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Selective Neurotoxicity
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Book Synopsis Selective Neurotoxicity by : Hans Herken
Download or read book Selective Neurotoxicity written by Hans Herken and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 891 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the overwhelmingly successful response to the first printing in hardcover, the hottest topics in Selective Neurotoxicity are now available in this special softcover edition". Researchers are provided with well-grounded information on the cellular and subcellular targets of neurotoxins and their mode of action at the level of ion-channels, receptors and neurotransmitters. The use of bacterial toxins as a tool in neuroscientific research is an important aspect in this context. The chapters that interest clinicians as well deal with protective barriers in the peripheral and central nervous system and metabolic disorders that cause neurotoxins to be built up in the human body. The induction of tumors by neuroptropic carcinogens is included.
Book Synopsis Site-Selective Neurotoxicity by : David S Lester
Download or read book Site-Selective Neurotoxicity written by David S Lester and published by CRC Press. This book was released on 2002-02-07 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique volume provides interdisciplinary coverage of the mechanistic perspective of neurotoxicity that focuses on the site of action of known neurotoxins. It provides the reader with an insight into the common characteristics of neurotoxin action on the nervous system and examines sites of action at three levels of complexity: molecular, cellu
Book Synopsis Environmental Neurotoxicology by : National Research Council
Download or read book Environmental Neurotoxicology written by National Research Council and published by National Academies Press. This book was released on 1992-02-01 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Book Synopsis Selective Neurotoxicity by : K. Aktories
Download or read book Selective Neurotoxicity written by K. Aktories and published by Springer Verlag. This book was released on 1992-01-01 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Selective Neurotoxicity by : Hans Herken
Download or read book Selective Neurotoxicity written by Hans Herken and published by Springer Verlag. This book was released on 1994-01-01 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Highly Selective Neurotoxins by : Richard Kostrzewa
Download or read book Highly Selective Neurotoxins written by Richard Kostrzewa and published by Springer Science & Business Media. This book was released on 1997-10-30 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert researchers critically review and evaluate the most common and important neurotoxins used today in neuroscience research. Each informative chapter thoroughly describes the significant mechanisms of action of a neurotoxin, as well as fully discussing the limits on their use and their clinical applicability. Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants. Highly Selective Neurotoxins provides all the basic knowledge needed to obtain a predictable experimental outcome with these neurotoxins.
Book Synopsis Site Selective Neurotoxicity by : B. Lester
Download or read book Site Selective Neurotoxicity written by B. Lester and published by Harwood Academic Publishers. This book was released on 2002-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurotoxicity : identifying and controlling poisons of the nervous system : new developments in neuroscience. by :
Download or read book Neurotoxicity : identifying and controlling poisons of the nervous system : new developments in neuroscience. written by and published by DIANE Publishing. This book was released on with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Behavioral Measures of Neurotoxicity by : National Research Council
Download or read book Behavioral Measures of Neurotoxicity written by National Research Council and published by National Academies Press. This book was released on 1990-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exposure to toxic chemicalsâ€"in the workplace and at homeâ€"is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs. This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed.
Book Synopsis MDMA-induced serotonergic neurotoxicity by : Dominik Buchmüller
Download or read book MDMA-induced serotonergic neurotoxicity written by Dominik Buchmüller and published by GRIN Verlag. This book was released on 2009-10-06 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seminar paper from the year 2009 in the subject Psychology - Biological Psychology, grade: A (100%), New College Durham (Duke University, Department of Psychology and Neuroscience), course: Behavior and Neurochemistry, language: English, abstract: It is the aim of this paper to review and integrate relevant empirical findings and theoretical discussions concerning the molecular and cellular mechanisms and effects of MDMA-induced 5-HT neurotoxicity in laboratory animals. 3,4-methylenedioxymethamphetamine (MDMA) is a derivative of the synthetic psychostimulant methamphetamine (METH). It also shares some structural and pharmacological properties of mescaline, a naturally occurring psychedelic hallucinogen. At the molecular level, all three substances resemble the monoamine neurotransmitters epinephrine (E) and dopamine (DA). They mimic the neurophysiological actions and effects of E and DA, as well as serotonin (5-HT). METH and MDMA do so by binding to, and reversal of monoamine-specific transporter proteins at the presynaptic plasma membrane. While the psychological effects of METH are mainly due its action as a DA release agent and reuptake inhibitor, MDMA primarily affects the serotonergic system. It has a high affinity for the serotonin-specific transporter (SERT), which carries it into the presynaptic neuron. Inside the cell, MDMA inhibits the vesicular monoamine transporter type 2 (VMAT2), pre-venting intracellular 5-HT from being stored in synaptic vesicles. In addition, MDMA phos-phorylates SERT, which causes a reversal of its reuptake function and, hence, non-exocytotic efflux of 5-HT by the means of passive diffusion. Because neurotransmitter release normally only occurs in case of an action potential, and the released transmitter is partly reabsorbed and recycled, the reverse functioning of SERT depletes 5-HT stores. The equivalent effect of METH via reversal of the DA transporter (DAT) has been linked to its neurotoxic properties (Yamamoto & Zhu, 1998). As a derivative of methamphetamine, MDMA is sometimes believed to have inherited the severe dopaminergic neurotoxicity of METH and its parent compound amphetamine. Such neurotoxic potential has been found in mice but not in rats (Colado, O’Shea, and Green, 2004), and remains to be established for non-human primates. The probably most prominent publication claiming that MDMA caused irreversible damage to primate DA neurons (Ricaurte et al., 2002) was shown to be in error and had to be retracted. Instead of a recreational dose of MDMA (3 2 mg/kg), the monkeys had, in fact, been given METH, which, at such doses, is known to be neurotoxic in primates (Villemagne et al., 1998). [...]
Book Synopsis Selective aluminum neurotoxicity in primary hippocampal, cerebellar, and astrocyte cell cultures by : Glen Kisby
Download or read book Selective aluminum neurotoxicity in primary hippocampal, cerebellar, and astrocyte cell cultures written by Glen Kisby and published by . This book was released on 1986 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Glia in Neurotoxicity by : Michael Aschner
Download or read book The Role of Glia in Neurotoxicity written by Michael Aschner and published by CRC Press. This book was released on 2004-12-28 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases.
Book Synopsis Handbook of Neurotoxicity by : Richard M. Kostrzewa
Download or read book Handbook of Neurotoxicity written by Richard M. Kostrzewa and published by Springer Nature. This book was released on 2023-01-02 with total page 2551 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specific neurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.
Book Synopsis Stereoselective Influence of Isomalathion on Neurotoxicity by : Suree Jianmongkol
Download or read book Stereoselective Influence of Isomalathion on Neurotoxicity written by Suree Jianmongkol and published by . This book was released on 1998 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Milestones in Neurotoxicity and Neuroprotection: A Tribute to Professor Toshiharu Nagatsu by : M. Naoi
Download or read book Milestones in Neurotoxicity and Neuroprotection: A Tribute to Professor Toshiharu Nagatsu written by M. Naoi and published by Gulf Professional Publishing. This book was released on 2002-09-25 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give us overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences. The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5.
Download or read book Neurotoxicity of Pesticides written by and published by Academic Press. This book was released on 2020-03-20 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Organophosphates, OPs, Nerve agents, Pyrethroids, Neonicotinoids and Formamidines, among others. Provides a unique, first of its kind resource Contributed to by world leaders in neurotoxicology Contains a diversity of topics (from molecular to epidemiology) in neurotoxicology
Book Synopsis From the Cover: Harmane-Induced Selective Dopaminergic Neurotoxicity in Caenorhabditis Elegans by :
Download or read book From the Cover: Harmane-Induced Selective Dopaminergic Neurotoxicity in Caenorhabditis Elegans written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
