Self Assembling Cyclic D L Peptide Nanotubes As Synthetic Transmembrane Channels From Chemical Biological And Practical Perspectives

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Self-assembling Cyclic D, L-peptide Nanotubes as Synthetic Transmembrane Channels from Chemical, Biological and Practical Perspectives

Author : Hui Sun Kim
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (514 download)

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Book Synopsis Self-assembling Cyclic D, L-peptide Nanotubes as Synthetic Transmembrane Channels from Chemical, Biological and Practical Perspectives by : Hui Sun Kim

Download or read book Self-assembling Cyclic D, L-peptide Nanotubes as Synthetic Transmembrane Channels from Chemical, Biological and Practical Perspectives written by Hui Sun Kim and published by . This book was released on 1999 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide nanotubes are cylindrical, open-ended, ß-sheet supramolecular structures formed from the self-assembly of cyclic peptides that can adopt a flat-ring conformation. In this work, the principles of molecular self-assembly in the lipid bilayer environment are explored through the study of the cyclic peptide nanotubes as synthetic transmembrane channels. Structural evidence for the cyclic peptides as a transmembrane channel is established through an orientational FT-IR analysis of the tubular peptide assembly in the lipid membrane. A biophysical investigation of substituted cyclic peptides using vesicular transport assays, single channel conductance measurements, and attenuated total reflectance FT-IR spectroscopy shows the significant impact of subunit sequence variations on the channel activity and structural organization of the supramolecular assembly in the membrane environment. The potential utility of the cyclic peptides is investigated through a study of their structure and behavior at interfaces, and by the design and synthesis of cyclic peptides with biological activity.

Peptide Self-Assembly and Engineering

Author : Xuehai Yan
Publisher : John Wiley & Sons
ISBN 13 : 3527841253
Total Pages : 933 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Peptide Self-Assembly and Engineering by : Xuehai Yan

Download or read book Peptide Self-Assembly and Engineering written by Xuehai Yan and published by John Wiley & Sons. This book was released on 2024-02-09 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Self-Assembly and Engineering State-of-the-art research in peptide self-assembly, with coverage of fundamental aspects of how peptides self-assemble and an extensive number of applications Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications (2V set) covers the latest progresses in the field of peptide self-assembly and engineering, including the fundamental principles of peptide self-assembly, new theory of nucleation and growth, thermodynamics and kinetics, materials design rules, and precisely controlled structures and unique functions. The broad contents from this book enable readers to obtain a systematical and comprehensive knowledge in the field of peptide self-assembly and engineering. Contributed by the leading scientists and edited by a highly qualified academic and an authority in the field, Peptide Self-Assembly and Engineering includes information on: Emerging areas in peptide assembly, such as immune agents, bioelectronics, energy conversion, flexible sensors, biomimetic catalysis, and more Existing applications in biomedical engineering, nanotechnology, and photoelectronics, including tissue engineering, drug delivery, and biosensing devices History of peptide self-assembly for design of functional materials and peptides’ unique mechanical, optical, electronic, and biological properties Various solvent conditions, such as pH, ionic strength, and polarity, that can affect the structure and stability of peptide assemblies A very comprehensive reference covering the latest progresses in the field of peptide self-assembly and engineering, Peptide Self-Assembly and Engineering is an essential resource for all scientists performing research intersecting with the subject, including biochemists, biotechnologists, pharmaceutical chemists, protein chemists, materials scientists, and medicinal chemists.

Cyclic Peptide Nanotubes

Author : Thomas Dudley Clark
Publisher :
ISBN 13 : 9780599009172
Total Pages : 492 pages
Book Rating : 4.0/5 (91 download)

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Book Synopsis Cyclic Peptide Nanotubes by : Thomas Dudley Clark

Download or read book Cyclic Peptide Nanotubes written by Thomas Dudley Clark and published by . This book was released on 1998 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent reports have shown that cyclic peptides composed of an even number of alternating sc D- and sc L-amino acids can adopt flat, disc-like conformations and stack through backbone-backbone hydrogen-bonding to form extended nanotubular structures. The present work details a general strategy for limiting this self-assembly process through backbone alkylation, thereby preventing formation of insoluble hydrogen-bonded aggregates and giving rise to dimeric peptide nanocylinders. The resulting peptide dimers are shown to self-assemble both in solution and the solid state through the expected antiparallel beta-sheet hydrogen-bonding network. Scope and limitations are explored through spectroscopic and x-ray diffraction studies of twenty cyclic peptides varying in cyclic peptide ring size, location and identity of backbone alkyl substituents, and amino acid composition. Additionally, dimer-forming peptides bearing reactive side chain functinalities are shown to undergo selective covalent capture through either intermolecular ring-forming olefin metathesis or disulfide bond formation. Noncovalent assembly is used to favor covalent dimer formation at the expense of higher oligomers. Finally, related cyclic peptides composed of homochiral alpha-unsubstituted-beta-chiral-beta-amino acids (cyclic beta-peptides) bearing suitable hydrophobic side chains are shown to form transmembrane ion channels with potassium transport rates nearly twice that of gramicidin A.

Peptide Materials

Author : Carlos Aleman
Publisher : John Wiley & Sons
ISBN 13 : 1118592417
Total Pages : 479 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Peptide Materials by : Carlos Aleman

Download or read book Peptide Materials written by Carlos Aleman and published by John Wiley & Sons. This book was released on 2013-03-29 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides are the building blocks of the natural world; with varied sequences and structures, they enrich materials producing more complex shapes, scaffolds and chemical properties with tailorable functionality. Essentially based on self-assembly and self-organization and mimicking the strategies that occur in Nature, peptide materials have been developed to accomplish certain functions such as the creation of specific secondary structures (a- or 310-helices, b-turns, b-sheets, coiled coils) or biocompatible surfaces with predetermined properties. They also play a key role in the generation of hybrid materials e.g. as peptide-inorganic biomineralized systems and peptide/polymer conjugates, producing smart materials for imaging, bioelectronics, biosensing and molecular recognition applications. Organized into four sections, the book covers the fundamentals of peptide materials, peptide nanostructures, peptide conjugates and hybrid nanomaterials, and applications with chapters including: Properties of peptide scaffolds in solution and on solid substrates Nanostructures, peptide assembly, and peptide nanostructure design Soft spherical structures obtained from amphiphilic peptides and peptide-polymer hybrids Functionalization of carbon nanotubes with peptides Adsorption of peptides on metal and oxide surfaces Peptide applications including tissue engineering, molecular switches, peptide drugs and drug delivery Peptide Materials: From Nanostructures to Applications gives a truly interdisciplinary review, and should appeal to graduate students and researchers in the fields of materials science, nanotechnology, biomedicine and engineering as well as researchers in biomaterials and bio-inspired smart materials.

Folded Synthetic Peptides for Biomedical Applications

Author : Alessandro Contini
Publisher : Frontiers Media SA
ISBN 13 : 2889630455
Total Pages : 145 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Folded Synthetic Peptides for Biomedical Applications by : Alessandro Contini

Download or read book Folded Synthetic Peptides for Biomedical Applications written by Alessandro Contini and published by Frontiers Media SA. This book was released on 2019-09-26 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folded peptides - and peptide motifs within proteins - are abundant in living organisms, where they are essential for the biological activities of the peptides and proteins. During the past decades, much research has been dedicated to understanding the rules that govern peptide folding. Simultaneously, a range of strategies have been established for the conformational stabilization of bioactive peptides, as well as for the de novo design of peptides with defined secondary structures. These methods are either based on the chemical modification of the peptide backbone, such as cyclization and stapled peptides, or on the use of a range of non-proteinogenic amino acids that, in a defined sequential arrangement, induce secondary structures peptides. Such building blocks include D- and other non-proteinogenic amino acids, as well as beta- and gamma-amino acids. This Research Topic comprises a collection of papers by an international group of 77 scientists with a background in synthetic, analytical, computational and medicinal chemistry, as well as in biochemistry and pharmacology. Their research is presented here in a total of 11 papers (8 original research reports and 3 reviews), covering diverse aspects of folded synthetic peptides. These studies include the preparation and characterization of new peptide monomers with interesting folding properties, the synthesis and conformational analysis of non-natural peptides, as well as the use of folded peptidomimetics as molecular switches. Additionally, a range of biomedical applications, such as antimicrobial, anti-inflammatory, antiangiogenic and immune-stimulating activities, are also reported. We hope this eBook will be a source of inspiration and knowledge for scientist in various disciplines related to folded peptides and their many applications, as well as for those who want to learn more about this fascinating field of research.

Molecular Self-Assembly

Author : Alex Li Dequan
Publisher : CRC Press
ISBN 13 : 9814316776
Total Pages : 472 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Molecular Self-Assembly by : Alex Li Dequan

Download or read book Molecular Self-Assembly written by Alex Li Dequan and published by CRC Press. This book was released on 2012-12-20 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several decades, molecular self-assembly has emerged as one of the main themes in chemistry, biology, and materials science. This book compiles and details cutting-edge research in molecular assemblies ranging from self-organized peptide nanostructures and DNA-chromophore foldamers to supramolecular systems and metal-directed assemblies, even to nanocrystal superparticles and self-assembled microdevices

Self-assembling Peptide Nanotubes

Author : Jeffrey Dale Hartgerink
Publisher :
ISBN 13 : 9780599322394
Total Pages : 304 pages
Book Rating : 4.3/5 (223 download)

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Book Synopsis Self-assembling Peptide Nanotubes by : Jeffrey Dale Hartgerink

Download or read book Self-assembling Peptide Nanotubes written by Jeffrey Dale Hartgerink and published by . This book was released on 1999 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembling peptide nanotubes are a new class of supramolecular structures based on the hydrogen bonded stacking of cyclic peptides with an even number of alternating D/L amino acids. This stacking forms an open channel of between 5 and 13Å depending on the number of amino acids making up the peptide ring. Because their preparation is based on the self-assembly of relatively small, easily prepared subunits consisting of amino acids, the diameter of the channel formed and the outer surface chemistry of the nanotube can be readily tailored simply by altering the number and choice of amino acids. This flexibility has allowed the preparation of peptide nanotubes with a wide variety of characteristics. This thesis describes the design, preparation, characterization and functional application of the subset of peptide nanotubes that form well ordered (crystalline) parallel packed arrays. Within this subset of peptide nanotubes two classes, charged and uncharged, are considered. Chapter 1 reviews the work leading up to the preparation of the first self-assembling peptide nanotube in 1993 and the current state of the field. Chapter 2 describes uncharged peptide nanotubes prepared from the cyclic peptides cyclo-[(Gln- D -Xxx)4] (Xxx = Ala, Val, Leu, Phe) by a solvent induced mechanism. Chapter 3 describes three nanotubes prepared from cyclo-[(Xxx-D -Leu) 4 ] (Xxx = Glu, Lys) by an electrostatic mediated and pH controlled assembly. Finally, chapter 4 discusses results obtained using the outer surface of carboxylate decorated nanotubes as a biomineralization directing agent in the reduction of transition metal salts.

Interaction of Self-assembling Cyclic Peptide-polymer Nanotubes with Biological Models

Author : Sean H. Ellacott
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis Interaction of Self-assembling Cyclic Peptide-polymer Nanotubes with Biological Models by : Sean H. Ellacott

Download or read book Interaction of Self-assembling Cyclic Peptide-polymer Nanotubes with Biological Models written by Sean H. Ellacott and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Interaction of Self-assembling Cyclic Peptide-polymer Nanotubes with Biological Models

Author : Sean Heinere Ellacott
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)

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Book Synopsis Interaction of Self-assembling Cyclic Peptide-polymer Nanotubes with Biological Models by : Sean Heinere Ellacott

Download or read book Interaction of Self-assembling Cyclic Peptide-polymer Nanotubes with Biological Models written by Sean Heinere Ellacott and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Theoretical Investigation of Self-assembled Peptide Nanostructures for Biotechnological and Biomedical Applications

Author : Jennifer Andrea Carvajal Diaz
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (85 download)

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Book Synopsis Theoretical Investigation of Self-assembled Peptide Nanostructures for Biotechnological and Biomedical Applications by : Jennifer Andrea Carvajal Diaz

Download or read book Theoretical Investigation of Self-assembled Peptide Nanostructures for Biotechnological and Biomedical Applications written by Jennifer Andrea Carvajal Diaz and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this dissertation, molecular simulation techniques are used for the theoretical prediction of nanoscale properties for peptide-based materials. This work is focused on two particular systems: peptide nanotubes formed by cyclic-D, L peptide units and peptide nanotubes formed by phenylalanine dipeptides [-Phe-Phe-]. Mechanical characterization of cyclic peptide nanotubes is a challenging problem due the anisotropy resulting from the nature of their molecular interactions. To address rigorously the thermo-mechanical stability of cyclic peptide nanotubes (CPNTs), a homogeneous deformation method combined with the generalized elasticity theory and molecular dynamics simulations (MD) were used for the calculation of second order anisotropic elastic constants. The results for anisotropic elastic constants, yield behavior and engineering Young̕ s modulus show remarkable mechanical stability for these materials supporting experiments for the development of their applications. Furthermore, the heat capacity, thermal expansion coefficient and isothermal compressibility were predicted using numerical difference methods and molecular dynamics. In order to understand the transport properties of confined water in cyclic peptide nanotubes, the influence of nanotube diameter was studied and self-diffusion coefficient, dipole correlation functions and hydrogen bond probabilities were calculated via molecular dynamics and statistical mechanics. Enhanced transport and higher diffusion rates for water were obtained in cyclic peptide nanotubes (CPNTs) compared with commonly used biomedical channels like carbon nanotubes (CNTs). The greater transport efficiency in CPNTs is attributed to the hydrophilic character and high hydrogen bonding presence along their tubular structure, versus the hydrophobic core of CNTs. One of the most important opportunities for cyclic peptide nanotubes is their utilization as artificial ion channels in antibacterial applications. Here, molecular dynamics methods were used to investigate the effect of confinement on the transport properties of Na+ and K+ ions under the influence of electric field; the ion mobility, selectivity, radial distribution function, coordination number and effect of temperature were studied and results from simulations proved their ability to transport ions. Additionally, the molecular organization of phenylalanine dipeptides into ordered peptide nanotubes was investigated, a model for the molecular structure of these nanotubes was proposed and optimized through molecular simulations; a helical pattern was found and characterized. Thermal stability results show that phenylalanine dipeptide nanotubes are stable up to about 400K; above this temperature, a significant decrease in hydrogen bonding was observed and the perfect pattern was altered. Findings from this work open new opportunities for research in the area of peptide based materials and provide tools and methods to study these systems efficiently at nanoscale.

Cyclic Peptide Design

Author : Gilles Goetz
Publisher :
ISBN 13 : 9781493995042
Total Pages : 332 pages
Book Rating : 4.9/5 (95 download)

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Book Synopsis Cyclic Peptide Design by : Gilles Goetz

Download or read book Cyclic Peptide Design written by Gilles Goetz and published by . This book was released on 2019 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature's cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.

Materials Nanoarchitectonics

Author : Katsuhiko Ariga
Publisher : Elsevier
ISBN 13 : 0323994733
Total Pages : 648 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Materials Nanoarchitectonics by : Katsuhiko Ariga

Download or read book Materials Nanoarchitectonics written by Katsuhiko Ariga and published by Elsevier. This book was released on 2023-12-07 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials Nanoarchitectonics: From Integrated Molecular Systems to Advanced Devices provides the latest information on the design and molecular manipulation of self-organized hierarchically structured systems using tailor-made nanoscale materials as structural and functional units. The book is organized into three main sections that focus on molecular design of building blocks and hybrid materials, formation of nanostructures, and applications and devices. Bringing together emerging materials, synthetic aspects, nanostructure strategies, and applications, the book aims to support further progress, by offering different perspectives and a strong interdisciplinary approach to this rapidly growing area of innovation. This is an extremely valuable resource for researchers, advanced students, and scientists in industry, with an interest in nanoarchitectonics, nanostructures, and nanomaterials, or across the areas of nanotechnology, chemistry, surface science, polymer science, electrical engineering, physics, chemical engineering, and materials science. - Offers a nanoarchitectonic perspective on emerging fields, such as metal-organic frameworks, porous polymer materials, or biomimetic nanostructures - Discusses different approaches to utilizing "soft chemistry" as a source for hierarchically organized materials - Offers an interdisciplinary approach to the design and construction of integrated chemical nano systems - Discusses novel approaches towards the creation of complex multiscale architectures

Analytical Methods in Supramolecular Chemistry

Author : Christoph A. Schalley
Publisher : John Wiley & Sons
ISBN 13 : 3527644148
Total Pages : 849 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Analytical Methods in Supramolecular Chemistry by : Christoph A. Schalley

Download or read book Analytical Methods in Supramolecular Chemistry written by Christoph A. Schalley and published by John Wiley & Sons. This book was released on 2012-09-25 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of "Analytical Methods in Supramolecular Chemistry" comes in two volumes and covers a broad range of modern methods and techniques now used for investigating supramolecular systems, e. g. NMR spectroscopy, mass spectrometry, extraction methods, crystallography, single molecule spectroscopy, electrochemisty, and many more. In this second edition, tutorial inserts have been introduced, making the book also suitable as supplementary reading for courses on supramolecular chemistry. All chapters have been revised and updated and four new chapters have been added. A must-have handbook for Organic and Analytical Chemists, Spectroscopists, Materials Scientists, and Ph.D. Students in Chemistry. From reviews of the first edition: "This timely book should have its place in laboratories dealing with supramolecular objects. It will be a source of reference for graduate students and more experienced researchers and could induce new ideas on the use of techniques other than those usually used in the laboratory." Journal of the American Chemical Society (2008) VOL. 130, NO. 1 doi: 10.1021/ja0769649 "The book as a whole or single chapters will stimulate the reader to widen his horizon in chemistry and will help him to have new ideas in his research." Anal Bioanal Chem (2007) 389:2039-2040 DOI: 10.1007/s00216-007-1677-1

Anion Receptor Chemistry

Author : Jonathan L Sessler
Publisher : Royal Society of Chemistry
ISBN 13 : 1847552471
Total Pages : 431 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Anion Receptor Chemistry by : Jonathan L Sessler

Download or read book Anion Receptor Chemistry written by Jonathan L Sessler and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world. Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own inventive processes. This book traces the origins of anion recognition chemistry as a unique sub-field in supramolecular chemistry while illustrating the basic approaches currently being used to effect receptor design. The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible. First, the authors detail the key design motifs that have been used to generate synthetic receptors and which are likely to provide the basis for further developments. They also highlight briefly some of the features that are present in naturally occurring anion recognition and transport systems and summarise the applications of anion recognition chemistry. Providing as it does a detailed review for practitioners in the field and a concise introduction to the topic for newcomers, Anion Receptor Chemistry reflects the current state of the art. Fully referenced and illustrated in colour, it is a welcome addition to the literature.

Biomolecular Structure and Dynamics

Author : G. Vergoten
Publisher : Springer Science & Business Media
ISBN 13 : 9401154848
Total Pages : 327 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Biomolecular Structure and Dynamics by : G. Vergoten

Download or read book Biomolecular Structure and Dynamics written by G. Vergoten and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomolecular Structure and Dynamics describes recent fundamental advances in the experimental and theoretical study of molecular dynamics and stochastic dynamic simulations, X-ray crystallography and NMR of biomolecules, the structure of proteins and its prediction, time resolved Fourier transform IR spectroscopy of biomolecules, the computation of free energy, applications of vibrational CD of nucleic acids, and solid state NMR. Further presentations include recent advances in UV resonance Raman spectroscopy of biomolecules, semiempirical MO methods, empirical force fields, quantitative studies of the structure of proteins in water by Fourier transform IR, and density functional theory. Metal-ligand interactions, DFT treatment of organometallic and biological systems, and simulation vs. X-ray and far IR experiments are also discussed in some detail. The book provides a broad perspective of the current theoretical aspects and recent experimental findings in the field of biomolecular dynamics, revealing future research trends, especially in areas where theoreticians and experimentalists could fruitfully collaborate.

The Physics and Physical Chemistry of Water

Author : Felix Franks
Publisher : Springer Science & Business Media
ISBN 13 : 146848334X
Total Pages : 610 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis The Physics and Physical Chemistry of Water by : Felix Franks

Download or read book The Physics and Physical Chemistry of Water written by Felix Franks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: to arrive at some temporary consensus model or models; and to present reliable physical data pertaining to water under a range of conditions, i.e., "Dorsey revisited," albeit on a less ambitious scale. I should like to acknowledge a debt of gratitude to several of my col leagues, to Prof. D. J. G. Ives and Prof. Robert L. Kay for valuable guidance and active encouragement, to the contributors to this volume for their willing cooperation, and to my wife and daughters for the understanding shown to a husband and father who hid in his study for many an evening. My very special thanks go to Mrs. Joyce Johnson, who did all the cor respondence and much of the arduous editorial work with her usual cheerful efficiency. F. FRANKS Biophysics Division Unilever Research Laboratory ColworthjWelwyn Colworth House, Sharnbrook, Bedford March 1972 Contents Chapter 1 Introduction-Water, the Unique Chemical F. Franks I. lntroduction ........................................ . 2. The Occurrence and Distribution of Water on the Earth 2 3. Water and Life ...................................... 4 4. The Scientific Study of Water-A Short History ........ 8 5. The Place of Water among Liquids . . . . . . . . . . . . . . . 13 . . . . . Chapter 2 The Water Moleeule C. W. Kern and M. Karplus 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 . . . . . . . . . . 2. Principles of Structure and Spectra: The Born-Oppenheimer Separation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 . . . . . . . . . . . . 3. The Electronic Motion ............................... 26 3.1. The Ground Electronic State of Water ............ 31 3.2. The Excited Electronic States of Water ........... 50 4. The Nuclear Motion ................................. 52 5. External-Field Effects ................................. 70 5.1. Perturbed Hartree-Fock Method . . . . . . . . . . . . . . . 74 . . .

Protein Self-Assembly

Author : Jennifer J. McManus
Publisher : Humana
ISBN 13 : 9781493996803
Total Pages : 266 pages
Book Rating : 4.9/5 (968 download)

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Book Synopsis Protein Self-Assembly by : Jennifer J. McManus

Download or read book Protein Self-Assembly written by Jennifer J. McManus and published by Humana. This book was released on 2020-08-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.