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Author : B. H. Morrison
Publisher :
ISBN 13 :
Total Pages : 332 pages
Book Rating : 4.M/5 ( download)
Download or read book Conference on Experimental Clinical Cancer Chemotherapy written by B. H. Morrison and published by . This book was released on 1960 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030918651X
Total Pages : 163 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Author :
Publisher :
ISBN 13 :
Total Pages : 760 pages
Book Rating : 4.3/5 ( download)
Download or read book Cancer Chemotherapy Reports written by and published by . This book was released on 1966 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : C. Herfarth
Publisher : Springer Science & Business Media
ISBN 13 : 3642673686
Total Pages : 421 pages
Book Rating : 4.6/5 (426 download)
Download or read book Gastric Cancer written by C. Herfarth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The problem of gastric cancer, with its multifaceted aspects, offers an example of diversified oncological research, which includes epidemiology, pathogenesis, histo morphology, surgical and conservative therapy in its spectrum. This disease not only constitutes an interesting and important subject for research, but it is also a challenge for the practitioner due to its inordinately poor prognosis. It therefore appeared a rewarding task to the editors to collect information from individual experts, in order to gain a topical summary of the problems pertaining to gastric cancer, as well as to provide a survey of the progress and the therapeutic possibilities in this field. This task was particularly enticing, as gastric cancer has lately come to belong to those tumors somewhat relegated to the shadows, although it is, despite its decreased fre quency in some western countries, still one of the most prevalent malignant diseases. This collection should emphasize the need for broadly based knowledge of individual problems as a prerequisite for any satisfactory therapy of an organ tumor. It is therefore the primary concern of this book to furnish anyone with an interest in oncology with this necessary survey. The editors thank Mrs. Karin Dohmeier and Mrs. Karin Kluge from Springer-Verlag for their cooperation in preparing this monograph. We extend our thanks to Mrs. Susanne Schenk and Mrs. Marga Wild, who contributed so much by her secretarial experience for the success of this volume. lJIm,September1979 Ch. Herfarth P. Schlag Table of Contents 1 Epidemiology and Pathogenesis . . . . . . . . . . .
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309157870
Total Pages : 317 pages
Book Rating : 4.3/5 (91 download)
Download or read book A National Cancer Clinical Trials System for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2010-07-08 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research.
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1000 pages
Book Rating : 4.:/5 (31 download)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1969 with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes subject section, name section, and 1968-1970, technical reports.
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 990 pages
Book Rating : 4.3/5 (91 download)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030904491X
Total Pages : 225 pages
Book Rating : 4.3/5 (9 download)
Download or read book The Changing Economics of Medical Technology written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Americans praise medical technology for saving lives and improving health. Yet, new technology is often cited as a key factor in skyrocketing medical costs. This volume, second in the Medical Innovation at the Crossroads series, examines how economic incentives for innovation are changing and what that means for the future of health care. Up-to-date with a wide variety of examples and case studies, this book explores how payment, patent, and regulatory policiesâ€"as well as the involvement of numerous government agenciesâ€"affect the introduction and use of new pharmaceuticals, medical devices, and surgical procedures. The volume also includes detailed comparisons of policies and patterns of technological innovation in Western Europe and Japan. This fact-filled and practical book will be of interest to economists, policymakers, health administrators, health care practitioners, and the concerned public.
Author : United States. Congress. House. Committee on Science and Technology. Subcommittee on Science, Research, and Technology
Publisher :
ISBN 13 :
Total Pages : 1308 pages
Book Rating : 4.:/5 (319 download)
Download or read book Science Policy Implications of DNA Recombinant Molecular Research written by United States. Congress. House. Committee on Science and Technology. Subcommittee on Science, Research, and Technology and published by . This book was released on 1977 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M.W. Büchler
Publisher : Springer Science & Business Media
ISBN 13 : 3540274499
Total Pages : 284 pages
Book Rating : 4.5/5 (42 download)
Download or read book Rectal Cancer Treatment written by M.W. Büchler and published by Springer Science & Business Media. This book was released on 2005-10-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rectal cancer is one of the most prevalent cancers world-wide. It is also a paradigm for multimodal management, as the combination of surgery, chemotherapy and radiotherapy is often necessary to achieve the optimal outcome. Recently, international experts met in Heidelberg, Germany to discuss the latest developments in the management of rectal cancer, including the anatomic and pathologic basis, staging tools, surgical concepts including fast-track surgery and laparoscopic resection, functional outcome after surgery and the role of radio- and chemotherapy. This monograph summarizes this meeting and gives an extensive overview of the current concepts in management of rectal cancer.
Author : United States. Veterans Administration
Publisher :
ISBN 13 :
Total Pages : 680 pages
Book Rating : 4.F/5 ( download)
Download or read book Medical Research in the Veterans Administration written by United States. Veterans Administration and published by . This book was released on with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Gaudillière
Publisher : Springer
ISBN 13 : 1349264431
Total Pages : 390 pages
Book Rating : 4.3/5 (492 download)
Download or read book The Invisible Industrialist written by J. Gaudillière and published by Springer. This book was released on 1998-07-13 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Industrial methods, and industrially produced instruments, reagents and living organisms are central to research activities today. They play a key role in the homogenization and the diffusion of laboratory practices, thus in their transformation into a stable and unproblematic knowledge about the natural world. This book displays the - frequently invisible - role of industry in the construction of fundamental scientific knowledge through the examination of case studies taken from the history of nineteenth and the twentieth century physics, chemistry and biomedical sciences.
Author : Uwe Reinhold
Publisher : Springer Science & Business Media
ISBN 13 : 9783540434689
Total Pages : 264 pages
Book Rating : 4.4/5 (346 download)
Download or read book Chemosensitivity Testing in Oncology written by Uwe Reinhold and published by Springer Science & Business Media. This book was released on 2002-10-31 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.
Author : Stephanie Green
Publisher : CRC Press
ISBN 13 : 1439814481
Total Pages : 266 pages
Book Rating : 4.4/5 (398 download)
Download or read book Clinical Trials in Oncology, Third Edition written by Stephanie Green and published by CRC Press. This book was released on 2012-05-09 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to cancer clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. In addition, the book has been restructured to have separate chapters and expanded discussions on general clinical trials issues, and issues specific to Phases I, II, and III. New sections cover innovations in Phase I designs, randomized Phase II designs, and overcoming the challenges of array data. Although this book focuses on cancer trials, the same issues and concepts are important in any clinical setting. As always, the authors use clear, lucid prose and a multitude of real-world examples to convey the principles of successful trials without the need for a strong statistics or mathematics background. Armed with Clinical Trials in Oncology, Third Edition, clinicians and statisticians can avoid the many hazards that can jeopardize the success of a trial.
Author :
Publisher :
ISBN 13 :
Total Pages : 194 pages
Book Rating : 4.:/5 (327 download)
Download or read book Cancer Incidence and Survival Among Children and Adolescents written by and published by . This book was released on 1999 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gw Sledge
Publisher : Clinical Pub
ISBN 13 : 9781846920660
Total Pages : 0 pages
Book Rating : 4.9/5 (26 download)
Download or read book Targeted Therapies in Breast Cancer written by Gw Sledge and published by Clinical Pub. This book was released on 2012-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.
Author : Hadley Kirkman
Publisher :
ISBN 13 :
Total Pages : 678 pages
Book Rating : 4.3/5 (91 download)
Download or read book Estrogen-induced Tumors of the Kidney in the Syrian Hamster written by Hadley Kirkman and published by . This book was released on 1959 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt:
