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Author : R. H. Skinner
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (598 download)
Download or read book Resistance to Antibiotics in Antibiotic-producing Streptomyces written by R. H. Skinner and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen W. Queener
Publisher : Elsevier
ISBN 13 : 0323162932
Total Pages : 441 pages
Book Rating : 4.3/5 (231 download)
Download or read book Antibiotic-Producing Stetomyces written by Stephen W. Queener and published by Elsevier. This book was released on 1986-03-28 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bacteria: Volume IX: Antibiotic-Producing Streptomyces explores how Streptomyces, including actinomycetes, produce a variety of antibiotics such as aminocyclitols, ansamycins, macrolides, and tetracyclines. Topics covered range from physiology and fermentation to genetic recombination and chromosome mapping in Streptomyces, biomodification of antibiotics by Streptomyces, and biosynthesis of tylosin and erythromycin. The genome structure and evolution of Streptomyces are also discussed. This volume is comprised of 10 chapters and begins with a discussion on the taxonomy of Streptomyces based on morphology, physiological characteristics, the composition of cell constituents such as cell walls, and the presence of characteristic lipids, sugars, and quinones. The discussion then turns to the intraspecific and interspecific recombination in Streptomyces; pathways of DNA repair and mutagenesis in Streptomyces fradiae; strategies for isolation of improved Streptomyces mutants for antibiotic production; and derivation of DNA cloning vectors from Streptomyces phages. The biology and use of Streptomyces plasmids as cloning vectors are also described. The final chapter is devoted to major structural classes of antibiotics produced by Streptomyces, including anthracyclines and other quinones, ß-lactams, macrolides, nucleosides, peptides, polyenes, polyether antibiotics, and tetracyclines. This book will be of value to microbiologists, bacteriologists, biochemists, and biologists.
Author : D. A. Hopwood
Publisher : Oxford University Press
ISBN 13 : 019515066X
Total Pages : 261 pages
Book Rating : 4.1/5 (951 download)
Download or read book Streptomyces in Nature and Medicine written by D. A. Hopwood and published by Oxford University Press. This book was released on 2007-02-03 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.
Author : Irwin C. Gunsalus
Publisher :
ISBN 13 : 9780123072092
Total Pages : 0 pages
Book Rating : 4.0/5 (72 download)
Download or read book The bacteria : a treatise on structure and function. 9. Antibiotic-producing Streptomyces written by Irwin C. Gunsalus and published by . This book was released on 1986 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.:/5 (921 download)
Download or read book Antibiotic Resistance in Non-antibiotic Producing Streptomyces Isolates written by and published by . This book was released on 2011 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dharumadurai Dhanasekaran
Publisher : BoD – Books on Demand
ISBN 13 : 9535122487
Total Pages : 401 pages
Book Rating : 4.5/5 (351 download)
Download or read book Actinobacteria written by Dharumadurai Dhanasekaran and published by BoD – Books on Demand. This book was released on 2016-02-11 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial utility, which covers isolation, cultivation methods, and identification of Actinobacteria and production and biotechnological potential of antibacterial compounds and enzymes from Actinobacteria. Moreover, this book also provides a comprehensive account on plant growth-promoting (PGP) and pollutant degrading ability of Actinobacteria and the exploitation of Actinobacteria as ecofriendly nanofactories for biosynthesis of nanoparticles, such as gold and silver. This book will be beneficial for the graduate students, teachers, researchers, biotechnologists, and other professionals, who are interested to fortify and expand their knowledge about Actinobacteria in the field of Microbiology, Biotechnology, Biomedical Science, Plant Science, Agriculture, Plant pathology, Environmental Science, etc.
Author : Jun Lin
Publisher : Frontiers Media SA
ISBN 13 : 2889195260
Total Pages : 226 pages
Book Rating : 4.8/5 (891 download)
Download or read book Mechanisms of antibiotic resistance written by Jun Lin and published by Frontiers Media SA. This book was released on 2015-06-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
Author : Richard Ford Freeman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)
Download or read book Studies of Antibiotic Resistance and Production in Streptomyces written by Richard Ford Freeman and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : D. A. Hopwood
Publisher :
ISBN 13 :
Total Pages : 378 pages
Book Rating : 4.3/5 (91 download)
Download or read book Genetic Manipulation of Streptomyces written by D. A. Hopwood and published by . This book was released on 1985 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Evi Stegmann
Publisher :
ISBN 13 : 9783039369102
Total Pages : 362 pages
Book Rating : 4.3/5 (691 download)
Download or read book Actinomycetes written by Evi Stegmann and published by . This book was released on 2020-09-04 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes
Author : Jonathan McGahon
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book The Effect of Environmental Stress on Antibiotic Production by Streptomyces written by Jonathan McGahon and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotic Resistance is a world-wide issue that increases with every year. The World Health Organisation (WHO) has identified priority pathogenic microorganisms with dangerous resistance to 'last-resort' antibiotics, these are the 'ESKAPE' pathogens.To face this problem, we investigated novel antibiotic-producing bacteria. The majority of currently available originate from organisms belonging to the Actinobacteria Phylum. Unfortunately, no significant compounds have been discovered in decades and so this has lead us to search in sparsely researched locations such as the hyper-arid Atacama Desert in Chile and compare them to more commonly researched North European soil samples which are naturally more hydrated. In this project we studied bacteria isolated from soil samples from Chiles Atacama Desert and the west of Scotland. Relevant strains were selected by unique morphology and by antimicrobial-activity. Bioactivity tests were performed on all isolates grown on 4 different media against 'ESKAPE' pathogens, Bacillus subtilis and Saccharomyces cerevisiae across which all were inhibited in the streak assays and all but Klebsiella pneumoniae and Pseudomonas aeruginosa in plug assays. Those presenting relevant bioactive profiles were taxonomically identified using 16S rRNAgene sequencing as members of the genera; Streptomyces, Micromonospora and Methylobacterium. Amongst those, isolate identified as Streptomyces narbones is presented activity against a clinical isolate of carbapenem-resistant Acinetobacterbaumannii. In Addition, Streptomyces puniceus presented a unique morphology that was not seen before in Streptomyces. Moreover, elicitation of bio-active compounds from antimicrobial-producing isolates was achieved by increasing osmotic stress or supplementing with Nitrogen or Humic acid. Further studies to compliment this project would include whole-genome sequencing of the most interesting strains in tandem with mass spectrometry to identify the active compounds and activation of crypticbiosynthetic gene clusters through elicitation.
Author : Rowan Paul Morris
Publisher :
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.:/5 (813 download)
Download or read book Intrinsic Multi-drug Resistance in the Antibiotic Producing Bacterium Streptomyces written by Rowan Paul Morris and published by . This book was released on 2001 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.3/5 (91 download)
Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Author : Irwin Clyde Gunsalus
Publisher :
ISBN 13 : 9780123072092
Total Pages : 458 pages
Book Rating : 4.0/5 (72 download)
Download or read book Antibiotic-producing Streptomyces written by Irwin Clyde Gunsalus and published by . This book was released on 1986 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bozzano G Luisa
Publisher : Elsevier
ISBN 13 : 0080984339
Total Pages : 510 pages
Book Rating : 4.0/5 (89 download)
Download or read book Actinomycetes in Biotechnology written by Bozzano G Luisa and published by Elsevier. This book was released on 2012-12-02 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: The actinomycetes are a group of bacteria well known as producers of antibiotics. With the advent of molecular biology they have become important to biotechnologists in the search for new antibiotics, vitamins, enzyme inhibitors, etc. They also play an important role in the biodegradation of wastes, and their wide (natural) distribution in soil, composts, water and elsewhere in the environment makes them important to the agricultural and waste industries. This research book presents a broad view of the current interest in actinomycetes, ranging from isolation/screening of actinomycetes, discovery of new antibiotics, a substantial contribution on genetic manipulation to actinomycetes in agriculture, forestry, and the threat of actinomycetes as pollutants in the environment.The chapters, which have been written by experts, are intended to provide a balanced view of the opportunities and problems in an expanding field of interest.
Author : G. Lancini
Publisher : Springer Science & Business Media
ISBN 13 : 147579522X
Total Pages : 240 pages
Book Rating : 4.4/5 (757 download)
Download or read book Biotechnology of Antibiotics and Other Bioactive Microbial Metabolites written by G. Lancini and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.
Author : André Bryskier
Publisher : Amer Society for Microbiology
ISBN 13 : 9781555812379
Total Pages : 1426 pages
Book Rating : 4.8/5 (123 download)
Download or read book Antimicrobial Agents written by André Bryskier and published by Amer Society for Microbiology. This book was released on 2005 with total page 1426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensively covers the history, chemistry, synthesis, mechanisms of action, pharmacology, and efficacy of all antimicrobial agents. Serves as a reference source for physicians, microbiologists, chemists, pharmacologists, research scientists, and all others involved in antimicrobial research and development.
