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Studies On The Surface Chemistry Of Bone
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Book Synopsis Studies on the Surface Chemistry of Bone by : W. F. Neuman
Download or read book Studies on the Surface Chemistry of Bone written by W. F. Neuman and published by . This book was released on 1950 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: The behavior of powdered, fresh bone when suspended in phosphate buffer has been studied. In solutions of constant composition, the bone mineral was found to undergo a rapid recrystallization.
Book Synopsis Bone as a Problem in Surface Chemistry by : W. F. Neuman
Download or read book Bone as a Problem in Surface Chemistry written by W. F. Neuman and published by . This book was released on 1950 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Surface Chemistry of Bone by : William Frederick Neuman
Download or read book The Surface Chemistry of Bone written by William Frederick Neuman and published by . This book was released on 1951 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Surface Chemistry of Bone by : William Frederick Neuman
Download or read book The Surface Chemistry of Bone written by William Frederick Neuman and published by . This book was released on 1952 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Surface Chemistry of Bone by : William Frederick Neuman
Download or read book The Surface Chemistry of Bone written by William Frederick Neuman and published by . This book was released on 1951 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Surface Chemistry of Bone by : John H. Weikel
Download or read book The Surface Chemistry of Bone written by John H. Weikel and published by . This book was released on 1954 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Surface Chemistry of Bone by : Eugene S. Boyd
Download or read book The Surface Chemistry of Bone written by Eugene S. Boyd and published by . This book was released on 1951 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Surface Chemistry of Bone by : W. F. Neuman
Download or read book The Surface Chemistry of Bone written by W. F. Neuman and published by . This book was released on 1950 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adsorption on and Surface Chemistry of Hydroxyapatite by : Dwarika N. Misra
Download or read book Adsorption on and Surface Chemistry of Hydroxyapatite written by Dwarika N. Misra and published by Springer. This book was released on 1984-03-01 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydroxyapatite is the structural prototype of the main inorganic constituent of bone and teeth and, together with fluorapatite, is also one of the principal minerals in commercial phosphate ores. The adsorption characteristics and surface chemistry of hydroxyapatite are important in understanding the growth, dissolution and adhesion mechanisms of bone and tooth tissues and in elucidating the factors in mineral beneficiation such as floation and flocculation. This volume essentially documents the proceedings of the symposium on the same topic held at the American Chemical Society Meeting in Kansas City, MO, September 12-17, 1982. It includes a few papers which were not presented at the symposium but does not comprise the entire program. This volume provides, on a limited scale, a multidisciplinary overview of current work in the field of adsorptive behavior and surface chemistry of hydroxyapatite and includes certain review articles. There are two papers each on adsorption, adsorption and its effects on crystal growth or dissolution kinetics, effects of electrochemical parameters on solubility and adsorption, and newer physical methods (exoemission and high-resolution NMR) of examining hydroxyapatite surface. There is one paper each on structure modelling of apatite surface based on octacalcium phosphate interface and on biodegradation of sintered hydroxyapatite.
Book Synopsis The Chemistry of Prehistoric Human Bone by : Theron Douglas Price
Download or read book The Chemistry of Prehistoric Human Bone written by Theron Douglas Price and published by CUP Archive. This book was released on 1989-08-10 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Surface Chemistry and Wettability of Microtextured Titanium Surfaces in Osteoblast Differentiation by : Jung Hwa Park
Download or read book The Role of Surface Chemistry and Wettability of Microtextured Titanium Surfaces in Osteoblast Differentiation written by Jung Hwa Park and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterial surface energy, chemical composition, charge, wettability and roughness all play an important role in determining the degree of the direct bone-to-implant interface, termed osseointegration. Surface chemistry, which is influenced by surface energy, wettability, and composition, is another factor that determines osteoblast phenotype and regulates osteoblast maturation. Increased surface energy is desirable for bone implants due to enhanced interaction between the implant surface and the biological environment. The extent of bone formation in vivo is also increased with increasing water wettability of implants. The physiological role of implant surface chemistry is important in determining the success of implant osseointegration because of molecular rearrangements, surface reactions, contamination, and release of toxic or biologically active ions that are determined by the starting chemistry. However, the role of surface chemistry on osteoblast response is not fully studied. Therefore, the overall goal of this dissertation is to understand how the surface chemistry, including wettability, chemical composition, and charge density, of titanium biomaterials impacts osteoblast maturation (in vitro). This study focuses on the general hypothesis that modifications of surface chemistry of titanium surfaces with sterilization or polyelectrolyte coating on titanium surfaces regulate osteoblast response.
Book Synopsis Effect of Microstructural and Chemical Cues on the in Vitro Cell Response to Calcium Phosphates by : Joanna Maria Sadowska
Download or read book Effect of Microstructural and Chemical Cues on the in Vitro Cell Response to Calcium Phosphates written by Joanna Maria Sadowska and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone has a natural ability to regenerate. However, it cannot bridge large defects without the additional help of a supporting material. Among the different synthetic bone grafts, calcium phosphates (CaPs) are excellent candidates for bone regeneration due to their close resemblance to the mineral phase of bone, as well as the bioactive and osteoinductive potential. The present thesis explores the effect of the physicochemical features of CaPs on the interaction with the cells involved in the different stages of the bone healing process: inflammation, angiogenesis and osteogenesis, paying special attention to biomimetic calcium deficient hydroxyapatite (CDHA). This is analysed through in vitro cell cultures with immune, endothelial and bone forming cells, respectively. An overview of bone biology and bone healing process is presented in Chapter 1. Moreover, the Chapter 1 describes synthetic bone grafts based on CaPs and the impact of their physicochemical features on cellular behaviour in vitro. Chapter 2 and Chapter 3 study the response of immune cells to calcium phosphates and its outcome on osteogenic differentiation of bone forming cells. Specifically, Chapter 2 explores the link between nanotopography, specific surface area and porosity of biomimetic CDHA and its immunomodulatory, osteoimmunomodulatory and antinflammatory features, demonstrating that neddle- like topography of CDHA stimulated the osteogenic activity of bone forming cells, whilst a reduction of porosity to CDHA substrates decreased the inflammatory state. Chapter 3 is devoted to study the interaction of two chemically and texturally different calcium phosphates i.e. biomimetic CDHA and sintered ß-tricalcium phosphate (ß-TCP) with macrophages under inflammatory environment and its further impact on osteogenic differentiation of mesenchymal (MSCs) and osteoblastic cells. Angiogenesis ensures the availability of oxygen and nutrients and controls the recruitment and osteogenic differentiation of bone forming cells, being one of the crucial processes during bone healing. Chapter 4 explores the interaction of two texturally different CDHA, i.e. needle-like and plate-like structured surfaces, as well as ß-TCP with endothelial progenitor cells (EPCs). Moreover, the cellular crosstalk between EPCs and MSCs is investigated by performing co-culture studies. Finally, the independent effect of surface chemistry and ionic exchange of sintered and biomimetic calcium phosphates on osteogenesis are explored in Chapter 5 and Chapter 6. Chapter 5 describes the response of MSCs and osteoblastic cells to biommimetic CDHA and sintered CaPs i.e. ß-TCP, a-tricalcium phosphate (a-TCP) and hydroxyapatite (HA). The results showed that the direct contact with substrate is required to induce the osteogenic differentiation of both MSCs and osteoblasts. Moreover, the culture with the CDHA resulted in greater upregulation of ALP secretion for both cell types suggesting osteoinductive capacity of this substrate. Nonetheless, MSCs proliferation was impaired both in direct and indirect cultures on CDHA, suggesting that the increased ionic fluctuations, triggered by high SSA and calcium deficiency of the substrate, were responsible for this scenario. Hence Chapter 5 revealed the complexity to assess the cell-material interactions of highly reactive substrates in static in vitro cultures. This is further explored in Chapter 6, where a strategy is proposed to analyse the parameters affecting the response of MSCs to CDHA. The approach consisted of adjusting the volume ratio between the cell culture medium and CaP substrate, which allowed mitigating the drastic ionic changes. The results demonstrated that the alterations of calcium and phosphate concentrations impaired cell adhesion by reducing the number of focal adhesions, this leading to cell shrinkage and apoptosis. On the contrary, when the ionic fluctuations were attenuated, MCSs spread, proliferated and differentiated over time.
Book Synopsis Bone Health and Osteoporosis by : United States Public Health Service
Download or read book Bone Health and Osteoporosis written by United States Public Health Service and published by . This book was released on 2004-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.
Book Synopsis The Role of Surface Chemistry in Osseointegration by : Emily Buck
Download or read book The Role of Surface Chemistry in Osseointegration written by Emily Buck and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Poly(etheretherketone) (PEEK) is a synthetic polymer with great potential for use as orthopedic implants with its radiolucency and mechanical properties close to those of native bone. Despite these advantages, PEEK implants tend to fail because immune cells, such as macrophages, prevent the attachment of bone by inducing chronic inflammation and fibrous encapsulation. Surface modification can improve osseointegration, but the mechanisms underlying the improvements are not well known. Since surface chemistry has been linked to reductions in fibrous encapsulation of model surfaces, this thesis aimed to investigate the effect of surface chemistry on the steps in the process of osseointegration, such as protein adsorption and macrophage responses, to provide insight about the role of surface chemistry in osseointegration. This thesis begins with a literature review that describes various surface modification strategies used to improve the integration of PEEK implants. The review proposed the development of surfaces with controlled properties to better understand how surface modifications influence the osseointegration of PEEK, and it highlighted a need for including protein adsorption and macrophage responses in future studies to better understand the full process of osseointegration around implants with modified surfaces. In the first study, a model surface, poly(styrene) (PS), with controlled surface chemistry was developed to investigate the effect of surface chemistry on protein adsorption and macrophage responses through diazonium chemistry reactions. Three common biological functional groups (COOH, NH2, and PO3H2) were selected and attached to PS surfaces in similar surface densities to compare the chemistries directly. Surfaces containing COOH groups increased the expression of anti-inflammatory macrophage markers while surfaces with NH2 groups exacerbated the response to an inflammatory stimulus. Characterization of the adsorbed protein layer demonstrated that surfaces with COOH groups adsorbed more proteins associated with integrin signaling from serum while surfaces with NH2 groups adsorbed more proteins associated with inflammatory reactions. These results demonstrated that surface chemistry could modulate macrophage responses through alterations in the layer of proteins adsorbed on the surfaces. In the second study, NH2 and COOH groups, which provoked pro- or anti-inflammatory macrophage responses, were selected and attached to PEEK surfaces to investigate whether these different macrophage responses could enhance the osseointegration of PEEK. In vitro, NH2 and COOH groups on PEEK promoted relatively pro- and anti-inflammatory macrophage responses as they did on PS, and protein adsorption on these surfaces also followed similar patterns. After 14 days in vivo, the NH2 groups promoted bone thinning while COOH groups had no effect. Surprisingly, the NH2 groups significantly increased adhesion to bone compared to the unmodified PEEK implants while COOH groups increased adhesion but not significantly. Since the NH2 groups were able to promote mineral deposition in acellular environments better than COOH groups, the NH2 groups may have enhanced mineral-binding in vivo. These results suggested different mechanisms involved in the osseointegration of NH2 and COOH-functionalized implants"--
Download or read book Research Awards Index written by and published by . This book was released on 1976 with total page 1248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Biochemistry and Physiology of Bone by : Geoffrey Howard Bourne
Download or read book The Biochemistry and Physiology of Bone written by Geoffrey Howard Bourne and published by . This book was released on 1956 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomaterials Surface Science by : Andreas Taubert
Download or read book Biomaterials Surface Science written by Andreas Taubert and published by John Wiley & Sons. This book was released on 2013-07-12 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a "who's who" of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.
