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Author :
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.:/5 (844 download)
Download or read book Research Progress in Alzheimer's Disease and Dementia written by and published by . This book was released on 2012 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Miao-Kun Sun
Publisher : Nova Publishers
ISBN 13 : 9781594549496
Total Pages : 492 pages
Book Rating : 4.5/5 (494 download)
Download or read book Research Progress in Alzheimer's Disease and Dementia written by Miao-Kun Sun and published by Nova Publishers. This book was released on 2007 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD) is the most common type of neurodegenerative disorder in the ageing population, with dementia as a common consequence. AD is defined pathologically by the appearance of extracellular senile plaques and intracellular neurofibrillary tangles, as described by Alois Alzheimer about a century ago. The causes for AD include genetic predisposition in a small population, ageing and environmental stresses in majority cases. The underlying pathogenic cascades, increases in expression of amyloid precursor protein and accumulation of Aß and reactive oxidant activity and inflammation, have the features of both adaptive, at least initially, and harmful when becoming excessive. Dementia, on the other hand, is a clinical diagnosis and is defined as globally, persistently impaired cognitive skills including memory. Alzheimer dementia refers to clinical dementia in patients who also have Alzheimer neuropathology. Alzheimer dementia is what brings the patients to seek medical treatments. An extraordinary inability to form new memory, especially of those episodic type, and executive dysfunction are among the earliest symptoms in AD patients. In end-stage AD, cognitive degeneration extends far beyond memory loss. The underlying causes include decreases in impaired brain metabolism, which results in impaired synaptic functions and capacities, thus impaired information processing, and eventually leads to neuronal injury and death. This book presents leading-edge research in this dynamic field.
Author : Miao-Kun Sun
Publisher :
ISBN 13 : 9781634852067
Total Pages : 255 pages
Book Rating : 4.8/5 (52 download)
Download or read book Research Progress in Alzheimer's Disease and Dementia written by Miao-Kun Sun and published by . This book was released on 2016 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Academies of Sciences Engineering and Medicine
Publisher :
ISBN 13 : 9780309495035
Total Pages : pages
Book Rating : 4.4/5 (95 download)
Download or read book Reducing the Impact of Dementia in America written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2022-04-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: As the largest generation in U.S. history - the population born in the two decades immediately following World War II - enters the age of risk for cognitive impairment, growing numbers of people will experience dementia (including Alzheimer's disease and related dementias). By one estimate, nearly 14 million people in the United States will be living with dementia by 2060. Like other hardships, the experience of living with dementia can bring unexpected moments of intimacy, growth, and compassion, but these diseases also affect people's capacity to work and carry out other activities and alter their relationships with loved ones, friends, and coworkers. Those who live with and care for individuals experiencing these diseases face challenges that include physical and emotional stress, difficult changes and losses in their relationships with life partners, loss of income, and interrupted connections to other activities and friends. From a societal perspective, these diseases place substantial demands on communities and on the institutions and government entities that support people living with dementia and their families, including the health care system, the providers of direct care, and others. Nevertheless, research in the social and behavioral sciences points to possibilities for preventing or slowing the development of dementia and for substantially reducing its social and economic impacts. At the request of the National Institute on Aging of the U.S. Department of Health and Human Services, Reducing the Impact of Dementia in America assesses the contributions of research in the social and behavioral sciences and identifies a research agenda for the coming decade. This report offers a blueprint for the next decade of behavioral and social science research to reduce the negative impact of dementia for America's diverse population. Reducing the Impact of Dementia in America calls for research that addresses the causes and solutions for disparities in both developing dementia and receiving adequate treatment and support. It calls for research that sets goals meaningful not just for scientists but for people living with dementia and those who support them as well. By 2030, an estimated 8.5 million Americans will have Alzheimer's disease and many more will have other forms of dementia. Through identifying priorities social and behavioral science research and recommending ways in which they can be pursued in a coordinated fashion, Reducing the Impact of Dementia in America will help produce research that improves the lives of all those affected by dementia.
Author : Miao-Kun Sun
Publisher : Nova Science Publishers
ISBN 13 : 9781619421929
Total Pages : 0 pages
Book Rating : 4.4/5 (219 download)
Download or read book Research Progress in Alzheimer's Disease and Dementia written by Miao-Kun Sun and published by Nova Science Publishers. This book was released on 2012-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fifth book volume brings together scientific frontiers in current Alzheimer's Disease/dementia research. The book will be highly valuable to students and scientists world-wide who are interested in the scientific research progress in Alzheimer's Disease and memory disorders.
Author : Jeffrey Cummings
Publisher : Cambridge University Press
ISBN 13 : 1108838669
Total Pages : 575 pages
Book Rating : 4.1/5 (88 download)
Download or read book Alzheimer's Disease Drug Development written by Jeffrey Cummings and published by Cambridge University Press. This book was released on 2022-03-31 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.
Author : Miao-Kun Sun
Publisher : Nova Science Pub Incorporated
ISBN 13 : 9781608761524
Total Pages : 306 pages
Book Rating : 4.7/5 (615 download)
Download or read book Research Progress in Alzheimer's Disease and Dementia written by Miao-Kun Sun and published by Nova Science Pub Incorporated. This book was released on 2009-10-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective prevention/treatments are developed. Since the publication of the third book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists world-wide. This fourth book volume contains 12 chapters, bringing together a presentation of scientific frontiers in current AD/dementia research. The topics include emotional memory in AD, amyloid-B clearance, synaptic transmission-mediated regulation of amyloid-B dynamics, anti-AD immunotherapy, clinical trials of AD therapeutics using AD transgenic mouse models, roles of apolipoprotein E, chronic inflammation, cathepsins, and gelsolin in AD pathogenesis and as anti-AD therapeutic targets/agents, declarative memory impairment and hippocampal atrophy in Parkinson's disease, fronto-temporal dementia, and cognitive impairment in schizophrenia. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists world-wide who are interested in the scientific research progress in AD and memory disorders.
Author : Samuel Barrack
Publisher : iMedPub
ISBN 13 : 1475095422
Total Pages : 117 pages
Book Rating : 4.4/5 (75 download)
Download or read book Advances in Research and Treatment for Alzheimer's Disease written by Samuel Barrack and published by iMedPub. This book was released on 2012-01-30 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD), is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death. The cause and progression of Alzheimer's disease are not well understood. Research indicates that the disease is associated with plaques and tangles in the brain. Current treatments only help with the symptoms of the disease. There are no available treatments that stop or reverse the progression of the disease. As of 2012, more than 1000 clinical trials have been or are being conducted to find ways to treat the disease, but it is unknown if any of the tested treatments will work. Because AD cannot be cured and is degenerative, the sufferer relies on others for assistance. The role of the main caregiver is often taken by the spouse or a close relative. Alzheimer's disease is known for placing a great burden on caregivers; the pressures can be wide-ranging, involving social, psychological, physical, and economic elements of the caregiver's life. In developed countries, AD is one of the most costly diseases to society. Research is the only hope to present and future patients and families suffering from this devastating disorder. This book compiles some of the most interesting articles on Alzheimer's disease published by PLoS journals lately: from epidemiology and prevention to management and treatment.
Author : Debomoy K. Lahiri
Publisher : Bentham Science Publishers
ISBN 13 : 1608058522
Total Pages : 463 pages
Book Rating : 4.6/5 (8 download)
Download or read book Advances in Alzheimer's Research written by Debomoy K. Lahiri and published by Bentham Science Publishers. This book was released on 2014-09-29 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is global – afflicting over 36 million people worldwide, with the number growing in an unabated and frightening manner. The goal of the series Advances in Alzheimer’s Research , with Volumes 1 and 2, is to provide an integrated approach to AD from basic and clinical research and to highlight the valuable information in order to unravel the origin, pathogenesis and prevention of AD. The aim of this book is to both capture and discuss improvements toward the diagnosis and potential treatment of AD by both established and novel strategies. This book series, including the Volume 2, provides an important mechanism to bring under the same roof a variety of scientific interests and expertise to specifically focus on AD and related dementias. The fullest attempt has been made to disseminate the most current knowledge on recent advances in potential therapy of AD.
Author : Suzanne Corkin
Publisher :
ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.3/5 (91 download)
Download or read book Alzheimer's Disease written by Suzanne Corkin and published by . This book was released on 1982 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Blas Gil-Extremera
Publisher : Bentham Science Publishers
ISBN 13 : 9811405123
Total Pages : 191 pages
Book Rating : 4.8/5 (114 download)
Download or read book Alzheimer's Disease: Pathological and Clinical Findings written by Blas Gil-Extremera and published by Bentham Science Publishers. This book was released on 2019-04-03 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is the most frequent cause of dementia that slowly and progressively causes cognitive impairment and profoundly alters the daily activities of the patients. Approximately, ten percent of all persons over the age of seventy experience significant memory loss, and in more than half of the cases, the cause is Alzheimer's disease. This reference book is an update on the most relevant pathological and clinical findings of this neurological disorder. Chapters cover the basic hypothesis of Alzheimer’s disease, pathological features of the disease in the brain, Alzheimer’s disease diagnosis and therapy. Information provided in the book is focused on research in developed countries. The book offers students of medicine and nursing as well as medical practitioners and specialists (internists, neurologists, gerontologists, and psychiatrists), the necessary information to understand the pathological and clinical aspects of the disease in depth, with the goal of improving medical outcomes in the care of their patients.
Author : Ahmad Salehi
Publisher : Bentham Science Publishers
ISBN 13 : 1681081385
Total Pages : 322 pages
Book Rating : 4.6/5 (81 download)
Download or read book Recent Advances in Alzheimer Research written by Ahmad Salehi and published by Bentham Science Publishers. This book was released on 2015-11-11 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Alzheimer Disease Research is a book series focusing on contemporary research on Alzheimer’s disease epidemiology, pathophysiology, diagnosis and therapy. The series features reviews by experts in neuroscience and aims to provide current information in the field to both researchers and clinicians. Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological hallmarks of Alzheimer's disease. Unfortunately, no extant treatments have proven beneficial for cognitive dysfunction for either Down syndrome or Alzheimer’s disease. An incomplete understanding of the common pathogenic mechanisms that link these two disorders has limited researchers’ progress to this end. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a novel attempt to fill this void, by summarizing the work of world-renowned scientists in the field of Alzheimer’s disease and Down syndrome, and thus providing an unprecedented opportunity to attract attention to Down syndrome as a tool for understanding the common molecular mechanisms that underlie Alzheimer’s disease and to develop new therapies for similar neurodegenerative disorders of the brain. The book covers the fundamental pathophysiology and molecular mechanisms behind the incidence of Alzheimer’s disease in Down syndrome affected individuals as well other key topics such as diagnosis and management, in vivo brain imaging studies, and progressive neurodegeneration of the monoaminergic system. The book concludes with a review of recent clinical trials of drugs designed to mitigate cognitive dysfunction in aging adults with Down syndrome and establishes a scientific warrant for the increased testing of candidate pharmacotherapies. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a useful reference clinicians involved in treating Down syndrome patients as well as for neuroscience researchers seeking to understand the influence of a specific case of aneuploidy on Alzheimer’s disease incidence and its progression at the molecular level.
Author : Christian Behl
Publisher : Springer Nature
ISBN 13 : 3031315707
Total Pages : 661 pages
Book Rating : 4.0/5 (313 download)
Download or read book Alzheimer’s Disease Research written by Christian Behl and published by Springer Nature. This book was released on 2023-08-14 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.
Author : Ronald Sahyouni
Publisher : World Scientific
ISBN 13 : 9811235120
Total Pages : 426 pages
Book Rating : 4.8/5 (112 download)
Download or read book Alzheimer's Disease Decoded: The History, Present, And Future Of Alzheimer's Disease And Dementia (Second Edition) written by Ronald Sahyouni and published by World Scientific. This book was released on 2021-12-23 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a 'global' perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world.Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research.Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease.Dr Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective.This book with appeal to a wide audience, regardless of their scientific or educational background.
Author : Jack C. de la Torre
Publisher : Springer
ISBN 13 : 3319340573
Total Pages : 256 pages
Book Rating : 4.3/5 (193 download)
Download or read book Alzheimer’s Turning Point written by Jack C. de la Torre and published by Springer. This book was released on 2016-06-25 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.
Author : Andrew E. Budson
Publisher : John Wiley & Sons
ISBN 13 : 1444344099
Total Pages : 676 pages
Book Rating : 4.4/5 (443 download)
Download or read book The Handbook of Alzheimer's Disease and Other Dementias written by Andrew E. Budson and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced field Summarizes the most recent developments in the fields of Alzheimer's disease and dementia Brings together articles from a prominent and international group of contributors Encompasses a unique range of topics, combining basic molecular perspectives and cognitive neurosciences
Author : American Psychopathological Association
Publisher : American Psychiatric Publishing
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)
Download or read book Progress in Alzheimer's Disease and Similar Conditions written by American Psychopathological Association and published by American Psychiatric Publishing. This book was released on 1997 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is a particularly insidious affliction that profoundly affects the patient as well as family and friends. Written by a distinguished group of researchers and clinicians, Progress in Alzheimer's Disease and Similar Conditions provides medical professionals who investigate and treat brain diseases with updated research findings and their implications. This treasury of clinical and research expertise presents important findings in genetics, epidemiology, pathology, pharmacology, and pathophysiology. This book covers a range of important issues, from basic clinical science to pharmacology and social support. In particular, Dr. Heston's book details the spectacular advances in research on human genetics that are broadening our knowledge of Alzheimer's disease and other related afflictions and that have profound implications for both clinical practice and further research. Two chapters describe disease mechanisms, including prions, that provide important insights into the role environment plays in the development of disease. Other chapters highlight the clinical challenges that Alzheimer's disease presents, including stories about the pain inflicted by this disease on the patients and their families and friends, as well as current efforts in management and treatment.
