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Author : Brian Herbert Clowers
Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.:/5 (647 download)
Download or read book Separation of Gas Phase Isomers Using Ion Mobiliby and Mass Spectrometry written by Brian Herbert Clowers and published by . This book was released on 2005 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : T.W. Carr
Publisher : Springer
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.:/5 (44 download)
Download or read book Plasma Chromatography written by T.W. Carr and published by Springer. This book was released on 1984-03-31 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alexandre A. Shvartsburg
Publisher : CRC Press
ISBN 13 : 9781420051070
Total Pages : 322 pages
Book Rating : 4.0/5 (51 download)
Download or read book Differential Ion Mobility Spectrometry written by Alexandre A. Shvartsburg and published by CRC Press. This book was released on 2008-12-24 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, scientific and engineering interests have been shifting from conventional ion mobility spectrometry (IMS) to field asymmetric waveform ion mobility spectrometry (FAIMS). Differential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS explores this new analytical technology that separates and characterizes ions by the difference between their mobility in gases at high and low electric fields. It also covers the novel topics of higher-order differential IMS and IMS with alignment of dipole direction. The book relates the fundamentals of FAIMS and other nonlinear IMS methods to the physics of gas-phase ion transport. It begins with the basics of ion diffusion and mobility in gases, covering the main attributes of conventional IMS that are relevant to all IMS approaches. Building on this foundation, the author reviews diverse high-field transport phenomena that underlie differential IMS. He discusses the conceptual implementation and first-principles optimization of FAIMS as a filtering technique, emphasizing the dependence of FAIMS performance metrics on instrumental parameters and properties of ion species. He also explores ion reactions in FAIMS caused by field heating and the effects of inhomogeneous electric field in curved FAIMS gaps. Written by an accomplished scientist in the field, this state-of-the-art book supplies the foundation to understand the new technology of nonlinear IMS methods.
Author : Kenneth W. Busch
Publisher : Elsevier
ISBN 13 : 0080469280
Total Pages : 721 pages
Book Rating : 4.0/5 (84 download)
Download or read book Chiral Analysis written by Kenneth W. Busch and published by Elsevier. This book was released on 2011-10-13 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chiral Analysis covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals. The target audience is scientific professionals with an undergraduate background in chemistry or a related discipline, specifically organic chemists, researchers in drug discovery, pharmaceutical researchers involved with process analysis or combinatorial libraries, and graduate students in chemistry. Chapters have been written with the nonspecialist in mind so as to be self-contained. * Broad coverage - spectroscopic and separation methods covered in a single volume * Up-to-date and detailed review of the various techniques available and/or under development in this field * Contributions from leading experts in the field
Author : Cherokee Sue Hoaglund Hyzer
Publisher :
ISBN 13 :
Total Pages : 1014 pages
Book Rating : 4.:/5 (489 download)
Download or read book Development of Gas-phase Ion Mobility Separation Methods Combined with Mass Spectrometry for the Analysis of Biological Mixtures written by Cherokee Sue Hoaglund Hyzer and published by . This book was released on 2001 with total page 1014 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alison E Ashcroft
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162899
Total Pages : 621 pages
Book Rating : 4.8/5 (391 download)
Download or read book Ion Mobility-Mass Spectrometry written by Alison E Ashcroft and published by Royal Society of Chemistry. This book was released on 2021-11-11 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, the use of ion mobility separation in combination with mass spectrometry analysis has developed significantly. This technique adds a unique extra dimension enabling the in-depth analysis of a wide range of complex samples in the areas of the chemical and biological sciences. Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and with numerous different commercial platforms to choose from, this book will help the end users understand the practicalities of using different instruments for different ion mobility purposes. The first section provides a detailed account of the fundamentals behind the technique and the current range of available instrumentation. The second section focusses on the wide range of applications that have benefitted from ion mobility – mass spectrometry and includes topics taken from current research in the pharmaceutical, metabolomics, glycomics, and structural molecular biology fields. The book is primarily aimed at researchers, appealing to practising chemists and biochemists, as well as those in the pharmaceutical and medical fields.
Author : Kimberly L. Davidson
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (11 download)
Download or read book Investigation of the Fundamentals of Electrospray Ionization and the Separation of Small Molecules Using Ion Mobility Mass Spectrometry written by Kimberly L. Davidson and published by . This book was released on 2017 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion mobility mass spectrometry (IM-MS) is a gas-phase technique used to separate ions based on their mass-to-charge ratio and collision cross section (i.e. shape). Accurate MS analysis of analytes, such as proteins and protein complexes, relies on the preservation of solution-phase oligomeric distributions during ionization. Gas-phase ions in IM-MS are typically formed using electrospray ionization (ESI), which is a gentle ionization source that preserves noncovalent interactions. One challenge in ESI is that multiple analytes in a single droplet can aggregate during solvent evaporation, biasing the oligomeric states of proteins or protein complexes observed during gas-phase measurements. Initial droplet diameters using electrokinetic nano-ESI were measured and reported to be ~60 nm at an ionization current of 30 nA, which is a typical current for native IM-MS experiments. Nonspecific aggregation of a monomeric protein, myoglobin, was measured as a function of concentration of the protein in solution as well as ionization current (i.e., initial droplet size). Results from those measurements show that nonspecific aggregation increases with ionization current, initial droplet size, and concentration of the analyte in solution. The ionization mechanism of macromolecules from solution to the gas phase was also analyzed by measuring the average charge states of proteins, ranging in mass from 8 – 468 kDa, in four different buffers (ammonium acetate, methylammonium acetate, dimethylammonium acetate, and trimethylammonium acetate). Those results were analyzed according to both the charged residue model and the more recent charged residue-field emission model. In IM, ions are separated using a drift cell that is filled with a neutral gas (typically He or N2) and has an applied electric field. The collision cross sections of 20 common amino acids were measured using a radio-frequency confining drift cell and five different drift gases (He, Ar, N2, CO2 and N2O), which were chosen based on their range of masses and polarizabilities. Drift gas selectivity was quantified using peak capacity and peak-to-peak resolution. Those results show that the identities of the pairs of amino acids separated depends on the drift gas and the number of pairs separated depends on peak capacity. The collision cross sections of ten petroleum-like compounds (containing aromatic isomers and double-bond equivalents) were also measured in He, Ar, N2 and CO2. Those results demonstrate the potential to improve separations of compounds with the same elemental composition by using gases with greater mass and polarizability.
Author :
Publisher : Elsevier
ISBN 13 : 0444641556
Total Pages : 278 pages
Book Rating : 4.4/5 (446 download)
Download or read book Advances in Ion Mobility-Mass Spectrometry: Fundamentals, Instrumentation and Applications written by and published by Elsevier. This book was released on 2019-01-10 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Mobility Spectrometry, Volume 83 will focuses on new trends, methods and instrumentation in the field, starting from the innovations of each technique, to the most progressive challenges of IM-MS. Chapters includes section on Recent advances in IM-MS, IM-MS Principles and Theory, IM-MS Applications and Instrumentation, and the Future of IM-MS. Presents the latest advancements in IM-MS that are essential for new applications Helps readers understand the state-of-the-art in the currently available IM-MS interfaces and their principle uses Provides information on different IM-MS instrumentation Delves into key applications of IM-MS
Author : G.A. Eiceman
Publisher : CRC Press
ISBN 13 : 1420038974
Total Pages : 367 pages
Book Rating : 4.4/5 (2 download)
Download or read book Ion Mobility Spectrometry written by G.A. Eiceman and published by CRC Press. This book was released on 2005-06-23 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key Developments for Faster, More Precise Detection Capabilities Driven by the demand for the rapid and advanced detection of explosives, chemical and biological warfare agents, and narcotics, ion mobility spectrometry (IMS) undergone significant refinements in technology, computational capabilities, and understanding of the principles of gas phase
Author : Guido Fridolin Verbeck
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (632 download)
Download or read book Development of a Variable-temperature Ion Mobility/ Time-of-flight Mass Spectrometer for Separation of Electronic Isomers written by Guido Fridolin Verbeck and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The construction of a liquid nitrogen-cooled ion mobility spectrometer coupled with time-of-flight mass spectrometry was implemented to demonstrate the ability to discriminate between electronic isomers. Ion mobility allows for the separation of ions based on differing cross-sections-to-charge ratio. This allows for the possible discrimination of species with same mass if the ions differ by cross-section. Time-of-flight mass spectrometry was added to mass identify the separated peak for proper identification. A liquid nitrogen-cooled mobility cell was employed for a two-fold purpose. First, the low temperatures increase the peak resolution to aid in resolving the separated ions. This is necessary when isomers may have similar cross-sections. Second, low temperature shortens the mean free path and decreases the neutral buffer gas speeds allowing for more interactions between the ions and the drift gas. Kr2 study was performed to verify instrument performance. The variable-temperature ion mobility spectrometer was utilized to separate the distonic and conventional ion forms of CH3OH, CH3F, and CH3NH2 and to discriminate between the keto and enol forms of the acetone radical cation. Density functional theory and ab initio calculations were employed to aid in proper identification of separating isomers. Monte Carlo integration tools were also developed to predict ion cross-section and resolution within a buffer gas.
Author : Catherine A. Srebalus Barnes
Publisher :
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.3/5 ( download)
Download or read book Gas-phase Separations of Combinatorial Libraries written by Catherine A. Srebalus Barnes and published by . This book was released on 2001 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John L. Holmes
Publisher : CRC Press
ISBN 13 : 0203492471
Total Pages : 468 pages
Book Rating : 4.2/5 (34 download)
Download or read book Assigning Structures to Ions in Mass Spectrometry written by John L. Holmes and published by CRC Press. This book was released on 2006-12-26 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assigning Structures to Ions in Mass Spectrometry describes the tools currently available for determining gas-phase ion structures. It surveys current experimental methods for ion production and separation as well as those designed to reveal qualitative and quantitative aspects of gas-phase ions. It also examines how and when to apply computational chemistry and theoretical calculations. Selected case studies illustrate specific challenges associated with ion structure assignment and thermochemical problems. Bringing together key results collected over the past four decades, the book contains the data for describing or identifying ions containing C alone and C with H, O, N, S, P, halogens, and small organic cations.
Author : Kris E. Sahlstrom
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (42 download)
Download or read book Investigations of Gas Phase Ion-molecule Reactions at Elevated Pressures Using Ion Mobility-mass Spectrometry written by Kris E. Sahlstrom and published by . This book was released on 1997 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yanyan Li
Publisher : Springer
ISBN 13 : 1493910108
Total Pages : 113 pages
Book Rating : 4.4/5 (939 download)
Download or read book Lasso Peptides written by Yanyan Li and published by Springer. This book was released on 2014-10-21 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Author : J. Rafael Montenegro Burke
Publisher :
ISBN 13 :
Total Pages : 228 pages
Book Rating : 4.:/5 (953 download)
Download or read book Enhanced Separations Strategies for Complex Sample Characterization Using Ion Mobility-mass Spectrometry written by J. Rafael Montenegro Burke and published by . This book was released on 2016 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Salvatore Fanali
Publisher : Elsevier
ISBN 13 : 0128093447
Total Pages : 840 pages
Book Rating : 4.1/5 (28 download)
Download or read book Liquid Chromatography written by Salvatore Fanali and published by Elsevier. This book was released on 2017-06-23 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. Emphasizes the integration of chromatographic methods and sample preparation Explains how liquid chromatography is used in different industrial sectors Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making
Author : Alana L. Rister
Publisher :
ISBN 13 : 9781392451793
Total Pages : 0 pages
Book Rating : 4.4/5 (517 download)
Download or read book Implementation of Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry for the Analysis of Steroids and Lipids written by Alana L. Rister and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroids and lipids are biologically important for cellular signaling and energy/metabolism, respectively. Steroid and lipids have many isobaric species, wide variance on biological concentration, and complicated ionization patterns. Therefore, this dissertation focuses on employing liquid chromatography (LC), ion mobility spectrometry (IMS), and mass spectrometry (MS) techniques to enhance the analysis of steroids and lipids. There are three major themes: (1) Increasing the accuracy of IMS collision cross section (CCS) calibration, (2) Enhancing separation of steroid and steroid conjugates through IMS using metal adduction, and (3) Applying these techniques to biological mixtures.The first four chapters focus on increasing the accuracy of IMS CCS calibration. Chapter 1 contains an introduction to IMS and discusses the current state of CCS calibration research. Chapter 2, Chapter 3, and Chapter 4 applies an analytical approach to understanding the best calibration function, experimental parameters, and calibrant to employ, respectively. This research will advance the accuracy of CCS calibration and is implemented for all CCS calibration performed in this dissertation.The next five chapters focus on the use of metal adduction to enhance the separation of steroids and steroid conjugates through IMS. Chapter 5 provides a background for steroid analysis through IMS. Chapter 6 and Chapter 7 examine separation of steroid isomers as group I metal adducts through IMS as one-componentand multicomponent mixtures, respectively. Chapter 8 focuses on group I metal adduction for separation of estradiol glucuronide isomers through IMS coupled with tandem mass spectrometry techniques for isomer discrimination. Chapter 9 incorporates LC analysis for the same isomers analyzed in Chapter 7 to enhance separation and apply to complex mixtures.Chapter 10 and 11 focus on the analysis of steroids and lipids in biological mixtures. Chapter 10 demonstrates a novel serum microextraction technique for simultaneous analysis of corticosterone and lipids. Chapter 11 then couples the Chapter 10 with mass spectrometry imaging (MSI) to analyze lipid alterations due to maternal diet in maternal serum, placentas, and fetuses at mid-gestation. Overall, this work covers the analysis of steroids and lipids from fundamental gas-phase chemistry to enhanced sample preparation to the analysis of a reproductive model.
