Structural Genomics, Part C

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Publisher : Academic Press
ISBN 13 : 0123814448
Total Pages : 105 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Structural Genomics, Part C by :

Download or read book Structural Genomics, Part C written by and published by Academic Press. This book was released on 2009-11-26 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. - Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy - Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Nuclear Magnetic Resonance of Biological Macromolecules, Part C

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Publisher : Academic Press
ISBN 13 : 0080549470
Total Pages : 670 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Nuclear Magnetic Resonance of Biological Macromolecules, Part C by :

Download or read book Nuclear Magnetic Resonance of Biological Macromolecules, Part C written by and published by Academic Press. This book was released on 2005-05-04 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences. Nuclear Magnetic Resonance of Biological Macromolecules, Part C is written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.* One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences

Structural Genomics

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Publisher : Academic Press
ISBN 13 : 9780123814432
Total Pages : 90 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Structural Genomics by : Andrzej Joachimiak

Download or read book Structural Genomics written by Andrzej Joachimiak and published by Academic Press. This book was released on 2009 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission.

Epigenetic Regulation of Cancer-Part C

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Publisher : Elsevier
ISBN 13 : 0443215472
Total Pages : 234 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Epigenetic Regulation of Cancer-Part C by :

Download or read book Epigenetic Regulation of Cancer-Part C written by and published by Elsevier. This book was released on 2024-08-23 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Regulation of Cancer, Part C, Volume 389 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic biomarkers in breast cancer, Contribution of epigenetics to virus-driven cancer, Cancer metabolism and epigenetics, Technologies for epigenome editing, Epigenetics and cancer stemness, Epigenetic modifications in obesity-associated cancers, Epigenetics in cf microRNA in blood of solid tumors, Integrative analysis of transcriptome, chromatin accessibility, cell surface antigen in single cell level for AML, and more.Additional chapters cover Epigenetics in lung cancer, Gene Regulatory Mechanisms underlying therapy resistance in Cancer, Role of miRNAs as epigenetic regulators of immune checkpoints in cancer immunity, Epigenetic contributions to Acute myeloid leukemia (AML), Contribution of epigenetics to chemoresistance, Epigenetic contribution to the relationship between obesity and cancer, and Epigenetic regulation in ovarian cancer. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike

Macromolecular Crystallography, Part C

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Publisher : Elsevier
ISBN 13 : 0080497098
Total Pages : 405 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Macromolecular Crystallography, Part C by : Charles W. Carter Jr.

Download or read book Macromolecular Crystallography, Part C written by Charles W. Carter Jr. and published by Elsevier. This book was released on 2003-12-15 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate molecular structures are vital for rational drug design and for structure-based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding.* Methodological methods in crystals* Methodological methods data analysis

Spectral Techniques In Proteomics

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Publisher : CRC Press
ISBN 13 : 1420017098
Total Pages : 474 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Spectral Techniques In Proteomics by : Daniel S. Sem

Download or read book Spectral Techniques In Proteomics written by Daniel S. Sem and published by CRC Press. This book was released on 2007-03-30 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Facilitating the innovation, development, and application of new spectroscopic methods in proteomics, Spectral Techniques in Proteomics provides a broad overview of the spectroscopic toolbox that can be used, either with proteome or sub-proteome mixtures or with individual/purified proteins studied in parallel. It gives a modest overview of

Molecular Biology of the Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structural Genomics

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Publisher : Academic Press
ISBN 13 : 9780123744425
Total Pages : 112 pages
Book Rating : 4.7/5 (444 download)

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Book Synopsis Structural Genomics by : Andrzej Joachimiak

Download or read book Structural Genomics written by Andrzej Joachimiak and published by Academic Press. This book was released on 2009-12-23 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Laboratory Methods in Enzymology: Protein Part C

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Publisher : Academic Press
ISBN 13 : 0124201784
Total Pages : 291 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis Laboratory Methods in Enzymology: Protein Part C by :

Download or read book Laboratory Methods in Enzymology: Protein Part C written by and published by Academic Press. This book was released on 2014-03-22 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume we have brought together a number of core protocols concentrating on Protein, carefully written and edited by experts. - Indispensable tool for the researcher - Carefully written and edited by experts to contain step-by-step protocols - In this volume we have brought together a number of core protocols concentrating on Protein

Encyclopedia of Bioinformatics and Computational Biology

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Publisher : Elsevier
ISBN 13 : 0128114320
Total Pages : 3421 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Bioinformatics and Computational Biology by :

Download or read book Encyclopedia of Bioinformatics and Computational Biology written by and published by Elsevier. This book was released on 2018-08-21 with total page 3421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Structural Genomics on Membrane Proteins

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Publisher : CRC Press
ISBN 13 : 1420016083
Total Pages : 401 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Structural Genomics on Membrane Proteins by : Kenneth H. Lundstrom

Download or read book Structural Genomics on Membrane Proteins written by Kenneth H. Lundstrom and published by CRC Press. This book was released on 2006-02-23 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the genomic revolution has quickly led to the deposit of more than 30,000 structures in the protein data bank (PDB), less than one percent of those contributions represent membrane proteins despite the fact that membrane proteins constitute some 20 percent of all proteins. This discrepancy becomes significantly troublesome when it is coupled

Amyloid, Prions, and Other Protein Aggregates, Part C

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Author :
Publisher : Elsevier
ISBN 13 : 0080468977
Total Pages : 412 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Amyloid, Prions, and Other Protein Aggregates, Part C by :

Download or read book Amyloid, Prions, and Other Protein Aggregates, Part C written by and published by Elsevier. This book was released on 2006-10-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of polypeptides to form alternatively folded, polymeric structures such as amyloids and related aggregates is being increasingly recognized as a major new frontier in protein research. This new volume of Methods in Enzymology along with Part B (volume 412) on Amyloid, Prions and other Protein Aggregates continue in the tradition of the first volume (309) in containing detailed protocols and methodological insights, provided by leaders in the field, into the latest methods for investigating the structures, mechanisms of formation, and biological activities of this important class of protein assemblies. - Presents detailed protocols - Includes troubleshooting tips - Provides coverage on structural biology, computational methods, and biology

Mapping and Sequencing the Human Genome

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Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council

Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Structural Genomics and Drug Discovery

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Author :
Publisher : Springer Nature
ISBN 13 : 1493903543
Total Pages : 344 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Structural Genomics and Drug Discovery by : Wayne F. Anderson

Download or read book Structural Genomics and Drug Discovery written by Wayne F. Anderson and published by Springer Nature. This book was released on 2014-07-08 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Structural Genomics and Drug Discovery: Methods and Protocols seeks to aid scientists in the further study into structural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction.

Structural Biology in Drug Discovery

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1437 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1437 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Nuclear Magnetic Resonance

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Publisher : Royal Society of Chemistry
ISBN 13 : 184755847X
Total Pages : 387 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Nuclear Magnetic Resonance by : G A Webb

Download or read book Nuclear Magnetic Resonance written by G A Webb and published by Royal Society of Chemistry. This book was released on 2008-05-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Nucleic Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications. Volume 37 covers literature published from June 2006 to May 2007.

Fundamentals of Molecular Structural Biology

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Publisher : Academic Press
ISBN 13 : 0128148551
Total Pages : 518 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Fundamentals of Molecular Structural Biology by : Subrata Pal

Download or read book Fundamentals of Molecular Structural Biology written by Subrata Pal and published by Academic Press. This book was released on 2019-08-15 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche.