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Role Of The Slow Pressor Effect Of Angiotensin Ii In Experimental Hypertension
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Book Synopsis Role of the Slow Pressor Effect of Angiotensin II in Experimental Hypertension by : Matthew Gerard Melaragno
Download or read book Role of the Slow Pressor Effect of Angiotensin II in Experimental Hypertension written by Matthew Gerard Melaragno and published by . This book was released on 1995 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of the Slow Pressor Effect of Angiotensin II in the Development of Hypertension by : Vyvian Janet Gorbea-Oppliger
Download or read book The Role of the Slow Pressor Effect of Angiotensin II in the Development of Hypertension written by Vyvian Janet Gorbea-Oppliger and published by . This book was released on 1994 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Angiotensin II Receptor Blockade Physiological and Clinical Implications by : Naranjan S. Dhalla
Download or read book Angiotensin II Receptor Blockade Physiological and Clinical Implications written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such ·as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. The Manitoba Cardiovascular Forum on Angiotensin Receptor Blockade in Winnipeg was convened October 18-20, 1996 to examine the clinical and basic aspects of angiotensin receptor biology as they apply to hypertension and heart failure. In addition, the potential treatment of these conditions using specific angio tensin receptor antagonists was addressed within the context of their immediate therapeutic application and future potential.
Book Synopsis The Effects of Angiotensin II-induced Hypertension on the Baroreceptor Reflex by : Mark Gregory Tagett
Download or read book The Effects of Angiotensin II-induced Hypertension on the Baroreceptor Reflex written by Mark Gregory Tagett and published by . This book was released on 1986 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Heart, Lung, and Blood Institute. Hypertension Task Force Publisher : ISBN 13 : Total Pages :198 pages Book Rating :4.3/5 (91 download)
Book Synopsis Report of the Hypertension Task Force by : National Heart, Lung, and Blood Institute. Hypertension Task Force
Download or read book Report of the Hypertension Task Force written by National Heart, Lung, and Blood Institute. Hypertension Task Force and published by . This book was released on 1979 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Angiotensin II and Endothelin-1 in the Hypertension of Experimental Chronic Renal Failure by : Gregg Steven Potter
Download or read book The Role of Angiotensin II and Endothelin-1 in the Hypertension of Experimental Chronic Renal Failure written by Gregg Steven Potter and published by . This book was released on 1997 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Relationship Between Experimental Angiotensin II Induced Hypertension and Activation of the Endothelin System in Male Rats by : Jennifer Rebecca Ballew
Download or read book Relationship Between Experimental Angiotensin II Induced Hypertension and Activation of the Endothelin System in Male Rats written by Jennifer Rebecca Ballew and published by . This book was released on 2000 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Angiotensin II Receptors in Experimental Hypertension by : Bo Å Sahlgren
Download or read book Regulation of Angiotensin II Receptors in Experimental Hypertension written by Bo Å Sahlgren and published by . This book was released on 1992 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on the Role of the Anterior Hypothalamic Angiotensin II Pressor System in Experimental Renal Hypertension by : Diane Kathleen Hartle
Download or read book Studies on the Role of the Anterior Hypothalamic Angiotensin II Pressor System in Experimental Renal Hypertension written by Diane Kathleen Hartle and published by . This book was released on 1981 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Role of Angiotensin II Type 2 Receptor in Blood Pressure Regulation in Obese Rats by : Quaisar Ali
Download or read book Role of Angiotensin II Type 2 Receptor in Blood Pressure Regulation in Obese Rats written by Quaisar Ali and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Renin angiotensin system (RAS) consists of enzymes, hormones, proteins and peptides. Angiotensin II (Ang II) is an important peptide of RAS. Ang II acts via AT1 receptor (AT1R) and AT2 receptor (AT2R). While AT1R is known to cause antinatriuresis and increase in blood pressure, the role of AT2R in renal function and long-term BP regulation is not well defined. Recently our laboratory showed that AT2R are upregulated in the kidney of obese rats and selective activation of these receptors stimulates nitric oxide/cGMP pathway, inhibits proximal tubules Na+/K+-ATPase (NKA) activity and increases urinary sodium excretion. In light of those findings, we undertook this project to investigate the role of AT2R in renal function, long-term blood pressure control and interaction with renal AT1R function in obese Zucker rats, an animal model exhibiting hyperinsulinemia, hyperglycemia and hypertension. Also, we studied the mechanism associated with hyperglycemia induced AT2R upregulation in proximal tubule cells. First, we designed experiment to determine whether AT2R has a protective role in blood pressure increase in obese rats. We treated obese Zucker rats with AT2R antagonist PD123319 (PD) for two weeks and BP was measured. Treatment with PD significantly increased the blood pressure, which was associated with increased renal renin expression in obese rats. This suggested that AT2R protect against increase in blood pressure by keeping renal renin expression low. Then, we designed experiments to determine whether chronic AT2R activation affects Na-balance and lowers BP in obese rats. We treated lean and obese Zucker rats with AT2R agonist CGP42112A (CGP) for two weeks. Two weeks treatment caused a decrease in BP by 19 mmHg and in Na-balance in obese but not in lean rats. The plasma renin activity was significantly decreased in both lean and obese CGP-treated rats. The expression of AT2R, AT1R, angiotensin converting enzyme (ACE) and renin in the kidney cortex was not affected by the CGP-treatment of obese or lean rats. However, ACE2 expression and activity was significantly increased in CGP-treated obese rats and not in lean rats. These studies suggest that long-term activation of AT2R decreases BP in obese rats. The reduction in BP by AT2R agonist treatment may have been contributed by a decrease in Na-balance and an enhanced expression and activity of ACE2 in renal cortex. In order to determine whether the reduction in BP and decrease in Na-balance might have been contributed by the ability of AT2R to antagonize renal AT1R function in CGP-treated obese rats, we again treated the obese Zucker rats with CGP for two weeks. We performed the renal function study after two weeks under anesthesia. We found that CGP-treatment of obese rats caused reduction in Ang II pressor response and blunted the candesartan-induced natriuresis/diuresis in these rats suggesting that chronic activation of AT2R antagonizes the function of AT1R. Earlier studies from our laboratory suggest that AT2R promote Na-excretion but the contribution of different nephron segments in AT2R-induced natriuresis is not known. We investigated the involvement of proximal tubule AT2R in natriuresis by blocking the two important distal tubule Na-transporters (NaCl cotransporter and ENaC). We found that selective activation of AT2R with a novel AT2R agonist C21 promoted natriuresis predominantly via proximal tubules. We also performed in vitro experiments (HK2 cells) to elucidate the potential signaling mechanism involved in the proximal tubule AT2R upregulation in diabetes/hyperglycemia. In this experiment, we exposed HK2 cells with high glucose with and without IRF-1 siRNA. High glucose increased AT2R expression in HK2 cells and is mediated via transcriptional mechanism involving the transcription factor IRF-1. Collectively, the data suggest that long-term treatment with AT2R agonist attenuates positive Na-balance, lowers renal renin expression, antagonizes the function of AT1R and decreases blood pressure in obese Zucker rats. Moreover AT2R upregulation in response to hyperglycemia may be compensatory mechanism to exert a beneficial role in kidney function. These findings highlight the therapeutic potential of AT2R for treating obesity/diabetes related hypertension.
Book Synopsis Regulation of Angiotensin II Receptor Subtypes in Experimental Hypertension by : Stephen D. Phipps
Download or read book Regulation of Angiotensin II Receptor Subtypes in Experimental Hypertension written by Stephen D. Phipps and published by . This book was released on 2000 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Angiotensin II Receptor Antagonists by : Murray Epstein
Download or read book Angiotensin II Receptor Antagonists written by Murray Epstein and published by . This book was released on 2001 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent development of several new, non-peptide, orally active angiotensin II receptor antagonists is revolutionizing the treatment of patients with hypertension and various cardiovascular disorders. In this book experts review the current state of angiotensin II antagonists and survey the progress of these diverse applications. Issues relating to angiotensin II and their receptors are examined in relation to their effects on the kidney, non-diabetic renal disease, heart disease, diabetes mellitus, and various other disorders. The combination of AT1 receptor antagonists with other antihypertensive agents is reviewed in depth. The clinical attributes of these drugs are complemented by in-depth reviews of the physiology and pharmacology of angiotensin II peptides. The authors present the most recent findings in ligand recognition, activation, signal coupling, desensitization and functional alterations of vessels, especially small arteries, in patients with hypertension. This book constitutes the only available compendium on the clinical and experimental features of angiotensin II receptor antagonists. The unique features of the rapidly emerging class of drugs are surveyed throughout. Contributions have been made from international experts who have personally contributed to the discovery and development of these novel drugs. Recent cutting-edge physiology and pharmacology studies by renowned international experts provide a platform for considering the clinical applications of these agents.
Book Synopsis Thirst and Sodium Appetite by : Sebastian Peter Grossman
Download or read book Thirst and Sodium Appetite written by Sebastian Peter Grossman and published by . This book was released on 1990 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thirst and Sodium Appetite ...
Book Synopsis The ESC Textbook of Vascular Biology by : Rob Krams
Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Book Synopsis From Hypertension to Heart Failure by : Michael Böhm
Download or read book From Hypertension to Heart Failure written by Michael Böhm and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arterial hypertension, coronary heart disease and heart fail ure are the commonest cardiovascular conditions to present in clinical practice. Over the past few years it has become in creasingly clear that they are closely and causally interrelated and that their relationship can have a significant bearing on prognosis. Epidemiological studies have shown that arterial hypertension is one of the most important risk factors for de veloping heart failure. Only one in four patients with hyper tension is adequately managed, and in 50% of cases, the hypertension has not been recognised or treated. Patients with pre-existing hypertension who go on to suffer an acute myocardial infarction have usually not previously had typi cal angina symptoms, the infarct territory is larger, life threatening arrhythmias are commoner and hence in-hospi tal mortality and long-term prognosis are markedly worse. The presence of raised blood pressure in the post-infarct phase doubles the risk of manifest heart failure. The close relationship between hypertension, coronary heart disease and heart failure makes the choice of therapeu tic strategy particularly important. Agents and classes of agents that have prognostic value in all three conditions should be considered first, as synergy might result in addi tional benefits. In such patients, this sort of therapeutic deci sion-making might have further advantages. The use of these agents may prevent complications which are not yet clinically obvious (such as heart failure).
Book Synopsis Comprehensive Hypertension E-Book by : Gregory Y. H. Lip
Download or read book Comprehensive Hypertension E-Book written by Gregory Y. H. Lip and published by Elsevier Health Sciences. This book was released on 2007-06-28 with total page 1247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is today's most in-depth reference for any cardiologist, internist, or nephrologist interested in hypertension. Drawing from international experience in cardiology, physiology, and nephrology, Drs. Lip and Hall have assembled a group of section editors and contributors second to none. You'll find the long-term effects of primary and secondary hypertension and a lengthy section on hypertensions for special populations featured prominently. Prevention and treatment of hypertension are covered in detail, from lifestyle and diet issues to drug choice and delivery, and the section on comparison of guidelines is unique to this book. Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume. See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations. Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis. Get specific insight into prevention and treatment of hypertension in special populations. Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.
Book Synopsis The Sensory Circumventricular Organs of the Mammalian Brain by : Michael J. McKinley
Download or read book The Sensory Circumventricular Organs of the Mammalian Brain written by Michael J. McKinley and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the only book entirely devoted to the sensory circumventricular organs. It reviews research into their detailed anatomy, neurochemistry, neural connections, and functions, and provides the reader with many illustrations previously unpublished.
