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Author : Honami Naora
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.:/5 (223 download)
Download or read book Regulation of Lymphokine Gene Expression in Murine T Lymphocytes written by Honami Naora and published by . This book was released on 1993 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nicoleta Tsoudis
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.:/5 (221 download)
Download or read book Control of Lymphokine Gene Expression in Murine T Lymphocytes written by Nicoleta Tsoudis and published by . This book was released on 1993 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1468459430
Total Pages : 254 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation III written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.
Author : Kendall A Smith
Publisher : Elsevier
ISBN 13 : 0323139949
Total Pages : 334 pages
Book Rating : 4.3/5 (231 download)
Download or read book Interleukin 2 written by Kendall A Smith and published by Elsevier. This book was released on 2012-12-02 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukin 2 focuses on interleukin 2 (IL-2) and its impact on immunology. Topics covered include IL-2's mechanism of action, the structure of the IL-2 receptor, the characteristics of natural and recombinant human IL-2, regulation of IL-2 production by the T cell antigen receptor, how IL-2 binding induces the transcription of a novel set of genes, and the pathological roles of IL-2 receptor inducers in adult T cell leukemia. This book is comprised of 12 chapters and begins with a historical overview of IL-2, from the discovery of soluble mitogenic factors in culture media of stimulated lymphocytes to the discovery of IL-2 as the molecule responsible for stimulating T cell proliferation. The physicochemical and biological properties of purified recombinant IL-2 are then described, paying particular attention to natural IL-2 derived from human peripheral blood leukocytes. The chapters that follow discuss the different techniques used to gain insight into the functionally important regions of IL-2, the role of the T cell antigen receptor in regulating the production of IL-2, and the structure of the human high-affinity IL-2 receptor. The book also describes transmembrane signaling by IL-2, IL-2-inducible gene expression in T lymphocytes, abnormal IL-2 receptor expression in adult T cell leukemia, the use of IL-2 receptors in immunosuppressive therapy, and the use of IL-2 as a pharmacologic reagent. This book will be of interest to students and researchers in immunology and biochemistry.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1468453238
Total Pages : 333 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.
Author : Jeffrey Scott Riegel
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (33 download)
Download or read book Induction of T Cell Activation Gene Expression in Thymocyte Subsets written by Jeffrey Scott Riegel and published by . This book was released on 1990 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Edgar Pick
Publisher : Academic Press
ISBN 13 : 1483268187
Total Pages : 488 pages
Book Rating : 4.4/5 (832 download)
Download or read book Lymphokines written by Edgar Pick and published by Academic Press. This book was released on 2013-09-17 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lymphokines: A Forum for Immunoregulatory Cell Products, Volume 14, reviews the state of knowledge on lymphokines. The book opens with an integrative view of the role of lymphokines in the generation of fever. It stresses that pirogenicity is the attribute of more than one lymphokine: interleukin 1 (IL-1), interferon a, and tumor necrosis factor (TNF) all possess this quality. This is followed by separate chapters on the chemistry of IL-1 molecules and cloning of the gene for human monocyte IL-1; the production of lymphokine by cells of the central nervous system; the acute phase plasma protein response studied at the level of gene structure and expression; and the involvement of calcium and calcium-linked enzymes in T cell proliferation. Subsequent chapters deal with the involvement of pteridines in T cell activation; the discovery of cachectin and the establishment of its identity with TNF; the effect of IFN-? and several cytotoxic cytokines on the proliferation, differentiation, and function of normal and leukemic myeloid cells; and the cytotoxic lymphokines produced by effector T cells. The final chapter discusses the ways in which chemically defined changes in cell membranes affect cell division.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1489909877
Total Pages : 261 pages
Book Rating : 4.4/5 (899 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation V written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signaling through antigen receptor initiates a complex series of events resulting in the activation of genes that regulate the development, proliferation and differentiation of lymphocytes. During the past few years, rapid progress has been made in understanding the molecular basis of signaling pathways mediated by antigen and cytokine receptors. These pathways involve protein tyrosine kinases which are coupled to downstream regulatory molecules, including small guanine nucleotide binding proteins (e. g. p21'OS), serine threonine kinases (e. g. , members of the ERK family), and a large group of transcription factors. More recently, there have been breakthroughs in elucidating the genetic defects underlying three X-linked primary immunodeficiency diseases in humans. This volume surveys aspects of these rapidly developing areas of research. The book is divided into 5 different sections. Section I deals with signaling pathways in B lymphocytes. It includes a contemporary assessment of B cell antigen receptor structures, and discussion of the role of Ig-a/lg-B polypeptides in linking the antigen receptor to intracellular signal transduction pathways. The role of accessory molecules in the regulation of signaling by the B cell antigen receptor is also considered. Section II adopts a similar approach to the analysis of the antigen receptor on T lymphocytes. The importance of specialized signaling motifs in the CD3 polypeptides, mechanisms whereby these motifs may interact with the lymphocyte-specific protein tyrosine kinases, and the downstream consequences of these interactions are reviewed. In addition, the role of antigen-induced apoptosis in the generation of immunological tolerance is discussed.
Author : Cheng-Chi Chao
Publisher :
ISBN 13 :
Total Pages : 286 pages
Book Rating : 4.:/5 (835 download)
Download or read book Regulation of Adhesion Molecule Expression on Murine T Lymphocytes written by Cheng-Chi Chao and published by . This book was released on 1995 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul Robert Bohjanen
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.3/5 (91 download)
Download or read book Regulation of Lymphokine Gene Expression written by Paul Robert Bohjanen and published by . This book was released on 1993 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : S. Gupta
Publisher : Springer
ISBN 13 :
Total Pages : 168 pages
Book Rating : 4.:/5 (44 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation II written by S. Gupta and published by Springer. This book was released on 1989-08 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Second International Conference on [title] held in Feb. 1988. Seventeen contributions on: T cell receptors and activation; interleukin 1 and 2 receptors; B lymphocyte development and B cell activation; interleukins and B lymphocyte activation.
Author : Susan A. Lancaster
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (296 download)
Download or read book Regulation of THY-1 Expression by CAMP in Murine T Lymphocytes written by Susan A. Lancaster and published by . This book was released on 1993 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dale G. Schaar
Publisher :
ISBN 13 :
Total Pages : 302 pages
Book Rating : 4.:/5 (551 download)
Download or read book The Expression of a Murine Cytotoxic T Cell Receptor and the Lymphokine, Interleukin 2, as a Result of Retrovirus-mediated Gene Transfer written by Dale G. Schaar and published by . This book was released on 1991 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kiberley S. Smith
Publisher :
ISBN 13 :
Total Pages : 118 pages
Book Rating : 4.:/5 (262 download)
Download or read book Lymphokine Gene Expression in Anti-CD3 Stimulated Human T-lymphocytes written by Kiberley S. Smith and published by . This book was released on 1992 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Richard D. Granstein
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.:/5 (327 download)
Download or read book Mechanisms of Immune Regulation written by Richard D. Granstein and published by S. Karger AG (Switzerland). This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the topics reviewed are T and B cell tolerance, clonal deletion, suppressor cells, mechanisms of immune privileged sites and experimental models of tumor immunity. Oral tolerance, ultraviolet radiation and photosensitized effects on immunity, allograft management, T cell vaccination and regulation of immunity with T cell epitopes are discussed from the point of view of possible therapeutic application.
Author :
Publisher :
ISBN 13 :
Total Pages : 776 pages
Book Rating : 4.3/5 (91 download)
Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
