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Spectroscopic Studies Of The Interaction Of Platinum Ii Complexes With Amino Acids
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Book Synopsis Spectroscopic Studies of the Interaction of Platinum (II) Complexes with Amino Acids by : Wilmer Carrión Roca
Download or read book Spectroscopic Studies of the Interaction of Platinum (II) Complexes with Amino Acids written by Wilmer Carrión Roca and published by . This book was released on 1999 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Spectroscopic Studies of the Interaction of Platinum (IV) Complexes with Amino Acids, Glutathion, Guanine, and Guanosine by : Aida Nilsa Méndez Márquez
Download or read book Spectroscopic Studies of the Interaction of Platinum (IV) Complexes with Amino Acids, Glutathion, Guanine, and Guanosine written by Aida Nilsa Méndez Márquez and published by . This book was released on 1999 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Platinum(II) Complexes as Spectroscopic Probes for Biomolecules by :
Download or read book Platinum(II) Complexes as Spectroscopic Probes for Biomolecules written by and published by . This book was released on 1990 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of platinum(II) complexes as tags and probes for biomolecules is indeed advantageous for their reactivities can be selective for certain purposes through an interplay of mild reaction conditions and of the ligands bound to the platinum. The use of 195Pt NMR as a method of detecting platinum and its interactions with biomolecules was carried out with the simplest model of platinum(II) tagging to proteins. Variable-temperature 195Pt NMR spectroscopy proved useful in studying the stereodynamics of complex thioethers like methionine. The complex, Pt(trpy)Cl, with its chromophore has a greater potential for probing proteins. It is a noninvasive and selective tag for histidine and cysteine residues on the surface of cytochrome c at pH 5. The protein derivatives obtained are separable, and the tags are easily quantitated and differentiated through the metal-to-ligand charge transfer bands which are sensitive to the environment of the tag. Increasing the pH to 7.0 led to the modification by Pt(trpy)Clof Arg 91 in cytochrome c. Further studies with guanidine-containing ligands as models for arginine modification by Pt(trpy)Cl+ showed that guanidine can act as a terminal ligand and as a bridging ligand. Owing to the potential utility of Pt(trpy)L{sup n+} as electron dense probes of nucleic acid structure, interactions of this bis-Pt(trpy){sup 2+} complex with nucleic acids was evaluated. Indeed, the complex interacts non-covalently with nucleic acids. Its interactions with DNA are not exactly the same as those of its precedents. Most striking is its ability to form highly immobile bands of DNA upon gel electrophoresis. 232 refs.
Book Synopsis Spectroscopic Studies of Platinum (II) Complexes with N-donor Ligands by : John M. Charnock
Download or read book Spectroscopic Studies of Platinum (II) Complexes with N-donor Ligands written by John M. Charnock and published by . This book was released on 1980 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis DESIGN SYNTHESIS & SPECTROSCOP by : Charlotte Po
Download or read book DESIGN SYNTHESIS & SPECTROSCOP written by Charlotte Po and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Design, Synthesis and Spectroscopic Studies of Amphiphilic Platinum(II) Complexes With Tridentate N-donor Ligands: From Simple Molecules to Supramolecular Assemblies and Nanostructures" by Charlotte, Po, 布珮樂, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled DESIGN, SYNTHESIS AND SPECTROSCOPIC STUDIES OF AMPHIPHILIC PLATINUM(II) COMPLEXES WITH TRIDENTATE N-DONOR LIGANDS - FROM SIMPLE MOLECULES TO SUPRAMOLECULAR ASSEMBLIES AND NANOSTRUCTURES Submitted by PO Charlotte for the degree of Doctor of Philosophy at The University of Hong Kong in February 2014 Several series of amphiphilic platinum(II) complexes with tridentate N-donor ligands were synthesized and characterized. Their photophysical properties as well as the spectroscopic changes resulting from the supramolecular assemblies of the complexes were studied. Water-soluble platinum(II) bzimpy complexes have been shown to exhibit strong aggregation in water to give highly ordered nanostructures and by structural modification, various morphologies such as spherical and cylindrical micelles, vesicles and bilayer sheets were obtained. The differences in molecular packing and morphology have been found to give rise to an alteration of Pt---Pt interaction and hence a change in MMLCT absorption and MMLCT emission and such changes were utilized as a probe for the morphological transformation. - + Different hydrophilic groups of sulfonate (-SO ), trimethylammonium (-NMe ) and 3 3 triethylene glycol (TEG) were incorporated into the platinum(II) bzimpy complexes to render their water solubility. An interesting aggregation-partial deaggregation-aggregation process has been demonstrated by [Pt{bzimpy(PrSO ) }Cl]K and its alkynyl analogues via a change in the solvent 3 2 composition. A drastic rainbow-like color change from red to yellow to green and blue was observed via the increase in organic solvent content in the aqueous solution of [Pt{bzimpy(PrSO )}Cl]K. The color change and luminescence change were 3 2 monitored by UV-vis absorption and emission studies, and a change in the MMLCT absorption and emission due to the alteration in Pt---Pt interactions during the assembly and disassembly process was observed. Through microscopy studies, the spectroscopic changes were correlated to a morphological transformation from vesicle to rod. The degree of aggregation of the complexes with different hydrophilic groups was compared through their dimerization constant and the inferences of electrostatic interactions on assemblies were investigated through the modulation of salt content of the solution and via co-assembly studies of the highly charged complexes, [Pt{bzimpy(PrSO ) (OPrSO )}Cl]K and [Pt{bzimpy(C H -NMe ) }Cl]Cl . 3 2 3 2 10 20 3 2 3 Through the incorporation of hydrophilic alkynyl ligands, bolaamphiphilic complexes were also synthesized and their aggregation behavior in water was studied. The effect in tuning the hydrophobicity of the complexes was studied by varying the alkyl chain length of the sulfonate-pendant platinum(II) bzimpy (Pt{bzimpy(PrSO ) }) 3 2 complexes and an unexpected shift in the UV-vis absorption and emission was observed due to the formation of aggregates. The thermo-responsive behavior of a TEG-pendant alkynylplatinum(II) bzimpy complex, [Pt{bzimpy(TEG) }{C≡CC H - 2 6 3 (OC H )-3,5}]Cl, in aqueous solution was investigated and on increasing 12 25 2 temperature, a morphological transformation from bilayer sheet to spherical micelles was observed and a large hysteresis
Book Synopsis Spectroscopic Studies of Monoolefinaniline Complexes of Platinum (II). by : Daryl William Yaniuk
Download or read book Spectroscopic Studies of Monoolefinaniline Complexes of Platinum (II). written by Daryl William Yaniuk and published by . This book was released on 1977 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Spectroscopic Studies of Amphiphilic Platinum(II) Complexes with Tridentate N-donor Ligands by : 布珮樂
Download or read book Design, Synthesis and Spectroscopic Studies of Amphiphilic Platinum(II) Complexes with Tridentate N-donor Ligands written by 布珮樂 and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Spectroscopic and Kinetic Studies of Tetragonal Planar Complexes of Platinum (II) and Palladium (II) by : David Gordon Cooper
Download or read book Spectroscopic and Kinetic Studies of Tetragonal Planar Complexes of Platinum (II) and Palladium (II) written by David Gordon Cooper and published by c1976.. This book was released on 1976 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic and Spectroscopic Studies of Palladium (II) and Platinum (II) Dithioacid Complexes by : Margaret C. Cornock
Download or read book Synthetic and Spectroscopic Studies of Palladium (II) and Platinum (II) Dithioacid Complexes written by Margaret C. Cornock and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Spectroscopic and Kinetic Studies of Tetragonal Planar Complexes of Platinum (II) and Palladium (II) by : David Gordon Cooper
Download or read book Spectroscopic and Kinetic Studies of Tetragonal Planar Complexes of Platinum (II) and Palladium (II) written by David Gordon Cooper and published by . This book was released on 1976 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Functionalized Platinum (II) and Gold (I) Acetylide Complexes by : Yuen-Ting Shum
Download or read book Functionalized Platinum (II) and Gold (I) Acetylide Complexes written by Yuen-Ting Shum and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Functionalized Platinum (II) and Gold (I) Acetylide Complexes: Structural and Spectroscopic Properties and Anticancer Activities" by Yuen-ting, Shum, 岑婉婷, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled FUNCTIONALIZED PLATINUM(II) AND GOLD(I) ACETYLIDE COMPLEXES. STRUCTURAL AND SPECTROSCOPIC PROPERTIES AND ANTICANCER ACTIVITIES Submitted by SHUM YUEN TING For the degree of Doctor of Philosophy at The University of Hong Kong in April 2007 Planar [Pt(terpy)X] complexes (terpy = 2,2':6',2''-terpyridine; X = Cl, SR) have frequently been cited as classic DNA metallointercalators in bioinorganic chemistry; + however, application studies of [Pt(terpy)L] (L = monoanionic ligand) and its derivatives in metal-based therapeutics are limited. In this work, a series of platinum(II) terpyridine complexes containing different glycosylated acetylide and arylacetylide ligands were prepared and characterized, the photophysical properties of which were investigated. A low-energy absorption band at 409-476 nm, which was assignable to a MLCT transition was observed in its electronic absorption spectra. Upon photoexcitation, intense emission bands at 513-733 nm were observed and were believed to originate from the excited states of 3 3 MLCT and LLCT character. Cytotoxic activities of the ''Pt(terpy)(glycosylated arylacetylide)'' system with significant inhibitory effect toward a series of carcinoma cell lines were discovered. [Pt( Bu terpy)(L3)](CF SO ) (L3 = 4-ethynylphenoxy 3 3 3 -2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside) (IC = 0.06-0.1 M) was found to be 50 i260-fold more effective in growth inhibition of the human brain cancer cell line (SF-268) than cisplatin. The binding interactions of selected platinum(II) complexes 4 5 -1 3 to calf-thymus DNA featured binding constants of 10-10 mol dm . Significantly, the spectral data were found to support a specific binding mode at the AT sequences of DNA for selected complexes. The results of cytometry experiments showed that [Pt( Bu terpy)(L3)](CF SO ) 3 3 3 induce 52.4% apoptosis in NCI-H460 cells. Based on microarray and Western blotting analyses, down-regulation of anti-apoptotic proteins, including Bcl-2 and caspase-3, were observed for platinum-treated NCI-H460 cells. When taken together, the [Pt( Bu terpy)(L3)](CF SO)-induced apoptosis in NCI-H460 cells should 3 3 3 normally occur via the mitochondrial pathway. A family of mono- and binuclear Cy P-supported gold(I) complexes which contained various π-conjugated arylacetylide ligands, were prepared and characterized. The lowest-energy singlet transitions were predominately intraligand in nature and exhibited both phenyl and acetylenic (ππ*) character. The organic triplet emissions of arylacetylide groups were thus "illuminated" at ambient conditions by ligation to the [Au(PCy )] fragment. Strong photoluminescence was detected in solid and solution states of the gold(I) complexes under ambient conditions with lifetimes in the microsecond regime. Selected gold(I) complexes were also subjected to cytotoxicity analysis; only [Au(PCy )(C≡CC H )] showed cytotoxicities (IC = 3 10 7 50 4.9-14.5 M) that were comparable to clinical cisplatin. An acetylide ligand that was appended with lomefloxacin moiety was coordinated to ii with gold(I) and platinum(II) complexes to form [CyPAu(lome)] and [Pt( Bu tpy)(lome)] (CF SO ) (lome = modified lomefloxacin), both of which were 3 3 3 structurally characterized. Tw
Book Synopsis Synthetic and Spectroscopic Studies of Palladiun (II) and Platinum (II) Dithioacid Complexes by : M. C. Cornock
Download or read book Synthetic and Spectroscopic Studies of Palladiun (II) and Platinum (II) Dithioacid Complexes written by M. C. Cornock and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Platinum(II) Complexes as Spectroscopic Probes for Biomolecules by : Eva Marie Avanceña Ratilla
Download or read book Platinum(II) Complexes as Spectroscopic Probes for Biomolecules written by Eva Marie Avanceña Ratilla and published by . This book was released on 1990 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies of Some Platinum II Complexes by N.M.R. by : Joyce Margaret Edward
Download or read book Studies of Some Platinum II Complexes by N.M.R. written by Joyce Margaret Edward and published by . This book was released on 1976 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
Book Synopsis Platinum Coordination Complexes in Cancer Chemotherapy by : T.A. Connors
Download or read book Platinum Coordination Complexes in Cancer Chemotherapy written by T.A. Connors and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was a great pleasure and honour to have been invited to attend this Seminar and to present a final impression. The association in this field between the Chester Beatty Research Institute and Dr. Rosenberg's School at East Lansing is something which I specially value and many would doubtless like to know how it came about. In the course of its work in carcinogenesis and on chemotherapy over many years, the Chester Beatty Research Institute was frequently drawn to the importance of many metals - as for example lead, iron, metalloid arsenic and the metalloid quali ties of the carcinogenic hydrocarbons. Interest started in platinum many years ago, following the possibility, c1aimed by others, that various complexes between the metal and mercaptopurine might possess significant chemotherapeutic properties. Va rious attempts to confirm such findings ended, however, in complete failure. Interest in platinum was revived by the fresh observations of Dr. Rosenberg and his collea gues, and here the outcome was entirely different. Very soon it was possible to con firm the intense growth-inhibitory properties of cis-platinum (II) diamminedi chloride and related substances. After communicating these results to Dr. Rosenberg, it was a pleasure to welcome hirn in London where he gave a Seminar which greatly engaged the interest of many of the staff. Later, several of these were to enjoy Dr. Rosenberg's hospitality at an international conference on the subject to be held in East Lansing, where many rapidly developing aspects were open for discussion.
Book Synopsis Synthesis, Characterization and Redox Studies of Platinum and Palladium Complexes with Mer-coordinating Ligands by : Seher Kuyuldar Tastan
Download or read book Synthesis, Characterization and Redox Studies of Platinum and Palladium Complexes with Mer-coordinating Ligands written by Seher Kuyuldar Tastan and published by . This book was released on 2009 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic, structural, spectroscopic, and redox studies of platinum(II) and palladium(II) compounds with mer-coordinating ligands have been undertaken in an effort to better understand the role of the metal and the ligands in controlling d^6/d^8 electron-transfer reactions. A series of Pd(pip2NCN)X (pip2NCNH=1,3-bis(piperdylmethyl)benzene) and [Pd(pip2NNN)X]X (X=Cl, Br, I) (pip2NNN=2,6- bis(piperdyl-methyl)pyridine) complexes are reported. Electronic spectra are consistent with stabilization of ligand-to-metal-charge-transfer states as the ancillary ligand is varied along the ClBr
Book Synopsis Studies of Some Platinum II Complexes by N.M.R. by : Joyce Margaret Edward
Download or read book Studies of Some Platinum II Complexes by N.M.R. written by Joyce Margaret Edward and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
