Septins

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The Septins

Author : Peter A. Hall
Publisher : John Wiley & Sons
ISBN 13 : 9780470779699
Total Pages : 380 pages
Book Rating : 4.7/5 (796 download)

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Book Synopsis The Septins by : Peter A. Hall

Download or read book The Septins written by Peter A. Hall and published by John Wiley & Sons. This book was released on 2008-11-20 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference." –Microbiology Today, May 2009 Septins are an evolutionarily conserved group of GTP-binding and filament-forming proteins that were originally discovered in yeast. Once the preserve of a small band of yeast biologists, the field has grown rapidly in the past few years and now encompasses the whole of animal and fungal biology. Furthermore, septins are nowadays recognized to be involved in a variety of disease processes from neoplasia to neurodegenerative conditions. This book comprehensively examines the septin gene family and their proteins, providing those new to this research area with a detailed and wide ranging introduction to septin biology. It starts with a unique historical perspective on the development of the field, from its beginnings in the screen for cell division mutants by the Nobel Laureate Lee Hartwell. The evolution of the septin gene family then forms a basis for consideration of the biochemistry and functions of septins in yeast and other model organisms including C. elegans and Drosophila. A major part of the book considers the diversity of septins in mammals, their functions and properties as well as their involvement in normal and abnormal cellular states, followed by a speculative overview from the editors of the key questions in septin research and of where the field may be headed. In addition, several appendices summarise important information for those in, or just entering, the field, e.g. nomenclature and septin and septin-like sequences. This book is an essential source of reference material for researchers in septin biology, cell biology, genetics and medicine, in particular pathology, including areas of neurobiology, oncology, infectious disease and developmental biology.

Emerging Functions of Septins

Author : Manoj B. Menon
Publisher : Frontiers Media SA
ISBN 13 : 2889452875
Total Pages : 128 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Emerging Functions of Septins by : Manoj B. Menon

Download or read book Emerging Functions of Septins written by Manoj B. Menon and published by Frontiers Media SA. This book was released on 2017-10-10 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together with the microfilament, microtubule and intermediate-filament networks, septins constitute an integral part of the eukaryotic cytoskeleton. Historically identified as proteins critical for septum formation in the budding yeast Saccharomyces cerevisiae, septin family GTPases are expressed and participate in the process of cytokinesis in most eukaryotes except higher plants. More than a dozen septin genes in mammals, together with various splice variants displaying tissue-specific expression patterns and flexible hetero-polymeric higher-order assembly achieve an unfathomable complexity superior to the other cytoskeletal components. Even though the initial studies in the septin field was restricted to their evolutionarily conserved role in cell division, strong expression of septins in the non-dividing cells of the brain generated great interest in understanding their role in neuronal morphogenesis and other aspects of cellular function. On one hand, recent developments indicate complex non-canonical roles for septins in diverse processes ranging from neuronal development to immune response and calcium signaling. On the other hand several lines of data including those from knockout models question the universal role for septins in animal cell cytokinesis. Mammalian hematopoietic cells seem to proliferate and efficiently undergo cytokinesis in the absence of pivotal septin proteins in a context-dependent manner. The lack of septin-dependence of hematopoiesis also opens the possibility of safely targeting septin-dependent cytokinesis for solid-tumor therapy. Thus the septin field is perfectly poised with novel roles for septins being discovered and the basic understanding on septin assembly and its canonical functions constantly revisited. The objective of this research topic was to provide an exclusive platform for discussing these rapid advances in the septin field. With a mixture of reviews and research articles encompassing diverse areas of septin research, ranging from the humble yeast model to human cancer, this ebook will be an interesting reading material for both experts as well as new comers to the septin field.

Emerging Functions of Septins - Volume II

Author : Manoj B. Menon
Publisher : Frontiers Media SA
ISBN 13 : 2889765423
Total Pages : 119 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Emerging Functions of Septins - Volume II by : Manoj B. Menon

Download or read book Emerging Functions of Septins - Volume II written by Manoj B. Menon and published by Frontiers Media SA. This book was released on 2022-07-12 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Septins

Author :
Publisher : Academic Press
ISBN 13 : 0128040297
Total Pages : 404 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Septins by :

Download or read book Septins written by and published by Academic Press. This book was released on 2016-07-26 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Septins provides established septin and molecular and developmental biologists and researchers new to the field with proven, state-of-art techniques and relevant historical background and theory to aid efficient design and effective implementation of experimental methodologies. Topics include the purification of septin proteins from diverse systems, their visualization in live cells, and their analysis by a variety of cutting-edge microscopy approaches. Provides the latest information on septins Includes both established and new technologies Brings together specialists from the field who contribute their expertise

Encyclopedia of Biological Chemistry

Author :
Publisher : Academic Press
ISBN 13 : 0123786312
Total Pages : 3223 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Encyclopedia of Biological Chemistry by :

Download or read book Encyclopedia of Biological Chemistry written by and published by Academic Press. This book was released on 2013-01-08 with total page 3223 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4-volume Encyclopedia of Biological Chemistry, Second Edition, represents the current state of a dynamic and crucial field of study. The Encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry, with content experts carefully chosen by the Editorial Board to assure both breadth and depth in its coverage. Editors-In-Chief William J. Lennarz and M. Daniel Lane have crafted a work that proceeds from the acknowledgement that understanding every living process-from physiology, to immunology, and genetics-is impossible without a grasp on the basic chemistry that provides its underpinning. Each article in the work provides an up-to-date snapshot of a given topic, written by experts, as well as suggestions for further readings for students and researcher wishing to go into greater depth. Available on-line via SciVerse ScienceDirect, the functionality of the Encyclopedia will provide easy linking to referenced articles, electronic searching, as well an online index and glossary to aid comprehension and searchability. This 4-volume set, thoroughly up-to-date and comprehensive, expertly captures this fast-moving field Curated by two esteemed editors-in-chief and an illustrious team of editors and contributors, representing the state of the field Suggestions for further readings offer researchers and students avenues for deeper exploration; a wide-ranging glossary aids comprehension

The Cell Cycle

Author : David Owen Morgan
Publisher : New Science Press
ISBN 13 : 0878935088
Total Pages : 328 pages
Book Rating : 4.8/5 (789 download)

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Book Synopsis The Cell Cycle by : David Owen Morgan

Download or read book The Cell Cycle written by David Owen Morgan and published by New Science Press. This book was released on 2007 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cell Cycle: Principles of Control provides an engaging insight into the process of cell division, bringing to the student a much-needed synthesis of a subject entering a period of unprecedented growth as an understanding of the molecular mechanisms underlying cell division are revealed.

Encyclopedia of Cell Biology

Author :
Publisher : Academic Press
ISBN 13 : 0123947960
Total Pages : 2972 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Encyclopedia of Cell Biology by :

Download or read book Encyclopedia of Cell Biology written by and published by Academic Press. This book was released on 2015-08-07 with total page 2972 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

New and Future Developments in Microbial Biotechnology and Bioengineering

Author : Joginder Singh
Publisher : Elsevier
ISBN 13 : 0128225572
Total Pages : 302 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis New and Future Developments in Microbial Biotechnology and Bioengineering by : Joginder Singh

Download or read book New and Future Developments in Microbial Biotechnology and Bioengineering written by Joginder Singh and published by Elsevier. This book was released on 2020-09-21 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and Future Developments in Microbial Biotechnology and Bioengineering presents an account of recent developments and applied aspects of fungi and its metabolites for human welfare. The fungi and its metabolites are employed in diverse fields of agri-food, biochemistry, chemical engineering, diagnostics, pharmaceuticals and medical device development. The book contains chapters by the eminent researchers working with fungi and fungal metabolites who explain their importance and potential in manifold prospects. The book includes a description of various fungal metabolites and their chemistry and biotechnology. Highlights the latest developments surrounding the utilization of fungi and fungal metabolites Overviews applied aspects of fungi and their metabolites for human welfare Details the usage of fungi and their metabolites in diverse fields Identifies the importance and potential of fungi and fungal metabolites in manifold prospects Illustrates recent trends in fungal metabolite research using elaborate, expressive tables and figures with concise information

The Chlamydomonas Sourcebook

Author : Susan Dutcher
Publisher : Academic Press
ISBN 13 : 0128225092
Total Pages : 472 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis The Chlamydomonas Sourcebook by : Susan Dutcher

Download or read book The Chlamydomonas Sourcebook written by Susan Dutcher and published by Academic Press. This book was released on 2023-02-15 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chlamydomonas Sourcebook, 3rd Edition Cell Motility and Behavior (Volume 3) The gold-standard reference?introducing this multidisciplinary science,?fully revised and updated with the latest discoveries Originally published as the standalone Chlamydomonas Sourcebook, then expanded as the third volume in a three-part comprehensive gold-standard reference,?The Chlamydomonas Sourcebook: Cell Motility and Behavior has been fully revised and updated to include the wealth of new resources for the Chlamydomonas community. Reflecting the significant advancement in?the understanding of the role of basal bodies and cilia play in human diseases, this volume employs quantitative proteomics and mass spectroscopy as well as?cryo?EM tomography and single particle?cryo?EM. Other topics such as current insights?on?mitosis and cytokinesis, ciliary assembly and motility, intraflagellar?transport, and more help build an understanding of human diseases of the cilium. Cell Motility and Behavior presents the latest in research and best practices, making this a must-have resource for researchers and students working in plant science and photosynthesis, fertility, mammalian vision, and biochemistry; crop scientists; plant physiologists; and plant, molecular, and human disease biologists. Provides an essential reference to a model species for the study of mechanisms of motility in free living cells? Includes methods for Chlamydomonas motility research? Includes a table listing the known proteins (with NCBI accession numbers) for each structure discussed, and the known mutations that affect each structure and process

Identification, Cloning, and Characterization of Caenorhabditis Elegans Septins

Author : Quốc Trị Nguyễn
Publisher :
ISBN 13 :
Total Pages : 174 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Identification, Cloning, and Characterization of Caenorhabditis Elegans Septins by : Quốc Trị Nguyễn

Download or read book Identification, Cloning, and Characterization of Caenorhabditis Elegans Septins written by Quốc Trị Nguyễn and published by . This book was released on 1999 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biology of the Fungal Cell

Author : Richard J. Howard
Publisher : Springer Science & Business Media
ISBN 13 : 3662061015
Total Pages : 308 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Biology of the Fungal Cell by : Richard J. Howard

Download or read book Biology of the Fungal Cell written by Richard J. Howard and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: What makes the fungal cell unique among eukaryotes and what features are shared? This volume addresses some of the most persistent and fascinating questions as they pertain to the growth and development of both yeast and hyphal forms of fungi. Beginning with subcellular components, the book moves on to topics including cell organization and polarity. It then moves beyond these matters to examine the cell biology of spores, the biomechanics of invasive growth, and many other subjects.

International Review of Cell and Molecular Biology

Author : Kwang W. Jeon
Publisher : Academic Press
ISBN 13 : 0128004460
Total Pages : 363 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis International Review of Cell and Molecular Biology by : Kwang W. Jeon

Download or read book International Review of Cell and Molecular Biology written by Kwang W. Jeon and published by Academic Press. This book was released on 2014-04-08 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2012: 4.973. - Authored by some of the foremost scientists in the field - Provides comprehensive reviews and current advances - Wide range of perspectives on specific subjects - Valuable reference material for advanced undergraduates, graduate students and professional scientists

The Molecular Biology of the Yeast Saccharomyces, Life Cycle and Inheritance

Author : Jeffrey N. Strathern
Publisher :
ISBN 13 :
Total Pages : 776 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis The Molecular Biology of the Yeast Saccharomyces, Life Cycle and Inheritance by : Jeffrey N. Strathern

Download or read book The Molecular Biology of the Yeast Saccharomyces, Life Cycle and Inheritance written by Jeffrey N. Strathern and published by . This book was released on 1981 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Dynamics of Cell Division

Author : Sharyn A. Endow
Publisher : OUP Oxford
ISBN 13 : 0191565776
Total Pages : 346 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Dynamics of Cell Division by : Sharyn A. Endow

Download or read book Dynamics of Cell Division written by Sharyn A. Endow and published by OUP Oxford. This book was released on 1998-10-01 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the structural aspects of cell division - concentrating on both nuclear division (meiosis and mitosis) and cytoplasmic division (cytokinesis). Written as a companion volume to the earlier book in the series - Cell Cycle Control, this book provides an up-to-date account of developments in this exciting area of cell biology.

Septin Assembly Regulates Cell Cycle Progression Through Activation of a Protein Kinase Signalling Pathway

Author : Mark Justin Shulewitz
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.:/5 (34 download)

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Book Synopsis Septin Assembly Regulates Cell Cycle Progression Through Activation of a Protein Kinase Signalling Pathway by : Mark Justin Shulewitz

Download or read book Septin Assembly Regulates Cell Cycle Progression Through Activation of a Protein Kinase Signalling Pathway written by Mark Justin Shulewitz and published by . This book was released on 2000 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Septin CDCrel-1 [microform] : Protein Associations, Modifications and Effects on Exocytosis

Author : Crestina L. Beites
Publisher : National Library of Canada = Bibliothèque nationale du Canada
ISBN 13 : 9780612915961
Total Pages : 452 pages
Book Rating : 4.9/5 (159 download)

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Book Synopsis The Septin CDCrel-1 [microform] : Protein Associations, Modifications and Effects on Exocytosis by : Crestina L. Beites

Download or read book The Septin CDCrel-1 [microform] : Protein Associations, Modifications and Effects on Exocytosis written by Crestina L. Beites and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2004 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: SNARE proteins mediate the docking and/or fusion of the vesicle with the plasma membrane. However, it is not clearly understood how this process is regulated. In a search for potential SNARE regulators, we have identified a novel snare interacting protein, the septin CDCrel-1. Septins were first identified as filamentous proteins required for cytokinesis in yeast. However, in mammals little is known about their functions. I show here that cdcrel-1 is predominantly expressed in the brain where it associates with membranes via binding to syntaxin 1A. Wildtype CDCrel-1 transfected into HIT-T15 cells inhibits secretion while mutated forms of CDCrel-1 potentiate secretion, suggesting that cdcrel-1 may be regulating vesicle targeting and/or fusion events. I further map the CDCrel-1 domains important for syntaxin binding and investigate the ability of CDCrel-1 to bind to syntaxin when in various SNARE complexes. CDCrel-1 can bind syntaxin in a SNARE complex, but its binding is occluded by alpha-SNAP. This suggests that CDCrel-1 may act as a novel filamentous element, regulating the delivery and/or fusion of vesicles to the presynaptic membrane through its interaction with syntaxin and the 7S complex. The regulation of filaments may be via post-translational modifications. Indeed we have discovered a novel interaction between SUMO E3 PIAS proteins and CDCrel-1. The conjugation of SUMO to substrates is dependent upon an E1 and E2, whereas specificity is mediated by an E3. Although several SUMO-1 substrates have been characterized, conjugation solely by SUMO-2/3 has not been described. Here I describe the colocalization of CDCrel-1 with SUMO-2 and 3 but not SUMO-1. Transfection of SUMO-2/3 but not SUMO-1 causes a reorganization of CDCrel-1 distribution in CHO cells. Furthermore, CDCrel-1 sequesters the nuclear pool of SUMO-2/3 and of the E2 Ubc9 but not SUMO1 into the cytoplasm. Sumoylation of CDCrel-l is shown in vivo and putative SUMO modification sites on CDCrel-1 are investigated by deletion of lysine residues. These experiments strongly suggest that CDCrel-1 is sumoylated specifically by SUMO-2/3. Sumoylation of CDCrel-1 may therefore play a regulatory role in secretion and septin filament formation. Future work will be aimed at determining the functional significance of SUMO modified CDCrel-1.

Encyclopedia of Signaling Molecules

Author : Sangdun Choi
Publisher : Springer
ISBN 13 : 9781493968008
Total Pages : 6330 pages
Book Rating : 4.9/5 (68 download)

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Book Synopsis Encyclopedia of Signaling Molecules by : Sangdun Choi

Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.