Stimulus Response Coupling In Human Blood Platelets

Download Stimulus Response Coupling In Human Blood Platelets full books in PDF, epub, and Kindle. Read online Stimulus Response Coupling In Human Blood Platelets ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Mechanisms of Stimulus—Response Coupling in Platelets

Author : J. Westwick
Publisher : Springer Science & Business Media
ISBN 13 : 1461594421
Total Pages : 440 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Mechanisms of Stimulus—Response Coupling in Platelets by : J. Westwick

Download or read book Mechanisms of Stimulus—Response Coupling in Platelets written by J. Westwick and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell ular response by protein phosphorylation and calcium flux. The mech anism of these latter events occurs through the activity of phospho lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico sanoids, reinforce and make irreversible the cellular response.

Energetics of Secretion Responses

Author : J.W.N. Akkerman
Publisher : CRC Press
ISBN 13 : 1351365932
Total Pages : 158 pages
Book Rating : 4.3/5 (513 download)

DOWNLOAD NOW!

Book Synopsis Energetics of Secretion Responses by : J.W.N. Akkerman

Download or read book Energetics of Secretion Responses written by J.W.N. Akkerman and published by CRC Press. This book was released on 2019-01-15 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a multidisciplinary approach to the study of energetics of secretion responses by combining the knowledge and expertise of leading authorities from various fields.

Mechanisms of Platelet Activation and Control

Author : Kalwant S. Authi
Publisher : Springer Science & Business Media
ISBN 13 : 1461529948
Total Pages : 276 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Mechanisms of Platelet Activation and Control by : Kalwant S. Authi

Download or read book Mechanisms of Platelet Activation and Control written by Kalwant S. Authi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction in platelets from the identification of surface receptors, G proteins, phospholipases, protein kinases and phosphatases, intracellular receptors for inositol phosphates, the Ca2+ regulatory machinery, cytoskeletal constituents to the control mechanism employing cyclic nucleotides has seen an explosion of information regarding their importance and for each constituent in the family of molecules to which they belong. This information has been of interest to researchers across a wide spectrum of disciplines including biochemists, pharmacologists, cell biologists and clinicians. In April 1992 an International Symposium bearing the name of this volume was organised at the Thrombosis Research Institute to bring together scientists from across the world whose common interest was the study of platelet activation and its regulation. We were particularly encouraged by the positive response from our speakers and the participants, their detailed contributions and the very lively discussions that took place throughout the two days of the symposium. Almost every aspect of signal transduction in human platelets was represented. Of the invited speakers twelve were from Europe (including the U. K. ), eight from North America and one from Japan. This volume is a compilation of chapters submitted by the speakers and represents a concise but informative picture of the present knowledge of the mechanisms of platelet activation and control.

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 834 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomedical Index to PHS-supported Research

Author :
Publisher :
ISBN 13 :
Total Pages : 1060 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!

Book Synopsis Biomedical Index to PHS-supported Research by :

Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1990 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Platelet Membrane Glycoproteins

Author : James N. George
Publisher : Springer Science & Business Media
ISBN 13 : 1468448803
Total Pages : 420 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!

Book Synopsis Platelet Membrane Glycoproteins by : James N. George

Download or read book Platelet Membrane Glycoproteins written by James N. George and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was just about ten years ago that platelet membrane glycoproteins were first charac terized and their abnormalities in congenital bleeding disorders first recognized. Dur ing this decade there has been a remarkable growth in our understanding of the structure and membrane organization of the platelet surface glycoproteins, their in teractions with external ligands during the process of hemostasis, and their defects causing hemorrhagic disease. These studies have advanced the knowledge of platelet involvement in hemostasis from a cellular to a molecular level, and they have provided a model for contact interactions among other cell types. This seemed a proper time to ask those who contributed major observations and insights during these past years to review their progress and to assess the state of our present knowledge. We have planned this volume to begin with the biochemistry of platelet membrane glycoproteins themselves and proceed through their involvement in platelet function to the final considerations of the platelet's role in maintaining the integrity of the vascular system. Our aim was an integrated presentation on the blood platelet from the perspective of its highly specialized and reactive cell surface. James N. George Alan T. Nurden David R. Phillips vii Contents I. INTRODUCTION 1. Plasma Membrane Receptors and Platelet Response Ernst F. Wscher 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Platelet Receptor Functions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 . . . . . . . . . . 2. 1. Receptors Involved in Platelet Adhesion and in Cell-Cell Contact. . . 5 2. 2. Receptors Involved in Platelet Activation. . . . . . . . . . . . . . . . . . . 6 . . . . 3. Conclusion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 II.

Calcium and Cell Physiology

Author : D. Marme
Publisher : Springer Science & Business Media
ISBN 13 : 3642700705
Total Pages : 398 pages
Book Rating : 4.6/5 (427 download)

DOWNLOAD NOW!

Book Synopsis Calcium and Cell Physiology by : D. Marme

Download or read book Calcium and Cell Physiology written by D. Marme and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the present volume is to give a comprehensive and up-to-date 2 survey of the nature and role of calcium ions (Ca +) in the regulation of cel 2 lular function. Since Ca + has gained in interest over the past years as a cel lular messenger in signal transduction, and since the discovery of its cellular receptor protein, calmodulin, has helped in understanding its mode of action in molecular terms, we felt that an interdisciplinary selection of topics from the calcium field could provide a good source of information for all those in terested in calcium-mediated physiology. The volume begins with an overview on the synarchic nature of the two 2 cellular messengers, cyclic AMP and Ca +. The next three chapters deal with 2 the various transport mechanisms for Ca +. The biochemistry and molecular biology of calmodulin, as well as the cellular localization of calmodulin and calmodulin-binding proteins, are reviewed. Calcium regulation of smooth muscle contraction introduces the pharmacology of calcium antagonists.

Research Grants Index

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher :
ISBN 13 :
Total Pages : 1224 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute

Author : National Heart, Lung, and Blood Institute
Publisher :
ISBN 13 :
Total Pages : 538 pages
Book Rating : 4.3/5 ( download)

DOWNLOAD NOW!

Book Synopsis Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute by : National Heart, Lung, and Blood Institute

Download or read book Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute written by National Heart, Lung, and Blood Institute and published by . This book was released on 1976 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biochemistry of Platelets

Author : David Phillips
Publisher : Elsevier
ISBN 13 : 0323148972
Total Pages : 477 pages
Book Rating : 4.3/5 (231 download)

DOWNLOAD NOW!

Book Synopsis Biochemistry of Platelets by : David Phillips

Download or read book Biochemistry of Platelets written by David Phillips and published by Elsevier. This book was released on 2012-12-02 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate. Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets and megakaryocytes. The expression and function of adhesive proteins on the platelet surface is also discussed. Comprised of 12 chapters, this book begins with a description of the morphological and metabolic responses to agonists, as well as the involvement of certain processes in the coupling of agonist-receptor interactions to platelet responses. The following chapter deals with platelet arachidonate metabolism and platelet-activating factor, focusing on the release of arachidonate from platelet lipid stores; pathways of platelet arachidonate metabolism and effects of arachidonate metabolites; and inhibition of platelet arachidonate metabolism by aspirin. The structure, function, and modification in disease of platelet membrane glycoproteins are then discussed, along with prothrombin activation on platelets and platelet regulation of thrombus formation. Secreted platelet proteins as markers for pathological disorders are also considered. This monograph is intended as a reference for investigators involved in platelet research as well as a source of information for those working in other areas of biological investigation.

Purines in Cellular Signaling

Author : Kenneth A. Jacobson
Publisher : Springer Science & Business Media
ISBN 13 : 146123400X
Total Pages : 459 pages
Book Rating : 4.4/5 (612 download)

DOWNLOAD NOW!

Book Synopsis Purines in Cellular Signaling by : Kenneth A. Jacobson

Download or read book Purines in Cellular Signaling written by Kenneth A. Jacobson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on purine derivatives as potent and selective modulators of physiologic functions has moved to center stage. This volume covers the biology and chemistry of purines and of their receptors broadly under these section headings: - Adenosine Receptors and Effector Systems - Adenine Nucleotide Receptors and Effector Systems - Phosphodiesterase Enzymes and Inhibitors The presentations focus on the potential development of clinically useful drugs and powerful agents that activate or block purinergic receptors or that inhibit phosphodiesterases. Xanthines (caffeine and theophylline) represent one class of such agents. This volume is for pharmacologists, biochemists, and medical chemists in research labs of universities, gov- ernment, and the pharmaceutical industry.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1044 pages
Book Rating : 4.:/5 (31 download)

DOWNLOAD NOW!

Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1982 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunopharmacology of Platelets

Author : M. Joseph
Publisher : Academic Press
ISBN 13 : 0080534562
Total Pages : 267 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!

Book Synopsis Immunopharmacology of Platelets by : M. Joseph

Download or read book Immunopharmacology of Platelets written by M. Joseph and published by Academic Press. This book was released on 1995-07-05 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets have long been the subject of much investigation in the areas of vascular physiology, biochemistry, immunology and physiopathology. Their ability to react to environmental stimuli, to modify their shape and metabolism despite being anuclear, has fascinated scientists.This volume looks specifically at the involvement of blood platelets outside their 'classical' field of application, in the physiopathological mechanics of allergy and inflammation. The coverage includes the role of platelets in bacterial, parasitic and viral diseases and in tumour cell interactions.

The Platelets

Author : Gesina Longenecker
Publisher : Elsevier
ISBN 13 : 0323147704
Total Pages : 508 pages
Book Rating : 4.3/5 (231 download)

DOWNLOAD NOW!

Book Synopsis The Platelets by : Gesina Longenecker

Download or read book The Platelets written by Gesina Longenecker and published by Elsevier. This book was released on 2012-12-02 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Platelets: Physiology and Pharmacology is a critical review of the basic platelet systems, methodologic critiques, and platelet involvement in major disease states. This book is composed of 20 chapters that specifically deal with the physiology and biochemistry of the platelet system, along with possibilities for, and consequences of, pharmacologic manipulation. The opening chapters examine the basic processes of platelet aggregation and adhesion. These topics are followed by discussions on the types and functions of platelet a-granule proteins; the aspects of adenine nucleotide levels, regulation, and storage; and receptors for catecholamines and consequences of their agonism. Other chapters are devoted to the metabolism of arachidonic acid, its manipulation, consequences, and metabolite receptors. The discussion then shifts to the second-messenger entities, specifically calmodulin, calcium, and cyclic adenosine monophosphate. A chapter presents the comparisons of man and commonly used laboratory animals concerning platelet behavior variability. Another chapter looks into the use and appropriateness of the use of platelets as models of neurons, with a special emphasis on serotonergic neurons. The remaining chapters contain critical reviews of platelet involvement in diabetes, hypertension and peripheral vascular disease, atherogenesis/atherosclerosis, and ischemic heart disease. These chapters also include specific techniques for platelet analysis, including lumiaggregometry, eicosanoid measurements, and serotonin uptake and release. This book is an invaluable source for pharmacologists, biochemists, researchers, and clinicians who are interested in platelet involvement in disease.

Hemostasis and Thrombosis

Author :
Publisher :
ISBN 13 :
Total Pages : 1392 pages
Book Rating : 4.:/5 (31 download)

DOWNLOAD NOW!

Book Synopsis Hemostasis and Thrombosis by :

Download or read book Hemostasis and Thrombosis written by and published by . This book was released on 1976 with total page 1392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cumulated from monthly issues.

The Year in Hematology

Author : J. LoBue
Publisher : Springer
ISBN 13 : 1489966889
Total Pages : 607 pages
Book Rating : 4.4/5 (899 download)

DOWNLOAD NOW!

Book Synopsis The Year in Hematology by : J. LoBue

Download or read book The Year in Hematology written by J. LoBue and published by Springer. This book was released on 2013-11-11 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Platelets

Author : Alan D. Michelson
Publisher : Elsevier
ISBN 13 : 0080465862
Total Pages : 1386 pages
Book Rating : 4.0/5 (84 download)

DOWNLOAD NOW!

Book Synopsis Platelets by : Alan D. Michelson

Download or read book Platelets written by Alan D. Michelson and published by Elsevier. This book was released on 2011-08-29 with total page 1386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. - First edition won Best Book in Medical Science Award from the Association of American Publishers - Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias - A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references