Review Of Draft Trichloroethylene Health Risk Assessment

Download Review Of Draft Trichloroethylene Health Risk Assessment full books in PDF, epub, and Kindle. Read online Review Of Draft Trichloroethylene Health Risk Assessment ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309499240
Total Pages : 77 pages
Book Rating : 4.3/5 (94 download)

DOWNLOAD NOW!

Book Synopsis Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene by : National Academies of Sciences, Engineering, and Medicine

Download or read book Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-01-13 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trichloroethylene (TCE) is a solvent that is used as a degreasing agent, a chemical intermediate in refrigerant manufacture, and a component of spot removers and adhesives. It is produced in mass quantities but creates dangerous vapors and is an environmental contaminant at many industrial and government facilities, including facilities run by the U.S. Department of Defense (DoD). It is important to determine the safe occupational exposure level (OEL) for the solvent in order to protect the health of workers who are exposed to its vapors. However, there are concerns that the current occupational standards insufficiently protect workers from these health threats. Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene makes recommendations to improve the DoD's approach to developing an OEL for TCE, strengthen transparency of the process, and improve confidence in the final OEL value. This report reviews the DoD's approach using a literature review, evidence synthesis based on weight of evidence [WOE], point-of-departure derivation, physiologically based pharmacokinetic modeling, extrapolation tools, and explores other elements of the process of deriving an OEL for TCE. It examines scientific approaches to developing exposure values and cancer risk levels, defining the scope of the problem, and improving hazard identification.

Assessing the Human Health Risks of Trichloroethylene

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309102839
Total Pages : 449 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Assessing the Human Health Risks of Trichloroethylene by : National Research Council

Download or read book Assessing the Human Health Risks of Trichloroethylene written by National Research Council and published by National Academies Press. This book was released on 2007-01-08 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews. Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment. Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk.

Review of Draft Trichloroethylene Health Risk Assessment

Author :
Publisher :
ISBN 13 :
Total Pages : 83 pages
Book Rating : 4.:/5 (758 download)

DOWNLOAD NOW!

Book Synopsis Review of Draft Trichloroethylene Health Risk Assessment by :

Download or read book Review of Draft Trichloroethylene Health Risk Assessment written by and published by . This book was released on 2003 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Special Occupational Hazard Review of Trichloroethylene

Author : Norbert P. Page
Publisher :
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.:/5 (318 download)

DOWNLOAD NOW!

Book Synopsis Special Occupational Hazard Review of Trichloroethylene by : Norbert P. Page

Download or read book Special Occupational Hazard Review of Trichloroethylene written by Norbert P. Page and published by . This book was released on 1978 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309152356
Total Pages : 187 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene by : National Research Council

Download or read book Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene written by National Research Council and published by National Academies Press. This book was released on 2010-03-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tetrachloroethylene is a volatile, chlorinated organic hydrocarbon that is widely used as a solvent in the dry-cleaning and textile-processing industries and as an agent for degreasing metal parts. It is an environmental contaminant that has been detected in the air, groundwater, surface waters, and soil. In June 2008, the U.S. Environmental Protection Agency released its draft Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). The draft IRIS assessment provides quantitative estimates of cancer and noncancer effects of exposure to tetrachloreothylene, which will be used to establish airquality and water-quality standards to protect public health and to set cleanup standards for hazardous waste sites. At the request of EPA, the National Research Council conducted an independent scientific review of the draft IRIS assessment of tetrachloroethylene from toxicologic, epidemiologic, and human clinical perspectives. The resulting book evaluates the adequacy of the EPA assessment, the data and methods used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation cancer unit risks posed by tetrachloroethylene; evaluates whether the key studies underlying the draft IRIS assessment are of requisite quality, reliability, and relevance to support the derivation of the reference values and cancer risks; evaluates whether the uncertainties in EPA's risk assessment were adequately described and, where possible, quantified; and identifies research that could reduce the uncertainty in the current understanding of human health effects associated with tetrachloroethylene exposure.

Health Risk Assessment of Trichloroethylene (TCE) in California Drinking Water

Author :
Publisher :
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.3/5 (121 download)

DOWNLOAD NOW!

Book Synopsis Health Risk Assessment of Trichloroethylene (TCE) in California Drinking Water by :

Download or read book Health Risk Assessment of Trichloroethylene (TCE) in California Drinking Water written by and published by . This book was released on 1988 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Health assessment document for trichloroethylene

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (478 download)

DOWNLOAD NOW!

Book Synopsis Health assessment document for trichloroethylene by :

Download or read book Health assessment document for trichloroethylene written by and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trichloroethylene (TCE) Evaluation of Human Health Hazards

Author : California. Hazard Evaluation System and Information Service
Publisher :
ISBN 13 :
Total Pages : 88 pages
Book Rating : 4.:/5 (311 download)

DOWNLOAD NOW!

Book Synopsis Trichloroethylene (TCE) Evaluation of Human Health Hazards by : California. Hazard Evaluation System and Information Service

Download or read book Trichloroethylene (TCE) Evaluation of Human Health Hazards written by California. Hazard Evaluation System and Information Service and published by . This book was released on 1982 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicological Profile for Trichloroethylene

Author :
Publisher :
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.:/5 (321 download)

DOWNLOAD NOW!

Book Synopsis Toxicological Profile for Trichloroethylene by :

Download or read book Toxicological Profile for Trichloroethylene written by and published by . This book was released on 1995 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trichloroethylene Health Risks

Author : Cheryl Siegel Scott
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 ( download)

DOWNLOAD NOW!

Book Synopsis Trichloroethylene Health Risks by : Cheryl Siegel Scott

Download or read book Trichloroethylene Health Risks written by Cheryl Siegel Scott and published by . This book was released on 2000 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

An Exposure and Risk Assessment for Trichloroethylene

Author : Richard G. Thomas
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (136 download)

DOWNLOAD NOW!

Book Synopsis An Exposure and Risk Assessment for Trichloroethylene by : Richard G. Thomas

Download or read book An Exposure and Risk Assessment for Trichloroethylene written by Richard G. Thomas and published by . This book was released on 1981 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Proposed Identification of Trichloroethylene as a Toxic Air Contaminant: Public comments and ARB

Author :
Publisher :
ISBN 13 :
Total Pages : 74 pages
Book Rating : 4.:/5 (318 download)

DOWNLOAD NOW!

Book Synopsis Proposed Identification of Trichloroethylene as a Toxic Air Contaminant: Public comments and ARB by :

Download or read book Proposed Identification of Trichloroethylene as a Toxic Air Contaminant: Public comments and ARB written by and published by . This book was released on 1990 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Proposed Identification of Trichloroethylene as a Toxic Air Contaminant: Health assessment

Author :
Publisher :
ISBN 13 :
Total Pages : 138 pages
Book Rating : 4.3/5 (121 download)

DOWNLOAD NOW!

Book Synopsis Proposed Identification of Trichloroethylene as a Toxic Air Contaminant: Health assessment by :

Download or read book Proposed Identification of Trichloroethylene as a Toxic Air Contaminant: Health assessment written by and published by . This book was released on 1990 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trichloroethylene Health Risk Assessment--synthesis and Characterization

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (53 download)

DOWNLOAD NOW!

Book Synopsis Trichloroethylene Health Risk Assessment--synthesis and Characterization by :

Download or read book Trichloroethylene Health Risk Assessment--synthesis and Characterization written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Special Occupational Hazard Review of Trichloroethyleme

Author : U.S. Department of Health, Education, and Welfare
Publisher :
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.F/5 ( download)

DOWNLOAD NOW!

Book Synopsis Special Occupational Hazard Review of Trichloroethyleme by : U.S. Department of Health, Education, and Welfare

Download or read book Special Occupational Hazard Review of Trichloroethyleme written by U.S. Department of Health, Education, and Welfare and published by . This book was released on 1978 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trichloroethylene

Author : Medical University of South Carolina. Environmental Biosciences Program
Publisher :
ISBN 13 : 9780965765077
Total Pages : 136 pages
Book Rating : 4.7/5 (65 download)

DOWNLOAD NOW!

Book Synopsis Trichloroethylene by : Medical University of South Carolina. Environmental Biosciences Program

Download or read book Trichloroethylene written by Medical University of South Carolina. Environmental Biosciences Program and published by . This book was released on 2004-10-01 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific papers prepared in conjunction with symposium (Charleston, SC; October, 2004) presentations providing a comprehensive review of knowledge related to potential human health risks associated with trichloroethylene exposure and the scientific research that is ongoing and is needed to diminish uncertainty in the assessment of such potential risks.

Trichloroethylene: Toxicity and Health Risks

Author : Kathleen M. Gilbert
Publisher : Springer
ISBN 13 : 9781447172413
Total Pages : 0 pages
Book Rating : 4.1/5 (724 download)

DOWNLOAD NOW!

Book Synopsis Trichloroethylene: Toxicity and Health Risks by : Kathleen M. Gilbert

Download or read book Trichloroethylene: Toxicity and Health Risks written by Kathleen M. Gilbert and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.