Structural And Functional Network Organization Of The Brain

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Fundamentals of Brain Network Analysis

Author : Alex Fornito
Publisher : Academic Press
ISBN 13 : 0124081185
Total Pages : 496 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Fundamentals of Brain Network Analysis by : Alex Fornito

Download or read book Fundamentals of Brain Network Analysis written by Alex Fornito and published by Academic Press. This book was released on 2016-03-04 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. Winner of the 2017 PROSE Award in Biomedicine & Neuroscience and the 2017 British Medical Association (BMA) Award in Neurology Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain

Micro-, Meso- and Macro-Connectomics of the Brain

Author : Henry Kennedy
Publisher : Springer
ISBN 13 : 3319277774
Total Pages : 173 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Micro-, Meso- and Macro-Connectomics of the Brain by : Henry Kennedy

Download or read book Micro-, Meso- and Macro-Connectomics of the Brain written by Henry Kennedy and published by Springer. This book was released on 2016-03-10 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.

Discovering the Brain

Author : National Academy of Sciences
Publisher : National Academies Press
ISBN 13 : 0309045290
Total Pages : 195 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Discovering the Brain by : National Academy of Sciences

Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Networks of the Brain

Author : Olaf Sporns
Publisher : MIT Press
ISBN 13 : 0262528983
Total Pages : 433 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis Networks of the Brain by : Olaf Sporns

Download or read book Networks of the Brain written by Olaf Sporns and published by MIT Press. This book was released on 2016-02-12 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrative overview of network approaches to neuroscience explores the origins of brain complexity and the link between brain structure and function. Over the last decade, the study of complex networks has expanded across diverse scientific fields. Increasingly, science is concerned with the structure, behavior, and evolution of complex systems ranging from cells to ecosystems. In Networks of the Brain, Olaf Sporns describes how the integrative nature of brain function can be illuminated from a complex network perspective. Highlighting the many emerging points of contact between neuroscience and network science, the book serves to introduce network theory to neuroscientists and neuroscience to those working on theoretical network models. Sporns emphasizes how networks connect levels of organization in the brain and how they link structure to function, offering an informal and nonmathematical treatment of the subject. Networks of the Brain provides a synthesis of the sciences of complex networks and the brain that will be an essential foundation for future research.

Handbook of Neuroengineering

Author : Nitish V. Thakor
Publisher : Springer Nature
ISBN 13 : 9811655405
Total Pages : 3686 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Handbook of Neuroengineering by : Nitish V. Thakor

Download or read book Handbook of Neuroengineering written by Nitish V. Thakor and published by Springer Nature. This book was released on 2023-02-02 with total page 3686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.

Structural and Functional Network Organization of the Brain

Author : David Grayson
Publisher :
ISBN 13 : 9780355150209
Total Pages : pages
Book Rating : 4.1/5 (52 download)

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Book Synopsis Structural and Functional Network Organization of the Brain by : David Grayson

Download or read book Structural and Functional Network Organization of the Brain written by David Grayson and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Substantial research effort is currently being directed at establishing the system of pathways that connect the functional regions of the normal human brain. At the same time, the past decade has seen an explosion of network science as a new methodology to study human brain structure and function. Despite the impressive scale of these efforts, the relationship between brain structure and brain function is still murky. It remains a difficult and crucial challenge to relate functional aberrations (e.g. changes in brain activity and/or behavior) seen in neuropsychiatric disorders to underlying changes in neuroanatomy. This dissertation aims to contribute new knowledge in this area through controlled experimental manipulations in animal models and through investigation of brain structural connectivity in people with Autism Spectrum Disorder (ASD). Functional and structural connectivity data were obtained in these experiments via non-invasive magnetic resonance imaging (MRI). First, the effects of focal perturbation were examined via pharmacogenetic inactivation of the amygdala in rhesus monkeys. Positive and negative downstream changes in functional connectivity (i.e. correlated activity between other regions) were examined via resting-state fMRI. These changes were shown to be partly predictable using a network-based analysis of experimentally established structural connectivity to simulate disconnection of the amygdala. The results of this study validated the use of a particular network metric of mutual communication, termed communicability, for predicting baseline functional connectivity measurements from structural connectivity networks and for simulating the effects of focal perturbation. Next, the long-term structural consequences of early focal damage were examined in adult rhesus monkeys that received amygdala lesions as neonates. These monkeys demonstrated permanent atrophy of areas typically well-connected with the amygdala and impaired communicability of temporal and orbitofrontal cortex. On the other hand, these animals exhibited an abnormally large middle cingulate cortex. The spatial distribution of altered gray matter morphometry bore meaningful overlap with the pattern of altered functional connectivity due to transient inactivation. Finally, alterations in communicability were examined within a large dataset of young children with and without ASD. There were significant network-level alterations in children with ASD relative to their typically developing peers. Within the cohort of children with ASD, there were effects of different biological variables such as 1) sex, 2) age, 3) sex-by-age interactions, and 4) having a disproportionately large brain relative to body size. Together, these experiments demonstrate that focal perturbations in brain structure result in distributed impacts on brain structure and function that are at least partly predictable using network analysis. Network metrics that are useful for predicting function from structure (i.e. communicability) are shown here to be valuable for assessing the neurophenotype of ASD and exploring clinical heterogeneity.

Functional and structural brain network construction, representation and application

Author : Mingxia Liu
Publisher : Frontiers Media SA
ISBN 13 : 2832520014
Total Pages : 534 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Functional and structural brain network construction, representation and application by : Mingxia Liu

Download or read book Functional and structural brain network construction, representation and application written by Mingxia Liu and published by Frontiers Media SA. This book was released on 2023-04-06 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Atlas of Morphology and Functional Anatomy of the Brain

Author : T. Scarabino
Publisher : Springer Science & Business Media
ISBN 13 : 3540299432
Total Pages : 128 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Atlas of Morphology and Functional Anatomy of the Brain by : T. Scarabino

Download or read book Atlas of Morphology and Functional Anatomy of the Brain written by T. Scarabino and published by Springer Science & Business Media. This book was released on 2006-01-16 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent advances in neuroimaging techniques, particularly magnetic re- nance (MR), have greatly improved our knowledge of brain anatomy and related brain function. Morphological and functional investigations of the brain using high-definition MR have made detailed study of the brain possible and provided new data on anatomo-functional correlations. These studies have fuelled the interest in central nervous system imaging by clinicians (n- roradiologists, neurosurgeons, neurologists, neurophysiologists, and psych- trists) as well as biophysicists and bioengineers, who are at work on new and ever more sophisticated acquisition and processing techniques to continue to improve the potential of brain imaging methods. The possibility of obtaining high-definition MR images using a 3.0-T m- net prompted us, despite the broad existing literature, to conceive an atlas illustrating in a simple and effective way the anatomy of the brain and correl- ed functions. Following an introductory chapter by Prof. Pierre Rabischong, the atlas is divided into a morphological and a functional imaging section. The morphological atlas includes 3D surface images, axial, coronal, and sagittal scans acquired with high-definition T2 fast spin echo (FSE) sequences, and standard and inverted-contrast images. The MR scans are shown side by side with the corresponding anatomical brain sections, provided by Prof. Henri Duvernoy, for more effective comparison. The anatomical nomenclature adopted for both the MR and the anatomical images is listed in an jacket flap for easier consultation.

Quantitative Functionally-defined Relationships Between Structural and Functional Connectivity Within the Human Brain

Author : Kevin Grant Solar
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)

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Book Synopsis Quantitative Functionally-defined Relationships Between Structural and Functional Connectivity Within the Human Brain by : Kevin Grant Solar

Download or read book Quantitative Functionally-defined Relationships Between Structural and Functional Connectivity Within the Human Brain written by Kevin Grant Solar and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural connectivity (SC) describes the white matter pathways that provide the electrochemical basis of functional connectivity (FC: temporally-coherent brain activity amongst anatomically-distinct brain regions). Initial human SC-FC relationship studies using magnetic resonance imaging (MRI) were largely exploratory and used only anatomical brain parcellations (failing to account for functional network organization), and revealed that SC reliably predicts FC, but that FC does not appear to predict SC. The purpose of this thesis is to elucidate SC-FC coupling within resting state functional networks. Diffusion tensor and myelin water MRI were applied to measure SC, with resting state functional MRI to measure FC. I tested the strength of SC-FC relationships by linear correlation and regression analyses. This thesis provides novel empirical evidence for divergent and non-overlapping SC-FC coupling within resting state networks, and importantly reveals a few specific brain regions that appear to be disproportionally involved in SC-FC coupling.

Brain Informatics

Author : Bin Hu
Publisher : Springer
ISBN 13 : 3642236057
Total Pages : 347 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Brain Informatics by : Bin Hu

Download or read book Brain Informatics written by Bin Hu and published by Springer. This book was released on 2011-08-27 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the International Conference on Brain Informatics, BI 2011, held in Lanzhou, China, in September 2011. The 27 revised full papers and 6 keynote talks were carefully reviewed and selected for inclusion in the book. They are grouped in topcial sections on thinking and perception-centric investigations of human information processing systems; information technologies for the management, analysis and use of brain data; cognition-inspired applications. Furthermore, there is a section with 8 papers from the workshop on meta-synthesis and complex systems.

Atlas of Human Brain Connections

Author : Marco Catani
Publisher : Oxford University Press, USA
ISBN 13 : 0199541167
Total Pages : 533 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Atlas of Human Brain Connections by : Marco Catani

Download or read book Atlas of Human Brain Connections written by Marco Catani and published by Oxford University Press, USA. This book was released on 2012-06-14 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major challenges of modern neuroscience is to define the complex pattern of neural connections that underlie cognition and behaviour. This atlas capitalises on novel diffusion MRI tractography methods to provide a comprehensive overview of connections derived from virtual in vivo tractography dissections of the human brain.

Neural Organization

Author : Michael A. Arbib
Publisher : MIT Press
ISBN 13 : 9780262011594
Total Pages : 442 pages
Book Rating : 4.0/5 (115 download)

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Book Synopsis Neural Organization by : Michael A. Arbib

Download or read book Neural Organization written by Michael A. Arbib and published by MIT Press. This book was released on 1998 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Neural Organization, Arbib, Erdi, and Szentagothai integrate structural, functional, and dynamical approaches to the interaction of brain models and neurobiologcal experiments. Both structure-based "bottom-up" and function- based "top-down" models offer coherent concepts by which to evaluate the experimental data. The goal of this book is to point out the advantages of a multidisciplinary, multistrategied approach to the brain.Part I of Neural Organization provides a detailed introduction to each of the three areas of structure, function, and dynamics. Structure refers to the anatomical aspects of the brain and the relations between different brain regions. Function refers to skills and behaviors, which are explained by means of functional schemas and biologically based neural networks. Dynamics refers to the use of a mathematical framework to analyze the temporal change of neural activities and synaptic connectivities that underlie brain development and plasticity--in terms of both detailed single-cell models and large-scale network models.In part II, the authors show how their systematic approach can be used to analyze specific parts of the nervous system--the olfactory system, hippocampus, thalamus, cerebral cortex, cerebellum, and basal ganglia--as well as to integrate data from the study of brain regions, functional models, and the dynamics of neural networks. In conclusion, they offer a plan for the use of their methods in the development of cognitive neuroscience."

Defining and Describing the Functional Network Organization of the Healthy Human Brain, with Observations on Development and Disease

Download Defining and Describing the Functional Network Organization of the Healthy Human Brain, with Observations on Development and Disease PDF Online Free

Author : Jonathan David Power
Publisher :
ISBN 13 :
Total Pages : 273 pages
Book Rating : 4.:/5 (885 download)

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Book Synopsis Defining and Describing the Functional Network Organization of the Healthy Human Brain, with Observations on Development and Disease by : Jonathan David Power

Download or read book Defining and Describing the Functional Network Organization of the Healthy Human Brain, with Observations on Development and Disease written by Jonathan David Power and published by . This book was released on 2014 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis concerns the general functional organization of the healthy human brain. In contrast to studies of organization based on lesions or task-evoked activity, brain organization is studied using task-free measures of association between brain regions, namely resting state functional connectivity fMRI (RSFC). This technique measures relationships between brain regions using correlations in spontaneous, low-frequency BOLD signal, and is described in Chapter 1. In Chapter 2, we outline the general RSFC network structure of the healthy adult brain. In Chapter 3, we examine brain network structure for evidence of critical nodes in the system. In Chapter 4, as part of a collaboration, we test and confirm these predictions in a large neuropsychological database. Chapter 5 describes a novel motion-related artifact in resting state fMRI. Chapter 6 describes methods to eliminate artifactual influences of motion on cohort comparisons. Chapter 7 describes ongoing and future efforts building on the data presented in Chapters 2-6.

Neuroscience of Creativity

Author : Oshin Vartanian
Publisher : MIT Press
ISBN 13 : 0262314703
Total Pages : 331 pages
Book Rating : 4.2/5 (623 download)

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Book Synopsis Neuroscience of Creativity by : Oshin Vartanian

Download or read book Neuroscience of Creativity written by Oshin Vartanian and published by MIT Press. This book was released on 2013-08-30 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts describe current perspectives and experimental approaches to understanding the neural bases of creativity. This volume offers a comprehensive overview of the latest neuroscientific approaches to the scientific study of creativity. In chapters that progress logically from neurobiological fundamentals to systems neuroscience and neuroimaging, leading scholars describe the latest theoretical, genetic, structural, clinical, functional, and applied research on the neural bases of creativity. The treatment is both broad and in depth, offering a range of neuroscientific perspectives with detailed coverage by experts in each area. The contributors discuss such issues as the heritability of creativity; creativity in patients with brain damage, neurodegenerative conditions, and mental illness; clinical interventions and the relationship between psychopathology and creativity; neuroimaging studies of intelligence and creativity; the neuroscientific basis of creativity-enhancing methodologies; and the information-processing challenges of viewing visual art. Contributors Baptiste Barbot, Mathias Benedek, David Q. Beversdorf, Aaron P. Blaisdell, Margaret A. Boden, Dorret I. Boomsma, Adam S. Bristol, Shelley Carson, Marleen H. M. de Moor, Andreas Fink, Liane Gabora, Dennis Garlick, Elena L. Grigorenko, Richard J. Haier, Rex E. Jung, James C. Kaufman, Helmut Leder, Kenneth J. Leising, Bruce L. Miller, Apara Ranjan, Mark P. Roeling, W. David Stahlman, Mei Tan, Pablo P. L. Tinio, Oshin Vartanian, Indre V. Viskontas, Dahlia W. Zaidel

Brain Networks for Studying Healthy and Pathological Aging Mechanisms and Intervention Efficacy

Author : Christos Frantzidis
Publisher : Frontiers Media SA
ISBN 13 : 2889661229
Total Pages : 577 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Brain Networks for Studying Healthy and Pathological Aging Mechanisms and Intervention Efficacy by : Christos Frantzidis

Download or read book Brain Networks for Studying Healthy and Pathological Aging Mechanisms and Intervention Efficacy written by Christos Frantzidis and published by Frontiers Media SA. This book was released on 2020-11-18 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previous studies showed that both healthy and pathological aging are associated with changes in brain structure and function of the mature human brain. The most prominent anatomical alteration are changes in prefrontal cortex morphology, volume loss and reduced white-matter integrity and hippocampal atrophy. Cognitive decline affects mainly the performance of episodic memory, speed of sensory information processing, working memory, inhibitory function and long-term memory. It has been also proposed that due to the aforementioned changes the aging brain engages in compensatory brain mechanism such as a broader activation of cortical regions (mainly frontal) rather than specialized activation. Evidence suggests that similar changes occur with pathological aging but to a greater extent. In this case information flow is disrupted due to neurodegeneration, functional activation of posterior (occipito-temporal) regions is decreased and as a consequence the brain fails to process sensorial input in the ventral pathway and cognitive deficits appear. In the last years, functional alterations associated with aging have been studied using the mathematical notion of graph theory that offers an integrative approach since it examines different properties of the brain network: 1) Organization level 2) amount of local information processing, 3) information flow 4) cortical community structure and 5) identification of functional / anatomical hubs. So, graph theory offers an attractive way to model brain networks organization and to quantify their pathological deviations. Previous studies have already employed this mathematical notion and demonstrated that age-related neurodegeneration is often accompanied by loss of optimal network organization either due to diminished local information processing or due to progressive isolation of distant brain regions. They have also found that changes in network properties may be present even in the preclinical phase, which could be taken as a biological marker of disease.

Discovering the Human Connectome

Author : Olaf Sporns
Publisher : MIT Press
ISBN 13 : 0262304805
Total Pages : 253 pages
Book Rating : 4.2/5 (623 download)

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Book Synopsis Discovering the Human Connectome by : Olaf Sporns

Download or read book Discovering the Human Connectome written by Olaf Sporns and published by MIT Press. This book was released on 2012-09-07 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneer in the field outlines new empirical and computational approaches to mapping the neural connections of the human brain. Crucial to understanding how the brain works is connectivity, and the centerpiece of brain connectivity is the connectome, a comprehensive description of how neurons and brain regions are connected. In this book, Olaf Sporns surveys current efforts to chart these connections—to map the human connectome. He argues that the nascent field of connectomics has already begun to influence the way many neuroscientists collect, analyze, and think about their data. Moreover, the idea of mapping the connections of the human brain in their entirety has captured the imaginations of researchers across several disciplines including human cognition, brain and mental disorders, and complex systems and networks. Discovering the Human Connectome offers the first comprehensive overview of current empirical and computational approaches in this rapidly developing field.

Handbook of Brain Connectivity

Author : Viktor K. Jirsa
Publisher : Springer
ISBN 13 : 3540715126
Total Pages : 525 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Handbook of Brain Connectivity by : Viktor K. Jirsa

Download or read book Handbook of Brain Connectivity written by Viktor K. Jirsa and published by Springer. This book was released on 2007-08-16 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our contemporary understanding of brain function is deeply rooted in the ideas of the nonlinear dynamics of distributed networks. Cognition and motor coordination seem to arise from the interactions of local neuronal networks, which themselves are connected in large scales across the entire brain. The spatial architectures between various scales inevitably influence the dynamics of the brain and thereby its function. But how can we integrate brain connectivity amongst these structural and functional domains? Our Handbook provides an account of the current knowledge on the measurement, analysis and theory of the anatomical and functional connectivity of the brain. All contributors are leading experts in various fields concerning structural and functional brain connectivity. In the first part of the Handbook, the chapters focus on an introduction and discussion of the principles underlying connected neural systems. The second part introduces the currently available non-invasive technologies for measuring structural and functional connectivity in the brain. Part three provides an overview of the analysis techniques currently available and highlights new developments. Part four introduces the application and translation of the concepts of brain connectivity to behavior, cognition and the clinical domain.