Small Molecule Inhibitors Of Protein Protein Interactions

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Inhibitors of Protein–Protein Interactions

Author : Ali Tavassoli
Publisher : Royal Society of Chemistry
ISBN 13 : 178801569X
Total Pages : 357 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Inhibitors of Protein–Protein Interactions by : Ali Tavassoli

Download or read book Inhibitors of Protein–Protein Interactions written by Ali Tavassoli and published by Royal Society of Chemistry. This book was released on 2020-12-07 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.

Targeting Protein-Protein Interactions by Small Molecules

Author : Chunquan Sheng
Publisher : Springer
ISBN 13 : 9811307733
Total Pages : 332 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Targeting Protein-Protein Interactions by Small Molecules by : Chunquan Sheng

Download or read book Targeting Protein-Protein Interactions by Small Molecules written by Chunquan Sheng and published by Springer. This book was released on 2018-06-26 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.

Protein-protein Complexes

Author : Martin Zacharias
Publisher : World Scientific
ISBN 13 : 184816338X
Total Pages : 401 pages
Book Rating : 4.8/5 (481 download)

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Book Synopsis Protein-protein Complexes by : Martin Zacharias

Download or read book Protein-protein Complexes written by Martin Zacharias and published by World Scientific. This book was released on 2010 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.

Small-Molecule Inhibitors of Protein-Protein Interactions

Author : Lyubomir Vassilev
Publisher : Springer Science & Business Media
ISBN 13 : 3642170838
Total Pages : 180 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Small-Molecule Inhibitors of Protein-Protein Interactions by : Lyubomir Vassilev

Download or read book Small-Molecule Inhibitors of Protein-Protein Interactions written by Lyubomir Vassilev and published by Springer Science & Business Media. This book was released on 2011-01-18 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Development and Characterization of Small-molecule Inhibitors of Protein-protein Interactions

Author : Sabine Schubert
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (119 download)

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Book Synopsis Development and Characterization of Small-molecule Inhibitors of Protein-protein Interactions by : Sabine Schubert

Download or read book Development and Characterization of Small-molecule Inhibitors of Protein-protein Interactions written by Sabine Schubert and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein-Protein Interactions

Author : Michael D. Wendt
Publisher : Springer Science & Business Media
ISBN 13 : 3642289657
Total Pages : 276 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Protein-Protein Interactions by : Michael D. Wendt

Download or read book Protein-Protein Interactions written by Michael D. Wendt and published by Springer Science & Business Media. This book was released on 2012-06-26 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Michael D. Wendt Protein-Protein Interactions as Drug Targets Shaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev Kumar Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics Kurt Deshayes , Jeremy Murray , Domagoj Vucic The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer John F. Kadow , David R. Langley , Nicholas A. Meanwell , Michael A. Walker , Kap-Sun Yeung , Richard Pracitto Protein-Protein Interaction Targets to Inhibit HIV-1 Infection Nicholas A. Meanwell , David R. Langley Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion – a Focus on Respiratory Syncytial Virus Andrew B. Mahon , Stephen E. Miller , Stephen T. Joy , Paramjit S. Arora Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces Michael D. Wendt The Discovery of Navitoclax, a Bcl-2 Family Inhibitor

Small Molecule — Protein Interactions

Author : Herbert Waldmann
Publisher : Springer Science & Business Media
ISBN 13 : 3662053144
Total Pages : 248 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Small Molecule — Protein Interactions by : Herbert Waldmann

Download or read book Small Molecule — Protein Interactions written by Herbert Waldmann and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters are written by leading experts in the field, who present and discuss the most recent state-of-the-art tools and techniques for the development of novel drugs. The value of the book lies in surveying and summarizing the approaches taken by different companies and institutions giving the reader a balanced view on the use of the latest techniques on the one hand and experience-based assistance in selecting appropriate tools for their own work on the other hand.

Biochemical Characterization of Small-molecule Inhibitors of Protein-protein Interactions

Author : Stefan Rubner
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (113 download)

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Book Synopsis Biochemical Characterization of Small-molecule Inhibitors of Protein-protein Interactions by : Stefan Rubner

Download or read book Biochemical Characterization of Small-molecule Inhibitors of Protein-protein Interactions written by Stefan Rubner and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inhibition of Transcription Factors by Small-molecule Inhibitors of Protein-protein Interactions

Author : Thorsten Berg
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (634 download)

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Book Synopsis Inhibition of Transcription Factors by Small-molecule Inhibitors of Protein-protein Interactions by : Thorsten Berg

Download or read book Inhibition of Transcription Factors by Small-molecule Inhibitors of Protein-protein Interactions written by Thorsten Berg and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structure-Based Design and Discovery of Small Molecule Inhibitors of Protein-Protein Interactions

Author : Yipin Lu
Publisher :
ISBN 13 :
Total Pages : 526 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Structure-Based Design and Discovery of Small Molecule Inhibitors of Protein-Protein Interactions by : Yipin Lu

Download or read book Structure-Based Design and Discovery of Small Molecule Inhibitors of Protein-Protein Interactions written by Yipin Lu and published by . This book was released on 2006 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Disruption of Protein-Protein Interfaces

Author : Stefano Mangani
Publisher : Springer
ISBN 13 : 9783642433894
Total Pages : 0 pages
Book Rating : 4.4/5 (338 download)

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Book Synopsis Disruption of Protein-Protein Interfaces by : Stefano Mangani

Download or read book Disruption of Protein-Protein Interfaces written by Stefano Mangani and published by Springer. This book was released on 2015-08-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.

Targeting Clinically Viable Protein-protein Interactions Via Rationally Designed Small Molecule Inhibitors

Author : Sina Haftchenary
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (977 download)

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Book Synopsis Targeting Clinically Viable Protein-protein Interactions Via Rationally Designed Small Molecule Inhibitors by : Sina Haftchenary

Download or read book Targeting Clinically Viable Protein-protein Interactions Via Rationally Designed Small Molecule Inhibitors written by Sina Haftchenary and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein-Protein Interactions

Author : Michael D. Wendt
Publisher : Springer
ISBN 13 : 9783642289644
Total Pages : 0 pages
Book Rating : 4.2/5 (896 download)

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Book Synopsis Protein-Protein Interactions by : Michael D. Wendt

Download or read book Protein-Protein Interactions written by Michael D. Wendt and published by Springer. This book was released on 2012-06-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Michael D. Wendt Protein-Protein Interactions as Drug Targets Shaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev Kumar Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics Kurt Deshayes , Jeremy Murray , Domagoj Vucic The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer John F. Kadow , David R. Langley , Nicholas A. Meanwell , Michael A. Walker , Kap-Sun Yeung , Richard Pracitto Protein-Protein Interaction Targets to Inhibit HIV-1 Infection Nicholas A. Meanwell , David R. Langley Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion – a Focus on Respiratory Syncytial Virus Andrew B. Mahon , Stephen E. Miller , Stephen T. Joy , Paramjit S. Arora Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces Michael D. Wendt The Discovery of Navitoclax, a Bcl-2 Family Inhibitor

Protein Surface Recognition

Author : Ernest Giralt
Publisher : John Wiley & Sons
ISBN 13 : 1119957214
Total Pages : 296 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Protein Surface Recognition by : Ernest Giralt

Download or read book Protein Surface Recognition written by Ernest Giralt and published by John Wiley & Sons. This book was released on 2011-07-07 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease. Protein Surface Recognition presents a detailed treatment of this strategy, with topics including: an extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspective the fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfaces examples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systems a survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to in silico and in vitro methods for the discovery of novel protein ligands. Protein Surface Recognition provides an intellectual “tool-kit” for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery.

Small-molecule Inhibitors of Protein-protein Interactions Selectively Induce Chemoresistant/caspase-3-deficient Cancer Cell Death

Download Small-molecule Inhibitors of Protein-protein Interactions Selectively Induce Chemoresistant/caspase-3-deficient Cancer Cell Death PDF Online Free

Author : Shih-Hsun Chen
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (897 download)

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Book Synopsis Small-molecule Inhibitors of Protein-protein Interactions Selectively Induce Chemoresistant/caspase-3-deficient Cancer Cell Death by : Shih-Hsun Chen

Download or read book Small-molecule Inhibitors of Protein-protein Interactions Selectively Induce Chemoresistant/caspase-3-deficient Cancer Cell Death written by Shih-Hsun Chen and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Disruption of Protein-Protein Interfaces

Author : Stefano Mangani
Publisher : Springer Science & Business Media
ISBN 13 : 3642379990
Total Pages : 167 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Disruption of Protein-Protein Interfaces by : Stefano Mangani

Download or read book Disruption of Protein-Protein Interfaces written by Stefano Mangani and published by Springer Science & Business Media. This book was released on 2013-06-28 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.