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Response Relapse Models For Clinical Trials
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Book Synopsis Small Clinical Trials by : Institute of Medicine
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Book Synopsis Addictive Behaviors by : G. Alan Marlatt
Download or read book Addictive Behaviors written by G. Alan Marlatt and published by Amer Psychological Assn. This book was released on 1997-01 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: The destructive power of addiction manifests itself in ill health effects, social and family problems, and economic an and legal troubles. This extensive collection of reprinted articles from American Psychological Association journals provides a current view of psychological research on addictive behaviors.
Book Synopsis Pathways of Addiction by : Institute of Medicine
Download or read book Pathways of Addiction written by Institute of Medicine and published by National Academies Press. This book was released on 1996-10-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Book Synopsis Relapse Prevention by : G. Alan Marlatt
Download or read book Relapse Prevention written by G. Alan Marlatt and published by Guilford Press. This book was released on 2007-12-26 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important work elucidates why relapse is so common for people recovering from addictive behavior problems--and what can be done to keep treatment on track. It provides an empirically supported framework for helping people with addictive behavior problems develop the skills to maintain their treatment goals, even in high-risk situations, and deal effectively with setbacks that occur. The expert contributors clearly identify the obstacles that arise in treating specific problem behaviors, review the factors that may trigger relapse at different stages of recovery, and present procedures for teaching effective cognitive and behavioral coping strategies.
Book Synopsis Transforming Clinical Research in the United States by : Institute of Medicine
Download or read book Transforming Clinical Research in the United States written by Institute of Medicine and published by National Academies Press. This book was released on 2010-10-22 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls far short of this vision. The process of generating medical evidence through clinical trials in the United States is expensive and lengthy, includes a number of regulatory hurdles, and is based on a limited infrastructure. The link between clinical research and medical progress is also frequently misunderstood or unsupported by both patients and providers. The focus of clinical research changes as diseases emerge and new treatments create cures for old conditions. As diseases evolve, the ultimate goal remains to speed new and improved medical treatments to patients throughout the world. To keep pace with rapidly changing health care demands, clinical research resources need to be organized and on hand to address the numerous health care questions that continually emerge. Improving the overall capacity of the clinical research enterprise will depend on ensuring that there is an adequate infrastructure in place to support the investigators who conduct research, the patients with real diseases who volunteer to participate in experimental research, and the institutions that organize and carry out the trials. To address these issues and better understand the current state of clinical research in the United States, the Institute of Medicine's (IOM) Forum on Drug Discovery, Development, and Translation held a 2-day workshop entitled Transforming Clinical Research in the United States. The workshop, summarized in this volume, laid the foundation for a broader initiative of the Forum addressing different aspects of clinical research. Future Forum plans include further examining regulatory, administrative, and structural barriers to the effective conduct of clinical research; developing a vision for a stable, continuously funded clinical research infrastructure in the United States; and considering strategies and collaborative activities to facilitate more robust public engagement in the clinical research enterprise.
Download or read book Mindfulness written by Katie Witkiewitz and published by Hogrefe Publishing GmbH. This book was released on 2018-03-13 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clear and compact guidance on integrating mindfulness into practice This clear and concise book provides practical, evidence-based guidance on the use of mindfulness in treatment: its mechanism of action, the disorders for which there is empirical evidence of efficacy, mindfulness practices and techniques, and how to integrate them into clinical practice. Leading experts describe the concepts and roots of mindfulness, and examine the science that has led to this extraordinarily rich and ancient practice becoming a foundation to many contemporary, evidenced-based approaches in psychotherapy. The efficacy of mindfulness-based interventions in conditions as diverse as borderline personality disorder, post-traumatic stress disorder, depression, alcohol and substance use, emotional dysregulation, attention-deficit hyperactivity disorder, chronic stress, eating disorders, and other medical conditions including type 2 diabetes and rheumatoid arthritis is also described. The book is invaluable reading for all those curious about the current science around mindfulness and about how and when to incorporate it effectively into clinical practice.
Book Synopsis Analysis of Survival Data by : D.R. Cox
Download or read book Analysis of Survival Data written by D.R. Cox and published by CRC Press. This book was released on 1984-06-01 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph contains many ideas on the analysis of survival data to present a comprehensive account of the field. The value of survival analysis is not confined to medical statistics, where the benefit of the analysis of data on such factors as life expectancy and duration of periods of freedom from symptoms of a disease as related to a treatment applied individual histories and so on, is obvious. The techniques also find important applications in industrial life testing and a range of subjects from physics to econometrics. In the eleven chapters of the book the methods and applications of are discussed and illustrated by examples.
Book Synopsis Psychosocial Treatments by : Elinore McCance-Katz
Download or read book Psychosocial Treatments written by Elinore McCance-Katz and published by Routledge. This book was released on 2004-06-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors of this volume have assembled recent articles discussing elements of each of the several commonly used psychosocial interventions -- including relapse prevention therapy, community reinforcement, voucher-based programs, self-help therapies, and motivational enhancement therapy--in addition to research-based articles that demonstrate the efficacy of these approaches. The selections in this book will provide the reader with a broad overview of the field as well as the specific information needed to use these therapies in a variety of clinical settings.
Book Synopsis Sharing Clinical Research Data by : Institute of Medicine
Download or read book Sharing Clinical Research Data written by Institute of Medicine and published by National Academies Press. This book was released on 2013-06-07 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical companies, academic researchers, and government agencies such as the Food and Drug Administration and the National Institutes of Health all possess large quantities of clinical research data. If these data were shared more widely within and across sectors, the resulting research advances derived from data pooling and analysis could improve public health, enhance patient safety, and spur drug development. Data sharing can also increase public trust in clinical trials and conclusions derived from them by lending transparency to the clinical research process. Much of this information, however, is never shared. Retention of clinical research data by investigators and within organizations may represent lost opportunities in biomedical research. Despite the potential benefits that could be accrued from pooling and analysis of shared data, barriers to data sharing faced by researchers in industry include concerns about data mining, erroneous secondary analyses of data, and unwarranted litigation, as well as a desire to protect confidential commercial information. Academic partners face significant cultural barriers to sharing data and participating in longer term collaborative efforts that stem from a desire to protect intellectual autonomy and a career advancement system built on priority of publication and citation requirements. Some barriers, like the need to protect patient privacy, pre- sent challenges for both sectors. Looking ahead, there are also a number of technical challenges to be faced in analyzing potentially large and heterogeneous datasets. This public workshop focused on strategies to facilitate sharing of clinical research data in order to advance scientific knowledge and public health. While the workshop focused on sharing of data from preplanned interventional studies of human subjects, models and projects involving sharing of other clinical data types were considered to the extent that they provided lessons learned and best practices. The workshop objectives were to examine the benefits of sharing of clinical research data from all sectors and among these sectors, including, for example: benefits to the research and development enterprise and benefits to the analysis of safety and efficacy. Sharing Clinical Research Data: Workshop Summary identifies barriers and challenges to sharing clinical research data, explores strategies to address these barriers and challenges, including identifying priority actions and "low-hanging fruit" opportunities, and discusses strategies for using these potentially large datasets to facilitate scientific and public health advances.
Book Synopsis Cognitive-Behavioral Interventions by : Philip C. Kendall
Download or read book Cognitive-Behavioral Interventions written by Philip C. Kendall and published by Academic Press. This book was released on 2013-10-02 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognitive-Behavioral Interventions: Theory, Research, and Procedures surveys a variety of areas to which cognitive-behavioral strategies have been applied. The various contributors represent some of the major innovators in the field. Each has developed and systematically evaluated programs which apply sound empirically based procedures to cognitive and behavioral phenomena. The opening chapter traces the short developmental history and describes the current professional environment of the cognitive-behavioral movement. The chapters that follow represent major contributions by the leading investigators across a number of areas of intervention. Each chapter describes a summary of research in the respective area, a description of the actual intervention procedures with supporting empirical data, and a consideration of the theoretical foundations and potential implications associated with the intervention. The chapter contents vary across three dimensions. First, the interventions range from those that focus on the acquisition of new capacities to those that deal with the control and modification of existing processes. Second, several chapters focus on adult populations, several on child populations, and some on both. Finally, whereas a number of the chapters deal with problems that have been areas of traditional clinical concern, several others explore new and interesting applications for cognitive-behavioral interventions.
Book Synopsis The Bipolar Book by : Aysegül Yildiz
Download or read book The Bipolar Book written by Aysegül Yildiz and published by Oxford University Press, USA. This book was released on 2015 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bipolar Book covers not only clinical and pathophysiological matters, but also technical aspects of the evidence accumulation for treatment of bipolar disorder. This approach brings in stimulating discussions on available data originating from current randomized controlled trials with specified considerations of bipolar mania, depression, and prophylaxis by providing accompanying recommendations for an improved evidence formation and synthesis. The Bipolar Book provides a clinician-friendly view of debatable issues on the existing randomized trials based evidence and the ways of improving them by respecting distinctive fluctuating pattern of bipolar disorder.
Book Synopsis Mindfulness-Based Cognitive Therapy for Depression, First Edition by : Zindel V. Segal
Download or read book Mindfulness-Based Cognitive Therapy for Depression, First Edition written by Zindel V. Segal and published by Guilford Press. This book was released on 2001-11-14 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an innovative eight-session program that has been clinically proven to bolster recovery from depression and prevent relapse. Developed by leading scientist-practitioners, and solidly grounded in current psychological research, the approach integrates cognitive therapy principles and practice into a mindfulness framework. Clinicians from any background will find vital tools to help clients maintain gains made by prior treatment and to expand the envelope of care to remission and beyond. Illustrative transcripts and a wealth of reproducible materials, including session summaries and participant forms, enhance the clinical utility of the volume. More than 35 reproducibles are also provided in a large-size format on Guilford's website for bookbuyers to download.
Book Synopsis Assessing Alcohol Problems by : John P. Allen
Download or read book Assessing Alcohol Problems written by John P. Allen and published by DIANE Publishing. This book was released on 2003 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: A revision of the landmark study by D.J. Lettieri "Alcoholism Treatment Assessment Research Instruments". Assists in locating, examining, and selecting instruments appropriate for use in all stages of the assessment process. Includes state-of-the-art reviews of and recommendations for assessment procedures. Written with the clinician and the less experienced researcher in mind. Includes screening, diagnosis, assessment of drinking behavior, treatment planning, treatment and process assessment, and outcome evaluation. Also Fact Sheets and Sample Instruments.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1980 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mindfulness-Based Cognitive Therapy for Depression, Second Edition by : Zindel Segal
Download or read book Mindfulness-Based Cognitive Therapy for Depression, Second Edition written by Zindel Segal and published by Guilford Publications. This book was released on 2018-06-04 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This acclaimed work, now in a new edition, has introduced tens of thousands of clinicians to mindfulness-based cognitive therapy (MBCT) for depression, an 8-week program with proven effectiveness. Step by step, the authors explain the "whys" and "how-tos" of conducting mindfulness practices and cognitive interventions that have been shown to bolster recovery from depression and prevent relapse. Clinicians are also guided to practice mindfulness themselves, an essential prerequisite to teaching others. Forty-five reproducible handouts are included. Purchasers get access to a companion website featuring downloadable audio recordings of the guided mindfulness practices (meditations and mindful movement), plus all of the reproducibles, ready to download and print in a convenient 8 1/2" x 11" size. A separate website for use by clients features the audio recordings only. New to This Edition *Incorporates a decade's worth of developments in MBCT clinical practice and training. *Chapters on additional treatment components: the pre-course interview and optional full-day retreat. *Chapters on self-compassion, the inquiry process, and the three-minute breathing space. *Findings from multiple studies of MBCT's effectiveness and underlying mechanisms. Includes studies of adaptations for treating psychological and physical health problems other than depression. *Audio files of the guided mindfulness practices, narrated by the authors, on two separate Web pages--one for professionals, together with the reproducibles, and one just for clients. See also the authors' related titles for clients: The Mindful Way through Depression demonstrates these proven strategies in a self-help format, with in-depth stories and examples. The Mindful Way Workbook gives clients additional, explicit support for building their mindfulness practice, following the sequence of the MBCT program. Plus, for professionals: Mindfulness-Based Cognitive Therapy with People at Risk of Suicide extends and refines MBCT for clients with suicidal depression.
Book Synopsis Practical Approaches in the Treatment of Women who Abuse Alcohol and Other Drugs by :
Download or read book Practical Approaches in the Treatment of Women who Abuse Alcohol and Other Drugs written by and published by U.S. Government Printing Office. This book was released on 1994 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Agency for Health Care Research and Quality (U.S.) Publisher :Government Printing Office ISBN 13 :1587634236 Total Pages :236 pages Book Rating :4.5/5 (876 download)
Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
