Signalling Mechanisms From Transciption Factors To Oxidative Stress

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Signalling Mechanisms — from Transcription Factors to Oxidative Stress

Author : Lester Packer
Publisher : Springer Science & Business Media
ISBN 13 : 3642796753
Total Pages : 461 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Signalling Mechanisms — from Transcription Factors to Oxidative Stress by : Lester Packer

Download or read book Signalling Mechanisms — from Transcription Factors to Oxidative Stress written by Lester Packer and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NATO Advanced Study Institute on "Molecular Mechanisms of Transcellular Signaling: from the Membrane to the Gene" was held on the Island of Spetsai, Greece, from August 15- 27, 1994. The aim of this Institute was to bring together researchers in the field of signal transduction mechanisms, transcription factors and gene regulation with those actively involved in studies on the implications of oxygen radicals and antioxidant defence mechanisms for cell function. As diverse as these fields may be, the emergence of their interconnection during the course of the Institute was an eye-opener for students and lecturers alike. 2 Presentations and discussions focussed on the role of Ca +, G-proteins, protein kinase C and phospholipases in signaling mechanisms. These broad principles were extended to transcription factors and gene regulation with an emphasis on the steroid hormone receptor superfamily and NFKB. Basic principles of free radical formation and antioxidant action (vitamin E and C) were presented and discussed in connection with effects on signaling pathways. This book present the content of the major lectures and a selection of the most relevant posters. These proceedings offer a comprehensive account of the most important topics discussed at the Institute. The book is intended to make the proceedings accessible to a large audience.

Signalling Mechanisms from Transciption Factors to Oxidative Stress

Author : Lester Packer
Publisher :
ISBN 13 : 9780387591278
Total Pages : 456 pages
Book Rating : 4.5/5 (912 download)

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Book Synopsis Signalling Mechanisms from Transciption Factors to Oxidative Stress by : Lester Packer

Download or read book Signalling Mechanisms from Transciption Factors to Oxidative Stress written by Lester Packer and published by . This book was released on 1995-06-22 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oxidative Stress and Signal Transduction

Author : H.J. Forman
Publisher : Springer Science & Business Media
ISBN 13 : 1461559812
Total Pages : 484 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Oxidative Stress and Signal Transduction by : H.J. Forman

Download or read book Oxidative Stress and Signal Transduction written by H.J. Forman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.

Oxidative Stress Mechanisms and their Modulation

Author : Mohinder Bansal
Publisher : Springer
ISBN 13 : 8132220323
Total Pages : 183 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Oxidative Stress Mechanisms and their Modulation by : Mohinder Bansal

Download or read book Oxidative Stress Mechanisms and their Modulation written by Mohinder Bansal and published by Springer. This book was released on 2014-10-17 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.

Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders

Download Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders PDF Online Free

Author : Terry D. Hinds, Jr
Publisher : Frontiers Media SA
ISBN 13 : 2889715272
Total Pages : 206 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders by : Terry D. Hinds, Jr

Download or read book Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders written by Terry D. Hinds, Jr and published by Frontiers Media SA. This book was released on 2021-10-21 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editors Terry Hinds and David Stec have submitted patents related to bilirubin and obesity related disorders. The other Topic Editor declare no potential conflicts of interest with regards to the Research Topic subject.

Dietary Modulation of Cell Signaling Pathways

Author : Zigang Dong
Publisher : CRC Press
ISBN 13 : 0849381495
Total Pages : 504 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Dietary Modulation of Cell Signaling Pathways by : Zigang Dong

Download or read book Dietary Modulation of Cell Signaling Pathways written by Zigang Dong and published by CRC Press. This book was released on 2008-09-26 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Die

Oxidative Stress in Plants

Author : Dirk Inze
Publisher : CRC Press
ISBN 13 : 0203303148
Total Pages : 417 pages
Book Rating : 4.2/5 (33 download)

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Book Synopsis Oxidative Stress in Plants by : Dirk Inze

Download or read book Oxidative Stress in Plants written by Dirk Inze and published by CRC Press. This book was released on 2001-10-18 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants depend on physiological mechanisms to combat adverse environmental conditions, such as pathogen attack, wounding, drought, cold, freezing, salt, UV, intense light, heavy metals and SO2. Many of these cause excess production of active oxygen species in plant cells. Plants have evolved complex defense systems against such oxidative stress. The

A Master Regulator of Oxidative StressThe Transcription Factor Nrf2

Author : Jose Antonio Morales-Gonzalez
Publisher : BoD – Books on Demand
ISBN 13 : 953512837X
Total Pages : 212 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis A Master Regulator of Oxidative StressThe Transcription Factor Nrf2 by : Jose Antonio Morales-Gonzalez

Download or read book A Master Regulator of Oxidative StressThe Transcription Factor Nrf2 written by Jose Antonio Morales-Gonzalez and published by BoD – Books on Demand. This book was released on 2016-12-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.

Oxidative Stress in Vertebrates and Invertebrates

Author : Tahira Farooqui
Publisher : John Wiley & Sons
ISBN 13 : 1118148118
Total Pages : 433 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Oxidative Stress in Vertebrates and Invertebrates by : Tahira Farooqui

Download or read book Oxidative Stress in Vertebrates and Invertebrates written by Tahira Farooqui and published by John Wiley & Sons. This book was released on 2011-10-24 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Redox Regulation of Cell Signaling and Its Clinical Application

Author : Junji Yodoi
Publisher : CRC Press
ISBN 13 : 9780824719616
Total Pages : 366 pages
Book Rating : 4.7/5 (196 download)

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Book Synopsis Redox Regulation of Cell Signaling and Its Clinical Application by : Junji Yodoi

Download or read book Redox Regulation of Cell Signaling and Its Clinical Application written by Junji Yodoi and published by CRC Press. This book was released on 1999-03-29 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents recent developments in the rapidly expanding field of redox regulation research. The book examines insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult T-cell leukemia-derived factor (ADF).

Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

Author : H.J. Forman
Publisher : Springer Science & Business
ISBN 13 : 0306484129
Total Pages : 432 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles by : H.J. Forman

Download or read book Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles written by H.J. Forman and published by Springer Science & Business. This book was released on 2006-02-17 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.

Oxidative Stress and Signal Transduction

Author : H.J. Forman
Publisher : Springer
ISBN 13 : 9781461559825
Total Pages : 475 pages
Book Rating : 4.5/5 (598 download)

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Book Synopsis Oxidative Stress and Signal Transduction by : H.J. Forman

Download or read book Oxidative Stress and Signal Transduction written by H.J. Forman and published by Springer. This book was released on 2011-10-08 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.

Inflammation and Cancer

Author : Bharat B. Aggarwal
Publisher : Springer
ISBN 13 : 3034808372
Total Pages : 489 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal

Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Antioxidants in Sport Nutrition

Author : Manfred Lamprecht
Publisher : CRC Press
ISBN 13 : 1466567570
Total Pages : 304 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Antioxidants in Sport Nutrition by : Manfred Lamprecht

Download or read book Antioxidants in Sport Nutrition written by Manfred Lamprecht and published by CRC Press. This book was released on 2014-09-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Oxidative Stress and Redox Regulation

Author : Ursula Jakob
Publisher : Springer Science & Business Media
ISBN 13 : 9400757875
Total Pages : 488 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Oxidative Stress and Redox Regulation by : Ursula Jakob

Download or read book Oxidative Stress and Redox Regulation written by Ursula Jakob and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Antioxidants and Antioxidant Enzymes in Higher Plants

Author : Dharmendra K. Gupta
Publisher : Springer
ISBN 13 : 3319750887
Total Pages : 306 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Antioxidants and Antioxidant Enzymes in Higher Plants by : Dharmendra K. Gupta

Download or read book Antioxidants and Antioxidant Enzymes in Higher Plants written by Dharmendra K. Gupta and published by Springer. This book was released on 2018-03-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of antioxidants and antioxidant enzymes and their role in the mechanisms of signaling and cellular tolerance under stress in plant systems. Major reactive oxygen species (ROS)-scavenging/modulating enzymes include the superoxide dismutase (SOD) that dismutates O2 into H2O2, which is followed by the coordinated action of a set of enzymes including catalase (CAT), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and peroxiredoxins (Prx) that remove H2O2. In addition to the ROS scavenging enzymes, a number of other enzymes are found in various subcellular compartments, which are involved in maintaining such redox homeostasis either by directly scavenging particular ROS and ROS-byproducts or by replenishing antioxidants. In that respect, these enzymes can be also considered antioxidants. Such enzymes include monodehydroascorbate reductase (MDAR), dehydroascorbate reductase (DHAR), glutathione reductase (GR), alternative oxidases (AOXs), peroxidases (PODs) and glutathione S-transferases (GSTs). Some non-enzymatic antioxidants, such as ascorbic acid (vitamin C), carotenes (provitamin A), tocopherols (vitamin E), and glutathione (GSH), work in concert with antioxidant enzymes to sustain an intracellular steady-state level of ROS that promotes plant growth, development, cell cycles and hormone signaling, and reinforces the responses to abiotic and biotic environmental stressors. Offering a unique compilation of information on antioxidants and antioxidant enzymes, this is a valuable resource for advanced students and researchers working on plant biochemistry, physiology, biotechnology, and signaling in cell organelles, and those specializing in plant enzyme technology.

Diabetes Mellitus

Author : Derek LeRoith
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781740975
Total Pages : 1606 pages
Book Rating : 4.7/5 (49 download)

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Book Synopsis Diabetes Mellitus by : Derek LeRoith

Download or read book Diabetes Mellitus written by Derek LeRoith and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 1606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.