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Solving The Plasmalogen Puzzle From Basic Science To Clinical Application
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Book Synopsis Solving the plasmalogen puzzle – from basic science to clinical application by : Masanori Honsho
Download or read book Solving the plasmalogen puzzle – from basic science to clinical application written by Masanori Honsho and published by Frontiers Media SA. This book was released on 2023-02-17 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Concepts and Principles of Pharmacology by : James E. Barrett
Download or read book Concepts and Principles of Pharmacology written by James E. Barrett and published by Springer Nature. This book was released on 2019-12-24 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Book Synopsis Harper's Illustrated Biochemistry, 28th Edition by : Robert K. Murray
Download or read book Harper's Illustrated Biochemistry, 28th Edition written by Robert K. Murray and published by McGraw Hill Professional. This book was released on 2009-07-03 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biochemistry text that every medical student must own--now in full color! Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease. The Twenty-Eighth Edition has undergone sweeping changes -- including a conversion to full-color artwork and the substantial revision and updating of every chapter -- all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject. Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic. NEW to this edition: Full-color presentation, including 600+ illustrations Every chapter opens with a Summary of the Biomedical Importance and concludes with a Summary reviewing the topics covered Two all-new chapters: "Free Radicals and Antioxidant Nutrients" and "Biochemical Case Histories" which offers an extensive presentation of 16 clinical conditions A new appendix containing basic clinical laboratory results and an updated one with a list of important websites and online journals NEW or updated coverage of important topics including the Human Genome Project and computer-aided drug delivery
Book Synopsis Metabolomics: From Fundamentals to Clinical Applications by : Alessandra Sussulini
Download or read book Metabolomics: From Fundamentals to Clinical Applications written by Alessandra Sussulini and published by Springer. This book was released on 2017-01-28 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.
Book Synopsis Harper's Illustrated Biochemistry 31e by : Victor W. Rodwell
Download or read book Harper's Illustrated Biochemistry 31e written by Victor W. Rodwell and published by . This book was released on 2018-05-23 with total page 789 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Thirty-First Edition of Harper’s Illustrated Biochemistry continues to emphasize the link between biochemistry and the understanding of disease states, disease pathology, and the practice of medicine. Featuring a full-color presentation and numerous medically relevant examples, Harper’s presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school. "--Résumé de l'éditeur.
Book Synopsis Enzymes in Lipid Modification by : Uwe Theo Bornscheuer
Download or read book Enzymes in Lipid Modification written by Uwe Theo Bornscheuer and published by Wiley-Blackwell. This book was released on 2000-09-13 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic methods of lipid modification, particularly of fats and oils, have developed rapidly since the 1980s. In parallel to the rapid progress in research a wide range of applications have emerged, e.g. in the food industry. The book is written by leading experts in the field and reflects the state-of-the-art of enzymatic lipid modification. It provides the reader with guidelines how to select suitable enzymes and how to apply them efficiently. Applications of lipases and phospholipases, lipoxygenases and P450-monooxygenases and the use of whole-cell systems in lipid modification are described. Cloning, expression and mutagenesis as well as attempts to understand the molecular basis of specificity and stereoselectivity are outlined. In addition engineering aspects and the choice of solvent systems are addressed.
Book Synopsis Breaking Alzheimer's by : Dayan Goodenowe
Download or read book Breaking Alzheimer's written by Dayan Goodenowe and published by Independently Published. This book was released on 2021-06-21 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breaking Alzheimer's is Dr. Dayan Goodenowe's story of personal and scientific perseverance. The biochemical mechanisms of neurological disease is his area of expertise and was his area of expertise for 15 years before he serendipitously discovered that low plasmalogen levels were causing Alzheimer's. Dr. Goodenowe had never heard of plasmalogens and he had never been taught about them. There are now 15 years of supportive validation of this discovery and access to plasmalogen testing and supplementation is now available to everyone. By sheer will, Dr. Goodenowe has completed the beginning and the middle of this journey such that the plasmalogen genie cannot be put back in the bottle. This book is about bringing the reader up to speed as to where we currently are on this journey and where we are going from here. The Breaking Alzheimer's Video Series and Audio Book will be available through Dr. Dayan Goodenowe's website soon. Learn more about Dr. Goodenowe and his educational content here: https: //drgoodenowe.com To learn more about Dr. Goodenowe's scientifically designed supplements and blood testing technology visit the Prodrome Sciences website here: https: //prodrome.com ADVANCE PRAISE "A paradigm-altering view of Alzheimer's." Dale Bredesen, MD Author of The New York Times Bestseller The End of Alzheimer's "A brilliant and ground-breaking text on the science and clinical application of plasmalogens for the therapeutic amelioration of Alzheimer's Dementia. I have had the good fortune of observing firsthand the significant, clinical benefits in my patients with neurodegenerative disorders for whom I've prescribed plasmalogen therapy." Mitchel Fleisher M.D., D.Ht., D.A.B.F.M., Dc.A.B.C.T. Medical Director, Center for Integrative & Regenerative Medicine "A bold and promising approach. Dr. Goodenowe has performed groundbreaking and compelling research which is detailed in the book so that afflicted patients and health professionals will become aware of a discovery which may very well change our approach to Alzheimer's. We have been deploying plasmalogen precursors at the Regenesis Project and have found that within the timeframe of a few weeks, people become more alert and cognizant." Sheldon Jordan, MD, FAAN, DABPN, DABCN Medical Director, the Regenesis Project "Dr. Goodenowe has not only identified a biomarker-plasmalogen-that is strongly correlated with dementia, but he has also discovered a way to track and improve that marker allowing ApoE4 carriers, at the highest genetic risk for Alzheimer's, to potentially avoid disease onset. Indeed, many of our members have had a noticeable improvement after addressing low levels." Julie Gregory Founder & President of ApoE4.Info "I strongly recommend this book which I hope will be as transformative for you as it has been for me. It is easy to read and understand and will impact your everyday decision making." Bijan Pourat MD ACC FRCP(C) "Dayan Goodenowe has drilled down to the very core of what makes us tick. His patient 25 year journey of research and invention has unpacked unique and marvelous understanding into how our metabolic engine works. We have a whole new field of medicine opening up called "metabolic medicine" and it runs right through Dr. Goodenowe's inventions. Like tuning your carburetor and timing your engine, we can now heal your mitochondria and make your peroxisomes whistle with the careful measurement and replacement of plasmalogens. The implications of his inventions can't be overstated. This is the end of Alzheimer's, Parkinson's, cancer....and who knows what lies ahead in the paradigm shift to true wellness with the absence of disease." John E. Whitcomb, MD Brookfield Longevity Medical Clinic
Book Synopsis Druggable Lipid Signaling Pathways by : Yasuyuki Kihara
Download or read book Druggable Lipid Signaling Pathways written by Yasuyuki Kihara and published by Springer. This book was released on 2021-09-22 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.
Book Synopsis Encyclopedia of Biology by : Don Rittner
Download or read book Encyclopedia of Biology written by Don Rittner and published by Infobase Publishing. This book was released on 2004-08 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains approximately 800 alphabetical entries, prose essays on important topics, line illustrations, and black-and-white photographs.
Download or read book Lipidomics written by Xianlin Han and published by John Wiley & Sons. This book was released on 2016-05-02 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes
Book Synopsis Medical Applications of Mass Spectrometry by : Karoly Vekey
Download or read book Medical Applications of Mass Spectrometry written by Karoly Vekey and published by Elsevier. This book was released on 2011-08-11 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry.* Guides the reader from basic principles and methods to cutting edge applications.* There is NO comparable book on the market to fill this fast growing field.
Book Synopsis Mass Spectrometry-Based Lipidomics by : Fong-Fu Hsu
Download or read book Mass Spectrometry-Based Lipidomics written by Fong-Fu Hsu and published by Humana. This book was released on 2021-05-29 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume covers conventional MS-based “shotgun lipidomics” by which samples are introduced by infusion or loop injection, as well as LC-MS-based lipidomics, which are becoming increasingly important due to the ever-increasing demand for a complete and precise lipid analysis of the complex and diversified lipids in nature. The volume features protocols applying chemical reactions, the on-line photochemical reactions combined with various MS methods for comprehensive characterization of various lipid classes, and quantification of specific and rare lipids. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry-Based Lipidomics: Methods and Protocols serves as an invaluable guide for biochemists and mass spectroscopists who are interested in lipid studies.
Book Synopsis Practice of High Performance Liquid Chromatography by : Heinz Engelhardt
Download or read book Practice of High Performance Liquid Chromatography written by Heinz Engelhardt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: During its short 20 year history High Performance Liquid Chro matography (HPLC) has won itself a firm place amongst the instrumental methods of analysis. HPLC has caused a revolution in biological and pharmaceutical chemistry. Approximately two thirds of the publications on HPLC are concerned with problems from this area of life science. Biotechnology, where it is necessary to isolate substances from complicated mixtures, is likely to give further impetus to the dissemination of modern liquid chromatog raphy in columns, particularly on the preparative scale. This book presents, by means of examples, the application of HPLC to various fields, as well as fundamental discussions of chromatographic methods. The quality of the analytical result is decisively dependent on the qualities of the equipment employed (by Colin, Guiochon, and Martin). Especially the demands are discussed that are placed on the components of the instrument including those for data acquisition and processing. The section on "quantitative analy sis" (by ABhauer, Ullner) covers besides the principles also the problems of ensuring the quality of the data in detail. The basic problems arising by enlarging the sample size to preparative di mensions and the requirements put on the aparatus are discussed in the section on "preparative applications" (by Wehrli).
Book Synopsis Peroxisomal Disorders and Regulation of Genes by : Frank Roels
Download or read book Peroxisomal Disorders and Regulation of Genes written by Frank Roels and published by Springer. This book was released on 2003-12-31 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: In most peroxisomal disorders the nervous system is severely affected which explains the clinical and community burden they represent. This is the first book to focus not only on the mutations causing these inherited illnesses, but also on mechanisms that regulate, suppress or enhance expression of genes and their products (enzymes). Indeed since the success and completion of the Human Genome Project all genes (coding DNA sequences) are known. However, of many, their function, and the role of the gene product has not been determined. An example is X-linked adrenoleukodystrophy, the most frequent peroxisomal disorder. Children are born healthy, but in more than 1 out of 3, demyelination of the brain starts unpredictably and they die in a vegetative state. The gene mutated in most families has been known for 10 years; but the true role of the encoded protein, ALDp, is still speculative; and within the same family, very severe and asymptomatic clinical histories co-exist, unexplained by the mutation.
Book Synopsis Encyclopedia of Chemistry by : Don Rittner
Download or read book Encyclopedia of Chemistry written by Don Rittner and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The comprehensive Encyclopedia of Chemistry, Third Edition is the definitive reference to this vast subject area.
Download or read book Food Lipids written by Casimir C. Akoh and published by CRC Press. This book was released on 2017-03-16 with total page 1048 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining the high standards that made the previous editions such well-respected and widely used references, Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition provides a new look at lipid oxidation and highlights recent findings and research. Always representative of the current state of lipid science, this edition provides 16 new chapters and 21 updated chapters, written by leading international experts, that reflect the latest advances in technology and studies of food lipids. New chapters Analysis of Fatty Acid Positional Distribution in Triacylglycerol Physical Characterization of Fats and Oils Processing and Modification Technologies for Edible Oils and Fats Crystallization Behavior of Fats: Effect of Processing Conditions Enzymatic Purification and Enrichment and Purification of Polyunsaturated Fatty Acids and Conjugated Linoleic Acid Isomers Microbial Lipid Production Food Applications of Lipids Encapsulation Technologies for Lipids Rethinking Lipid Oxidation Digestion, Absorption and Metabolism of Lipids Omega-3 Polyunsaturated Fatty Acids and Health Brain Lipids in Health and Disease Biotechnologically Enriched Cereals with PUFAs in Ruminant and Chicken Nutrition Enzyme-Catalyzed Production of Lipid Based Esters for the Food Industry: Emerging Process and Technology Production of Edible Oils Through Metabolic Engineering Genetically Engineered Cereals for Production of Polyunsaturated Fatty Acids The most comprehensive and relevant treatment of food lipids available, this book highlights the role of dietary fats in foods, human health, and disease. Divided into five parts, it begins with the chemistry and properties of food lipids covering nomenclature and classification, extraction and analysis, and chemistry and function. Part II addresses processing and food applications including modification technologies, microbial production of lipids, crystallization behavior, chemical interesterification, purification, and encapsulation technologies. The third part covers oxidation, measurements, and antioxidants. Part IV explores the myriad interactions of lipids in nutrition and health with information on heart disease, obesity, and cancer, with a new chapter dedicated to brain lipids. Part V continues with contributions on biotechnology and biochemistry including a chapter on the metabolic engineering of edible oils.
Book Synopsis Principles of Biochemistry by : H. Robert Horton
Download or read book Principles of Biochemistry written by H. Robert Horton and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introductory text which provides coverage of biomolecular structure, function, metabolism, and molecular biology with major emphasis on three-dimensional biochemistry. Computer-generated stereo views depict the conformation of biomolecules; a free stere
