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Author : Catherine Anna Butler
Publisher :
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.:/5 (153 download)
Download or read book Spectroscopic Studies of Drug-DNA Interactions written by Catherine Anna Butler and published by . This book was released on 1993 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kazuo Nakamoto
Publisher : John Wiley & Sons
ISBN 13 : 0470369167
Total Pages : 475 pages
Book Rating : 4.4/5 (73 download)
Download or read book Drug-DNA Interactions written by Kazuo Nakamoto and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
Author : Fadwa Dhafer Hamad
Publisher :
ISBN 13 :
Total Pages : 114 pages
Book Rating : 4.:/5 (11 download)
Download or read book Novel Spectroscopic Tools to Differentiate Drug-DNA Binding Interactions written by Fadwa Dhafer Hamad and published by . This book was released on 2017 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA-drug interactions play a major role in therapeutics, diagnostics, forensics and imaging. Drugs bind to DNA in several ways based on the mode of interaction and they alter protein-DNA interactions or breaks/cleaves DNA that can lead to the cure of the disease. The major goal of the research carried out in this thesis is to develop novel optical spectroscopic tools that can differentiate Drug-DNA binding interactions mode whether its intercalation or minor-groove binding. To achieve this goal, we developed two-photon absorption (2PA) cross-section based technique to differentiate between Drug-DNA binding modes. The investigations were carried out on two drug molecules, DAPI and Thiazole Orange (ThO) binding to Salmon Sperm-DNA and Calf Thymus-DNA. DAPI binds to the DNA via minor-groove while ThO intercalates with DNA. Relative 2PA cross-section studies have shown about 3-fold enhancement for DAPI whereas ThO has shown no enhancement. These results confirmed our hypothesis. To further establish this method, studies were carried out using two more drug molecules, Netropsin and Doxorubicin with Salmon Sperm-DNA. Netropsin is a non-fluorescent drug that required a marker to read its binding interaction with DNA. Two types of markers have been used, Hoechst-33258 was used as minor-groove marker and Thioflavine T as intercalator. Doxorubicin drug is fluorescent and the binding results via the 2PA cross-sections have shown a slight decrease in 2PA-fluorescence, suggesting the intercalation binding mode with DNA.
Author : Meni Wanunu
Publisher : CRC Press
ISBN 13 : 1439839743
Total Pages : 397 pages
Book Rating : 4.4/5 (398 download)
Download or read book Methods for Studying Nucleic Acid/Drug Interactions written by Meni Wanunu and published by CRC Press. This book was released on 2016-04-19 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the eff
Author : Mark S. Searle
Publisher :
ISBN 13 :
Total Pages : 78 pages
Book Rating : 4.:/5 (71 download)
Download or read book NMR Studies of Drug-DNA Interactions written by Mark S. Searle and published by . This book was released on 1993 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marcio Santos Rocha
Publisher : Elsevier
ISBN 13 : 0323993850
Total Pages : 268 pages
Book Rating : 4.3/5 (239 download)
Download or read book DNA Interactions with Drugs and Other Small Ligands written by Marcio Santos Rocha and published by Elsevier. This book was released on 2023-03-01 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Interactions With Drugs and Other Small Ligands: Single Molecule Approaches and Techniques provides the reader with all the main information, a "state-of-the-art" of sorts and an overall review of the field. There is no other book currently available that covers all these subjects together. On the contrary, the different subjects that are developed in this book are currently scattered in journal articles and other books. Presents a review of the fundamental knowledge, techniques and relevant information surrounding the field of DNA interactions with drugs and other ligands Provides a resource like no other book available Includes valuable information from the author who is a highly experienced researcher in the field
Author : Mark S. Searle
Publisher :
ISBN 13 :
Total Pages : 78 pages
Book Rating : 4.:/5 (71 download)
Download or read book NMR Studies of Drug-DNA Interactions written by Mark S. Searle and published by . This book was released on 1993 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bernard Pullman
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 624 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular Basis of Specificity in Nucleic Acid-drug Interactions written by Bernard Pullman and published by Springer Science & Business Media. This book was released on 1990 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutual Conformational Adaptation of Both Ligand and Receptor in Antitumor Drug-DNA Complexes.- DNA Drug Interactions studied with Polarized Light Spectroscopy: the DAPI Case.- Drug-DNA Recognition: Sequence Specificity of the DNA Minor Groove Binder Berenil.- Binding of Minor Groove Ligands to Short DNA Segments: Berenil Complexed with d(GCAATTGC)2 and d(GCTTAAGC)2.- The Sequence Specificity of Damage Caused by [125I]-Labelled Hoechst 33258 and UV/IodoHoechst 33258 in Intact Cells and in Cloned Sequences of Purified DNA which differ by a Small Number of Base Substitutions.- Structure and Dynamics of a [1:1] Drug-DNA Complex: Analysis of 2D NMR Data Using Molecular Mechanics and Molecular Dynamics Calculations.- Determination of Distamycin-A Binding Modes by NMR.- Molecular Mechanisms of DNA Sequence Recognition by Groove Binding Ligands: Biochemical and Biological Consequences.- Daunomycin Binding to DNA: from the Macroscopic to the Microscopic.- In Vitro Transcription Analysis of the Sequence Specificity of Reversible and Irreversible Complexes of Adriamycin with DNA.- Quantitative Footprinting Analysis of the Actiomycin D-DNA Interaction.- Structural Requirements for DNA Topoisomerase II Inhibition by Anthracyclines.- Thermodynamic Studies of Amsacrine Antitumor Agents with Nucleic Acids.- Kinetic and Equilibrium Binding Studies of a Series of Intercalating Agents that Bind by Threading a Sidechain Through the DNA Helix.- Aminoacyl-Anthraquinones: DNA-Binding and Sequence Specificity.- The Molecular Basis of Specific Recognition Between Echinomycin and DNA.- Bis-Pyrrolecarboxamides Linked to Intercalating Chromophore Oxazolopyridocarbazole (OPC): Properties Related to the Selective Binding to DNA at Rich Sequences.- Parallel-Stranded Nucleic Acids and their Interaction with Intercalating and Groove Binding Drugs.- Design of Bifunctional Nucleic Acid Ligands.- Sequence-Specific Recognition and CLeavage of Duplex DNA by Derivatized Oligonucleotides.- Bis(Platinum) Complexes. Chemistry, Antitumor Activity and DNA-Binding.- Interaction of Calicheamicin with DNA.- The Effects of Ligand Structure on Binding Mode and Specificity in the Interaction of Unfused Aromatic Cations with DNA.- Modulation of Protein-DNA Interactions by Intercalating and Nonintercalating Agents.- Antitumor Antibiotics Endowed with DNA Sequence Specificity.- Cationic Porphyrin-DNA Complexes: Specificity of Binding Modes.- Complementary Studies on Sequence Specificity in DNA-Antitumor Drugs Interactions.- Uranyl Photofootpring. DNA Structural Changes upon Binding of Mithramycin.- Characteristics of Noncovalent and Covalent Interactions of (+) and (-) Anti-Benzo[a]pyrene Diol Epoxide Stereoisomers of Different Biological Activities with DNA.- Aflatoxin-DNA Binding and the Characterization of Aflatoxin B1-Oligodeoxynucleotide Adducts by 1H NMR Spectroscopy.- Sequence Specific Isotope Effects on the Cleavage of DNA by Radical-Generating Drugs.- Quinolone-DNA Interaction: How a Small Drug Molecule Acquires High DNA Binding Affinity and Specificity.- Mechanisms of DNA Sequence Selective Modifications by Alkylating Agents.- Contrasting Mechanisms for the Sequence Recognition of DNA by(+)- and (-)-CC-1065.- Course of Recognition and Covalent Reactions Between Mitomycin C and DNA: Sequence Selectivity of a Cross-Linking Drug.- Triplex Forming Oligonucleotide Reagents: Rationalization of DNA Site Selectivity and Application in a Pharmaceutical Context.- Experimental Proofs of a Drug's DNA Specificity.
Author : Kazuo Nakamoto
Publisher : Wiley
ISBN 13 : 9780471786269
Total Pages : 392 pages
Book Rating : 4.7/5 (862 download)
Download or read book Drug-DNA Interactions written by Kazuo Nakamoto and published by Wiley. This book was released on 2008-09-02 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
Author : W. Guschlbauer
Publisher : Springer
ISBN 13 : 9781468453843
Total Pages : 290 pages
Book Rating : 4.4/5 (538 download)
Download or read book DNA-Ligand Interactions written by W. Guschlbauer and published by Springer. This book was released on 2013-06-14 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Maratea. Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. While much has been learned about the way the cellular machinery maintains and transmits the genetic heritage. as well as how these processes are regulated. little is Known about how the interactions between the various partners involved are taKing place. The interactions of drugs and proteins with nucleic acids are of evident importance in the understanding of these problems. The spectacular advances in recombinant DNA technology and the increased sophistication of biophysical techniques. in particular >:-ray diffraction and nuclear magnetic resonance. have created a scientific environment which is highly promising for the future of research in molecular biology. These advances permH the serious hope that biology on the molecular level may become a r-eality. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.
Author : Nick Hadjiliadis
Publisher : John Wiley & Sons
ISBN 13 : 9781405194105
Total Pages : 544 pages
Book Rating : 4.1/5 (941 download)
Download or read book Metal Complex - DNA Interactions written by Nick Hadjiliadis and published by John Wiley & Sons. This book was released on 2009-03-30 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions and metal complexes have long been recognized ascritically important components of nucleic acid chemistry, both inregulation of gene expression and as promising therapeutic agents.Understanding how metal complexes interact with DNA has become anactive research area at the interface between chemistry, molecularbiology and medicine. Metal Complex - DNA Interactions provides a comprehensiveoverview of this increasingly diverse field, presenting recentdevelopments and the latest research with particular emphasis onmetal-based drugs and metal ion toxicity. The text is divided intofour parts: Basic Structural and Kinetic Aspects: includes chapterson sequence-selective metal binding to DNA and thermodynamicmodels. Medical Applications: focuses on anticancer platinumdrugs, including discussions on DNA repair in antitumor effects ofplatinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describesprobes for DNA recognition, artificial restriction agents,metallo-DNAzymes for metal sensing applications and metal iondependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies ofmercury–DNA interactions, chromium-induced DNA damage andrepair, and the effect of arsenic and nickel on DNAintegrity. This book will be a valuable resource for academic researchersand professionals from a range of pharmaceutical and chemicalindustries, particularly those involved in the development of newand less toxic anticancer metallo-drugs, and in the field ofenvironmental and toxicological chemistry.
Author : Danzhou Yang
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (774 download)
Download or read book High-resolution NMR Spectroscopic Analysis of Anticancer Drugs, DNA and Their Interactions: 1. Platinum Anticancer Compounds - DNA Interactions. 2. Anthracycline Drugs - DNA Interactions and Modified DNA written by Danzhou Yang and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapy with anticancer drugs is one of the main method of cancer treatment. The exploitation of the stereochemical interactions between anticancer drugs and DNA is of great importance for the ultimate clinical advances of cancer chemotherapy, which needs the detailed structural knowledge of DNA, drugs, and their interactions. Cisplatin is one of the most effecient and widely used anticancer drugs in the world. Extensive effort has been devoted to designing the new better anticancer platinum compounds. The structural studies on interactions of two anticancer platinum compounds, cisplatin and the third-generation bisplatinum compound 1,1/t,t, with DNA are described in this thesis. The structure of an intrastrand cisplatin-crosslinked didentate DNA duplex consisting of d(CCTG$rmsp*Gsp*$TCC) and its complement d(GGACCAGG) is determined by NMR spectroscopy. The refined duplex is unwound ($sim{-}21spcirc$) and kinked (${sim}58spcirc$) toward the major groove at the $rm Gsp*Gsp*$ site and the minor groove is significantly widened. The stability of the major intrastrand cisplatin-G$rmsp*pGsp*$ adduct has been studied and this intrastrand cisplatin-crosslinked adduct appears to be converted into an interstrand crosslink adduct. Three palindromic DNA oligonucleotides, each having a single intrastrand cisplatin crosslinked at GpG site, have also been studied by NMR spectroscopy. The structural consequence of the incorporation of the $rm Gsp*Gsp*$ lesions into palindromic sequences is dependent on the location of the lesion sites in the sequence. Such alternative structural distortions may be relevant in understanding the protein recognition of the cisplatin-induced lesions. A new anticancer bisplatinum compound 1,1/t,t exhibits excellent cytotoxicity towards cisplatin-resistant cancer cells. The structure of the interstrand adduct of 1,1/t,t with a palindromic DNA oligomer CATGCATG has been determined by NMR spectroscopy. Upon platination by 1,1/t,t, the DNA octamer forms a novel hairpin structure with the platinated G$sb4$ residue adopting a syn conformation and with the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion induced by the bisplatinum compound is completely different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds. Anthracycline antibiotics are important anticancer intercalative drugs. The solution structures of anticancer anthracycline drugs aclacinomycin A and B, nogalamycin and disnogalamycin, complexed to a DNA hexamer have all been determined by high resolution NMR spectroscopy. Structural modification of DNA through covalent interactions have significant functional consequences and/or anticancer activities. Structural analysis of the C$sp2$-methyl-hypoxanthine:Cytosine base pair and O$sp6$-ethyl-Guanine:Cytosine base pair in B-DNA help understand their biological functions.
Author :
Publisher :
ISBN 13 :
Total Pages : 412 pages
Book Rating : 4.:/5 (94 download)
Download or read book Modelling Studies on Drug-DNA Interactions written by and published by . This book was released on 1992 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bernhard Lippert
Publisher : John Wiley & Sons
ISBN 13 : 9783906390208
Total Pages : 628 pages
Book Rating : 4.3/5 (92 download)
Download or read book Cisplatin written by Bernhard Lippert and published by John Wiley & Sons. This book was released on 1999 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.
Author : Kuan Rong Lee
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.:/5 (899 download)
Download or read book Solution Spectroscopic Studies of Drug-nucleic Acid Complexes written by Kuan Rong Lee and published by . This book was released on 1981 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lisa Castagno
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (115 download)
Download or read book A Study of Drug-DNA Interactions by Circular Dichroism Spectroscopy of Substituted Aza and Diazaanthracene-9, 10-diones in Liquid Crystals and DNA Helicies written by Lisa Castagno and published by . This book was released on 1984 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. William Lown
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 788 pages
Book Rating : 4.3/5 (91 download)
Download or read book Anthracycline and Anthracenedione-based Anticancer Agents written by J. William Lown and published by Elsevier Publishing Company. This book was released on 1988 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt:
