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Download Regulation Of The Class Ii Mhc Gene Expression By Macrophages From Bcgr And Bcgs Mice And The Regulation Of Surface Expression Of Class Ii Molecules By Pge2 full books in PDF, epub, and Kindle. Read online Regulation Of The Class Ii Mhc Gene Expression By Macrophages From Bcgr And Bcgs Mice And The Regulation Of Surface Expression Of Class Ii Molecules By Pge2 ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author :
Publisher :
ISBN 13 :
Total Pages : 1590 pages
Book Rating : 4.0/5 ( download)
Download or read book Abridged Index Medicus written by and published by . This book was released on 1989 with total page 1590 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.:/5 (319 download)
Download or read book DOE/ET. written by and published by . This book was released on 1980 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G. Eric Blair
Publisher : Cambridge University Press
ISBN 13 : 9780521495783
Total Pages : 462 pages
Book Rating : 4.4/5 (957 download)
Download or read book Modulation of MHC Antigen Expression and Disease written by G. Eric Blair and published by Cambridge University Press. This book was released on 1995-11-09 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.
Author : Emil Unanue
Publisher : Elsevier
ISBN 13 : 0323146678
Total Pages : 540 pages
Book Rating : 4.3/5 (231 download)
Download or read book Macrophage Regulation of Immunity written by Emil Unanue and published by Elsevier. This book was released on 2012-12-02 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophage Regulation of Immunity contains the proceedings of a conference held in Augusta, Michigan, on March 12-14, 1979. The papers examine the role of macrophages in the regulation of cellular immune reactions. They highlight the interaction between macrophages and T cells, along with immune response gene control and macrophage secretion of a number of lymphostimulatory molecules. Organized into six sections encompassing 35 chapters, this volume begins with an overview of antigen handling and presentation, immune response gene control, antigen-presenting cells, and factors affecting lymphocyte-macrophage interactions. It then discusses genetic control of T cell-macrophage interaction in helper cell induction in vitro; mechanisms underlying the interaction of guinea pig T lymphocytes with antigen-pulsed macrophages; and secretion of arachidonic acid oxygenation products by mononuclear phagocytes and their possible role as modulators of lymphocyte function. The book also covers regulation of intracellular killing by extracellular stimulation of the monocyte membrane, and adjuvant activation of macrophage functions. Students and scientists will find this book extremely helpful.
Author : Igor K. Egorov
Publisher : Springer Science & Business Media
ISBN 13 : 3642754422
Total Pages : 323 pages
Book Rating : 4.6/5 (427 download)
Download or read book Transgenic Mice and Mutants in MHC Research written by Igor K. Egorov and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers presented at the international conference on "Transgenic Mice and Mutants in MHC Research", held in Bar Harbor, Maine, in June, 1989. The meeting brought together eighty researchers working in the field. While mouse H-2 mutants have been known for many years their studies continue to contribute a great deal to our understanding of structure/function relationships and evolution of MHC molecules. Recently a new direction of research has emerged on regulation, expression and function of MHC genes using transgenic animals carrying exogenous MHC genes from the same or other species or engineered MHC genes. With the introduction of transgenic mice more specific questions about the various functions of MHC genes can be answered as, for example, the role of soluble and membrane-bound MHC molecules in self tolerance and elimination of specific T cell clones, recognition of human MHC antigens by the mouse immune system, the role of individual human MHC genes in disease susceptibility. New approaches for evaluation of the role of MHC linked and unlinked genes in susceptibility of mice to malignant tumors and their metastases have been also reported. Our purpose has been to provide a forum for discussion of these new developments. Many questions remain to be answered but the necessary tools have become available. We thank the contributors and hope that the readers will benefit from this Pro ceedings. We wish to acknowledge the financial sponsorship for the meeting by The Pew Charitable Trust and Howard Hughes Medical Institute.
Author : Kathleen E. Sullivan
Publisher :
ISBN 13 :
Total Pages : 324 pages
Book Rating : 4.:/5 (45 download)
Download or read book MHC Gene Regulation written by Kathleen E. Sullivan and published by . This book was released on 1987 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert G. Urban
Publisher : Springer
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.:/5 ( download)
Download or read book MHC Molecules: Expression, Assembly and Function written by Robert G. Urban and published by Springer. This book was released on 1996-06-27 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3 nant expression systems have been used to make MHC molecules con taining a single peptide of interest. To date, fifteen single peptide class I structures (incorporating three different HLA and two different H-2 allotypes/isotypes) and four additional class II structures (two single peptide complexes and two superantigen complexes) have been reported. These advances have enabled us to study the atomic detail of antigen presentation and the general mechanisms behind peptide binding, and begin to construct models of T cell recognition. Another area of research which has exploded over the past five years has been the identification of MHC-associated peptides. There are several methods one can use to determine the sequence identity of MHC restricted peptides. Historically, the most successful technique, albeit crude and encumbered with serious limitations, has been the use of overlapping synthetic peptides and T cell clones. Unfortunately, this method absolutely requires: (i) knowledge of the target antigen; (ii) availability of T cell clones; and (iii) a relatively short overall length for the target source protein, such that a set of overlapping pep tides can be affordably synthesized. Briefly, the entire sequence of the tar get protein is chemically synthesized using overlapping peptides which are then screened for biological activity using standard T cell presen tation assays. Despite its limitations, this method was used to identify the first immunodominant epitopes reported in the literature and con tinues to be used successfully today.
