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Spectroscopic Characterization Of Polyamido Amine Dendrimers And Their Application In High Performance Liquid Chromatography
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Book Synopsis Spectroscopic Characterization of Polyamido Amine Dendrimers and Their Application in High Performance Liquid Chromatography by : Charlotte Lynn Larson
Download or read book Spectroscopic Characterization of Polyamido Amine Dendrimers and Their Application in High Performance Liquid Chromatography written by Charlotte Lynn Larson and published by . This book was released on 2001 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of Dendrimers with Reversed Phase High Performance Liquid Chromatography, Capillary Electrophoresis, Mass Spectrometry and Polyacrylamide Gel Electrophoresis by : ShaRhonda Dennis
Download or read book Characterization of Dendrimers with Reversed Phase High Performance Liquid Chromatography, Capillary Electrophoresis, Mass Spectrometry and Polyacrylamide Gel Electrophoresis written by ShaRhonda Dennis and published by . This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2005 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Empire Vignoble. 1re division des ivrognes. Place du tonneau. Certificat de bonne conduite by :
Download or read book Empire Vignoble. 1re division des ivrognes. Place du tonneau. Certificat de bonne conduite written by and published by . This book was released on 1867 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Materials and Devices for Separation of Polyamido[a]mine Dendrimers by : Yolanda H. Tennico
Download or read book Development of Materials and Devices for Separation of Polyamido[a]mine Dendrimers written by Yolanda H. Tennico and published by . This book was released on 2005 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, the use of highly branched macromolecules, called dendrimers, is emerging. Polyamidoamine (PAMAM) dendrimers, in particular, have attracted high interest due to their unique properties, such as well-defined size, shape, and solubility in water. Our group, as part of an interdisciplinary team, is currently working on developing a nanoextraction technology for high-yield dendrimer syntheses. Impurities may occur during the synthesis of these dendrimers, and therefore, to achieve higher purity products, chromatographic separations of dendrimers are an important part toward this goal. This thesis describes approaches toward this objective, focusing in two areas: at first, development of materials and devices that will enable separations of dendrimers in confines of capillary and chromatographic columns, and second, evaluation of the feasibility of transferring the separation techniques previously developed to the channels of microfluidic devices. The results showed that PAMAM dendrimers of various generations were successfully analyzed using capillary zone electrophoresis (CZE), capillary electrochromatography (CEC), and high-performance liquid chromatography (HPLC). Both CZE and HPLC have allowed for fast generational separations up to the fifth generation. Moreover, CZE can also assess the homogeneity and presence of side products in the synthesized dendrimers. RP-HPLC, on the other hand, allowed for separations of dendrimers with terminal amino and carboxyl groups. PAMAM dendrimers can also be used as template molecules to prepare monolithic capillary columns for liquid chromatography and capillary electrochromatography. This method has provided two advantages: 1) dendrimers can be used as template molecules for controlling pore structures, 2) selective sorbents can be produced with surface sites that are complementary in chemical functionality to the dendrimer template molecule. These highly selective sorbents were able to provide separation of dendrimers from various generations, particularly of high generations, in the CEC mode. As the first step toward the development of a nanoextraction technology for high yield dendrimer syntheses, the feasibility of extending the separation techniques developed on-column into channels of a microfluidic chip was examined. In this study, electrophoresis was employed to separate different generations of dendrimers in glass microfluidic chips using laser-induced fluorescence detection. The use of microfluidic system for dendrimer application offers great potential due to its rapid analysis times, small sample volume requirements, and the ability to integrate several steps of analyses in one chip.
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 2000 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Spectroscopic Investigations of Poly(amidoamine) and Poly(propyleneimine) Dendrimers by : Dana Lynn Richter-Egger
Download or read book Spectroscopic Investigations of Poly(amidoamine) and Poly(propyleneimine) Dendrimers written by Dana Lynn Richter-Egger and published by . This book was released on 2001 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interior physical and chemical properties of amine-terminated poly(amidoamine), PAMAM, and poly(propyleneimine), PPI, dendrimers were investigated using the solvatochromic probes ET-30 and phenol blue. Dendrimers are polymers that are produced using a highly-controlled, stepwise synthetic scheme, which results in very regularly and highly branched, three-dimensional, monodisperse polymers. Their synthetic controllability and unique structural properties has led to exciting application possibilities. Though some characterization of these dendrimers has been published, an improved understanding of the chemical and physical properties of the interior regions of these dendrimers is still needed and is vital to their successful use in future applications. In this research, ET-30 and phenol blue are used as extrinsic probe molecules to elucidate the unique properties of the PAMAM and PPI dendrimers, in part because efforts to provide detailed conformational/structure information via direct methods have had little success. These molecules exhibit different behavior depending upon the properties of their surrounding environment; in particular, both have well characterized responses to microenvironmental polarity. Methods used were UV/Vis absorption spectroscopy and fluorescence emission, anisotropy and lifetime measurements. For every aqueous PAMAM and PPI dendrimer generation studied, two discrete dye populations were clearly observed. Model compounds that mimic the surface groups and branching moieties of both dendrimer families were used to better define the associated dye's location. The mimics confirmed that these probes associated inside the dendrimer, and in the case of phenol blue, it did not interact with the dendrimer surface groups. Both families of dendrimers were shown to form nonpolar associations with the two dyes beyond the surface of the dendrimer. While ET-30 proved too large to be completely encapsulated by the PAMAM dendrimers, phenol blue was found to reside within the PAMAM and PPI dendrimer interior, near their cores. In general, the interior microenvironments of these dendrimers were observed to decrease in polarity for successively larger generation dendrimers. However, the interior polarity of the largest generations of each family remained relatively constant. Important differences among the generations within a dendrimer family and between the two were elucidated. Trends in polarity, rigidity, binding affinity and shape were all observed. In addition, it was found that phenol blue fit better inside the PPI dendrimers, compared to PAMAM. This finding was not a total surprise considering their structures.
Book Synopsis Synthesis, Characterization, and Applications of Dendrimers by : Xiaozheng Dou
Download or read book Synthesis, Characterization, and Applications of Dendrimers written by Xiaozheng Dou and published by . This book was released on 2015 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this work, I have synthesized a series of poly(ethylene glycol)-block-polyamide dendrimers and have characterized them by NMR spectroscopy. I have also studied the potential applications of methoxy poly(ethylene glycol)-block-poly(ether sulfide) [or mPEG-block-poly(ether sulfide)] dendrimers in drug delivery by examining the solubility of pyrene in water in the presence of the various concentrations of the dendrimers. It was found that generation 3 of mPEG-block-poly(ether sulfide) dendrimer modestly increased the solubility of pyrene in water. Applications of these dendrimers as phase transfer catalysts have also been investigated. It was found that generation 3 of mPEG-block-poly(ether sulfide) dendrimer acted as an excellent phase transfer catalyst in the dehydrohalogenation of 2-bromoethyl benzene. The effect of mPEG-block-poly(ether sulfide) dendrimer on calf-thymus DNA has also been investigated by circular dichroism (CD). Finally, the effects of mPEG and mPEG-block-poly(amido amine) dendrimers on Dickerson-Drew Dodecamer DNA have been studied by NMR spectroscopy and CD and the results are presented and discussed.
Book Synopsis Synthesis and Characterization of Melamine-based Dendrimers with Potential Biological Applications by : Hannah Louise Crampton
Download or read book Synthesis and Characterization of Melamine-based Dendrimers with Potential Biological Applications written by Hannah Louise Crampton and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The convergent strategy towards dendrimer synthesis is well-suited to generate macromolecules with a diverse periphery, at the expense of time and effort, while the divergent strategy has historically been effective at yielding higher generation dendrimers, although they are often plagued by impurities. Both the convergent and divergent routes were applied to the synthesis of melamine-based dendrimers, offering a comparison of the routes within a system. Generation-1 dendrons heterogeneously functionalized with Boc-protected amines and hydrazones were synthesized convergently and coupled to a generation-1 tris(piperazine) core to yield a generation-2 dendrimer bearing 18 Boc-amines and three hydrazones. Although the yield for the final coupling step was rather low (56%), the yields for all intermediate steps were quite high. Attempts toward obtaining a generation-3 dendrimer through this route were unsuccessful due presumably to steric hindrance. The materials obtained showed no impurities in their 1H and 13C NMR and mass spectra, although several chromatographic purifications were necessary throughout the synthesis. A divergent strategy based on addition of a dichlorotriazine monomer to polyamine cores was used to synthesize dendrimers of generations 1-5. All intermediates and dendrimers were either purified by precipitation, or did not need purification. 1H NMR spectroscopy indicated that reactions were complete up to G4-NH2 by integration, and mass spectroscopy confirmed that assignment. HPLC and GPC of Gn-Cl dendrimers showed sharp peaks for G1-G3, but G4-Cl appeared to have a small amount of impurities that are similar in size and polarity to the fully-substituted dendrimer. The G1-G3 dendrimers were confidently assigned as pure by conventional organic chemistry standards, but the assignment of purity to higher generations remained tentative. A G1-Cl dendrimer was functionalized with imidazole, and then deprotected and PEGylated with PEG5000 to yield a water soluble dendrimer. The imidazole-capped, Boc-protected dendrimer and the deprotected dendrimer were characterized by 1H and 13C NMR spectroscopy and mass spectrometry. The degree of PEGylation on the PEGylated material could not be definitively ascertained; however, the material is capable of solubilizing very hydrophobic Zn-phthalocyanines in water.
Book Synopsis Progress and Prospect of Nanocarriers by : Sushil K. Kashaw
Download or read book Progress and Prospect of Nanocarriers written by Sushil K. Kashaw and published by Academic Press. This book was released on 2024-05-17 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress and Prospect of Nanocarriers: Design, Concept, and Recent Advances examines the different nanocarriers that are currently being developed for specific applications in biomedical drug delivery, disease management, diagnosis and therapy. Nanosized drug delivery systems have gained tremendous amounts of clinical interest due to their effective bio-distribution and enhanced pharmacokinetic and selective targeting capability which results in high therapeutic potential, low side effects, and the generation of cost-effective drug delivery systems. Numerous effective nanocarriers have been evolving, including polymeric nanoparticles, liposomes, microspheres, dendrimers, and carbon nanotubes.This book is a helpful reference for scientists and students in the fields of drug delivery, biomaterials and nanomedicine, as well as scientists and engineers in industrial disciplines of drug delivery and drug formulation. Focuses on multiple nanocarrier platforms Examines the different technologies that have improved drug delivery and suggests where the technology is headed Written for researchers and students by diverse experts in biomaterials, drug delivery and nanomedicine
Download or read book Journal of Chromatography written by and published by . This book was released on 2002 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Developments in Nanosensors for Pharmaceutical Analysis by : Sibel A. Ozkan
Download or read book New Developments in Nanosensors for Pharmaceutical Analysis written by Sibel A. Ozkan and published by Academic Press. This book was released on 2019-05-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Developments for Nanosensors in Pharmaceutical Analysis presents an overview of developments in nanosensor usage in pharmaceutical analysis, thereby helping pharmaceutical companies attain reliable, precise, and accurate analysis of pharmaceuticals. This book presents very simple, precise, sensitive, selective, fast, and relatively inexpensive methods for pre-treatment, prior to analysis. These methods may be considered for further application in clinical studies and assays. The book includes the manufacturing of sensors for pharmaceutical analysis at nano- or smaller scales, and gives simple and relatable designs for the fabrication of sensors. Twelve chapters cover an introduction to the topic, immobilization techniques, mechanism effect of nanomaterials on structure, optical nanosensors for pharmaceutical detection, chemical nanosensors in pharmaceutical analysis, noble metal nanoparticles in electrochemical analysis of drugs, photo-electrochemical nanosensors for drug analysis, molecularly imprinted polymer based nanosensors for pharmaceutical analysis, nanomaterials for drug delivery systems, nanomaterials enriched nucleic acid-based biosensors, nanosensors in biomarker detection, and nanomaterials-based enzyme biosensors for electrochemical applications. Presents nanosensor types, synthesis, immobilizations and applications in different fields Gives simple repeatable designs for the fabrication of sensors for pharmaceutical analysis Details how to carry out sensitive analysis of pharmaceuticals using nanosensors Describes how to synthesize and immobilize nanosensors, and how nanosensors can be applied in drug assay Proposes innovative ways to optimize pharmaceutical processes with nanosensors
Book Synopsis Investigation of Properties of Polyamido Amine (PAMAM) Dendrimers by Flourescence Spectroscopy by : Hongling Han
Download or read book Investigation of Properties of Polyamido Amine (PAMAM) Dendrimers by Flourescence Spectroscopy written by Hongling Han and published by . This book was released on 2004 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Thermodynamics and Biophysics of Biomedical Nanosystems by : Costas Demetzos
Download or read book Thermodynamics and Biophysics of Biomedical Nanosystems written by Costas Demetzos and published by Springer. This book was released on 2019-03-04 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism. In 2018, Prof. Demetzos was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology.
Book Synopsis Polymer Science: A Comprehensive Reference by :
Download or read book Polymer Science: A Comprehensive Reference written by and published by Newnes. This book was released on 2012-12-05 with total page 7752 pages. Available in PDF, EPUB and Kindle. Book excerpt: The progress in polymer science is revealed in the chapters of Polymer Science: A Comprehensive Reference, Ten Volume Set. In Volume 1, this is reflected in the improved understanding of the properties of polymers in solution, in bulk and in confined situations such as in thin films. Volume 2 addresses new characterization techniques, such as high resolution optical microscopy, scanning probe microscopy and other procedures for surface and interface characterization. Volume 3 presents the great progress achieved in precise synthetic polymerization techniques for vinyl monomers to control macromolecular architecture: the development of metallocene and post-metallocene catalysis for olefin polymerization, new ionic polymerization procedures, and atom transfer radical polymerization, nitroxide mediated polymerization, and reversible addition-fragmentation chain transfer systems as the most often used controlled/living radical polymerization methods. Volume 4 is devoted to kinetics, mechanisms and applications of ring opening polymerization of heterocyclic monomers and cycloolefins (ROMP), as well as to various less common polymerization techniques. Polycondensation and non-chain polymerizations, including dendrimer synthesis and various "click" procedures, are covered in Volume 5. Volume 6 focuses on several aspects of controlled macromolecular architectures and soft nano-objects including hybrids and bioconjugates. Many of the achievements would have not been possible without new characterization techniques like AFM that allowed direct imaging of single molecules and nano-objects with a precision available only recently. An entirely new aspect in polymer science is based on the combination of bottom-up methods such as polymer synthesis and molecularly programmed self-assembly with top-down structuring such as lithography and surface templating, as presented in Volume 7. It encompasses polymer and nanoparticle assembly in bulk and under confined conditions or influenced by an external field, including thin films, inorganic-organic hybrids, or nanofibers. Volume 8 expands these concepts focusing on applications in advanced technologies, e.g. in electronic industry and centers on combination with top down approach and functional properties like conductivity. Another type of functionality that is of rapidly increasing importance in polymer science is introduced in volume 9. It deals with various aspects of polymers in biology and medicine, including the response of living cells and tissue to the contact with biofunctional particles and surfaces. The last volume is devoted to the scope and potential provided by environmentally benign and green polymers, as well as energy-related polymers. They discuss new technologies needed for a sustainable economy in our world of limited resources. Provides broad and in-depth coverage of all aspects of polymer science from synthesis/polymerization, properties, and characterization methods and techniques to nanostructures, sustainability and energy, and biomedical uses of polymers Provides a definitive source for those entering or researching in this area by integrating the multidisciplinary aspects of the science into one unique, up-to-date reference work Electronic version has complete cross-referencing and multi-media components Volume editors are world experts in their field (including a Nobel Prize winner)
Book Synopsis Acyclic Acids—Advances in Research and Application: 2012 Edition by :
Download or read book Acyclic Acids—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acyclic Acids—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Acyclic Acids. The editors have built Acyclic Acids—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Acyclic Acids in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Acyclic Acids—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Polymeric Materials Encyclopedia, Twelve Volume Set by : Joseph C. Salamone
Download or read book Polymeric Materials Encyclopedia, Twelve Volume Set written by Joseph C. Salamone and published by CRC Press. This book was released on 1996-07-23 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Polymeric Materials Encyclopedia presents state-of-the-art research and development on the synthesis, properties, and applications of polymeric materials. This groundbreaking work includes the largest number of contributors in the world for a reference publication in polymer science, and examines many fields not covered in any other reference. With multiple articles on many subjects, the encyclopedia offers you a broad-based perspective on a multitude of topics, as well as detailed research information, figures, tables, illustrations, and references. Updates published as new research unfolds will continue to provide you with the latest advances in polymer science, and will keep the encyclopedia at the forefront of the field well into the future. From novices to experienced researchers in the field, anyone and everyone working in polymer science today needs this complete assessment of the state of the art. The entire 12-volume set will be available in your choice of printed or CD-ROM format.
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