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Signal Transduction In Lung Cells
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Book Synopsis Signal Transduction in Lung Cells by : Jerome Brody
Download or read book Signal Transduction in Lung Cells written by Jerome Brody and published by CRC Press. This book was released on 1993-03-30 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference offers detailed discussions of the basic aspects of signal transduction, and examines their applications in lung cell biology. Providing an overview of current research directions, Signal Transduction in Lung Cells covers: the structure and function of receptors; the structure and regulation of G proteins; second messenger systems including kinases and phosphatases; airway and alveolar cells; smooth muscle cells; inflammatory and immune cells; muscle tone, ion channels, growth factors and cytokines.;With over 1900 literature citations and figures, Signal Transduction in Lung Cells is intended as a resource for pulmonologists, physiologists, molecular and cell biologists, pharmacologists, and graduate and medical school students in these disciplines.
Book Synopsis Targeting Cellular Signalling Pathways in Lung Diseases by : Kamal Dua
Download or read book Targeting Cellular Signalling Pathways in Lung Diseases written by Kamal Dua and published by Springer Nature. This book was released on 2021-07-02 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.
Book Synopsis Lung Biology and Pathophysiology by : Yutong Zhao
Download or read book Lung Biology and Pathophysiology written by Yutong Zhao and published by CRC Press. This book was released on 2024-02-20 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics. Key Features Highlights the role the lungs play as an interface between the body and the environment Describes the underlying mechanism of lung diseases Emphasizes the ways nutrition contributes to lung health as well as the ways pollution adversely affect lung function Includes contributions from leading researchers Chapters 8 and 13 of this book are available for free in PDF format as Open Access from the individual product page at www.routledge.com. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.
Book Synopsis Receptors and Cell Activation by : Marc G. Caron
Download or read book Receptors and Cell Activation written by Marc G. Caron and published by . This book was released on 1987 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this conference was to discuss characterization of the cell surface receptors and their signal transduction mechanisms. These mechanisms are particularly relevant to the physiology of the cardiovascular system. They are used by hormones and neurotransmitters, such as catecholamines and acetylcholine, which are released from the autonomic nervous system. The autonomic nervous system plays an important role in the regulation of the physiological properties of the heart, blood vessels, and lungs. Further, alterations in receptors mediating the effects of these and other hormones and neurotransmitters are likely to be involved in different disorders of the cardiovascular, pulmonary, and central nervous systems. Finally, these receptors are the sites of action of many important drugs currently in use in clinical medicine.
Download or read book Receptors and Cell Activation written by and published by . This book was released on 1987 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Signal Transduction and Its Effect on GRP and C-fos Gene Expression in Small Cell Lung Carcinoma Cell Lines by : Muriel Draoui
Download or read book Signal Transduction and Its Effect on GRP and C-fos Gene Expression in Small Cell Lung Carcinoma Cell Lines written by Muriel Draoui and published by . This book was released on 1992 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cell Signaling in Vascular Inflammation by : Jahar Bhattacharya
Download or read book Cell Signaling in Vascular Inflammation written by Jahar Bhattacharya and published by Humana Press. This book was released on 2010-11-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.
Book Synopsis Modeling, Simulation, and Analysis of Signal Transduction Pathways Induced by Bacterium Pseudomonas Aeruginosa in the Human Lung Cell by : Abhinav C. Yarlagadda
Download or read book Modeling, Simulation, and Analysis of Signal Transduction Pathways Induced by Bacterium Pseudomonas Aeruginosa in the Human Lung Cell written by Abhinav C. Yarlagadda and published by . This book was released on 2007 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Simultaneous Inhibition of Multiple Signal Transduction Pathways by : William Scott Holland
Download or read book Simultaneous Inhibition of Multiple Signal Transduction Pathways written by William Scott Holland and published by . This book was released on 2007 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Signal Transduction in Cancer by : David A. Frank
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Book Synopsis The Role of Tyrosine Kinases in Signal Transduction Mechanisms Utilised by Human Lung Mast Cells and Basophils by : Sandra Elizabeth Lavens-Phillips
Download or read book The Role of Tyrosine Kinases in Signal Transduction Mechanisms Utilised by Human Lung Mast Cells and Basophils written by Sandra Elizabeth Lavens-Phillips and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Assessment of the Impact of Deregulated Signal Transduction Pathways on the Radiotherapy Response of Non-small-cell Lung Cancer by : Sarah Alexandra Wieczorek
Download or read book Assessment of the Impact of Deregulated Signal Transduction Pathways on the Radiotherapy Response of Non-small-cell Lung Cancer written by Sarah Alexandra Wieczorek and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Regulation of Mitogen Stimulated Signal Transduction Pathways in Human Lung Cancer by : Andrea Frankel
Download or read book The Regulation of Mitogen Stimulated Signal Transduction Pathways in Human Lung Cancer written by Andrea Frankel and published by . This book was released on 1994 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Established human lung cancer exhibits a complex pattern of genetic changes as well as several distinct autocrine growth factor loops for regulatory peptides. The best studied example is that of gastrin-releasing peptide or GRP, the mammalian homolog of the amphibian bombesin. Three human bombesin receptor subtypes have been cloned. They are the gastrin-releasing peptide receptor (GRP-R), the neuromedin-B receptor (NMB-R), and the bombesin-receptor subtype-3 (BRS-3). Low level expression of the GRP-R and NMB-R mRNA was detected in cultures of human bronchial epithelium. BRS-3 mRNA was undetected in these cells. An elevation of intracellular calcium concentration was observed in response to bradykinin, but not to bombesin, vasopressin or cholecystokinin. Such responses are frequently noted in lung cancer cell lines. This suggests that broad responsiveness to multiple neuropeptides is acquired during bronchial carcinogenesis. However, homologous desensitization of intracellular calcium responses to bombesin is present in lung cancer cells and can be mimicked by protein kinase C-activating phorbol esters. However, upon inhibition of protein kinase C, homologous desensitization to bombesin persists. The data indicate that protein kinase C is not a dominant component in the homologous desensitization to bombesin in small cell lung cancer cells." --
Book Synopsis Lung Cancer and Personalized Medicine by : Aamir Ahmad
Download or read book Lung Cancer and Personalized Medicine written by Aamir Ahmad and published by Springer. This book was released on 2015-12-14 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.
Book Synopsis Mucus Hypersecretion in Respiratory Disease by : Derek J. Chadwick
Download or read book Mucus Hypersecretion in Respiratory Disease written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2003-07-07 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanisms that underlie and maintain this hypersecretory phenotype is therefore crucial for the development of rational approaches to therapy. Despite a high and increasing prevalence and cost to healthcare services and society, mucus hypersecretion in chronic respiratory disease has received little attention until recently, probably because of the difficulties inherent in studying this pathology. Only in the last few years have some of the genes involved in mucus secretion been characterized. The recent availability of genomic sequence information and specific antibodies has led to an explosion of interest in this area making this publication particularly timely. This book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem. Coverage includes epidemiology, airways infection and mucus hypersecretion, the genetics and regulation of mucus production, models of mucus hypersecretion, and the implications of new knowledge for the development of novel therapies.
Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Book Synopsis Pulmonary Metastasis by : Leonard Weiss
Download or read book Pulmonary Metastasis written by Leonard Weiss and published by Macmillan Reference USA. This book was released on 1978 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
