Signaling Pathways Involved In Mechanical Stimulation And Ecm Geometry In Bone Cells

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Genetics of Bone Biology and Skeletal Disease

Author : Rajesh V. Thakker
Publisher : Academic Press
ISBN 13 : 0128041986
Total Pages : 880 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genetics of Bone Biology and Skeletal Disease by : Rajesh V. Thakker

Download or read book Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker and published by Academic Press. This book was released on 2017-10-31 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Basic and Applied Bone Biology

Author : David B. Burr
Publisher : Academic Press
ISBN 13 : 0123914590
Total Pages : 390 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Basic and Applied Bone Biology by : David B. Burr

Download or read book Basic and Applied Bone Biology written by David B. Burr and published by Academic Press. This book was released on 2013-06-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. - Presents an in-depth overview of skeletal biology from the molecular to the organ level - Offers "refresher" level content for clinicians or researchers outside their areas of expertise - Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology

Bone Tissue Engineering

Author : Jeffrey O. Hollinger
Publisher : CRC Press
ISBN 13 : 1135501912
Total Pages : 462 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Bone Tissue Engineering by : Jeffrey O. Hollinger

Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Tissue Repair, Contraction and the Myofibroblast

Author : Christine Chaponnier
Publisher : Springer Science & Business Media
ISBN 13 : 0387336508
Total Pages : 154 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Tissue Repair, Contraction and the Myofibroblast by : Christine Chaponnier

Download or read book Tissue Repair, Contraction and the Myofibroblast written by Christine Chaponnier and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue Repair, Contraction and the Myofibroblast summarizes the latest findings concerning the biology of the myofibroblast, a cell involved in the evolution and contraction of granulation tissue and of fibrotic changes. Coverage shows that the myofibroblast is responsible for the development of hypertrophic scars, pulmonary and renal fibrosis and bronchial asthma. Reviews the cell biology and pathology of the myofibroblast as well as mechanisms of fibrosis evolution in many organs and tissues.

Extracellular and Intracellular Signaling

Author : James D. Adams
Publisher : Royal Society of Chemistry
ISBN 13 : 1849731608
Total Pages : 319 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Extracellular and Intracellular Signaling by : James D. Adams

Download or read book Extracellular and Intracellular Signaling written by James D. Adams and published by Royal Society of Chemistry. This book was released on 2011 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.

Mimicking the Extracellular Matrix

Author : Gregory A Hudalla
Publisher : Royal Society of Chemistry
ISBN 13 : 178801815X
Total Pages : 422 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Mimicking the Extracellular Matrix by : Gregory A Hudalla

Download or read book Mimicking the Extracellular Matrix written by Gregory A Hudalla and published by Royal Society of Chemistry. This book was released on 2019-03-15 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Extracellular Matrix in Development

Author : Douglas W. DeSimone
Publisher : Springer Science & Business Media
ISBN 13 : 3642359353
Total Pages : 260 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Extracellular Matrix in Development by : Douglas W. DeSimone

Download or read book Extracellular Matrix in Development written by Douglas W. DeSimone and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Biological Soft Matter

Author : Corinne Nardin
Publisher : John Wiley & Sons
ISBN 13 : 3527810994
Total Pages : 288 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Biological Soft Matter by : Corinne Nardin

Download or read book Biological Soft Matter written by Corinne Nardin and published by John Wiley & Sons. This book was released on 2021-04-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Soft Matter Explore a comprehensive, one-stop reference on biological soft matter written and edited by leading voices in the field Biological Soft Matter: Fundamentals, Properties and Applications delivers a unique and indispensable compilation of up-to-date knowledge and material on biological soft matter. The book presents a thorough overview about biological soft matter, beginning with different substance classes, including proteins, nucleic acids, lipids, and polysaccharides. It goes on to describe a variety of superstructures and aggregated and how they are formed by self-assembly processes like protein folding or crystallization. The distinguished editors have included materials with a special emphasis on macromolecular assembly, including how it applies to lipid membranes, and proteins fibrillization. Biological Soft Matter is a crucial resource for anyone working in the field, compiling information about all important substance classes and their respective roles in forming superstructures. The book is ideal for beginners and experts alike and makes the perfect guide for chemists, physicists, and life scientists with an interest in the area. Readers will also benefit from the inclusion of: An introduction to DNA nano-engineering and DNA-driven nanoparticle assembly Explorations of polysaccharides and glycoproteins, engineered biopolymers, and engineered hydrogels Discussions of macromolecular assemblies, including liquid membranes and small molecule inhibitors for amyloid aggregation A treatment of inorganic nanomaterials as promoters and inhibitors of amyloid fibril formation An examination of a wide variety of natural and artificial polymers Perfect for materials scientists, biochemists, polymer chemists, and protein chemists, Biological Soft Matter: Fundamentals, Properties and Applications will also earn a place in the libraries of biophysicists and physical chemists seeking a one-stop reference summarizing the rapidly evolving topic of biological soft matter.

Advanced Techniques in Bone Regeneration

Author : Alessandro Rozim Zorzi
Publisher : BoD – Books on Demand
ISBN 13 : 9535125389
Total Pages : 388 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Advanced Techniques in Bone Regeneration by : Alessandro Rozim Zorzi

Download or read book Advanced Techniques in Bone Regeneration written by Alessandro Rozim Zorzi and published by BoD – Books on Demand. This book was released on 2016-08-31 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.

Pocket Reference to Osteoporosis

Author : Serge Livio Ferrari
Publisher : Springer
ISBN 13 : 3319267574
Total Pages : 103 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Pocket Reference to Osteoporosis by : Serge Livio Ferrari

Download or read book Pocket Reference to Osteoporosis written by Serge Livio Ferrari and published by Springer. This book was released on 2018-12-28 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book responds to the daily needs of all clinicians treating patients with osteoporosis and provides a key reference guide for any challenges that arise in clinical practice. This book also covers the genetics of the disease, clinical presentation, diagnosis, and current and upcoming treatment recommendations in accordance with the latest international guidelines. Osteoporosis is a disease in which the density and quality of bone are greatly reduced, and as bones become more porous and fragile the risk of fracture increases greatly. It is one of the most common metabolic bone diseases globally with one in three women and one in five men at risk of an osteoporotic fracture, and can result in devastating physical, psychosocial, and economic consequences. However, in spite of this osteoporosis can often be overlooked and undertreated, thus there is a real need to raise awareness of this disease.

Biomaterials Science and Technology

Author : Yaser Dahman
Publisher : CRC Press
ISBN 13 : 0429878354
Total Pages : 377 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Biomaterials Science and Technology by : Yaser Dahman

Download or read book Biomaterials Science and Technology written by Yaser Dahman and published by CRC Press. This book was released on 2019-02-11 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials Science and Technology: Fundamentals and Developments presents a broad scope of the field of biomaterials science and technology, focusing on theory, advances, and applications. It reviews the fabrication and properties of different classes of biomaterials such as bioinert, bioactive, and bioresorbable, in addition to biocompatibility. It further details traditional and recent techniques and methods that are utilized to characterize major properties of biomaterials. The book also discusses modifications of biomaterials in order to tailor properties and thus accommodate different applications in the biomedical engineering fields and summarizes nanotechnology approaches to biomaterials. This book targets students in advanced undergraduate and graduate levels in majors related to fields of Chemical Engineering, Materials Engineering and Science, Biomedical Engineering, Bioengineering, and Life Sciences. It assists in understanding major concepts of fabrication, modification, and possible applications of different classes of biomaterials. It is also intended for professionals who are interested in recent advances in the emerging field of biomaterials.

Decellularized Extracellular Matrix

Author : Takashi Hoshiba
Publisher : Royal Society of Chemistry
ISBN 13 : 1788014677
Total Pages : 368 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Decellularized Extracellular Matrix by : Takashi Hoshiba

Download or read book Decellularized Extracellular Matrix written by Takashi Hoshiba and published by Royal Society of Chemistry. This book was released on 2019-12-05 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using this book, the reader will gain a good foundation to the field complemented with a broad overview of characterisation, microfabrication and applications.

Hematopoietic Stem Cell Development

Author : Isabelle Godin
Publisher : Springer Science & Business Media
ISBN 13 : 0387335358
Total Pages : 188 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Hematopoietic Stem Cell Development by : Isabelle Godin

Download or read book Hematopoietic Stem Cell Development written by Isabelle Godin and published by Springer Science & Business Media. This book was released on 2010-05-27 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.

Advanced Healthcare Materials

Author : Ashutosh Tiwari
Publisher : John Wiley & Sons
ISBN 13 : 1118773683
Total Pages : 421 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Advanced Healthcare Materials by : Ashutosh Tiwari

Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers

Bone Pathology

Author : Jasvir S. Khurana
Publisher : Springer Science & Business Media
ISBN 13 : 1597453471
Total Pages : 419 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Bone Pathology by : Jasvir S. Khurana

Download or read book Bone Pathology written by Jasvir S. Khurana and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.

Resident Stem Cells and Regenerative Therapy

Author : Regina Coeli dos Santos Goldenberg
Publisher : Academic Press
ISBN 13 : 0124160123
Total Pages : 306 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Resident Stem Cells and Regenerative Therapy by : Regina Coeli dos Santos Goldenberg

Download or read book Resident Stem Cells and Regenerative Therapy written by Regina Coeli dos Santos Goldenberg and published by Academic Press. This book was released on 2012-09-26 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides explanations of experiments with animal models and clinical trials that are transforming the field of regeneration.

Bones

Author : John D. Currey
Publisher : Princeton University Press
ISBN 13 : 0691128049
Total Pages : 456 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis Bones by : John D. Currey

Download or read book Bones written by John D. Currey and published by Princeton University Press. This book was released on 2006-07-23 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive and accessible overview of what is known about the structure and mechanics of bone, bones, and teeth. In it, John Currey incorporates critical new concepts and findings from the two decades of research since the publication of his highly regarded The Mechanical Adaptations of Bones. Crucially, Currey shows how bone structure and bone's mechanical properties are intimately bound up with each other and how the mechanical properties of the material interact with the structure of whole bones to produce an adapted structure. For bone tissue, the book discusses stiffness, strength, viscoelasticity, fatigue, and fracture mechanics properties. For whole bones, subjects dealt with include buckling, the optimum hollowness of long bones, impact fracture, and properties of cancellous bone. The effects of mineralization on stiffness and toughness and the role of microcracking in the fracture process receive particular attention. As a zoologist, Currey views bone and bones as solutions to the design problems that vertebrates have faced during their evolution and throughout the book considers what bones have been adapted to do. He covers the full range of bones and bony tissues, as well as dentin and enamel, and uses both human and non-human examples. Copiously illustrated, engagingly written, and assuming little in the way of prior knowledge or mathematical background, Bones is both an ideal introduction to the field and also a reference sure to be frequently consulted by practicing researchers.