Sequencing Apple's DNA

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Publisher : John Wiley & Sons
ISBN 13 : 1848219199
Total Pages : 245 pages
Book Rating : 4.8/5 (482 download)

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Book Synopsis Sequencing Apple's DNA by : Patrick Corsi

Download or read book Sequencing Apple's DNA written by Patrick Corsi and published by John Wiley & Sons. This book was released on 2016-01-19 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to extract the "molecular genes" leading to craziness! Geniuses are the ones who are "crazy enough to think they can change the world" and boldly go where no one has gone before. Where no past habit and usage are available, there is no proof of viability, as nobody has done it yet, or even imagined it, and no roadmap for guidance or market study has come up with it. The authors call upon Leonardo Da Vinci, the Renaissance genius, who as strange as it seems, shared many traits of personality with that of Steve Jobs, in terms of the ways of performing. Da Vinci helps in understanding Jobs, and hence Apple, with his unique way of designing radically novel concepts, which were actually quite crazy for his time. In order to shed light on a special creative posture, the indomitable sense of specifying undecidable objects – a hallmark of the late Steve Jobs – is what led the authors to match it with a specific design innovation theory. A real theory, backed by solid mathematical proof, exists and can account for the business virtue of a prolific ability to move into unknown crazy fields! The authors postulate that, by bringing the power of C-K theory to crack open a number of previous observations made about Apple’s methods, it is possible to identify most of the genes of this company. The authors analyze how and why an Apple way of doing business is radically different from standard business practices and why it is so successful. Genes are a measure of the entity at hand and can encourage past business education routine approaches, then become transferable across the spectrum of the socio-economic world.

The Apple Genome

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Author :
Publisher : Springer Nature
ISBN 13 : 3030746828
Total Pages : 412 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis The Apple Genome by : Schuyler S. Korban

Download or read book The Apple Genome written by Schuyler S. Korban and published by Springer Nature. This book was released on 2021-07-14 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers information on the economics; botany, taxonomy, and origin; germplasm resources; cytogenetics and nuclear DNA; genetic improvement efforts of scion cultivars; genetic and genomic improvement efforts of rootstocks; genetic and physical mapping; genomic resources; genome and epigenome; regulatory sequences; utility of whole-genome sequencing and gene editing in trait dissection; flowering and juvenility; cold hardiness and dormancy; fruit color development; fruit acidity and sugar content; metabolomics; biology and genomics of the microbiome; apple domestication; as well as other ‘omics’ opportunities and challenges for genetic improvement of the apple. The cultivated apple (Malus x domestica Borkh.) is one of the most important tree fruit crops of temperate regions of the world. It is widely cultivated and grown in North America, Europe, and Asia. The apple fruit is a highly desirable fruit due to its flavor, sugar and acid content, metabolites, aroma, as well as its overall texture and palatability. Furthermore, it is a rich source of important nutrients, including antioxidants, vitamins, and dietary fiber.

The Genome Odyssey

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Publisher : Celadon Books
ISBN 13 : 1250234972
Total Pages : 221 pages
Book Rating : 4.2/5 (52 download)

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Book Synopsis The Genome Odyssey by : Dr. Euan Angus Ashley

Download or read book The Genome Odyssey written by Dr. Euan Angus Ashley and published by Celadon Books. This book was released on 2021-02-23 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

Improbable Destinies

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Publisher : Penguin
ISBN 13 : 0399184937
Total Pages : 386 pages
Book Rating : 4.3/5 (991 download)

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Book Synopsis Improbable Destinies by : Jonathan B. Losos

Download or read book Improbable Destinies written by Jonathan B. Losos and published by Penguin. This book was released on 2017-08-08 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major new book overturning our assumptions about how evolution works Earth’s natural history is full of fascinating instances of convergence: phenomena like eyes and wings and tree-climbing lizards that have evolved independently, multiple times. But evolutionary biologists also point out many examples of contingency, cases where the tiniest change—a random mutation or an ancient butterfly sneeze—caused evolution to take a completely different course. What role does each force really play in the constantly changing natural world? Are the plants and animals that exist today, and we humans ourselves, inevitabilities or evolutionary flukes? And what does that say about life on other planets? Jonathan Losos reveals what the latest breakthroughs in evolutionary biology can tell us about one of the greatest ongoing debates in science. He takes us around the globe to meet the researchers who are solving the deepest mysteries of life on Earth through their work in experimental evolutionary science. Losos himself is one of the leaders in this exciting new field, and he illustrates how experiments with guppies, fruit flies, bacteria, foxes, and field mice, along with his own work with anole lizards on Caribbean islands, are rewinding the tape of life to reveal just how rapid and predictable evolution can be. Improbable Destinies will change the way we think and talk about evolution. Losos's insights into natural selection and evolutionary change have far-reaching applications for protecting ecosystems, securing our food supply, and fighting off harmful viruses and bacteria. This compelling narrative offers a new understanding of ourselves and our role in the natural world and the cosmos.

The Extraordinary Story of the Apple

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Author :
Publisher : Royal Botanic Gardens Kew
ISBN 13 : 9781842466551
Total Pages : 0 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis The Extraordinary Story of the Apple by : Barry Juniper

Download or read book The Extraordinary Story of the Apple written by Barry Juniper and published by Royal Botanic Gardens Kew. This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a new edition of the book published under the title Story of the apple, 2006"--Title page verso.

National Research Initiative Competitive Grants Program

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Author :
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Research Initiative Competitive Grants Program by :

Download or read book National Research Initiative Competitive Grants Program written by and published by . This book was released on 1997 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Abstracts of Funded Research

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Author :
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Abstracts of Funded Research by : National Research Initiative Competitive Grants Program (United States. Cooperative State Research, Education, and Extension Service)

Download or read book Abstracts of Funded Research written by National Research Initiative Competitive Grants Program (United States. Cooperative State Research, Education, and Extension Service) and published by . This book was released on 1997 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Introgressing Multiple Disease Resistance Alleles Into Elite Apple Cultivars by DNA-informed Breeding

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Author :
Publisher :
ISBN 13 :
Total Pages : 196 pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis Introgressing Multiple Disease Resistance Alleles Into Elite Apple Cultivars by DNA-informed Breeding by : Feixiong Luo

Download or read book Introgressing Multiple Disease Resistance Alleles Into Elite Apple Cultivars by DNA-informed Breeding written by Feixiong Luo and published by . This book was released on 2019 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major apple diseases cause significant damage to apple production worldwide because highly susceptible cultivars are widely planted, particularly for apple foliar mildew, fire blight, and blue mold. Diseases losses can be minimized if cultivars with durable resistance are planted. Most sources of resistance are apple wild relatives that usually have poor fruit quality. Developing cultivars with durable resistance combined with required elite fruit quality phenotypically is difficult and time-consuming. DNA markers would be useful for efficiently identifying suitable offspring by the detection of disease resistance alleles and genome-wide tracking of DNA segments from apple wild relatives. The objectives of this project were to: 1) develop DNA tests for apple foliar mildew (source: 'White Angel'), fire blight (source: 'Enterprise'), and blue mold resistance (source: Malus sieversii PI 613981); and 2) demonstrate efficient introgression for blue mold resistance. For creating new DNA tests, four families used were 'Fuji' x 'White Angel' (n = 102) and 'Golden Delicious' x 'White Angel' (n = 92) for mildew and 'Enterprise' x T1190 (n = 219) for fire blight, and 'Gala' x PI 613981 (n = 89) for blue mold. For introgression of blue mold resistance, the families used were GMAL4593-128 and -175 ['Gala' x PI 613981] x T1190 [BpMADS4-transgenic 'Pinova' x 'Idared'] (n = 141). Apple 20K SNP array data was used to trace the inheritance of M. sieversii DNA segments. Three locus-specific DNA tests, Md-Plw8-SSR, Md-Ea7-SSR, and Md-Pe3-SSR, were successfully developed, which were able to distinguish susceptible individuals from resistant ones. These DNA tests themselves or combined with other disease resistance DNA tests could be used to efficiently detect the presence of resistance alleles from multiple sources. Within two years, among greenhouse-grown 141 individuals, three were selected with the resistance allele, the least proportion of M. sieversii DNA segments, and favorable positions of these segments on the same chromosome as the resistance allele. The combined use of a locus-specific DNA test, high-density SNP array data, and rapid cycle breeding was successfully demonstrated. Outcomes of this project could empower the development of new apple cultivars with durable resistance and elite fruit quality.

Genetics and Genomics of Rosaceae

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387774912
Total Pages : 633 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Genetics and Genomics of Rosaceae by : Kevin M. Folta

Download or read book Genetics and Genomics of Rosaceae written by Kevin M. Folta and published by Springer Science & Business Media. This book was released on 2009-05-28 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book on Rosaceae genomics. It covers progress in recent genomic research among the Rosaceae, grounding this firmly in the historical context of genetic studies and in the application of genomics technologies for crop development.

Understanding the Genome

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Publisher : Hachette UK
ISBN 13 : 075952758X
Total Pages : 160 pages
Book Rating : 4.7/5 (595 download)

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Book Synopsis Understanding the Genome by : Editors of Scientific American

Download or read book Understanding the Genome written by Editors of Scientific American and published by Hachette UK. This book was released on 2002-06-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawn from the pages of Scientific American and collected here for the first time, this work contains updated and condensed information, made accessible to a general popular science audience, on the subject of understanding the genome.

Biotechnology of Fruit and Nut Crops, 2nd Edition

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Publisher : CABI
ISBN 13 : 1780648278
Total Pages : 704 pages
Book Rating : 4.7/5 (86 download)

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Book Synopsis Biotechnology of Fruit and Nut Crops, 2nd Edition by : Richard E. Litz

Download or read book Biotechnology of Fruit and Nut Crops, 2nd Edition written by Richard E. Litz and published by CABI. This book was released on 2020-01-29 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the biotechnology of all the major fruit and nut species. Since the very successful first edition of this book in 2004, there has been rapid progress for many fruit and nut species in cell culture, genomics and genetic transformation, especially for citrus and papaya. This book covers both these cutting-edge technologies and regeneration pathways, protoplast culture, in vitro mutagenesis, ploidy manipulation techniques that have been applied to a wider range of species. Three crop species, Diospyros kaki (persimmon), Punica granatum (pomegranate) and Eriobotrya japonica (loquat) are included for the first time. The chapters are organized by plant family to make it easier to make comparisons and exploitation of work with related species. Each chapter discusses the plant family and the related wild species for 38 crop species, and has colour illustrations. It is essential for scientists and post graduate students who are engaged in the improvement of fruit, nut and plantation crops.

Abiotic Stress Response in Plants

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Publisher : John Wiley & Sons
ISBN 13 : 3527694587
Total Pages : 456 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Abiotic Stress Response in Plants by : Narendra Tuteja

Download or read book Abiotic Stress Response in Plants written by Narendra Tuteja and published by John Wiley & Sons. This book was released on 2016-01-08 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding abiotic stress responses in plants is critical for the development of new varieties of crops, which are better adapted to harsh climate conditions. The new book by the well-known editor team Narendra Tuteja and Sarvajeet Gill provides a comprehensive overview on the molecular basis of plant responses to external stress like drought or heavy metals, to aid in the engineering of stress resistant crops. After a general introduction into the topic, the following sections deal with specific signaling pathways mediating plant stress response. The last part covers translational plant physiology, describing several examples of the development of more stress-resistant crop varieties.

DNA.

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Publisher :
ISBN 13 :
Total Pages : 556 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis DNA. by :

Download or read book DNA. written by and published by . This book was released on 1989 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Barley Genome

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Publisher : Springer
ISBN 13 : 3319925288
Total Pages : 400 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis The Barley Genome by : Nils Stein

Download or read book The Barley Genome written by Nils Stein and published by Springer. This book was released on 2018-08-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the state-of-the-art in barley genome analysis, covering all aspects of sequencing the genome and translating this important information into new knowledge in basic and applied crop plant biology and new tools for research and crop improvement. Unlimited access to a high-quality reference sequence is removing one of the major constraints in basic and applied research. This book summarizes the advanced knowledge of the composition of the barley genome, its genes and the much larger non-coding part of the genome, and how this information facilitates studying the specific characteristics of barley. One of the oldest domesticated crops, barley is the small grain cereal species that is best adapted to the highest altitudes and latitudes, and it exhibits the greatest tolerance to most abiotic stresses. With comprehensive access to the genome sequence, barley’s importance as a genetic model in comparative studies on crop species like wheat, rye, oats and even rice is likely to increase.

New Genetic and Transcriptomic Insights Into Apple Fruit Development, Acidity and Storability

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Publisher :
ISBN 13 :
Total Pages : 221 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis New Genetic and Transcriptomic Insights Into Apple Fruit Development, Acidity and Storability by : Seunghyun Ban

Download or read book New Genetic and Transcriptomic Insights Into Apple Fruit Development, Acidity and Storability written by Seunghyun Ban and published by . This book was released on 2020 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fruit acidity has a significant effect on fruit quality. Previous apple studies have reported that low (3.0 mg/ml in titratable acidity (TA)) fruit acidity was predominantly controlled by two major quantitative trait loci (QTLs) Ma and Ma3. However, genetic linkage regions for high (10.0 mg/ml in TA) acidity apples remain unknown. Chapter two of this dissertation identifies two QTLs putatively associated with high acidity, Ma4 and Ma5 on chromosomes four and six respectively, using a pooled genome sequencing approach with an F1 population segregating for fruit acidity. To further study apple fruit acidity, the third chapter investigates the evolution of apple acidity based on the functional allele of the Ma1 gene located in the Ma region. There is still limited information how Ma1 has been affected by nature and/or human selection during evolution. To achieve this goal, targeted genome sequencing analysis of the Ma region in diverse Malus accessions was conducted. We conclude that apples have evolved to avoid homozygous high acidity alleles, not only by human selection, but also pre-domestication adaptation. The fourth and fifth chapters represent the comparative transcriptome analysis of a somatic mutation bud sport and its parent apple to identify mechanisms responsible for the delayed maturation, different ripening behavior, and better shelf life. The difference between the two was also analyzed through the characterization of apple fruit and hormone accumulation patterns. In chapter four, transcriptome and Sanger sequencing analyses reveals a loss of heterozygosity in the 2.8 Mb occurring in mutant and inferred that fruit development and maturation would be delayed due to an absence of wild Actin7 allele in the mutant. In chapter five, putative major regulators, such as ethylene and cell walls have been identified that may contribute to the superior shelf life of a mutant.

The Code Breaker

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Publisher : Simon and Schuster
ISBN 13 : 1982115874
Total Pages : 560 pages
Book Rating : 4.9/5 (821 download)

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Book Synopsis The Code Breaker by : Walter Isaacson

Download or read book The Code Breaker written by Walter Isaacson and published by Simon and Schuster. This book was released on 2021-03-09 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington Post The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies. When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species.

Beginning Perl for Bioinformatics

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Author :
Publisher : "O'Reilly Media, Inc."
ISBN 13 : 0596550472
Total Pages : 388 pages
Book Rating : 4.5/5 (965 download)

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Book Synopsis Beginning Perl for Bioinformatics by : James Tisdall

Download or read book Beginning Perl for Bioinformatics written by James Tisdall and published by "O'Reilly Media, Inc.". This book was released on 2001-10-22 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its highly developed capacity to detect patterns in data, Perl has become one of the most popular languages for biological data analysis. But if you're a biologist with little or no programming experience, starting out in Perl can be a challenge. Many biologists have a difficult time learning how to apply the language to bioinformatics. The most popular Perl programming books are often too theoretical and too focused on computer science for a non-programming biologist who needs to solve very specific problems.Beginning Perl for Bioinformatics is designed to get you quickly over the Perl language barrier by approaching programming as an important new laboratory skill, revealing Perl programs and techniques that are immediately useful in the lab. Each chapter focuses on solving a particular bioinformatics problem or class of problems, starting with the simplest and increasing in complexity as the book progresses. Each chapter includes programming exercises and teaches bioinformatics by showing and modifying programs that deal with various kinds of practical biological problems. By the end of the book you'll have a solid understanding of Perl basics, a collection of programs for such tasks as parsing BLAST and GenBank, and the skills to take on more advanced bioinformatics programming. Some of the later chapters focus in greater detail on specific bioinformatics topics. This book is suitable for use as a classroom textbook, for self-study, and as a reference.The book covers: Programming basics and working with DNA sequences and strings Debugging your code Simulating gene mutations using random number generators Regular expressions and finding motifs in data Arrays, hashes, and relational databases Regular expressions and restriction maps Using Perl to parse PDB records, annotations in GenBank, and BLAST output