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Review Of The Environmental Protection Agencyaeurs Draft Iris Assessment Of Tetrachloroethylene
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Book Synopsis Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene by : National Research Council
Download or read book Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene written by National Research Council and published by National Academies Press. This book was released on 2010-03-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tetrachloroethylene is a volatile, chlorinated organic hydrocarbon that is widely used as a solvent in the dry-cleaning and textile-processing industries and as an agent for degreasing metal parts. It is an environmental contaminant that has been detected in the air, groundwater, surface waters, and soil. In June 2008, the U.S. Environmental Protection Agency released its draft Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). The draft IRIS assessment provides quantitative estimates of cancer and noncancer effects of exposure to tetrachloreothylene, which will be used to establish airquality and water-quality standards to protect public health and to set cleanup standards for hazardous waste sites. At the request of EPA, the National Research Council conducted an independent scientific review of the draft IRIS assessment of tetrachloroethylene from toxicologic, epidemiologic, and human clinical perspectives. The resulting book evaluates the adequacy of the EPA assessment, the data and methods used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation cancer unit risks posed by tetrachloroethylene; evaluates whether the key studies underlying the draft IRIS assessment are of requisite quality, reliability, and relevance to support the derivation of the reference values and cancer risks; evaluates whether the uncertainties in EPA's risk assessment were adequately described and, where possible, quantified; and identifies research that could reduce the uncertainty in the current understanding of human health effects associated with tetrachloroethylene exposure.
Book Synopsis Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene by : National Research Council (U.
Download or read book Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene written by National Research Council (U. and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Review of EPA's Integrated Risk Information System (IRIS) Process by : National Research Council
Download or read book Review of EPA's Integrated Risk Information System (IRIS) Process written by National Research Council and published by National Academies Press. This book was released on 2014-06-25 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and other organizations have come to rely on IRIS assessments for setting regulatory standards, establishing exposure guidelines, and estimating risks to exposed populations. Over the last decade, the National Research Council (NRC) has been asked to review some of the more complex and challenging IRIS assessments, including those of formaldehyde, dioxin, and tetrachloroethylene. In 2011, an NRC committee released its review of the IRIS formaldehyde assessment. Like other NRC committees that had reviewed IRIS assessments, the formaldehyde committee identified deficiencies in the specific assessment and more broadly in some of EPA's general approaches and specific methods. Although the committee focused on evaluating the IRIS formaldehyde assessment, it provided suggestions for improving the IRIS process and a roadmap for its revision in case EPA decided to move forward with changes to the process. Congress directed EPA to implement the report's recommendations and then asked the National Research Council to review the changes that EPA was making (or proposing to make) in response to the recommendations. Review of EPA's Integrated Risk Information System (IRIS) Process provides an overview of some general issues associated with IRIS assessments. This report then addresses evidence identification and evaluation for IRIS assessments and discusses evidence integration for hazard evaluation and methods for calculating reference values and unit risks. The report makes recommendations and considerations for future directions. Overall, Review of EPA's Integrated Risk Information System Process finds that substantial improvements in the IRIS process have been made, and it is clear that EPA has embraced and is acting on the recommendations in the NRC formaldehyde report. The recommendations of this report should be seen as building on the progress that EPA has already made.
Book Synopsis Review of the Environmental Protection Agencyâ€s Draft IRIS Assessment of Tetrachloroethylene by :
Download or read book Review of the Environmental Protection Agencyâ€s Draft IRIS Assessment of Tetrachloroethylene written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight Publisher : ISBN 13 : Total Pages :328 pages Book Rating :4.:/5 (319 download)
Book Synopsis EPA's IRIS Program by : United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight
Download or read book EPA's IRIS Program written by United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight and published by . This book was released on 2011 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Review of Draft Trichloroethylene Health Risk Assessment by :
Download or read book Review of Draft Trichloroethylene Health Risk Assessment written by and published by . This book was released on 2003 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis IRIS Toxicological Review of Tetrachloroethylene (perchloroethylene) (external Review Draft). by :
Download or read book IRIS Toxicological Review of Tetrachloroethylene (perchloroethylene) (external Review Draft). written by and published by . This book was released on 2008 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Academies of Sciences, Engineering, and Medicine Publisher : ISBN 13 :9780309090889 Total Pages :120 pages Book Rating :4.0/5 (98 download)
Book Synopsis Review of U. S. EPA's ORD Staff Handbook for Developing IRIS Assessments by : National Academies of Sciences, Engineering, and Medicine
Download or read book Review of U. S. EPA's ORD Staff Handbook for Developing IRIS Assessments written by National Academies of Sciences, Engineering, and Medicine and published by . This book was released on 2022-08-30 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) program develops human health assessments that focus on hazard identification and dose-response analyses for chemicals in the environment. The ORD Staff Handbook for Developing IRIS Assessments (the handbook) provides guidance to scientists who perform the IRIS assessments in order to foster consistency in the assessments and enhance transparency about the IRIS assessment process. At the request of the EPA, this report reviews the procedures and considerations for operationalizing the principles of systematic reviews and the methods described in the handbook for determining the scope of the IRIS assessments, evidence integration, extrapolation techniques, dose-response analyses, and characterization of uncertainties.
Book Synopsis Health Assessment Document for Tetrachloroethylene (perchloroethylene) by : Mark M. Greenberg
Download or read book Health Assessment Document for Tetrachloroethylene (perchloroethylene) written by Mark M. Greenberg and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Health Assessment Document for Tetrachloroethylene (perchloroethylene) by : Mark M. Greenberg
Download or read book Health Assessment Document for Tetrachloroethylene (perchloroethylene) written by Mark M. Greenberg and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Academies of Sciences, Engineering, and Medicine (U.S.). Committee to Review Advances Made to the IRIS Process Publisher : ISBN 13 : Total Pages :119 pages Book Rating :4.:/5 (13 download)
Book Synopsis Progress Toward Transforming the Integrated Risk Information System (IRIS) Program by : National Academies of Sciences, Engineering, and Medicine (U.S.). Committee to Review Advances Made to the IRIS Process
Download or read book Progress Toward Transforming the Integrated Risk Information System (IRIS) Program written by National Academies of Sciences, Engineering, and Medicine (U.S.). Committee to Review Advances Made to the IRIS Process and published by . This book was released on 2018 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Over the past several years, the US Environmental Protection Agency (EPA) has been transforming the procedures of its Integrated Risk Information System (IRIS), a program that produces hazard and dose‒response assessments of environmental chemicals and derives toxicity values that can be used to estimate risks posed by exposures to them. The transformation was initiated after suggestions for program reforms were provided in a 2011 report from the National Academies of Sciences, Engineering, and Medicine that reviewed a draft IRIS assessment of formaldehyde. In 2014, the National Academies released a report that reviewed the IRIS program and evaluated the changes implemented in it since the 2011 report. Since 2014, new leadership of EPA’s National Center for Environmental Assessment (NCEA) and IRIS program has instituted even more substantive changes in the IRIS program in response to the recommendations in the 2014 report. Progress Toward Transforming the Integrated Risk Information System Program: A 2018 Evaluation reviews the EPA’s progress toward addressing the past recommendations from the National Academies" -- Publisher's description
