Regulation Of Non Canonical Map Kinase Signaling

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Regulation of Non-canonical MAP Kinase Signaling

Author : Gergory Omerza
Publisher :
ISBN 13 :
Total Pages : 436 pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Regulation of Non-canonical MAP Kinase Signaling by : Gergory Omerza

Download or read book Regulation of Non-canonical MAP Kinase Signaling written by Gergory Omerza and published by . This book was released on 2016 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitogen activated protein kinases (MAPKs) are signaling enzymes that control diverse processes in eukaryotic cells including proliferation, differentiation, and development. Many MAPKs are activated through well-studied canonical signaling pathways in which a MAPK kinase phosphorylates a T-X-Y motif in the activation loop of the MAPK. However, MAPKs can also be activated by non-canonical mechanisms. Smk1 is a meiosis-specific MAPK in the yeast S. cerevisiae that controls spore wall morphogenesis. The Smk1 pathway provides a model system to interrogate mechanisms of non-canonical MAPK signaling in the context of a developmental program. Previous genetic studies identified CAK1, AMA1 , IME2 and SSP2 as genes that regulate Smk1. Cak1 is a cyclin-dependent kinase (CDK)-activating kinase. Ama1 is a meiosis-specific targeting factor of the APC/C E3 ubiquitin ligase that controls exit from meiosis II (MII). Ime2 is a meiosis-specific CDK-like kinase. Ssp2 is a meiosis-specific protein required for spore morphogenesis, whose biochemical function has not previously been described. In this thesis we provide evidence for a novel spatiotemporal regulatory mechanism in which Cak1 phosphorylates Smk1 on its activation-loop T (T207) as the meiotic divisions are taking place. Smk1 autophosphorylates its activation-loop Y (Y209) as Ssp2 binds Smk1 at membranes that surround haploid products (prospore membranes; PSMs) during exit from meiosis II. Ssp2/Smk1 complex formation is regulated through multiple mechanisms, preventing premature MAPK activity. First, although both SMK1 and SSP2 are transcriptionally induced as cells enter meiosis I (MI), SMK1 mRNA is translated almost immediately, while SSP2 mRNA is translationally repressed until Ime2 triggers its derepression at MII. Next, Ssp2 localizes to PSMs, but inhibitory phosphates prevent it from binding Smk1. These phosphates are removed during meiotic exit, as PSMs close around each meiotic product in a step that requires Ama1. Finally, dephosphorylated Ssp2 binds Smk1, inducing RRM-like domains in the C-terminus of Ssp2 bind Smk1. Taken together, this work has defined novel mechanisms for spatiotemporally regulating the smk1 MAPK during meiotic development.

Spatiotemporal Regulation of Non-canonical MAPK Signaling

Author : Chong Wai Tio
Publisher :
ISBN 13 :
Total Pages : 454 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Spatiotemporal Regulation of Non-canonical MAPK Signaling by : Chong Wai Tio

Download or read book Spatiotemporal Regulation of Non-canonical MAPK Signaling written by Chong Wai Tio and published by . This book was released on 2016 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitogen activated protein kinases (MAPKs) are conserved signaling enzymes that regulate an array of essential cellular processes in eukaryotic cells. Canonical MAPK signaling is defined by a three-tier kinase module in which a dual-specificity MAPK kinase phosphorylates the T-X-Y motif in the activation loop of the MAPK. MAPKs can also be activated by non-canonical signaling pathways, yet relatively little is known about these pathways and how they are controlled. Smk1 is a non-canonically activated MAPK in the yeast S. cerevisiae that is expressed specifically in meiotic cells and controls spore wall morphogenesis. The Smk1 pathway represents an excellent model to study mechanisms that control non-canonical MAPKs in the context of a developmental program. Prior studies demonstrated that the activation loop T in Smk1 (T207) is phosphorylated by the CDK activating kinase, Cak1, and the activation-loop Y (Y209) is autophosphorylated in an intramolecular reaction that requires a meiosis-specific protein, Ssp2. Data presented in this thesis show that Smk1 is almost immediately phosphorylated by Cak1 on T207 when it is produced during meiosis I, yet this early form of Smk1 is inactive and Smk1 is not activated until later in the program. Activation occurs specifically at membranes that surround incipient haploids termed prospore membranes (PSMs) in a switch-like fashion as cells exit meiosis II. This tight spatiotemporal control of Smk1 activation is achieved through Ssp2. The temporal control is achieved by a meiosis-specific translational regulatory pathway that represses SSP2 mRNA until anaphase II, while spatial control is achieved by an amino-terminal domain of Ssp2 that is both necessary and sufficient for PSM targeting. Kinase activation is achieved by Ssp2's carboxy-terminal kinase activating domain (KAD) that activates catalysis by directly binding to Smk1. Ssp2 binding also triggers Smk1 autophosphorylation of Y209. Heterologous expression/reconstitution experiments demonstrate that phosphorylation of SMK1-T207 and Y209 increases Ssp2/Smk1 catalytic activity. These studies also identify Y-X-X-X-S/T-P as the unique phosphorylation consensus motif of Smk1. Together, these data dafine a novel mechanism of non-canonical MAPK activation and provide new insights into how MAPKs are spatiotemporally regulated in the context of a developmental program.

Regulation of Tissue Responses: The TWEAK/Fn14 Pathway and other TNF/ TNFR Superfamily Members that Activate Noncanonical NFkB Signaling

Download Regulation of Tissue Responses: The TWEAK/Fn14 Pathway and other TNF/ TNFR Superfamily Members that Activate Noncanonical NFkB Signaling PDF Online Free

Author : Linda C. Burkly
Publisher : Frontiers Media SA
ISBN 13 : 288919700X
Total Pages : 203 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Regulation of Tissue Responses: The TWEAK/Fn14 Pathway and other TNF/ TNFR Superfamily Members that Activate Noncanonical NFkB Signaling by : Linda C. Burkly

Download or read book Regulation of Tissue Responses: The TWEAK/Fn14 Pathway and other TNF/ TNFR Superfamily Members that Activate Noncanonical NFkB Signaling written by Linda C. Burkly and published by Frontiers Media SA. This book was released on 2016-01-21 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system mediates tissue responses under both physiological and pathological conditions, impacting the inflammatory, fibrogenic and regenerative components. In addition to various leukocyte subsets, it is now recognized that epithelial, endothelial and other non-hematopoietic tissue cell types actively contribute to the interplay shaping tissue responses. Further understanding the molecular pathways and mechanisms mediating these tissue responses is of great interest. In the past decade, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, FGF-inducible molecule-14 (Fn14), members of the TNF/TNFR superfamily, have emerged as a prominent molecular axis regulating tissue responses. Generally leukocyte-derived, TWEAK signals through Fn14 which is highly induced in injured and diseased tissues on the surface of parenchymal, stromal and progenitor cells, thereby orchestrating a host of tissue-shaping responses, including inflammation, angiogenesis, cell proliferation or death, and the regulation of progenitor cells. Compelling preclinical results indicate that whereas transient TWEAK/Fn14 activation promotes productive tissue responses after acute injury, excessive or persistent TWEAK/Fn14 activation drives pathological tissue responses, leading to progressive damage and degeneration in target organs of injury, autoimmune and inflammatory diseases and cancer. Given that the highly inducible pattern of Fn14 expression is well conserved between mouse and man, the role of TWEAK/Fn14 in human disease is an area of intense investigation. Recent findings have also begun to shed light on how the TWEAK/Fn14 pathway fits into the immune network, interplaying with other well-established pathways, including TNFa, IL-17, IL-13 and TGFb, in regulating tissue responses. The noncanonical nuclear factor kB (NF?B) pathway plays a role in immunity and disease pathologies and appears to be activated by only a subset of TNF/ TNFR superfamily members. Of the various signaling pathways downstream of TWEAK/Fn14, particular attention has been placed on the noncanonical NF?B pathway given that given that TWEAK induces acute activation of canonical NF?B but prolonged activation of noncanonical pathway. Thus dovetailing of the TWEAK/Fn14 axis with noncanonical NF?B pathway activation may be a key mechanism underlying tissue responses. Also of great interest is a deeper understanding of where, when and how tissue responses are regulated by other TNF/ TNFR superfamily members that can signal through noncanonical NF?B. This Research Topic issue will cover: 1. TWEAK/Fn14 pathway biology, role in tissue responses, injury, and disease pathogenesis 2. Role of noncanonical NFkB signaling cascade in tissue responses 3. Translational studies of relevance of TWEAK/Fn14 and noncanonical NFkB in human disease 4. Other TNF superfamily members’ signaling through noncanonical NFkB in the regulation of tissue responses 5. Reviews and Perspectives on the above

Stress-Activated Protein Kinases

Author : Francesc Posas
Publisher : Springer Science & Business Media
ISBN 13 : 3540755691
Total Pages : 322 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Stress-Activated Protein Kinases by : Francesc Posas

Download or read book Stress-Activated Protein Kinases written by Francesc Posas and published by Springer Science & Business Media. This book was released on 2008-01-24 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.

Canonical and Non-canonical Regulation of AMP-activated Protein Kinase

Author : Francesca Romana Auciello
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Canonical and Non-canonical Regulation of AMP-activated Protein Kinase by : Francesca Romana Auciello

Download or read book Canonical and Non-canonical Regulation of AMP-activated Protein Kinase written by Francesca Romana Auciello and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Non-canonical Cyclic Nucleotides

Author : Roland Seifert
Publisher : Springer
ISBN 13 : 3319526731
Total Pages : 379 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Non-canonical Cyclic Nucleotides by : Roland Seifert

Download or read book Non-canonical Cyclic Nucleotides written by Roland Seifert and published by Springer. This book was released on 2017-04-28 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

MAP Kinase Signaling Protocols

Author : Rony Seger
Publisher : Springer Science & Business Media
ISBN 13 : 1592596711
Total Pages : 335 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis MAP Kinase Signaling Protocols by : Rony Seger

Download or read book MAP Kinase Signaling Protocols written by Rony Seger and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitogen-activated protein kinase (MAPK) signaling cascades are a group of protein kinases that play a central role in the intracellular transmission of extracellular signals. These cascades operate as major lines of communication within a complicated signaling network that regulates many cellular processes, including proliferation, differentiation, development, stress response, and apoptosis. More than 15,000 papers on MAPKs have been published over the past few years, with the number of publications increasing each year. More and more laboratories embark on the study of MAPK cascades in many d- tinct cellular systems and in particular their role in disease. Future challenges in the study of MAPK cascades remain in understa- ing the role of the various components and isoforms of the cascades in the multiple critical functions that they regulate in the whole organism, as well as the diseases caused by their malfunction. Data from gene-disrupted mice s- gest that inhibition of the MAPK cascades may have serious consequences on the development and growth of the animals. For example, targeted deletion of MEK1 is lethal, owing to developmental problems of placental vasculature and abnormal fibroblast migration. This lethality occurs in spite of the normal expression of MEK2, indicating that although the two MEK isoforms are apparently similar, they do have distinct functions, at least during embryog- esis. The ERK cascade was also shown to play a central role in brain function and in learning and memory.

Structures, Signaling Mechanisms, and Functions of Types I and III Interferons

Author : Ronald L. Rabin
Publisher : Frontiers Media SA
ISBN 13 : 2889666808
Total Pages : 133 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Structures, Signaling Mechanisms, and Functions of Types I and III Interferons by : Ronald L. Rabin

Download or read book Structures, Signaling Mechanisms, and Functions of Types I and III Interferons written by Ronald L. Rabin and published by Frontiers Media SA. This book was released on 2021-04-23 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Walter receives financial support from Pfizer. The other Topic Editor declares no competing interest with regards to the Research Topic theme.

The Dopamine Receptors

Author : Kim Neve
Publisher : Springer Science & Business Media
ISBN 13 : 1603273336
Total Pages : 650 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis The Dopamine Receptors by : Kim Neve

Download or read book The Dopamine Receptors written by Kim Neve and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.

Regulation of Immunity by Non-Immune Cells

Author : Kenji Kabashima
Publisher : Frontiers Media SA
ISBN 13 : 288971604X
Total Pages : 130 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Regulation of Immunity by Non-Immune Cells by : Kenji Kabashima

Download or read book Regulation of Immunity by Non-Immune Cells written by Kenji Kabashima and published by Frontiers Media SA. This book was released on 2021-11-08 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systems Biology of Transcription Regulation

Author : Ekaterina Shelest
Publisher : Frontiers Media SA
ISBN 13 : 2889199673
Total Pages : 191 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Systems Biology of Transcription Regulation by : Ekaterina Shelest

Download or read book Systems Biology of Transcription Regulation written by Ekaterina Shelest and published by Frontiers Media SA. This book was released on 2016-09-09 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription regulation is a complex process that can be considered and investigated from different perspectives. Traditionally and due to technical reasons (including the evolution of our understanding of the underlying processes) the main focus of the research was made on the regulation of expression through transcription factors (TFs), the proteins directly binding to DNA. On the other hand, intensive research is going on in the field of chromatin structure, remodeling and its involvement in the regulation. Whatever direction we select, we can speak about several levels of regulation. For instance, concentrating on TFs, we should consider multiple regulatory layers, starting with signaling pathways and ending up with the TF binding sites in the promoters and other regulatory regions. However, it is obvious that the TF regulation, also including the upstream processes, represents a modest portion of all processes leading to gene expression. For more comprehensive description of the gene regulation, we need a systematic and holistic view, which brings us to the importance of systems biology approaches. Advances in methodology, especially in high-throughput methods, result in an ever-growing mass of data, which in many cases is still waiting for appropriate consideration. Moreover, the accumulation of data is going faster than the development of algorithms for their systematic evaluation. Data and methods integration is indispensable for the acquiring a systematic as well as a systemic view. In addition to the huge amount of molecular or genetic components of a biological system, the even larger number of their interactions constitutes the enormous complexity of processes occurring in a living cell (organ, organism). In systems biology, these interactions are represented by networks. Transcriptional or, more generally, gene regulatory networks are being generated from experimental ChIPseq data, by reverse engineering from transcriptomics data, or from computational predictions of transcription factor (TF) – target gene relations. While transcriptional networks are now available for many biological systems, mathematical models to simulate their dynamic behavior have been successfully developed for metabolic and, to some extent, for signaling networks, but relatively rarely for gene regulatory networks. Systems biology approaches provide new perspectives that raise new questions. Some of them address methodological problems, others arise from the newly obtained understanding of the data. These open questions and problems are also a subject of this Research Topic.

Progress in Heritable Soft Connective Tissue Diseases

Author : Jaroslava Halper
Publisher : Springer Science & Business Media
ISBN 13 : 9400778937
Total Pages : 246 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Progress in Heritable Soft Connective Tissue Diseases by : Jaroslava Halper

Download or read book Progress in Heritable Soft Connective Tissue Diseases written by Jaroslava Halper and published by Springer Science & Business Media. This book was released on 2014-01-18 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.

Regulation of Organelle and Cell Compartment Signaling

Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0123822130
Total Pages : 553 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Regulation of Organelle and Cell Compartment Signaling by : Ralph A. Bradshaw

Download or read book Regulation of Organelle and Cell Compartment Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2011-04-12 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.

Germline Development

Author : Joan Marsh
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Germline Development by : Joan Marsh

Download or read book Germline Development written by Joan Marsh and published by John Wiley & Sons. This book was released on 1994-08-16 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connects classical cellular descriptive studies with more recent work on the molecular and genetic aspects regarding germline development. Prominent scientists discuss research on a range of organisms including insects, worms, birds, fish, amphibia, mammals and green algae. Specification of germ cells, their migration to the gonads and subsequent interactions with the soma and evolutionary factors of their segregation are among the topics covered.

Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II

Download Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II PDF Online Free

Author : Estela Maris Muñoz
Publisher : Frontiers Media SA
ISBN 13 : 2832533817
Total Pages : 169 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II by : Estela Maris Muñoz

Download or read book Transcription Regulation - Brain Development and Homeostasis - A Finely Tuned and Orchestrated Scenario in Physiology and Pathology, Volume II written by Estela Maris Muñoz and published by Frontiers Media SA. This book was released on 2023-10-03 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: A finely tuned regulation of gene expression is essential for shaping the nervous system and for maintaining its homeostasis throughout life. Disruptions in gene regulation can impact brain development and physiology in ways that contribute to diverse pathologies. The master orchestrators of gene activity in the nucleus are transcription factors, proteins that recognize and bind to specific DNA motifs in regulatory regions and drive changes in gene expression. Transcription factors act with the help of other co-factor proteins, including components of the Mediator complex, histone modifying enzymes, chromatin modelers, and DNA methylases. In addition, transcription factor activity in the nervous system can be modulated by extracellular signals, including growth factors, hormones, neuropeptides and neurotransmitters that activate specific receptors and intracellular transduction pathways. An in-depth understanding of the mechanisms of transcription regulation is needed in order to better describe how each element, from genes to cells, defines and maintains identities and functionalities in the healthy and diseased brain. This Research Topic is oriented to developing an integrative view about transcription regulation within the nervous system, focusing on developmental and homeostatic processes, dysregulation in functionality and expression levels and consequent associated pathologies such as neurodevelopmental disorders, brain tumors, and neurodegenerative diseases. Transcription regulation investigations will specifically focus on transcription factors that belong to the bHLH (e.g. NeuroD), homeobox (e.g. Islet, Pax, Rax, and Lhx) and CREB families, and on their roles over defined nervous system areas: cerebral cortex, thalamic and hypothalamic areas, interacting with the developing brain.

The Smoothened Receptor in Cancer and Regenerative Medicine

Author : Martial Ruat
Publisher : Springer
ISBN 13 : 331919755X
Total Pages : 213 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis The Smoothened Receptor in Cancer and Regenerative Medicine by : Martial Ruat

Download or read book The Smoothened Receptor in Cancer and Regenerative Medicine written by Martial Ruat and published by Springer. This book was released on 2015-06-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Nuclear Signaling Pathways and Targeting Transcription in Cancer

Author : Rakesh Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1461480396
Total Pages : 442 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Nuclear Signaling Pathways and Targeting Transcription in Cancer by : Rakesh Kumar

Download or read book Nuclear Signaling Pathways and Targeting Transcription in Cancer written by Rakesh Kumar and published by Springer Science & Business Media. This book was released on 2013-08-23 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the "classic" papers as well as perspectives on future directions for the field.