Responsible Research With Biological Select Agents And Toxins

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Responsible Research with Biological Select Agents and Toxins

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030914535X
Total Pages : 188 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Responsible Research with Biological Select Agents and Toxins by : National Research Council

Download or read book Responsible Research with Biological Select Agents and Toxins written by National Research Council and published by National Academies Press. This book was released on 2010-02-12 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effort to understand and combat infectious diseases has, during the centuries, produced many key advances in science and medicine-including the development of vaccines, drugs, and other treatments. A subset of this research is conducted with agents that, like anthrax, not only pose a severe threat to the health of humans, plants, and animals but can also be used for ill-intended purposes. Such agents have been listed by the government as biological select agents and toxins. The 2001 anthrax letter attacks prompted the creation of new regulations aimed at increasing security for research with dangerous pathogens. The outcome of the anthrax letter investigation has raised concern about whether these measures are adequate. Responsible Research with Biological Select Agents and Toxins evaluates both the physical security of select agent laboratories and personnel reliability measures designed to ensure the trustworthiness of those with access to biological select agents and toxins. The book offers a set of guiding principles and recommended changes to minimize security risk and facilitate the productivity of research. The book recommends fostering a culture of trust and responsibility in the laboratory, engaging the community in oversight of the Select Agent Program, and enhancing the operation of the Select Agent Program.

Dual Use Research of Concern in the Life Sciences

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309458889
Total Pages : 115 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Dual Use Research of Concern in the Life Sciences by : National Academies of Sciences, Engineering, and Medicine

Download or read book Dual Use Research of Concern in the Life Sciences written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-10-01 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential misuse of advances in life sciences research is raising concerns about national security threats. Dual Use Research of Concern in the Life Sciences: Current Issues and Controversies examines the U.S. strategy for reducing biosecurity risks in life sciences research and considers mechanisms that would allow researchers to manage the dissemination of the results of research while mitigating the potential for harm to national security.

High-Containment Laboratories

Author : United States Government Accountability Office
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781984167101
Total Pages : 104 pages
Book Rating : 4.1/5 (671 download)

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Book Synopsis High-Containment Laboratories by : United States Government Accountability Office

Download or read book High-Containment Laboratories written by United States Government Accountability Office and published by Createspace Independent Publishing Platform. This book was released on 2018-02-03 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-Containment Laboratories: National Strategy for Oversight Is Needed

Biotechnology Research in an Age of Terrorism

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309089778
Total Pages : 164 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Biotechnology Research in an Age of Terrorism by : National Research Council

Download or read book Biotechnology Research in an Age of Terrorism written by National Research Council and published by National Academies Press. This book was released on 2004-03-02 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

Biodefense in the Age of Synthetic Biology

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309465184
Total Pages : 189 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Biodefense in the Age of Synthetic Biology by : National Academies of Sciences, Engineering, and Medicine

Download or read book Biodefense in the Age of Synthetic Biology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Responsible Research with Biological Select Agents and Toxins

Author : Committee on Laboratory Security and Personnel Reliability Assurance Systems for Laboratories Conducting Research on Biological Select Agents and Toxins
Publisher :
ISBN 13 : 9780309385411
Total Pages : pages
Book Rating : 4.3/5 (854 download)

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Book Synopsis Responsible Research with Biological Select Agents and Toxins by : Committee on Laboratory Security and Personnel Reliability Assurance Systems for Laboratories Conducting Research on Biological Select Agents and Toxins

Download or read book Responsible Research with Biological Select Agents and Toxins written by Committee on Laboratory Security and Personnel Reliability Assurance Systems for Laboratories Conducting Research on Biological Select Agents and Toxins and published by . This book was released on 2010-01-12 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The effort to understand and combat infectious diseases has, during the centuries, produced many key advances in science and medicine--including the development of vaccines, drugs, and other treatments. A subset of this research is conducted with agents that, like anthrax, not only pose a severe threat to the health of humans, plants, and animals but can also be used for ill-intended purposes. Such agents have been listed by the government as biological select agents and toxins. The 2001 anthrax letter attacks prompted the creation of new regulations aimed at increasing security for research with dangerous pathogens. The outcome of the anthrax letter investigation has raised concern about whether these measures are adequate. Responsible Research with Biological Select Agents and Toxins evaluates both the physical security of select agent laboratories and personnel reliability measures designed to ensure the trustworthiness of those with access to biological select agents and toxins. The book offers a set of guiding principles and recommended changes to minimize security risk and facilitate the productivity of research. The book recommends fostering a culture of trust and responsibility in the laboratory, engaging the community in oversight of the Select Agent Program, and enhancing the operation of the Select Agent Program.

Potential Risks and Benefits of Gain-of-Function Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309367867
Total Pages : 131 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Potential Risks and Benefits of Gain-of-Function Research by : National Research Council

Download or read book Potential Risks and Benefits of Gain-of-Function Research written by National Research Council and published by National Academies Press. This book was released on 2015-04-13 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research. Potential Risks and Benefits of Gain-of-Function Research is the summary of a two-day public symposia on GOF research. Convened in December 2014 by the Institute of Medicine and the National Research Council, the main focus of this event was to discuss principles important for, and key considerations in, the design of risk and benefit assessments of GOF research. Participants examined the underlying scientific and technical questions that are the source of current discussion and debate over GOF research involving pathogens with pandemic potential. This report is a record of the presentations and discussion of the meeting.

Biological Safety

Author : Dawn P. Wooley
Publisher : John Wiley & Sons
ISBN 13 : 155581963X
Total Pages : 759 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Biological Safety by : Dawn P. Wooley

Download or read book Biological Safety written by Dawn P. Wooley and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk—no matter how small—must be considered, assessed, and properly mitigated. If the science isn't safe, it isn't good. Now in its fifth edition, Biological safety: Principles and Practices remains the most comprehensive biosafety reference. Led by editors Karen Byers and Dawn Wooley, a team of expert contributors have outlined the technical nuts and bolts of biosafety and biosecurity within these pages. This book presents the guiding principles of laboratory safety, including: the identification, assessment, and control of the broad variety of risks encountered in the lab; the production facility; and, the classroom. Specifically, Biological Safety covers protection and control elements—from biosafety level cabinets and personal protection systems to strategies and decontamination methods administrative concerns in biorisk management, including regulations, guidelines, and compliance various aspects of risk assessment covering bacterial pathogens, viral agents, mycotic agents, protozoa and helminths, gene transfer vectors, zooonotic agents, allergens, toxins, and molecular agents as well as decontamination, aerobiology, occupational medicine, and training A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological safety is also a critical reference for laboratory managers, and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses.

The Comprehensive Sourcebook of Bacterial Protein Toxins

Author : Joseph E. Alouf
Publisher : Elsevier
ISBN 13 : 0080456987
Total Pages : 1072 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis The Comprehensive Sourcebook of Bacterial Protein Toxins by : Joseph E. Alouf

Download or read book The Comprehensive Sourcebook of Bacterial Protein Toxins written by Joseph E. Alouf and published by Elsevier. This book was released on 2005-12-20 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology - Includes the major toxins of both basic and clinical interest are described in depth - Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology - Evolutionary and functional aspects of bacterial toxins evaluated and summarized - Toxin applications in cell biology presented - Therapy (cancer therapy, dystonias) discussed - Vaccines (native and genetically engineered vaccines) featured - Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309225752
Total Pages : 216 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories by : National Research Council

Download or read book Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories written by National Research Council and published by National Academies Press. This book was released on 2012-04-02 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: During July 10-13, 2011, 68 participants from 32 countries gathered in Istanbul, Turkey for a workshop organized by the United States National Research Council on Anticipating Biosecurity Challenges of the Global Expansion of High-containment Biological Laboratories. The United States Department of State's Biosecurity Engagement Program sponsored the workshop, which was held in partnership with the Turkish Academy of Sciences. The international workshop examined biosafety and biosecurity issues related to the design, construction, maintenance, and operation of high-containment biological laboratories- equivalent to United States Centers for Disease Control and Prevention biological safety level 3 or 4 labs. Although these laboratories are needed to characterize highly dangerous human and animal pathogens, assist in disease surveillance, and produce vaccines, they are complex systems with inherent risks. Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories summarizes the workshop discussion, which included the following topics: Technological options to meet diagnostic, research, and other goals; Laboratory construction and commissioning; Operational maintenance to provide sustainable capabilities, safety, and security; and Measures for encouraging a culture of responsible conduct. Workshop attendees described the history and current challenges they face in their individual laboratories. Speakers recounted steps they were taking to improve safety and security, from running training programs to implementing a variety of personnel reliability measures. Many also spoke about physical security, access controls, and monitoring pathogen inventories. Workshop participants also identified tensions in the field and suggested possible areas for action.

Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309486564
Total Pages : 121 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts by : National Academies of Sciences, Engineering, and Medicine

Download or read book Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-05-01 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: On June 27-28, 2018, the U.S. National Academies of Sciences, Engineering, and Medicine (the National Academies) convened an international workshop in Amsterdam, the Netherlands, on developing norms for the provision of laboratories in low-resource contexts. The U.S. Department of State's Biosecurity Engagement Program requested that the National Academies organize this workshop to engage an international group of organizations that provide funding for construction, upgrades, and maintenance of biological laboratories in countries without the means to build such labs themselves. Twenty-one people from 19 organizations participated. The intent was to advance the conversation about the identification and application of guiding principles and common norms for use by these organizations in their grants, partnerships, and aid. This publication summarizes the presentations and discussions from the workshop.

Research Regulatory Compliance

Author : Mark A. Suckow
Publisher : Academic Press
ISBN 13 : 0124200656
Total Pages : 345 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis Research Regulatory Compliance by : Mark A. Suckow

Download or read book Research Regulatory Compliance written by Mark A. Suckow and published by Academic Press. This book was released on 2015-06-14 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research Regulatory Compliance offers the latest information on regulations and compliance in the laboratory. With the increasing complexity of regulations and need for institutional infrastructure to deal with compliance of animal use issues, as well as a requirement surrounding human subjects, this publication provides reputable guidance and information. The book is extremely helpful as a resource for researchers, administrators, and technicians in the laboratory, and is also a great asset for faculty or new researchers coming in to the laboratory environment. It will help prepare users for the deluge of regulatory and compliance issues they will face while conducting their scientific programs. The book is edited and authored by known leaders in the field of compliance and regulations, and contains extensive research on the topics. It represents the new standard for information in every laboratory. - Provides a "one-stop" , go-to resource for the many regulatory and compliance issues that affect laboratory study and research models - Extremely helpful as a resource for researchers, administrators, and technicians in the laboratory, and also a great asset for faculty or new researchers coming in to the laboratory environment - Focuses on United States regulations, covering both animal models and human subjects - Written and edited by known leaders in the field of regulatory compliance who bring many years of collective experience to the book

Responsible Conduct of Research

Author : Adil E. Shamoo
Publisher : Oxford University Press
ISBN 13 : 0199709602
Total Pages : 441 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Responsible Conduct of Research by : Adil E. Shamoo

Download or read book Responsible Conduct of Research written by Adil E. Shamoo and published by Oxford University Press. This book was released on 2009-02-12 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scandals and controversies, such as data fabrication in federally funded science, data manipulation and distortion in private industry, and human embryonic stem cell research, illustrate the importance of ethics in science. Responsible Conduct of Research, now in a completely updated second edition, provides an introduction to the social, ethical, and legal issues facing scientists today.

Bioterrorism and Biocrimes

Author : W. Seth Carus
Publisher : The Minerva Group, Inc.
ISBN 13 : 9781410100238
Total Pages : 224 pages
Book Rating : 4.1/5 (2 download)

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Book Synopsis Bioterrorism and Biocrimes by : W. Seth Carus

Download or read book Bioterrorism and Biocrimes written by W. Seth Carus and published by The Minerva Group, Inc.. This book was released on 2002 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The working paper is divided into two main parts. The first part is a descriptive analysis of the illicit use of biological agents by criminals and terrorists. It draws on a series of case studies documented in the second part. The case studies describe every instance identifiable in open source materials in which a perpetrator used, acquired, or threatened to use a biological agent. While the inventory of cases is clearly incomplete, it provides an empirical basis for addressing a number of important questions relating to both biocrimes and bioterrorism. This material should enable policymakers concerned with bioterrorism to make more informed decisions. In the course of this project, the author has researched over 270 alleged cases involving biological agents. This includes all incidents found in open sources that allegedly occurred during the 20th Century. While the list is certainly not complete, it provides the most comprehensive existing unclassified coverage of instances of illicit use of biological agents.

Biosafety in the Laboratory

Author : Division on Engineering and Physical Sciences
Publisher : National Academies Press
ISBN 13 : 0309039754
Total Pages : 237 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Biosafety in the Laboratory by : Division on Engineering and Physical Sciences

Download or read book Biosafety in the Laboratory written by Division on Engineering and Physical Sciences and published by National Academies Press. This book was released on 1989-01-01 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosafety in the Laboratory is a concise set of practical guidelines for handling and disposing of biohazardous material. The consensus of top experts in laboratory safety, this volume provides the information needed for immediate improvement of safety practices. It discusses high- and low-risk biological agents (including the highest-risk materials handled in labs today), presents the "seven basic rules of biosafety," addresses special issues such as the shipping of dangerous materials, covers waste disposal in detail, offers a checklist for administering laboratory safetyâ€"and more.

Aerobiology

Author : Harry Salem
Publisher : Royal Society of Chemistry
ISBN 13 : 1849735948
Total Pages : 518 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Aerobiology by : Harry Salem

Download or read book Aerobiology written by Harry Salem and published by Royal Society of Chemistry. This book was released on 2016-04-26 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focusses on the toxicological aspects of aerobiology, considering the adverse health effects associated with the inhalation of airborne biological particulates.

Heart and Toxins

Author : Dr. Meenakshisundaram Sundaram Ramachandran
Publisher : Elsevier
ISBN 13 : 0124165990
Total Pages : 668 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Heart and Toxins by : Dr. Meenakshisundaram Sundaram Ramachandran

Download or read book Heart and Toxins written by Dr. Meenakshisundaram Sundaram Ramachandran and published by Elsevier. This book was released on 2014-08-12 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Heart and Toxins brings together global experts to provide the latest information and clinical trials that make the connection between genetic susceptibility, gene expression, and environmental factors in cardiovascular diseases. This unique reference, edited by renowned cardiologist Meenakshi Sundaram Ramachandran, solves the problem of managing multiple clinical cases of cardiovascular toxicity. It allows connections to be made between research, diagnosis, and treatment to avoid higher morbidity and mortality rates as a result of cardiovascular toxicity. - Structured to bring together exploration into the epidemiology, molecular mechanism, pathogenesis, environmental factors and management in cardiovascular toxins - Included various topics on cardiovascular toxins such as plant, chemical, animal, nanomaterial and marine biology induced cardiac damage – which are new ideas discussed in detail - Comprehensive chapters on the cardiovascular toxicity from drugs, radiotherapy and radiological imaging - Enables you to manage multiple clinical cases of cardiovascular toxicity - Outlined conclusions at the end of each chapter providing "key learning points to help you organize the chapter's details without losing insight