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Regulation Of The Ras Signalling Network
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Book Synopsis Regulation of the RAS Signalling Network by : Hiroshi Maruta
Download or read book Regulation of the RAS Signalling Network written by Hiroshi Maruta and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which was written by the current leaders in the field of Ras research, provides the readers with the most comprehensive and up-to-date view of the major oncogene Ras. This volume is valuable not only for university students in molecular biology, biochemistry or medicine, but also for senior scientists currently conducting cancer research.
Book Synopsis Regulation of the Ras Signalling Network by : Hiroshi Maruta
Download or read book Regulation of the Ras Signalling Network written by Hiroshi Maruta and published by . This book was released on 2014-01-15 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of the RAS Signaling Network by : Hiroshi Maruta
Download or read book Regulation of the RAS Signaling Network written by Hiroshi Maruta and published by . This book was released on 1996 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which was written by the current leaders in the field of Ras research, provides the readers with the most comprehensive and up-to-date view of the major oncogene Ras. This volume is valuable not only for university students in molecular biology, biochemistry or medicine, but also for senior scientists currently conducting cancer research.
Book Synopsis Regulation of the RAS Signaling Network by : Hiroshi Maruta
Download or read book Regulation of the RAS Signaling Network written by Hiroshi Maruta and published by Chapman & Hall. This book was released on 1996-01-01 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ras Signaling Network and Regulation in S. Cerevisiae by : Cemile Gökc̦e Güldal
Download or read book Ras Signaling Network and Regulation in S. Cerevisiae written by Cemile Gökc̦e Güldal and published by . This book was released on 2007 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ras proteins mediate cellular growth and differentiation in response to external cues. Mammalian H-ras protein and its homologs in eukaryotes are central signaling hubs in coordinating cellular responses to changes in the environment, such as nutrient availability and a variety of stresses. This dissertation explores the topology of the Ras signaling network in yeast as well as its regulation.
Book Synopsis RAS Family GTPases by : Channing Der
Download or read book RAS Family GTPases written by Channing Der and published by Springer Science & Business Media. This book was released on 2007-04-29 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Book Synopsis Investigating the Regulation of Ras Signalling by ROS in «Caenorhabditis Elegans» by : Maximilian Kramer-Drauberg
Download or read book Investigating the Regulation of Ras Signalling by ROS in «Caenorhabditis Elegans» written by Maximilian Kramer-Drauberg and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Reactive oxygen species (ROS) are highly reactive molecules which have the potential to damage all biological macromolecules, yet they can also function as signalling molecules (Shibata, Branicky et al. 2003, Sena and Chandel 2012, Putker, Madl et al. 2013, Holmstrom and Finkel 2014). In this thesis, I explore the regulatory effects of reactive oxygen species (ROS) on the Ras signalling cascade in Caenorhabditis elegans vulva development and aging. Oncogenic Ras is one of the deadliest drivers of human cancer (Papke and Der 2017). 30% of all human cancers are driven by oncogenic Ras mutations, including a high percentage of the most lethal cancers: lung, colon and pancreatic cancer (Cox, Fesik et al. 2014). Unfortunately, despite more than three decades of research, no effective pharmacological inhibitor of oncogenic Ras has yet been clinically approved (McCormick 2015). As such, there remains a critical need for innovative therapeutic strategies to counteract the effects of oncogenic Ras mutations. In C. elegans, let-60 encodes the homolog of mammalian Ras isoforms. This gene regulates many processes including the development of the vulva (Reiner and Lundquist 2016). We used the let-60(n1046gf) mutant which encodes an oncogenic LET-60 protein (LET-60rasgf) and exhibits a multivulva (Muv) phenotype (Han and Sternberg 1990) to study regulatory effects of ROS on LET-60rasgf signalling. We uncovered a ROS signalling network which regulates vulval formation through LET-60rasgf signalling and by other mechanisms. In particular, we found that oxidation of the conserved cysteine 118 (C118) of LET-60rasgf by cytoplasmic hydrogen peroxide inhibits its activity and leads to the inhibition of the Muv phenotype. Confirming the effectiveness of hydrogen peroxide to inhibit oncogenic LET-60rasgf, we found that substituting C118 with an aspartic acid (C118D), which mimics permanent oxidation by hydrogen peroxide, fully suppressed LET-60rasgf. Increased production of mitochondrial ROS (mtROS) increases the lifespan of C. elegans (Van Raamsdonk and Hekimi 2009, Yang and Hekimi 2010). However, the exact molecular targets of mtROS that trigger longevity are unknown. In our study, we also found that C118 of LET-60 appears to be a target of pro-longevity mtROS. Indeed, in some situations, the pro-longevity action of mtROS is inhibited by the substitution of C118 with a non-oxidable serine (C118S), suggesting that C118 is indeed one of the targets of pro-longevity mtROS"--
Book Synopsis Ras Signalling in the Fission Yeast Schizosaccharomyces Pombe by : Michael Edward Bond
Download or read book Ras Signalling in the Fission Yeast Schizosaccharomyces Pombe written by Michael Edward Bond and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ras signalling is vital to many cellular processes. Ras proteins mediate a vast array of cellular signalling networks, and are conserved from humans to unicellular eukaryotes. The study of ras signalling in higher eukaryotes presents a number of technical challenges, due to the presence of multiple ras isoforms, regulatory proteins and activators. The fission yeast Sz. pombe represents an ideal system for the investigation of ras signalling, as it contains a single, nonessential ras protein (Ras1). In addition, Ras1 is involved in the regulation of a number of downstream pathways. A number of studies in recent years have highlighted the role of subcellular localisation in ras signalling output. The localisation of Ras1 in Sz. pombe has also been described as key in effector selection, with Ras1 at the plasma membrane regulating mating and Ras1 at the endomembranes regulating cell morphology. This thesis describes a series of studies utilising Ras1 mutants and chimeric Ras1 proteins which display differing localisation patterns to determine the role of Ras1 localisation in signalling. The data presented herein support the notion of a revised model for the role of Ras1 localisation in signalling, suggesting that the localisation of Ras1 to the plasma membrane is key to all signalling events downstream of Ras1. This thesis also describes the characterisation of oncogenic mutants of Ras1, demonstrating the importance of signalling magnitude in functional output. In addition, the importance of Ras1 regulation in cell viability and chromosome stability is also demonstrated. Finally, the functional expression of three human ras isoforms is described, validating the use of Sz. pombe as a model system for the heterologous expression of human ras signalling components.
Book Synopsis Biochemistry of Signal Transduction and Regulation by : Gerhard Krauss
Download or read book Biochemistry of Signal Transduction and Regulation written by Gerhard Krauss and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This all-new edition of a classic text has been thoroughly revised to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes. Directed to advanced students, teachers, and researchers in biochemistry and molecular biology, this book describes the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis. "Provides a comprehensive account of cell signaling and signal transduction and, where possible, explains these processes at the molecular level" (Angewandte Chemie) "The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemistry) "This book is actually two books: Regulation and Signal Transduction." (Drug Research)
Book Synopsis Signaling Networks and Cell Cycle Control by : J. Silvio Gutkind
Download or read book Signaling Networks and Cell Cycle Control written by J. Silvio Gutkind and published by Springer Science & Business Media. This book was released on 2000-04-14 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent dramatic expansion of our knowledge about how cell surface receptors transmit signals to the nucleus, together with the identification of key signaling and cell-cycle-regulating molecules, has provided a major opportunity to search for novel targets for therapeutic intervention in many diseases. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, leading scientists summarize this knowledge and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Rich in cutting-edge insights and authoritative critical analysis, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.
Book Synopsis Signal Transduction in Cancer by : David A. Frank
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Book Synopsis Signaling Mechanisms Regulating T Cell Diversity and Function by : Jonathan Soboloff
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author :Ashok K. Srivastava Publisher :Springer Science & Business Media ISBN 13 :9780792381136 Total Pages :206 pages Book Rating :4.3/5 (811 download)
Book Synopsis Insulin Action by : Ashok K. Srivastava
Download or read book Insulin Action written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.
Book Synopsis PI3K signalling by : Klaus Okkenhaug
Download or read book PI3K signalling written by Klaus Okkenhaug and published by Frontiers Media SA. This book was released on 2015-03-05 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.
Book Synopsis Biochemistry of Cell Membranes by : S. Papa
Download or read book Biochemistry of Cell Membranes written by S. Papa and published by Birkhäuser. This book was released on 2012-12-06 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book consists of a series of reviews on selected topics within the rapidly and vastly expanding field of membrane biology. Its aim is to highlight the most significant and important advances that have been made in recent years in understanding the structure, dynamics and functions of cell membranes. Areas covered in this monograph include: • Signal Transduction • Membrane Traffic: Protein and Lipids • Bioenergetics: Energy Transfer and Membrane Transport • Cellular Ion Homeostasis • Growth Factors and Adhesion Molecules • Structural Analysis of Membrane Proteins • Membranes and Disease. Biochemistry of Cell Membranes should serve as a benchmark for indicating the most important lines for future research in these areas.
Book Synopsis Protein Kinase-mediated Decisions Between Life and Death by : Ayse Basak Engin
Download or read book Protein Kinase-mediated Decisions Between Life and Death written by Ayse Basak Engin and published by Springer Nature. This book was released on 2021-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Conquering RAS written by Asfar Azmi and published by Academic Press. This book was released on 2016-08-11 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. - Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities - Showcases recent advancements in RAS research under one comprehensive volume - Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research
