Safety And Efficacy Of Radiopharmaceuticals 1987

Download Safety And Efficacy Of Radiopharmaceuticals 1987 full books in PDF, epub, and Kindle. Read online Safety And Efficacy Of Radiopharmaceuticals 1987 ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Safety and efficacy of radiopharmaceuticals 1987

Author : Knud Kristensen
Publisher : Springer Science & Business Media
ISBN 13 : 9400933754
Total Pages : 370 pages
Book Rating : 4.4/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Safety and efficacy of radiopharmaceuticals 1987 by : Knud Kristensen

Download or read book Safety and efficacy of radiopharmaceuticals 1987 written by Knud Kristensen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Safety and Efficacy of Radiopharmaceuticals was established as a very important and comprehensive subject at the First Europe an Symposium on Radiopharmacy and Radiopharmaceuticals in Denmark in 1983. The interest in this subject has grown considerably since then due to the growing interest among national authorities to deal with radiopharmaceuticals. The introduction in recent years of nuclear medicine techniques based on radioactive labelled cells and on monoclonal antibodies has stressed the importance of a well functioning approval system for the clinical trial and use of new radiopharmaceuticals. The process of transferring the experience from the non radioactive drug field into the area of radiopharmaceuticals is still ongoing. International organisations such as the World Health Organisa tion is also including this into their quality assurance programme from both the radiopharmaceutical and the radiation hygiene point of view. In order to give an up-to date survey of these areas, experts were invited to prepare review papers under the following headings: Safety and Efficacy of Radiophar maceuticals with Emphasis on Biological Products, Radiophar macy/Radiation Hygiene, Legal Aspects of the Introduction of New Radiopharmaceuticals and some selected aspects of Good Radiopharmacy Practice.

Safety and efficacy of radiopharmaceuticals

Author : Knud Kristensen
Publisher : Springer Science & Business Media
ISBN 13 : 9400967535
Total Pages : 392 pages
Book Rating : 4.4/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Safety and efficacy of radiopharmaceuticals by : Knud Kristensen

Download or read book Safety and efficacy of radiopharmaceuticals written by Knud Kristensen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Safety and efficacy of radiopharmaceuticals are elements of great importance in nuclear medicine. Since the first meeting in 1965 in Oak Ridge with the title Radiopharmaceuticals tremendous developments have taken place. In 1965 the whole technetium-99m area was just in its very beginning. Safety and efficacy of the non-radioactive pharmaceuticals have attracted great attention during the last 10 years and so have similar aspects of radiopharmaceuticals during the later years. Regulatory agencies are extending their work also to the preparation of radiopharmaceuticals at hospitals and to requirements for registration of radiopharmaceuticals. In a fast developing field there might be tendencies to confrontation between interests and there have certainly been some tendencies to put undue restrictions on the use of radio pharmaceuticals due to the lack of understanding between the industry and the regulatory authorities and between regulatory authorities and hospitals. Much of this may have been due to lack of information and certainly is due to the lack of fundamental scientific knowledge in many radiopharmaceutical aspects. A fast and safe introduction of new radio pharmaceuticals and the proper handling of these requires a lot of development work, but also an understanding of how general principles from the non-radioactive drug field may be sensibly transformed into the radiopharmaceutical area. It may even require compromises between requirements for safety in different areas such as radiation protection and pharmaceutical aspects.

Fundamentals of Nuclear Pharmacy

Author : Gopal B. Saha
Publisher : Springer
ISBN 13 : 3319575805
Total Pages : 428 pages
Book Rating : 4.3/5 (195 download)

DOWNLOAD NOW!

Book Synopsis Fundamentals of Nuclear Pharmacy by : Gopal B. Saha

Download or read book Fundamentals of Nuclear Pharmacy written by Gopal B. Saha and published by Springer. This book was released on 2017-11-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently an estimated 17 million nuclear medicine procedures are performed each year in the US and constantly evolving, as new radiopharmaceuticals and imaging techniques are introduced for better diagnosis and treatment of human diseases. In keeping up with new developments, the Seventh Edition of Fundamentals of Nuclear Pharmacy chronicles the advancements in radiopharmaceuticals and their use in clinical applications. It discusses basic concepts such as the atom, radioactive decay, instrumentation and production of radionuclides, and explores the design, labeling, characteristics and quality control of radiopharmaceuticals. Radiation regulations and diagnostic and therapeutic applications of radiopharmaceuticals are detailed. Thoroughly updated, the Seventh Edition includes new topics such as alternative productions of 99Mo; production of 64Cu, 86Y, 89Zr, 177Lu, 223Ra; synthesis and clinical uses of new radiopharmaceuticals such as DaTscan, Xofigo, Amyvid, Neuraceq, Vizamyl, Axumin and 68Ga-DOTATATE; dosimetry of new radiopharmaceuticals; theranostic agents and translational medicine. It features numerous examples, diagrams, and images to further clarify the information and offers end- of-chapter questions to help readers assess their comprehension of the material. Recognized as a classic text on nuclear chemistry and pharmacy and acclaimed for its concise and easy-to-understand presentation, Fundamentals of Nuclear Pharmacy is an authoritative resource for nuclear medicine physicians, residents, students, and technologists.

ICRP Publication 140

Author : ICRP
Publisher : Sage Publications Limited
ISBN 13 : 9781529700756
Total Pages : 104 pages
Book Rating : 4.7/5 (7 download)

DOWNLOAD NOW!

Book Synopsis ICRP Publication 140 by : ICRP

Download or read book ICRP Publication 140 written by ICRP and published by Sage Publications Limited. This book was released on 2019-11 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiopharmaceuticals are increasingly used for the treatment of various cancers with novel radionuclides, compounds, tracer molecules, and administration techniques. The goal of radiation therapy, including therapy with radiopharmaceuticals, is to optimise the relationship between tumour control probability and potential complications in normal organs and tissues. This report provides an overview of therapy procedures and a framework for calculating radiation doses for various treatment approaches.

Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects

Author : G. Stöcklin
Publisher : Springer Science & Business Media
ISBN 13 : 9780792323402
Total Pages : 210 pages
Book Rating : 4.3/5 (234 download)

DOWNLOAD NOW!

Book Synopsis Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects by : G. Stöcklin

Download or read book Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects written by G. Stöcklin and published by Springer Science & Business Media. This book was released on 1993-06-30 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today. This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 578 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

PET Studies on Amino Acid Metabolism and Protein Synthesis

Author : B.M. Mazoyer
Publisher : Springer Science & Business Media
ISBN 13 : 9401116202
Total Pages : 270 pages
Book Rating : 4.4/5 (11 download)

DOWNLOAD NOW!

Book Synopsis PET Studies on Amino Acid Metabolism and Protein Synthesis by : B.M. Mazoyer

Download or read book PET Studies on Amino Acid Metabolism and Protein Synthesis written by B.M. Mazoyer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts: biochemistry and animal studies; amino acids labelling with positron emittors, quality control and metabolites measurement; kinetic modelling of amino acids transport, metabolism, and protein incorporation; clinical use of amino acids. This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.

Nuclear Medicine in Tropical and Infectious Diseases

Author : Francisco José H.N. Braga
Publisher : Springer Science & Business Media
ISBN 13 : 9781402071911
Total Pages : 282 pages
Book Rating : 4.0/5 (719 download)

DOWNLOAD NOW!

Book Synopsis Nuclear Medicine in Tropical and Infectious Diseases by : Francisco José H.N. Braga

Download or read book Nuclear Medicine in Tropical and Infectious Diseases written by Francisco José H.N. Braga and published by Springer Science & Business Media. This book was released on 2002-09-30 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: "More than half of the world's population is at risk of the tropical diseases malaria, leprosy, schistosomiasis, lymphatic filariasis, onchocerciasis, Chagas' disease, African trypanosomiasis and leishmaniasis and half a billion are infected with at least one of these diseases". J. H. F. Remme, World Health Organisation, 1993. "If it is true that science is not limited by frontiers and all research Institutions then belong to mankind, so it is natural for each Institution to be responsible for the problems of those who live in the geographic area under its influence. There are no specific aspects concerning physical, chemical or philosophical concepts and facts, but specificity does exist concerning geology, sociology and pathology. It is the duty of each Institution to study the particular aspects concerning its geographic region, as missing links of the chain of universal knowledge may be found there." H. L. de Oliveira, fonner Rector of the University ofSiio Paulo, 1967. "Nuclear Medicine is cost effective, especially in the developing countries. ( ... ).

Radioiodination: Theory, Practice, and Biomedical Applications

Author : Mrinal K. Dewanjee
Publisher : Springer Science & Business Media
ISBN 13 : 1461535085
Total Pages : 627 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Radioiodination: Theory, Practice, and Biomedical Applications by : Mrinal K. Dewanjee

Download or read book Radioiodination: Theory, Practice, and Biomedical Applications written by Mrinal K. Dewanjee and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.

Brain Dopaminergic Systems: Imaging with Positron Tomography

Author : J.C Baron
Publisher : Springer Science & Business Media
ISBN 13 : 9401135282
Total Pages : 206 pages
Book Rating : 4.4/5 (11 download)

DOWNLOAD NOW!

Book Synopsis Brain Dopaminergic Systems: Imaging with Positron Tomography by : J.C Baron

Download or read book Brain Dopaminergic Systems: Imaging with Positron Tomography written by J.C Baron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging of the Dopaminergic system in the human brain with the in vivo use of Positron Emis sion Tomography has emerged in the late 1980s as a tool of major importance in Clinical Neuros ciences and Pharmacology. The last few years have witnessed the rapid development of new radiotracers specific to receptors, reuptake sites and enzymes of the dopamine system; the application of these radiotracers has led to major breakthroughs in the pathophysiology and therapy of movement disorders and schizophrenic-like psychoses. This book is the first to collect, in a single volume, state-of-the-art contributions to the various aspects of this research. Its contents address methodological issues related to the design, labelling, quantitative imaging and compartmental modelisation of radioligands of the post-synaptic, pre-synaptic and enzyme sites of the dopamine system and to their use in clinical research in the fields of Parkinson's disease as well as other movement disorders, psychoses and neuroleptic receptor occupancy. The chapters were written by leading European scientists in the field of Positron Emission Tomography, gathered together in Caen (France, November 1990) under the aegis of the EEC Concerted Action on "PET Investigations of Cellular Regeneration and Degeneration. This book provides a current and comprehensive overview on PET studies of the brain dopamine system which should aid and interest neurologists, psychiatrists, pharmacologists and medical imaging scientists. J.C. Baron D. Comar L. Farde J.L. Martinot B. Mazoyer August 1991 ix LIST OF CONTRffiUTORS Dr Yves Agid DrL.

Clinical Application of Radiolabelled Platelets

Author : C. Kessler
Publisher : Springer Science & Business Media
ISBN 13 : 9400905815
Total Pages : 307 pages
Book Rating : 4.4/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Clinical Application of Radiolabelled Platelets by : C. Kessler

Download or read book Clinical Application of Radiolabelled Platelets written by C. Kessler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) were the first to publish a paper concerning the in vivo thrombus detection with 111- In-labelled platelets. Previous attempts at scintigraphic thrombus localisation had been disappointing because of the unspecific binding of a number of the isotopes used, as well as the poor labelling efficiency or an insufficient low gamma-emitting property. Because of its physical characteristics (2.8 days half-life, 94% gamma emission) 111 Indium turned out to be the best isotope for platelet kinetic studies as well as for the measurement of platelet incorporation by Thrombi to be used up until now. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets without altering the function or the life span of the platelets. This advantage has let to an increase in the clinical applications of 1211-In labelled platelets. Today, radiolabelled platelets are used for thrombus detection in several different medical areas such as cardiology, nephrology. angiology or neurology. Even though many scientists and hospital doctors now routinely use radiolabelled platelet as a diagnostic tool, there is as yet not a standardized labelling method. In addition to this, there are neither standardized image procedures for the different clinical applications nor an agreement about specificity and sensitivity of the method. In 1983, a symposium on Radiolabelled Cellular Blood Elements was organized by M.Thakur, M.R.Hardeman and M.D.

Progress in Radiopharmacy

Author : August P. Schubiger
Publisher : Springer Science & Business Media
ISBN 13 : 9401125848
Total Pages : 223 pages
Book Rating : 4.4/5 (11 download)

DOWNLOAD NOW!

Book Synopsis Progress in Radiopharmacy by : August P. Schubiger

Download or read book Progress in Radiopharmacy written by August P. Schubiger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of the invited papers, which were presented at the Fourth European Symposium on Radiopharmacy and Radiopharmaceuticals, which was held in Baden, Switz- land, 1-4 May, 1991. The First and Third Symposia on Radiopharmacy and Radiopharmaceuticals (Elsinore, Denmark, 1983, 1987) concentrated on the safety and efficacy of radiopharmaceuticals, whereas this Fourth Symposium to some extent followed up the subject of the Second Symposium (Cambridge, UK, 1985): recent developments in radiopharmacy and current research on radiopharmaceuticals. The symposium was organized by the Radiopharmacy Group of the Swiss Society of Medical Radiology (Section Nuclear Medicine) under the auspices of the task group on radiopharmaceu- cals of the European Association of Nuclear Medicine (EANM). The organizing committee consisted of the cochairmen Drs. P.A. Schubiger (Paul Scherrer Institute (PSI), Villigen) and G. Westera (University Hospital, ZiJrich) and the members H.-F. Beer, P. Bl~iuenstein, P. Hasler (all PSI) and H. M~icke (Cantonal Hospital, Basel). The subjects of this Symposium ranged from isotope production to clinical testing of radioph- maceuticals, including the organisational prerequisites. In addition, the development of new radiopharmaceuticals and of PET radiopharmacy, and the concomittant ongoing evolution of regulatory guidelines by national (various European countries, USA) and international (EC) authorities, induced us to honor the vivid interest in this subject and to make it an important part of this symposium.

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1178 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!

Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1989 with total page 1178 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Energy Abstracts for Policy Analysis

Author :
Publisher :
ISBN 13 :
Total Pages : 436 pages
Book Rating : 4.3/5 (129 download)

DOWNLOAD NOW!

Book Synopsis Energy Abstracts for Policy Analysis by :

Download or read book Energy Abstracts for Policy Analysis written by and published by . This book was released on 1988 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear Imaging in Drug Discovery, Development, and Approval

Author : BURNS
Publisher : Springer Science & Business Media
ISBN 13 : 1468468081
Total Pages : 347 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!

Book Synopsis Nuclear Imaging in Drug Discovery, Development, and Approval by : BURNS

Download or read book Nuclear Imaging in Drug Discovery, Development, and Approval written by BURNS and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is the purpose and business of the pharmaceutical industry to dis cover, develop, and make available drugs for the care of the sick. The purpose of universities and national laboratories is to provide people and scientific knowledge that can help in the process. This book presents the combined efforts of scientists from the drug in dustry, academic laboratories and national laboratories to describe advances in radiotracer technology in studies on experimental ani mals and living human beings. The authors believe that the technol ogy is now ready for widespread application in the pharmaceutical industry. The goal of this book is to help bring this about. The field of Nuclear Medicine is based on the concept that, if treatment of disease is chemical, the patient's diagnosis should be chemical. Anatomy and histopathology have been the principle ba sis for making a diagnosis. Histopathologic data suffer from being descriptive, subjective, not quantifiable, and based on the study of dead tissue. The era of histopathology as the dominant concept in medical practice is coming to an end. Histopathologic findings are often heterogeneous and a single biopsy will at times not reveal the true nature of the disease, such as the grading of malignancy. Far greater accuracy of staging of disease and in the planning of treat ment is possible through chemistry, as well as by making possible a more suitable selection of a histological biopsy site.

Conjugates and Malignant Disease

Author : Michael Magerstadt
Publisher : CRC Press
ISBN 13 : 9780849360893
Total Pages : 246 pages
Book Rating : 4.3/5 (68 download)

DOWNLOAD NOW!

Book Synopsis Conjugates and Malignant Disease by : Michael Magerstadt

Download or read book Conjugates and Malignant Disease written by Michael Magerstadt and published by CRC Press. This book was released on 1991-01-03 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of antibody conjugates for in vivo applications. It discusses each of the major classes of antibody conjugates used in cancer diagnosis and therapy, as well as the major chemical and biological aspects of antibody selection, conjugate preparation, characterization, and application. The book is designed to close the information gap that exists regarding these compounds between such diverse disciplines as radiochemists, immunochemists, oncologists, clinicians and immunologists. It also provides a thorough overview for newcomers to the field.

Radiopharmaceuticals for Therapy

Author : F. F. (Russ) Knapp
Publisher : Springer
ISBN 13 : 8132226070
Total Pages : 347 pages
Book Rating : 4.1/5 (322 download)

DOWNLOAD NOW!

Book Synopsis Radiopharmaceuticals for Therapy by : F. F. (Russ) Knapp

Download or read book Radiopharmaceuticals for Therapy written by F. F. (Russ) Knapp and published by Springer. This book was released on 2016-01-20 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.