Stress And Epigenetics In Suicide

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Stress and Epigenetics in Suicide

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Author : Vsevolod Rozanov
Publisher : Academic Press
ISBN 13 : 0128052864
Total Pages : 238 pages
Book Rating : 4.1/5 (28 download)

Book Synopsis Stress and Epigenetics in Suicide by : Vsevolod Rozanov

Download or read book Stress and Epigenetics in Suicide written by Vsevolod Rozanov and published by Academic Press. This book was released on 2017-02-13 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention. - Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational - Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment - Integrates social, psychological, and existential influences, giving readers a better understanding of the interdisciplinary nature of suicide risk factors - Presents future directions for suicide-prevention strategies that incorporate recent research on genomics and stress resilience

The Neurobiological Basis of Suicide

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Author : Yogesh Dwivedi
Publisher : CRC Press
ISBN 13 : 143983881X
Total Pages : 485 pages
Book Rating : 4.4/5 (398 download)

Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

The Epigenetics of Suicide

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Author : Benoit Labonté
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (922 download)

Book Synopsis The Epigenetics of Suicide by : Benoit Labonté

Download or read book The Epigenetics of Suicide written by Benoit Labonté and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Suicide is a problem resulting from the interaction between several factors. Among these factors, early-life adversity, characterized by child sexual and physical abuse as well as parental neglect, is one of the strongest risk factors for depression and suicidal behaviors. While it is clear that child abuse increases the risk for depression and suicide, the mechanisms mediating these effects are still unknown. Recent evidences suggest that epigenetic mechanisms may be involved in mediating the effects of early-life adversity on behavior. Early-life stress in animals has been shown to alter DNA methylation in genes regulatory regions what, in turn, has been associated with changes in gene expression and behavioral modifications. Importantly, similar changes have been reported in several genes in the human brain. However, although epigenetic modifications have been found in several genes, the extent of epigenetic changes induced by early-life adversity is still unknown and their impacts on increasing suicide risk are unclear. This thesis aims at expanding our understanding of suicide by investigating one potential mechanism by which early-life adversity may increase vulnerability to mood disorders and suicide, namely epigenetic regulation of gene expression. We first expanded our characterization of DNA methylation alterations induced by early and adult-life stress in the regulatory regions of the glucocorticoid receptor gene which is one of the most consistent alterations associated with stress, depression and suicidal behaviors. We then opted for a genome-wide characterization of DNA methylation alterations found in the brains of suicide completers with and without a history of child abuse using microarray analyses focusing on gene promoters throughout the genome. Our findings revealed several DNA methylation alterations in genes with known roles on behavioral regulation and identified several new genes and networks which may be specifically altered by early-life adversity. We also characterized the functional impact of these alterations on gene expression and promoter transcriptional activity. Overall, this work identifies and characterizes the molecular mechanisms by which environment induces behavioral changes conferring vulnerability toward mood disorders and suicidal behaviors. " --

Epigenetics in Psychiatry

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Author : Jacob Peedicayil
Publisher : Academic Press
ISBN 13 : 0128235780
Total Pages : 848 pages
Book Rating : 4.1/5 (282 download)

Book Synopsis Epigenetics in Psychiatry by : Jacob Peedicayil

Download or read book Epigenetics in Psychiatry written by Jacob Peedicayil and published by Academic Press. This book was released on 2021-08-21 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. - Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease - Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins - Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery - Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) - Features chapter contributions from international leaders in the field

Epigenetics of Stress and Stress Disorders

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Author : Nagy Youssef
Publisher : Academic Press
ISBN 13 : 0128230622
Total Pages : 422 pages
Book Rating : 4.1/5 (282 download)

Book Synopsis Epigenetics of Stress and Stress Disorders by : Nagy Youssef

Download or read book Epigenetics of Stress and Stress Disorders written by Nagy Youssef and published by Academic Press. This book was released on 2022-02-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or "epidrugs. - Examines the epigenetics of stress, trauma, and related stress disorders - Connects new research to clinical practice and highlights implications for patient care, drug discovery, and public health - Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigenetic alterations - Features chapter contributions from international experts in the field

Suicide

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Author : Danuta Wasserman
Publisher : Oxford University Press
ISBN 13 : 0191026832
Total Pages : 449 pages
Book Rating : 4.1/5 (91 download)

Book Synopsis Suicide by : Danuta Wasserman

Download or read book Suicide written by Danuta Wasserman and published by Oxford University Press. This book was released on 2016-01-14 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately one million people worldwide commit suicide each year, and at least ten times as many attempt suicide. A considerable number of these people are in contact with members of the healthcare sector, and encounters with suicidal individuals form a common part of the everyday work of many healthcare professionals. Suicide: An unnecessary death examines the pharmacological, psychotherapeutic, and psychosocial measures adopted by psychiatrists, GPs, and other health-care staff, and emphasizes the need for a clearer psychodynamic understanding of the self if patients are to be successfully recognized, diagnosed, and treated. Drawing on the latest research by leading international experts in the field of suicidology, this new edition provides clinicians with an accessible summary of the latest research into suicide and its prevention. The abundance of new literature can make it difficult for those whose clinical practice involves daily contact with suicidal patients to devote sufficient time to penetrating the research and, accordingly, apply new findings in their clinical practice. In light of the WHO Mental Health Action Plan 2013-2020, this new edition is a timely contribution to the field, and a vital and rapid overview, that will increase awareness of suicide prevention methods.

Suicide by Self-Immolation

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Author : César A. Alfonso
Publisher : Springer Nature
ISBN 13 : 303062613X
Total Pages : 261 pages
Book Rating : 4.0/5 (36 download)

Book Synopsis Suicide by Self-Immolation by : César A. Alfonso

Download or read book Suicide by Self-Immolation written by César A. Alfonso and published by Springer Nature. This book was released on 2021-02-02 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses biopsychosocial and transcultural determinants of suicide by self-immolation, populations at risk throughout the world and prevention strategies specifically designed for young women in fragile environments. Self-immolation, the act of burning oneself as a means of suicide, is rare in high-income countries, and is usually a symbolic display of political protest among men that generally receives international media coverage. In contrast, in low- and-middle-income countries it is highly prevalent, primarily affects women, and may be one of the most common suicide methods in regions of Central and South Asia and parts of Africa. Psychiatric conditions, like adjustment disorders, traumatic stress disorders, and major depression, and family dynamics that include intimate partner violence, forced marriages, the threat of honor killings, and interpersonal family conflicts in a cultural context of war-related life events, poverty, forced migration and ethnic conflicts are important contributing factors. Written by over 40 academic psychiatrists from all continents, sociologists, and historians, the book covers topics such as region-specific cultural and historical factors associated with suicide; the role of religion and belief systems; marginalization, oppression, retraumatization and suicide risk; countertransference aspects of working in burn centers; responsible reporting and the media; and suicide prevention strategies to protect those at risk.

Behavioral Neurobiology of Suicide and Self Harm

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Author : Enrique Baca-Garcia
Publisher : Springer Nature
ISBN 13 : 3030575748
Total Pages : 250 pages
Book Rating : 4.0/5 (35 download)

Book Synopsis Behavioral Neurobiology of Suicide and Self Harm by : Enrique Baca-Garcia

Download or read book Behavioral Neurobiology of Suicide and Self Harm written by Enrique Baca-Garcia and published by Springer Nature. This book was released on 2020-12-21 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide. Suicidal behavior, perhaps, is the most complex behavior that combines biological, social, and psychological factors. A new frontier and new opportunities are opening with the technologies of data acquisition and data analysis. Personalized models based on digital phenotype could provide promising strategies for preventing suicide.

Phenomenology of Suicide

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Author : Maurizio Pompili
Publisher : Springer
ISBN 13 : 3319479768
Total Pages : 221 pages
Book Rating : 4.3/5 (194 download)

Book Synopsis Phenomenology of Suicide by : Maurizio Pompili

Download or read book Phenomenology of Suicide written by Maurizio Pompili and published by Springer. This book was released on 2017-10-10 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will help the reader to understand the suicidal mind from a phenomenological point of view, shedding light on the feelings of suicidal individuals and also those of clinicians. In accordance with the importance that the phenomenological approach attaches to subjectivity and sense of self as the starting points for knowledge, emphasis is placed on the need for the clinician to focus on the subjective experiences of the at-risk individual, to set aside prior assumptions, judgments, or interpretations, and to identify ways of bridging gaps in communication associated with negative emotions. The vital importance of empathy is stressed, drawing attention to the insights offered by neuroimaging studies and the role of mirror neurons in social cognition. It is widely acknowledged that when a clinician meets a person who wants to die by suicide, the clinician does not fully understand what is going on inside the mind of that individual. This book recognizes that any approach to suicide prevention must promote understanding of suicidal thoughts and feelings. The awareness that it fosters and the innovative perspectives that it presents will appeal to a wide readership.

Handbook of Nutrition, Diet, and Epigenetics

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Author : Vinood B. Patel
Publisher : Springer
ISBN 13 : 9783319555294
Total Pages : 0 pages
Book Rating : 4.5/5 (552 download)

Book Synopsis Handbook of Nutrition, Diet, and Epigenetics by : Vinood B. Patel

Download or read book Handbook of Nutrition, Diet, and Epigenetics written by Vinood B. Patel and published by Springer. This book was released on 2019-02-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Oxford Textbook of Suicidology and Suicide Prevention

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Author : Danuta Wasserman
Publisher : Oxford University Press, USA
ISBN 13 : 0198834446
Total Pages : 857 pages
Book Rating : 4.1/5 (988 download)

Book Synopsis Oxford Textbook of Suicidology and Suicide Prevention by : Danuta Wasserman

Download or read book Oxford Textbook of Suicidology and Suicide Prevention written by Danuta Wasserman and published by Oxford University Press, USA. This book was released on 2021-01-08 with total page 857 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the authoritative Oxford Textbooks in Psychiatry series, the new edition of the Oxford Textbook of Suicidology and Suicide Prevention remains a key text in the field of suicidology, fully updated with new chapters devoted to major psychiatric disorders and their relation to suicide.

Environmental Epigenetics

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Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 327 pages
Book Rating : 4.4/5 (471 download)

Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

The Developing Genome

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Author : David Scott Moore
Publisher : Oxford University Press, USA
ISBN 13 : 0199922349
Total Pages : 321 pages
Book Rating : 4.1/5 (999 download)

Book Synopsis The Developing Genome by : David Scott Moore

Download or read book The Developing Genome written by David Scott Moore and published by Oxford University Press, USA. This book was released on 2015 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible introduction to behavioral epigenetics, The Developing Genome explores how experiences influence genetic activity. We develop as we do not because of the genes we have, but because of what our genes do. The Developing Genome explains this new discipline and its revolutionary implications, changing how we understand development and evolution.

The Oxford Handbook of Developmental Psychology, Vol. 1

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Author : Philip David Zelazo
Publisher : Oxford University Press
ISBN 13 : 0199958459
Total Pages : 1049 pages
Book Rating : 4.1/5 (999 download)

Book Synopsis The Oxford Handbook of Developmental Psychology, Vol. 1 by : Philip David Zelazo

Download or read book The Oxford Handbook of Developmental Psychology, Vol. 1 written by Philip David Zelazo and published by Oxford University Press. This book was released on 2013-03-21 with total page 1049 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a comprehensive survey of what is now known about psychological development, from birth to biological maturity, and it highlights how cultural, social, cognitive, neural, and molecular processes work together to yield human behavior and changes in human behavior.

Handbook of Youth Suicide Prevention

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Author : Regina Miranda
Publisher : Springer Nature
ISBN 13 : 3030824659
Total Pages : 448 pages
Book Rating : 4.0/5 (38 download)

Book Synopsis Handbook of Youth Suicide Prevention by : Regina Miranda

Download or read book Handbook of Youth Suicide Prevention written by Regina Miranda and published by Springer Nature. This book was released on 2022-01-11 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook examines research on youth suicide, analyzes recent data on suicide among adolescents, and addresses the subject matter as a serious public health concern. The book explores the research on youth suicide, examining its causes, new and innovative ways of determining suicide risk, and evidence-based intervention and prevention strategies. In addition, it focuses on specific under-studied populations, including adolescents belonging to ethnic, racial, and sexual minority groups, youth involved in the criminal justice system, and adolescents in foster care. The book discusses how culturally informed and targeted interventions can help to decrease suicide risk for these populations. Key areas of coverage include: Early childhood adversity, stress, and developmental pathways of suicide risk. The neurobiology of youth suicide. Suicide, self-harm, and the media. Assessment of youth suicidal behavior with explicit and implicit measures. Suicide-related risk among immigrant, ethnic, and racial minority youth. LGBTQ youth and suicide prevention. Psychosocial treatments for ethnoculturally diverse youth with suicidal thoughts and behaviors. Technology-enhanced interventions and youth suicide prevention. The Handbook of Youth Suicide Prevention is an essential resource for researchers, professors, graduate students as well as clinicians, therapists, and other professionals in developmental psychology, social work, public health, pediatrics, family studies, child and adolescent psychiatry, school and educational psychology, and all interrelated disciplines. Chapters 8, 9 and 16 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Functional Somatic Symptoms in Children and Adolescents

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Author : Kasia Kozlowska
Publisher : Springer Nature
ISBN 13 : 303046184X
Total Pages : 397 pages
Book Rating : 4.0/5 (34 download)

Book Synopsis Functional Somatic Symptoms in Children and Adolescents by : Kasia Kozlowska

Download or read book Functional Somatic Symptoms in Children and Adolescents written by Kasia Kozlowska and published by Springer Nature. This book was released on 2020-09-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.

The Deepest Well

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Author : Nadine Burke Harris
Publisher : Houghton Mifflin Harcourt
ISBN 13 : 0544828704
Total Pages : 273 pages
Book Rating : 4.5/5 (448 download)

Book Synopsis The Deepest Well by : Nadine Burke Harris

Download or read book The Deepest Well written by Nadine Burke Harris and published by Houghton Mifflin Harcourt. This book was released on 2018 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneering physician reveals how childhood stress leads to lifelong health problems, and what we can do to break the cycle.