Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

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Publisher : Frontiers Media SA
ISBN 13 : 288919647X
Total Pages : 143 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias by : George E. Billman

Download or read book Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias written by George E. Billman and published by Frontiers Media SA. This book was released on 2015-09-25 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question then is what went wrong, why have these interventions proven to be so ineffective? An obvious answer is the drugs were designed to attack the wrong therapeutic target. Clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. What then is the appropriate target? It is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. One obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. Due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing “electrotonic interdependence” between neighboring cells. Myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. In particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. The resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. Thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. It is the purpose of this Research Topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation.

Remodeling of Cardiac Passive Electrical Properties and Susceptibility to Ventricular and Atrial Arrhythmias

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Remodeling of Cardiac Passive Electrical Properties and Susceptibility to Ventricular and Atrial Arrhythmias by :

Download or read book Remodeling of Cardiac Passive Electrical Properties and Susceptibility to Ventricular and Atrial Arrhythmias written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that's prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question then is what went wrong, why have these interventions proven to be so ineffective? An obvious answer is the drugs were designed to attack the wrong therapeutic target. Clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. What then is the appropriate target? It is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. One obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. Due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing "electrotonic interdependence" between neighboring cells. Myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. In particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. The resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. Thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. It is the purpose of this Research Topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation.

Clinical Arrhythmology and Electrophysiology E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323568823
Total Pages : 752 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Clinical Arrhythmology and Electrophysiology E-Book by : Ziad Issa

Download or read book Clinical Arrhythmology and Electrophysiology E-Book written by Ziad Issa and published by Elsevier Health Sciences. This book was released on 2018-08-07 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the highly regarded Braunwald’s family of cardiology references, Clinical Arrhythmology and Electrophysiology, 3rd Edition, offers complete coverage of the latest diagnosis and management options for patients with arrhythmias. Expanded clinical content and clear illustrations keep you fully abreast of current technologies, new syndromes and diagnostic procedures, new information on molecular genetics, advances in ablation, and much more.

Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment

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Publisher : Frontiers Media SA
ISBN 13 : 2889746909
Total Pages : 537 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment by : Jose F. Rodriguez Matas

Download or read book Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment written by Jose F. Rodriguez Matas and published by Frontiers Media SA. This book was released on 2022-03-15 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiac Electrophysiology: From Cell to Bedside E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323448887
Total Pages : 1429 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Cardiac Electrophysiology: From Cell to Bedside E-Book by : Douglas P. Zipes

Download or read book Cardiac Electrophysiology: From Cell to Bedside E-Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2017-05-13 with total page 1429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323394833
Total Pages : 1200 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy E-Book by : Kenneth A. Ellenbogen

Download or read book Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy E-Book written by Kenneth A. Ellenbogen and published by Elsevier Health Sciences. This book was released on 2016-03-30 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Your must-have bench reference for cardiac electrophysiology is now better than ever! This globally recognized gold standard text provides a complete overview of clinical EP, with in-depth, expert information that helps you deliver superior clinical outcomes. In this updated 5th Edition, you’ll find all-new material on devices, techniques, trials, and much more – all designed to help you strengthen your skills in this fast-changing area and stay on the cutting edge of today’s most successful cardiac EP techniques. Expert guidance from world authorities who contribute fresh perspectives on the challenging clinical area of cardiac electrophysiology. New focus on clinical relevance throughout, with reorganized content and 15 new chapters. New coverage of balloons, snares, venoplasty, spinal and neural stimulation, subcutaneous ICDs and leadless pacing, non-CS lead implantation, His bundle pacing, and much more. New sections on cardiac anatomy and physiology and imaging of the heart, a new chapter covering radiography of devices, and thought-provoking new information on the basic science of device implantation. State-of-the-art guidance on pacing for spinal and neural stimulation, computer simulation and modeling, biological pacemakers, perioperative and pre-procedural management of device patients, and much more.

Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323757464
Total Pages : 1709 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside by : Jose Jalife

Download or read book Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside written by Jose Jalife and published by Elsevier Health Sciences. This book was released on 2021-12-16 with total page 1709 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. Packs each chapter with the latest information necessary for optimal basic research as well as patient care. Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. Includes 47 new standalone chapters that are organized into discrete topics for improved access. Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. Recipient of a 2018 Highly Commended award from the British Medical Association.

Applied Computer Sciences in Engineering

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Author :
Publisher : Springer Nature
ISBN 13 : 3030310191
Total Pages : 779 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Applied Computer Sciences in Engineering by : Juan Carlos Figueroa-García

Download or read book Applied Computer Sciences in Engineering written by Juan Carlos Figueroa-García and published by Springer Nature. This book was released on 2019-10-09 with total page 779 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume constitutes the refereed proceedings of the 6th Workshop on Engineering Applications, WEA 2019, held in Santa Marta, Colombia, in October 2019. The 62 revised full papers and 2 short papers presented in this volume were carefully reviewed and selected from 178 submissions. The papers are organized in the following topical sections: computer science; computational intelligence; bioengineering; Internet of things; power applications; simulation systems; optimization.

Advanced HPC-based Computational Modeling in Biomechanics and Systems Biology

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Publisher : Frontiers Media SA
ISBN 13 : 2889458172
Total Pages : 449 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Advanced HPC-based Computational Modeling in Biomechanics and Systems Biology by : Mariano Vázquez

Download or read book Advanced HPC-based Computational Modeling in Biomechanics and Systems Biology written by Mariano Vázquez and published by Frontiers Media SA. This book was released on 2019-04-04 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Recent Advances in Understanding the Basic Mechanisms of Atrial Fibrillation Using Novel Computational Approaches

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Publisher : Frontiers Media SA
ISBN 13 : 2889631842
Total Pages : 413 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Recent Advances in Understanding the Basic Mechanisms of Atrial Fibrillation Using Novel Computational Approaches by : Jichao Zhao

Download or read book Recent Advances in Understanding the Basic Mechanisms of Atrial Fibrillation Using Novel Computational Approaches written by Jichao Zhao and published by Frontiers Media SA. This book was released on 2019-11-25 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Veterinary Anesthesia and Analgesia

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Publisher : John Wiley & Sons
ISBN 13 : 1119830273
Total Pages : 1460 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Veterinary Anesthesia and Analgesia by : Leigh Lamont

Download or read book Veterinary Anesthesia and Analgesia written by Leigh Lamont and published by John Wiley & Sons. This book was released on 2024-07-23 with total page 1460 pages. Available in PDF, EPUB and Kindle. Book excerpt: VETERINARY ANESTHESIA AND ANALGESIA A thoroughly updated new edition of the foundational reference on veterinary anesthesia and analgesia Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones is a fully updated revision to this comprehensive, authoritative reference to all aspects of veterinary anesthesia and pain management. Encompassing both scientific principles and clinical applications, the new edition adds new knowledge, techniques, and discussion of emerging issues throughout. Fourteen new chapters significantly expand the coverage of patient monitoring modalities and nociception and pain, while presenting new information on safety culture, infection prevention and control, biomedical engineering, and point-of-care ultrasound. Logically organized into sections, information on basic principles, pharmacology, specific body systems, and specific species is easy to access. Comparative anesthetic considerations for dogs and cats, horses, ruminants, swine, laboratory animals, free-ranging terrestrial mammals, marine mammals, reptiles, amphibians, fish, and birds are discussed. Chapters are devoted to anesthesia and pain management of common domestic species and patient populations, including updated chapters on local and regional anesthetic and analgesic techniques. A companion website offers video clips of point-of-care ultrasound techniques and pain assessment and scoring. Readers of Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones will also find: Significantly expanded coverage of patient monitoring, including new chapters devoted to anesthetic depth and electroencephalography, electrocardiography, blood pressure, ventilation, oxygenation, and anesthetic gas monitoring. More in-depth coverage of respiratory physiology and pathophysiology, with new sections covering oxygen therapy, mechanical ventilation, anesthetic management considerations for bronchoscopy, intrathoracic procedures, including one-lung ventilation, and patients with respiratory disease. Expanded coverage of pain physiology and pathophysiology, recognition and quantification of pain, and clinical pain management, including both pharmacologic and nonpharmacologic modalities. A companion website incorporating video clips and example pain scoring sheets to complement the more than 500 images in the text itself. With its unparalleled multidisciplinary approach, Veterinary Anesthesia and Analgesia is a must-own volume for veterinary anesthesia specialists and researchers; specialists in other disciplines, including both small and large animal surgeons; practitioners; and students.

Cardiac Modeling: Aiming for Optimization of Therapy

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Publisher : Frontiers Media SA
ISBN 13 : 2889662195
Total Pages : 248 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Cardiac Modeling: Aiming for Optimization of Therapy by : Javier Saiz

Download or read book Cardiac Modeling: Aiming for Optimization of Therapy written by Javier Saiz and published by Frontiers Media SA. This book was released on 2020-12-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Muscle 2-Volume Set

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Publisher : Academic Press
ISBN 13 : 0123815118
Total Pages : 1528 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Muscle 2-Volume Set by : Joseph Hill

Download or read book Muscle 2-Volume Set written by Joseph Hill and published by Academic Press. This book was released on 2012-08-29 with total page 1528 pages. Available in PDF, EPUB and Kindle. Book excerpt: A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte. Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit. The only resource to focus on science before the clinical work and therapeutics Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth

Cardiac Electrophysiology: from Cell to Bedside

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Publisher : Elsevier Health Sciences
ISBN 13 : 145572856X
Total Pages : 1395 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Cardiac Electrophysiology: from Cell to Bedside by : Douglas P. Zipes

Download or read book Cardiac Electrophysiology: from Cell to Bedside written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2013-10-25 with total page 1395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald's Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.

Cardiac Arrhythmias

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1447153162
Total Pages : 678 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Cardiac Arrhythmias by : Ambrose S. Kibos

Download or read book Cardiac Arrhythmias written by Ambrose S. Kibos and published by Springer Science & Business Media. This book was released on 2013-12-13 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the major aspects associated with pathophysiological development of cardiac arrhythmias (covering enhanced or suppressed automaticity, triggered activity, or re-entry), from basic concepts through disease association, limitations of current pharmacotherapy and implant therapies and on-going trials and analysis of new biomarkers based on current knowledge of cellular interaction and signalling. The book describes novel and state-of-the-art methods for differentiating between the major types of arrhythmia, structural abnormalities and current practice guidelines and determination of risk stratification associated with sudden cardiac death. A particular focus is on arrhythmias associated with atrial fibrillation and includes details of associations with cardiac disease, current detection, analysis and imaging and future perspectives.​

Modeling and Simulating Cardiac Electrical Activity

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Publisher :
ISBN 13 : 9780750320641
Total Pages : 0 pages
Book Rating : 4.3/5 (26 download)

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Book Synopsis Modeling and Simulating Cardiac Electrical Activity by : David J. Christini

Download or read book Modeling and Simulating Cardiac Electrical Activity written by David J. Christini and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.

Cardiac Electrophysiology

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Author :
Publisher : Saunders
ISBN 13 :
Total Pages : 1192 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Cardiac Electrophysiology by : Douglas P. Zipes

Download or read book Cardiac Electrophysiology written by Douglas P. Zipes and published by Saunders. This book was released on 2009 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the many major recent developments in the field, the authors have completely updated this modern classic, making this edition the most significant revision yet. Practitioners will find all the state-of-the-art guidance they need to make informed, effective clinical decisions.