Rna Turnover In Eukaryotes Analysis Of Specialized And Quality Control Rna Decay Pathways

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RNA Turnover in Eukaryotes: Analysis of Specialized and Quality Control RNA Decay Pathways

Author : Lynne E. Maquat
Publisher : Academic Press
ISBN 13 : 0080923321
Total Pages : 463 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis RNA Turnover in Eukaryotes: Analysis of Specialized and Quality Control RNA Decay Pathways by : Lynne E. Maquat

Download or read book RNA Turnover in Eukaryotes: Analysis of Specialized and Quality Control RNA Decay Pathways written by Lynne E. Maquat and published by Academic Press. This book was released on 2011-09-02 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, and RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. - Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway - Expert researchers introduce the most advanced technologies and techniques - Offers step-by-step lab instructions, including necessary equipment and reagents

RNA Turnover in Prokaryotes

Author : Lynne Maquat
Publisher :
ISBN 13 :
Total Pages : 417 pages
Book Rating : 4.:/5 (799 download)

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Book Synopsis RNA Turnover in Prokaryotes by : Lynne Maquat

Download or read book RNA Turnover in Prokaryotes written by Lynne Maquat and published by . This book was released on 2008 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt:

RNA Turnover in Eukaryotes: Nucleases, Pathways and Analysis of mRNA Decay

Author : Lynne E. Maquat
Publisher : Academic Press
ISBN 13 : 0080922074
Total Pages : 661 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis RNA Turnover in Eukaryotes: Nucleases, Pathways and Analysis of mRNA Decay by : Lynne E. Maquat

Download or read book RNA Turnover in Eukaryotes: Nucleases, Pathways and Analysis of mRNA Decay written by Lynne E. Maquat and published by Academic Press. This book was released on 2009-01-30 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. - Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway - Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover, which are central to the process of gene expression - Offers step-by-step lab instructions, including necessary equipment and reagents

RNA Turnover in Eukaryotes

Author : Megerditch Kiledjian
Publisher :
ISBN 13 :
Total Pages : 607 pages
Book Rating : 4.:/5 (294 download)

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Book Synopsis RNA Turnover in Eukaryotes by : Megerditch Kiledjian

Download or read book RNA Turnover in Eukaryotes written by Megerditch Kiledjian and published by . This book was released on 2008 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear-Cytoplasmic Transport

Author : Weidong Yang
Publisher : Springer
ISBN 13 : 3319773097
Total Pages : 277 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Nuclear-Cytoplasmic Transport by : Weidong Yang

Download or read book Nuclear-Cytoplasmic Transport written by Weidong Yang and published by Springer. This book was released on 2018-07-27 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.

RNA Turnover in Prokaryotes

Author : Lynne Maquat
Publisher :
ISBN 13 :
Total Pages : 607 pages
Book Rating : 4.:/5 (799 download)

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Book Synopsis RNA Turnover in Prokaryotes by : Lynne Maquat

Download or read book RNA Turnover in Prokaryotes written by Lynne Maquat and published by . This book was released on 2008 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt:

RNA Exosome

Author : Torben Heick Jensen
Publisher : Springer Science & Business Media
ISBN 13 : 1441978410
Total Pages : 161 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis RNA Exosome by : Torben Heick Jensen

Download or read book RNA Exosome written by Torben Heick Jensen and published by Springer Science & Business Media. This book was released on 2011-06-29 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.

Laboratory Methods in Enzymology: RNA

Author : Jon Lorsch
Publisher : Academic Press
ISBN 13 : 0124200516
Total Pages : 472 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis Laboratory Methods in Enzymology: RNA by : Jon Lorsch

Download or read book Laboratory Methods in Enzymology: RNA written by Jon Lorsch and published by Academic Press. This book was released on 2013-09-11 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols. In this volume, we have brought together a number of core protocols concentrating on RNA, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes. - Indispensable tool for the researcher - Carefully written and edited by experts to contain step-by-step protocols - In this volume we have brought together a number of core protocols concentrating on RNA

RNA Helicases

Author : Eckhard Jankowsky
Publisher : Academic Press
ISBN 13 : 0123965462
Total Pages : 590 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis RNA Helicases by : Eckhard Jankowsky

Download or read book RNA Helicases written by Eckhard Jankowsky and published by Academic Press. This book was released on 2012-06-22 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work integrates the current knowledge about RNA helicases from diverse fields ranging from cell and developmental biology to mechanistic enzymology and structural biology into one useful resource.

Autophagy: Lower Eukaryotes and Non-Mammalian Systems, Part A

Author :
Publisher : Academic Press
ISBN 13 : 0080923267
Total Pages : 821 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Autophagy: Lower Eukaryotes and Non-Mammalian Systems, Part A by :

Download or read book Autophagy: Lower Eukaryotes and Non-Mammalian Systems, Part A written by and published by Academic Press. This book was released on 2011-09-02 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the companion volume to Daniel Klionsky's Autophagy: Lower Eukaryotes, which features the basic methods in autophagy covering yeasts and alternative fungi. Klionsky is one of the leading authorities in the field. He is the editor-in-chief of Autophagy. The November 2007 issue of Nature Reviews highlighted his article, "Autophagy: from phenomenology to molecular understanding in less than a decade. He is currently editing guidelines for the field, with 230 contributing authors that will publish in Autophagy.Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal "house-cleaning in the cell is called autophagy – literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 in yeast. These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes. In the future, this research will help to design clinical approaches that can turn on autophagy and halt tumor growth. - Establishes the functional roles of specific cellular proteins in selective and nonselective autophagy in mammalian cells, which aides researchers in determining why autophagy is shut down in neoplastia (growth of abnormal tissue mass) and turned on during bacterial invasion - Includes methods to evaluate the role of autophagy in the drug-induced cell death of cancer cells in culture, which helps researchers design clinical approaches that can turn on autophagy and halt tumor growth - Covers higher eukaryotes including lifespan in C.elegans to marine organisms and bridging into the clinical aspects, including autophagy in chronic myelogenous leukemia (CML is one of four types of leukemia), lung cancer, prostate cancer, and cardiac cells

The Interplay of Eukaryotic MRNA Translation and Degradation

Author : Wenqian Hu
Publisher :
ISBN 13 :
Total Pages : 121 pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis The Interplay of Eukaryotic MRNA Translation and Degradation by : Wenqian Hu

Download or read book The Interplay of Eukaryotic MRNA Translation and Degradation written by Wenqian Hu and published by . This book was released on 2010 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of mRNA translation and degradation is essential for proper gene expression. In eukaryotes, a major mRNA degradation pathway is initiated by deadenylation, followed by decapping, and ultimately 5'-3' exonucleolytic digestion. Removal of the mRNA 5' cap is an irreversible step in mRNA degradation, and is postulated to require dissociation of the mRNA from the ribosomes and packaging into sub-cellular, ribosome-free granules termed P-bodies. Based on this and other observations, a "two-step" model of eukaryotic mRNA degradation had been proposed that mRNA translation and degradation occur in different compartments within the cell. Recent findings suggest, however, that mRNA degradation may occur independent of P-bodies. Consequently, an important but unresolved issue in the field is to determine the context in which mRNA is degraded. In my study, I have demonstrated that the three steps of mRNA decay, deadenylation, decapping, and 5'-3' exonucleolytic digestion, occur co-translationally. Specifically, mRNA deadenylation does not lead to ribosome dissociation. Second, I found that decapped mRNA mainly bound to polyribosomes, suggesting that decapping occurs during translation. In addition, using kinetic analysis, I demonstrated that mRNA decapping is initiated while the mRNA is on polyribosomes. Third, I observed that in wild-type cells, exonucleolytic decay fragments are polyribosome associated when ribosome transit is slowed in cis. Lastly, using an innovative assay I designed, I detected decapping products from endogenous mRNAs mainly on polyribosomes in wild type cells. These results clearly demonstrate that under normal physiological conditions, mRNA degradation occurs while the mRNA is still associated with ribosomes. In addition to the normal mRNA turnover pathway, I observed that mRNA decapping triggered by nonsense-mediated mRNA decay, an important mRNA quality control mechanism, also occurs on polyribosomes. Collectively, these results indicate that polyribosomes are the major sites for destroying both normal and aberrant mRNAs within eukaryotic cells

Imaging and Spectroscopic Analysis of Living Cells

Author : P. Michael Conn
Publisher : Academic Press
ISBN 13 : 0123918561
Total Pages : 559 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Imaging and Spectroscopic Analysis of Living Cells by : P. Michael Conn

Download or read book Imaging and Spectroscopic Analysis of Living Cells written by P. Michael Conn and published by Academic Press. This book was released on 2012 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology is the third of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. Publisher's note.

Imaging and Spectroscopic Analysis of Living Cells

Author :
Publisher : Academic Press
ISBN 13 : 012391907X
Total Pages : 593 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Imaging and Spectroscopic Analysis of Living Cells by :

Download or read book Imaging and Spectroscopic Analysis of Living Cells written by and published by Academic Press. This book was released on 2012-03-15 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology is the second of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. - Expert authors who are leaders in the field - Extensively referenced and useful figures and tables - Provides hints and tricks to facilitate reproduction of methods

Biophysical, Chemical, and Functional Probes of RNA Structure, Interactions and Folding: Part A

Author : Daniel Herschlag
Publisher : Academic Press
ISBN 13 : 0080922139
Total Pages : 491 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Biophysical, Chemical, and Functional Probes of RNA Structure, Interactions and Folding: Part A by : Daniel Herschlag

Download or read book Biophysical, Chemical, and Functional Probes of RNA Structure, Interactions and Folding: Part A written by Daniel Herschlag and published by Academic Press. This book was released on 2009-11-16 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells. - Expert researchers introduce the most advanced technologies and techniques in protein structure and folding - Includes techniques on tiling assays

Laboratory Methods in Enzymology: DNA

Author :
Publisher : Elsevier
ISBN 13 : 0124199542
Total Pages : 405 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Laboratory Methods in Enzymology: DNA by :

Download or read book Laboratory Methods in Enzymology: DNA written by and published by Elsevier. This book was released on 2013-09-02 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols. In this volume, we have brought together a number of core protocols concentrating on DNA, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes. - Indispensable tool for the researcher - Carefully written and edited by experts to contain step-by-step protocols - In this volume we have brought together a number of core protocols concentrating on DNA

Natural Product Biosynthesis by Microorganisms and Plants Part B

Author :
Publisher : Academic Press
ISBN 13 : 012394628X
Total Pages : 463 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Natural Product Biosynthesis by Microorganisms and Plants Part B by :

Download or read book Natural Product Biosynthesis by Microorganisms and Plants Part B written by and published by Academic Press. This book was released on 2012-10-01 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The second of 3 volumes covering Natural product biosynthesis by microorganisms and plants. - This new volume continues the legacy of this premier serial - Contains quality chapters authored by leaders in the field - The second of 3 volumes it has chapters on such topics as biological chlorination, bromination and iodination, and phylogenetic approaches to natural product structure prediction

Ghrelin

Author :
Publisher : Academic Press
ISBN 13 : 0123812739
Total Pages : 519 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Ghrelin by :

Download or read book Ghrelin written by and published by Academic Press. This book was released on 2012-12-17 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volume covers ghrelin, and has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice. - Contains quality chapters authored by leaders in the field - Has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice