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Author : Gary Martinez
Publisher :
ISBN 13 :
Total Pages : 234 pages
Book Rating : 4.:/5 (125 download)
Download or read book Structure and Dynamics of Peptides in Solution written by Gary Martinez and published by . This book was released on 1997 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Klas G. J. Arvidsson
Publisher :
ISBN 13 : 9789171531988
Total Pages : 51 pages
Book Rating : 4.5/5 (319 download)
Download or read book Solution Structure and Dynamics of Peptides as Studied by NMR and CD written by Klas G. J. Arvidsson and published by . This book was released on 1994 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bernd Gutte
Publisher : Elsevier
ISBN 13 : 0080538592
Total Pages : 527 pages
Book Rating : 4.0/5 (85 download)
Download or read book Peptides written by Bernd Gutte and published by Elsevier. This book was released on 1995-10-24 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines
Download or read book Solution Structure and Dynamics of Bioactive Peptides Mimicking NGF. written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pinaki Gupta-Bhaya
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.:/5 (845 download)
Download or read book Nuclear Magnetic Resonance Studies of the Structure and Dynamics of Short-chain Peptides in Solution written by Pinaki Gupta-Bhaya and published by . This book was released on 1972 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vibin Ramakrishnan
Publisher : Springer Nature
ISBN 13 : 1071634054
Total Pages : 142 pages
Book Rating : 4.0/5 (716 download)
Download or read book Biophysical Characterization of Functional Peptides written by Vibin Ramakrishnan and published by Springer Nature. This book was released on 2023-08-02 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This protocol book presents reproducible and step-by-step procedures for the peptide synthesis, their characterization and applications. The volume includes an introductory section on in silico modelling of new peptide molecules, Molecular Dynamics Simulations, Docking, Electrostatic fingerprinting of peptides, and other modelling tools for peptide designing and optimization. Further, it covers protocols for the solid phase peptide synthesis, chromatographic and mass spectrometric characterization of peptides. Importantly, it covers methods for biophysical characterizations of peptides for their potential applications as drug delivery vehicles, peptide nano-assembly, bionanocatalysis, protein aggregation diseases, and peptide-based anti-bacterial.
Author : Michel Marraud
Publisher : John Libbey Eurotext
ISBN 13 : 9780861961511
Total Pages : 656 pages
Book Rating : 4.9/5 (615 download)
Download or read book Chemistry, Structure and Function of Peptides written by Michel Marraud and published by John Libbey Eurotext. This book was released on 1970 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes proceedings of the 2nd Forum on Peptides held in Nancy, 2 to 6 May 1988.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Wayne Robert Fiori
Publisher :
ISBN 13 :
Total Pages : 474 pages
Book Rating : 4.:/5 (52 download)
Download or read book Structural Transitions in Peptide Secondary Structure Geometry written by Wayne Robert Fiori and published by . This book was released on 1994 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Studies on the Structure and Dynamics of Bioactive Peptides written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT The present work focuses on the exploration of the conformational space of biological active peptides in different conditions with the aim of characterizing their conformational profile. Different techniques have been used within the molecular mechanics framework. A first hurdle is encountered in the exploration as the exhaustiveness of the exploration and the definition of a criterion for stopping the procedure were not well defined at the beginning of the present work. A solution to this problem is presented in the second chapter for the iterative simulated annealing. Determining the bioactive conformation is a requirement for the design of peptidomimetics in computer-aided drug design. The bioactive conformation can be simplified by the moieties that are known to interact with the receptor and the relative distances between these moieties, and this schematic entity is termed pharmacophore. The pharmacophore can be used to screen three-dimensional databases of molecules for the search of peptidomimetics. The compounds obtained in the search can be subsequently tested for activity and a new group of lead compounds can be thus identified. In chapter 3 an example of this procedure is described with the aim of obtaining a new group of bradykinin antagonists. Peptides have been traditionally considered as flexible molecules especially in polar solvents like water. This flexibility is difficult to measure by experimental techniques and as a consequence peptides have been regarded as molecules lacking of structure under such conditions. On the other hand, biological active peptides are known to interact with their receptors in a preferred conformation, often termed as the bioactive conformation. The most accepted hypothesis for explaining the interaction of peptides and their receptors is the induced fit. Thus, the peptide will exhibit in solution conformational motives that are part of the conformation adopted in the receptor. Subsequent to the binding of the p.
Author : J. Andrew McCammon
Publisher : Cambridge University Press
ISBN 13 : 9780521356527
Total Pages : 256 pages
Book Rating : 4.3/5 (565 download)
Download or read book Dynamics of Proteins and Nucleic Acids written by J. Andrew McCammon and published by Cambridge University Press. This book was released on 1988-04-29 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
Author : Cheng Lu
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (965 download)
Download or read book Modeling Protein Dynamics in Solution: Effects of Ligand Binding and Crowding written by Cheng Lu and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Zusammenfassung: In this thesis, molecular dynamics simulations have been performed to understand the effect of ligand binding or crowding on the structure and dynamics of proteins or peptides.Our findings show a long-range conformational response of the PDZ2 domain of human tyrosine phosphatase 1E to ligand release in the form of a collective shift of several rigid secondary structure elements and the C terminal loop relative to the rest of the protein away from the N-terminus.Considering a multi-domain protein as a next step, the allosteric coupling in the ligand-controlled oligomeric bacterial protease DegS between the active site and (i) the binding pocket of the ligand, as well as (ii) the sites in contact with other protomers has been analyzed. Our results indicate that only trimeric and not monomeric DegS is functional. The pathways via which ligand release or the disassembly of DegS into monomers leads to response at functionally relevant allosteric sites are revealed.Finally, we have the relationship between biomolecular conformational changes and water mediation in crowded environments. We find that molecular crowding, though barely changing the structural distribution of the peptide, substantially affects the kinetics of conformational changes. In view of the weak interaction between the peptides observed (a prerequisite for good crowders), our results provide evidence for a non-trivial role of the solvent for the slowing down in the kinetics of conformational transitions of the peptides
Author : Andrew Ernest Torda
Publisher :
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.:/5 (22 download)
Download or read book The Solution Structure and Dynamics of a Polypeptide Cardiostimulant Studied by ¹H NMR Spectroscopy written by Andrew Ernest Torda and published by . This book was released on 1988 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xuehai Yan
Publisher : John Wiley & Sons
ISBN 13 : 3527841253
Total Pages : 933 pages
Book Rating : 4.5/5 (278 download)
Download or read book Peptide Self-Assembly and Engineering written by Xuehai Yan and published by John Wiley & Sons. This book was released on 2024-02-09 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Self-Assembly and Engineering State-of-the-art research in peptide self-assembly, with coverage of fundamental aspects of how peptides self-assemble and an extensive number of applications Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications (2V set) covers the latest progresses in the field of peptide self-assembly and engineering, including the fundamental principles of peptide self-assembly, new theory of nucleation and growth, thermodynamics and kinetics, materials design rules, and precisely controlled structures and unique functions. The broad contents from this book enable readers to obtain a systematical and comprehensive knowledge in the field of peptide self-assembly and engineering. Contributed by the leading scientists and edited by a highly qualified academic and an authority in the field, Peptide Self-Assembly and Engineering includes information on: Emerging areas in peptide assembly, such as immune agents, bioelectronics, energy conversion, flexible sensors, biomimetic catalysis, and more Existing applications in biomedical engineering, nanotechnology, and photoelectronics, including tissue engineering, drug delivery, and biosensing devices History of peptide self-assembly for design of functional materials and peptides’ unique mechanical, optical, electronic, and biological properties Various solvent conditions, such as pH, ionic strength, and polarity, that can affect the structure and stability of peptide assemblies A very comprehensive reference covering the latest progresses in the field of peptide self-assembly and engineering, Peptide Self-Assembly and Engineering is an essential resource for all scientists performing research intersecting with the subject, including biochemists, biotechnologists, pharmaceutical chemists, protein chemists, materials scientists, and medicinal chemists.
Author : Susanne Olofsson
Publisher :
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.3/5 (91 download)
Download or read book Design, Synthesis, Structure, and Dynamics of a Polypeptide with Supersecondary Structure written by Susanne Olofsson and published by . This book was released on 1994 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Elsevier
ISBN 13 : 0080463568
Total Pages : 313 pages
Book Rating : 4.0/5 (84 download)
Download or read book Peptide Solvation and H-bonds written by and published by Elsevier. This book was released on 2006-03-02 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 72, Peptide Solvation and H-bonds, addresses the role of peptide backbone solvation in the energetics of protein folding. Particular attention is focused on modeling and computation. This volume will be of particular interest to biophysicists and structural biologists. Challenges the longstanding and basic assumptions of structural biology Discusses how to solve the problem of protein structure prediction Addresses the quantitation of the energetics of folding
Author : Helen E. Ferreira
Publisher :
ISBN 13 :
Total Pages : 133 pages
Book Rating : 4.:/5 (956 download)
Download or read book Characterization of the Structure and Dynamics of Biomimetic Peptides by Solid-state NMR written by Helen E. Ferreira and published by . This book was released on 2016 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diatoms and sponges use proteins, long chain polyamines, and other biomolecules to assemble silica structures of controlled morphology. Investigated here are biosilicification peptides. Under mild conditions, these peptides produce silica nanoparticles from solutions of silicic acid, whereas harsh methods are currently employed to produce these nanoparticles commercially. Biomimetic precipitation studies have shown that LK[alpha]14 (Ac-LKKLLKLLKKLLKL- C), an amphiphilic lysine/leucine repeat peptide with an [alpha]-helical secondary structure at polar/apolar interfaces, co-precipitates with silica to form nanospheres. Previous work confirmed the [alpha]-helical secondary structure in both the neat and silica-complexed states of the peptide and suggested that the tetrameric bundles of peptide that are known to form in solution persisted in the silica-complexed form. To further investigate the peptide aggregation, deuterium solid-state nuclear magnetic resonance (2H ssNMR) was used to establish how the site-specific leucine side-chain dynamics of LK[alpha]14 differ in the neat state, buffered state, and silica-precipitated form. Modeling the 2H ssNMR line shapes using code developed in-house helped probe the mechanisms of peptide pre-aggregation and silica co-precipitation. For the silica samples, the model was verified by fitting three types of 2H NMR data: static quadrupolar echo (QE), magic angle spinning (MAS), and T1 inversion recovery (T1IR) spectra. The resulting spectra demonstrate the presence of a tetrameric bundle in the neat state, which is disrupted with the introduction of buffer and then by silica co-precipitation. This work describes the development of the simulation framework used to model these types of experimental data, strategies for fitting these types of data, and finally, the expansion of the model beyond leucine for use with isoleucine.
