Relevance of N-nitroso Compounds to Human Cancer

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Publisher :
ISBN 13 :
Total Pages : 702 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Relevance of N-nitroso Compounds to Human Cancer by : National Cancer Institute (U.S.)

Download or read book Relevance of N-nitroso Compounds to Human Cancer written by National Cancer Institute (U.S.) and published by . This book was released on 1987 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensive volume offers 130 presentations that examine the relevance of N-nitroso compounds to human cancer. Significant advances are presented on the measurement of exposures to N-nitroso compounds and on possible links with several common human cancers. The contributions are from scientists in a wide range of disciplines, and cover clinical and epidemiological studies, tobacco/betel-quid carcinogenesis, endogenous formation, measurement of exposure, metabolism, reaction with cellular macromolecules, molecular mechanisms, and biological effects. This is the ninth in a biennial series of symposia, which is widely recognized to be the leading source in the field.

N-nitroso Compounds

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Publisher : Lyon : International Agency for Research on Cancer ; Oxford ; Toronto : Oxford University Press
ISBN 13 :
Total Pages : 1048 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis N-nitroso Compounds by : International Agency for Research on Cancer

Download or read book N-nitroso Compounds written by International Agency for Research on Cancer and published by Lyon : International Agency for Research on Cancer ; Oxford ; Toronto : Oxford University Press. This book was released on 1984 with total page 1048 pages. Available in PDF, EPUB and Kindle. Book excerpt:

N-nitroso Compounds

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Publisher : Lyon : International Agency for Research on Cancer ; Oxford ; Toronto : Oxford University Press
ISBN 13 : 9789283211570
Total Pages : 1011 pages
Book Rating : 4.2/5 (115 download)

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Book Synopsis N-nitroso Compounds by : I. K. O'Neill

Download or read book N-nitroso Compounds written by I. K. O'Neill and published by Lyon : International Agency for Research on Cancer ; Oxford ; Toronto : Oxford University Press. This book was released on 1984-01-01 with total page 1011 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Relevance to Human Cancer of N-nitroso Compounds, Tobacco, and Mycotoxins

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Publisher : World Health Organization
ISBN 13 : 9789283221050
Total Pages : 614 pages
Book Rating : 4.2/5 (21 download)

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Book Synopsis Relevance to Human Cancer of N-nitroso Compounds, Tobacco, and Mycotoxins by : I. K. O'Neill

Download or read book Relevance to Human Cancer of N-nitroso Compounds, Tobacco, and Mycotoxins written by I. K. O'Neill and published by World Health Organization. This book was released on 1991 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: The etiology and prevention of common human cancers are the subjects of the reviews and previously unpublished research presented in this volume arising from a multidisciplinary symposium on n-nitroso compounds, tobacco and mycotoxins. Although tobacco smoking and chewing have long been established as risk factors, the possible role of nitroso compounds has inspired extensive research. The 110 papers on these three classes of carcinogenic agents cover epidemiological updates, exposures and biological monitoring, exposure prevention and dietary anti-carcinogens, and biological mechanisms and effects. The volume includes many studies of these issues from the People's Republic of China. The relevance of this work is highlighted by the fact that the cancer sites causally or putatively associated with these exposures (liver, respiratory and alimentary tracts) are those at highest risk in developed and developing nations.

Nitrosamines and Human Cancer

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Publisher :
ISBN 13 :
Total Pages : 626 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Nitrosamines and Human Cancer by : Peter N. Magee

Download or read book Nitrosamines and Human Cancer written by Peter N. Magee and published by . This book was released on 1982 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemistry and Biology of N-Nitroso Compounds

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Publisher : Cambridge University Press
ISBN 13 : 0521346290
Total Pages : 483 pages
Book Rating : 4.5/5 (213 download)

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Book Synopsis Chemistry and Biology of N-Nitroso Compounds by : William Lijinsky

Download or read book Chemistry and Biology of N-Nitroso Compounds written by William Lijinsky and published by Cambridge University Press. This book was released on 1992-04-23 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1992, this volume looks in depth at the carcinogenic properties of N-nitroso compounds. These compounds occur widely in smoked foods and in meat and fish cured with nitrates; they are also formed in some industrial processes and in addition are found in cosmetics, tobacco and tobacco smoke. By focusing on the chemical and biological properties, the volume attempts to explain how these compounds exert their carcinogenic potential and, furthermore, goes on to explain how apparently harmless precursors such as nitrates and amines are transformed to produce carcinogens.

Carcinogens and Anticarcinogens in the Human Diet

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Publisher : National Academies Press
ISBN 13 : 0309175712
Total Pages : 433 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Carcinogens and Anticarcinogens in the Human Diet by : National Research Council

Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-02-12 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.

Mutation, Cancer, and Malformation

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Publisher : Springer Science & Business Media
ISBN 13 : 1461323991
Total Pages : 852 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Mutation, Cancer, and Malformation by : Ernest H.Y. Chu

Download or read book Mutation, Cancer, and Malformation written by Ernest H.Y. Chu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country.

N-nitroso Compounds

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Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (223 download)

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Book Synopsis N-nitroso Compounds by : Pavel Bogovski

Download or read book N-nitroso Compounds written by Pavel Bogovski and published by . This book was released on 1972 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Red Meat and Processed Meat

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Publisher : International Agency for Research on Cancer
ISBN 13 : 9789283201526
Total Pages : 0 pages
Book Rating : 4.2/5 (15 download)

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Book Synopsis Red Meat and Processed Meat by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Download or read book Red Meat and Processed Meat written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by International Agency for Research on Cancer. This book was released on 2018-07-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the IARC Monographs provides evaluations of the consumption of red meat and the consumption of processed meat. Red meat refers to unprocessed mammalian muscle meat (e.g. beef, veal, pork, lamb) including that which may be minced or frozen. Processed meat refers to meat that has been transformed through salting, curing, fermentation, smoking or other processes to enhance flavor or improve preservation. Most processed meats contain pork or beef, but may also contain other meats including poultry and offal (e.g. liver) or meat by-products such as blood. Red meat contains proteins of high biological value, and important micronutrients such as B vitamins, iron (both free iron and haem iron), and zinc. Carcinogens, including heterocyclic aromatic amines and polycyclic aromatic hydrocarbons, can be produced by cooking of meat, with greatest amounts generated at high temperatures by pan-frying, grilling, or barbecuing. Meat processing such as curing and smoking can result in formation of carcinogenic chemicals including N-nitroso compounds and polycyclic aromatic hydrocarbons. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of the consumption of red meat and processed meat. The Working Group assessed more than 800 epidemiological studies that investigated the association of cancer (more than 15 types) with consumption of red meat or processed meat, including large cohorts in many countries, from several continents, with diverse ethnicities and diets.

Environmental N-nitroso Compounds

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Publisher :
ISBN 13 :
Total Pages : 512 pages
Book Rating : 4.:/5 (62 download)

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Book Synopsis Environmental N-nitroso Compounds by :

Download or read book Environmental N-nitroso Compounds written by and published by . This book was released on 1976 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nitrate Contamination

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Publisher : Springer Science & Business Media
ISBN 13 : 3642760406
Total Pages : 438 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Nitrate Contamination by : Istvan Bogardi

Download or read book Nitrate Contamination written by Istvan Bogardi and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nitrate content of drinking water is rising at an alarming rate in several regions of NATO countries and elsewhere in the world. The increase is due to lack of proper sewage treatment, and primarily to excess fertilizer application. Also, eutrophication in several coastal areas is triggered by high nitrate concentrations. The main purpose of this book is to integrate scientific knowledge related to exposure assessment, health consequences and control of nitrate contamination in water. The motivation is related to the magnitude, the possible adverse health effects, and the high cost of control ling nitrate contamination. Future research tasks are defined by an interaction among hydro logists, toxicologists and environmental engineers in an integrated framework for nitrate risk management. The target readership of this book is a mix of university colleagues, practitioners from both the private and public sectors and advanced graduate students working with the hydrological, health science or environmental engineering aspects of nitrate contamination. The main conclusions include: 1. For risk assessment purposes, knowledge and sufficiently accurate models are available to predict nitrate load and its fate in water under changes in land use. 2. Once agricultural exposure controls are implemented, the response times in ground water may be so long as to make controls unrealistic. 3. It is still unknown whether agricultural best management practice is a compromise between nitrate risk reduction and agricultural revenue. 4. The current drinking water guidelines of 10 mg/L NOrN need not be changed.

Some N-nitroso Compounds

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Publisher : IARC Monographs on the Evaluat
ISBN 13 :
Total Pages : 372 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Some N-nitroso Compounds by : International Agency for Research on Cancer

Download or read book Some N-nitroso Compounds written by International Agency for Research on Cancer and published by IARC Monographs on the Evaluat. This book was released on 1978 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the carcinogenic risk to humans posed by exposure to some N-Nitroso Compounds.

How Tobacco Smoke Causes Disease

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Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by :

Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Biological Reactive Intermediates V

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Publisher : Springer Science & Business Media
ISBN 13 : 1475794800
Total Pages : 449 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Biological Reactive Intermediates V by : Robert R. Snyder

Download or read book Biological Reactive Intermediates V written by Robert R. Snyder and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

Environmental Carcinogens

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Publisher :
ISBN 13 : 9789283211457
Total Pages : 508 pages
Book Rating : 4.2/5 (114 download)

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Book Synopsis Environmental Carcinogens by :

Download or read book Environmental Carcinogens written by and published by . This book was released on 1983 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines

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Publisher : IARC
ISBN 13 : 9789283212850
Total Pages : 354 pages
Book Rating : 4.2/5 (128 download)

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Book Synopsis Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Download or read book Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC. This book was released on 2004 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: A working group of sixteen experts from seven countries re-evaluated the evidence of the carcinogenicity of betel-quid and areca-nut chewing and some areca-nut related nitrosamines. Betel-quid and areca-nut chewing are widely practised in many parts of Asia and in Asian-migrant communities elsewhere in the world. There are hundreds of millions of users worldwide. They evaluated betel quid with tobacco as carcinogenic to humans (Group 1) on the basis of sufficient evidence of an increased risk of cancer of the oral cavity, pharynx and oesophagus. The working group reviewed epidemiological studies of human cancer, mainly studies from India, Pakistan and Taiwan (China). Studies on betel quid with tobacco and areca nut with tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. The working group also evaluated betel quid without tobacco as carcinogenic to humans (Group 1), on the basis of sufficient evidence of an increased risk of oral cancer. Studies on betel quid without tobacco and areca nut without tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. Areca nut, a common ingredient of betel quid and many different chewing preparations, including those available commercially, has been observed to cause oral submucous fibrosis