazine A written by Vincent Poral and published by . This book was released on 2016 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Labiatin A by : Serena Carosso
Download or read book Studies Towards the Total Synthesis of Labiatin A written by Serena Carosso and published by . This book was released on 2011 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of (+)-retronecine and Anthracimycin by : Joshua C. Smith
Download or read book Studies Towards the Total Synthesis of (+)-retronecine and Anthracimycin written by Joshua C. Smith and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis Studies Directed Towards the Total Synthesis of (+)-trilobacin, (+)-trilobin and (+)-asitribin by : Michael John Mayer
Download or read book Synthesis Studies Directed Towards the Total Synthesis of (+)-trilobacin, (+)-trilobin and (+)-asitribin written by Michael John Mayer and published by . This book was released on 1998 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: