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Author : Honami Naora
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.:/5 (223 download)
Download or read book Regulation of Lymphokine Gene Expression in Murine T Lymphocytes written by Honami Naora and published by . This book was released on 1993 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul Robert Bohjanen
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.3/5 (91 download)
Download or read book Regulation of Lymphokine Gene Expression written by Paul Robert Bohjanen and published by . This book was released on 1993 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nicoleta Tsoudis
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.:/5 (221 download)
Download or read book Control of Lymphokine Gene Expression in Murine T Lymphocytes written by Nicoleta Tsoudis and published by . This book was released on 1993 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kendall A Smith
Publisher : Elsevier
ISBN 13 : 0323139949
Total Pages : 334 pages
Book Rating : 4.3/5 (231 download)
Download or read book Interleukin 2 written by Kendall A Smith and published by Elsevier. This book was released on 2012-12-02 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukin 2 focuses on interleukin 2 (IL-2) and its impact on immunology. Topics covered include IL-2's mechanism of action, the structure of the IL-2 receptor, the characteristics of natural and recombinant human IL-2, regulation of IL-2 production by the T cell antigen receptor, how IL-2 binding induces the transcription of a novel set of genes, and the pathological roles of IL-2 receptor inducers in adult T cell leukemia. This book is comprised of 12 chapters and begins with a historical overview of IL-2, from the discovery of soluble mitogenic factors in culture media of stimulated lymphocytes to the discovery of IL-2 as the molecule responsible for stimulating T cell proliferation. The physicochemical and biological properties of purified recombinant IL-2 are then described, paying particular attention to natural IL-2 derived from human peripheral blood leukocytes. The chapters that follow discuss the different techniques used to gain insight into the functionally important regions of IL-2, the role of the T cell antigen receptor in regulating the production of IL-2, and the structure of the human high-affinity IL-2 receptor. The book also describes transmembrane signaling by IL-2, IL-2-inducible gene expression in T lymphocytes, abnormal IL-2 receptor expression in adult T cell leukemia, the use of IL-2 receptors in immunosuppressive therapy, and the use of IL-2 as a pharmacologic reagent. This book will be of interest to students and researchers in immunology and biochemistry.
Author : Edgar Pick
Publisher : Academic Press
ISBN 13 : 1483268187
Total Pages : 488 pages
Book Rating : 4.4/5 (832 download)
Download or read book Lymphokines written by Edgar Pick and published by Academic Press. This book was released on 2013-09-17 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lymphokines: A Forum for Immunoregulatory Cell Products, Volume 14, reviews the state of knowledge on lymphokines. The book opens with an integrative view of the role of lymphokines in the generation of fever. It stresses that pirogenicity is the attribute of more than one lymphokine: interleukin 1 (IL-1), interferon a, and tumor necrosis factor (TNF) all possess this quality. This is followed by separate chapters on the chemistry of IL-1 molecules and cloning of the gene for human monocyte IL-1; the production of lymphokine by cells of the central nervous system; the acute phase plasma protein response studied at the level of gene structure and expression; and the involvement of calcium and calcium-linked enzymes in T cell proliferation. Subsequent chapters deal with the involvement of pteridines in T cell activation; the discovery of cachectin and the establishment of its identity with TNF; the effect of IFN-? and several cytotoxic cytokines on the proliferation, differentiation, and function of normal and leukemic myeloid cells; and the cytotoxic lymphokines produced by effector T cells. The final chapter discusses the ways in which chemically defined changes in cell membranes affect cell division.
Author : Gregory R. Bock
Publisher : John Wiley & Sons
ISBN 13 : 0470514272
Total Pages : 290 pages
Book Rating : 4.4/5 (75 download)
Download or read book Polyfunctional Cytokines written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts from a variety of areas compare and discuss IL-6 and LIF in order to provide a new understanding of their modes of action, the significance of their polyfunctionalization--why the body chooses to use one molecule to regulate various cell types--and their functional overlap. Covers such topics as actions of IL-6 and LIF on lymphoid populations, on megakaryocyte and platelet production, on bone metabolism, their effects on leukemic cells and much more. Includes contributions from researchers working on a variety of cell types and organ systems along with potential clinical applications regarding these two factors.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1468459430
Total Pages : 254 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation III written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.
Author : Jeffrey Scott Riegel
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (33 download)
Download or read book Induction of T Cell Activation Gene Expression in Thymocyte Subsets written by Jeffrey Scott Riegel and published by . This book was released on 1990 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Gene Expression During Lymphocyte Activation written by and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dan Yang Huang
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (187 download)
Download or read book The Regulation of Interleukin 2-induced Proliferating Cell Nuclear Antigen Gene Expression in a Cloned T Lymphocyte written by Dan Yang Huang and published by . This book was released on 1995 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pravinkumar B. Sehgal
Publisher :
ISBN 13 :
Total Pages : 608 pages
Book Rating : 4.F/5 ( download)
Download or read book Regulation of the Acute Phase and Immune Responses written by Pravinkumar B. Sehgal and published by . This book was released on 1989 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. Baxter
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cytokine Interactions and Their Control written by A. Baxter and published by . This book was released on 1991-12-20 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a group of international experts with the intention of furthering the understanding of cytokines' progress in recent years. Coverage includes new cytokines continually being cloned plus recent studies of their interaction and control.
Author : Arnab Nayak
Publisher :
ISBN 13 :
Total Pages : 178 pages
Book Rating : 4.:/5 (246 download)
Download or read book Sumoylation Modulates NFATc1-mediated Lymphokine Gene Expression written by Arnab Nayak and published by . This book was released on 2007 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 9 pages
Book Rating : 4.:/5 (495 download)
Download or read book An Inducible Cytoplasmic Factor (AU-B) Binds Selectively to AUUUA Multimers in the 3' Untranslated Region of Lymphokine MRNA. written by and published by . This book was released on 1991 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the primary control of eukaryotic gene expression occurs at the transcriptional level, it has become clear that posttranscriptional mechanisms also play important roles in gene regulation. For instance, the efficiency of nuclear RNA splicing and processing has been suggested to play a regulatory role in the expression of some genes (21). Within the cytoplasm, selective mRNA compartmentalization, translation, and degradation, can each influence the final level of gene expression. In order for gene expression to be regulated selectively at any level, the cell must have a means to discriminate between genes or their products. For example, selective gene expression is regulated at the transcriptional level in part by interactions between sequence- specific nuclear DNA-binding proteins (transcription factors) and sequence motifs within promoter/enhancer regions. This study was undertaken to determine whether similar sequence-specific cytoplasmic RNA-binding factors are involved in regulating cytoplasmic mRNA metabolism.
Author : David R. Webb
Publisher : Springer Science & Business Media
ISBN 13 : 1461245982
Total Pages : 495 pages
Book Rating : 4.4/5 (612 download)
Download or read book Molecular Basis of Lymphokine Action written by David R. Webb and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.
Author : Stanley Cohen
Publisher : CRC Press
ISBN 13 : 9780849364273
Total Pages : 292 pages
Book Rating : 4.3/5 (642 download)
Download or read book The Role of Lymphokines in the Immune Response written by Stanley Cohen and published by CRC Press. This book was released on 1989-12-27 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a broad overview of all aspects of modern lymphokine research. It begins with the ways in which lymphokines play a role in the activation of the immune response and concludes with their participation in various facets of host defense. It devotes special attention to structure, mechanism of action, and range application. In addition, this fascinating work also shows how lymphokines are involved in other physiologic responses, such as reparative reactions involving fibrosis and angiogenesis. This is an excellent resource for students and investigators in the biomedical sciences, as well as clinicians who require up-to-date information about our current understanding of immune processes.
Author : Prakash Chandra
Publisher : Springer Science & Business Media
ISBN 13 : 1468452428
Total Pages : 397 pages
Book Rating : 4.4/5 (684 download)
Download or read book New Experimental Modalities in the Control of Neoplasia written by Prakash Chandra and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acquisition of new knowledge about the biological and bio chemical nature of neoplastic cells has led to the design and development of several experimental approaches in the tre&tment of cancer. These approaches emerge from the recent work in tu mor virology, e. g. the control of vital cellular genes by viral regulatory signals; the implication of monoclonal antibodies as a vehicle for the targeted drug delivery and selective de struction of tumor cells; immunologic advances in the recog nition of some specific events during metastatic growth; the role of biological response modifiers in modifying or rever sing malignant growth; and biochemical advances, such as the role of gene amplification in drug resistance and the app roaches to the reversal of resistance in drug refractory cancer, the role of membranes in designing useful strategies, the identification of new enzymic targets in some types of cancer cells, and the characterization of metabolically active forms of cytostatic compounds. These are the important issues which were addressed in an international NATO Advanced Study Institute (ASI) attended by scientists from allover the world representing a wide spectrum of scientific disciplines. Although the acquired immune deficiency syndrome (AIDS) is not a malignant disease, but the etiological involvement of a retrovirus belonging to the family of human T-cell lympho tropic viruses which cause leukemia and lymphomas in man, justifies its inclusion in the agenda of this Study Institute. Scientific presentations from Drs.
