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Author : Frank Lundquist
Publisher :
ISBN 13 :
Total Pages : 850 pages
Book Rating : 4.3/5 (91 download)
Download or read book Regulation of Hepatic Metabolism written by Frank Lundquist and published by . This book was released on 1974 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : K. Jungermann
Publisher : Springer Science & Business Media
ISBN 13 : 1468450417
Total Pages : 495 pages
Book Rating : 4.4/5 (684 download)
Download or read book Regulation of Hepatic Metabolism written by K. Jungermann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: The liver is an exceptionally complex and diverse organ that functions both as an exocrine and an endocrine gland. It secretes bile, which contains many con stituents in addition to bile salts, and it synthesizes and releases many substances in response to the body's demands, including prohormones, albumin, clotting factors, glucose, fatty acids, and various lipoproteins. It has a dual blood supply providing a rich mixture of nutrients and other absorbed substances via the portal vein and oxygen-rich blood via the hepatic artery. This functional heterogeneity is accompanied by cellular heterogeneity. The liver contains many cell types including hepatic parachymal cells, Kiipffer cells, Ito cells, and endothelial cells. The most abundant cell type, the parenchymal cells, are biochemically and structurally heterogeneous. The cells in the oxygen-rich areas of the portal triad appear more dependent on oxidative metabolism, whereas those around the central vein (pericentral, perivenous, or centrolobular areas) are more dependent upon an anaerobic mechanism. Throughout this volume the latter three terms are used synonymously by various authors to indicate the five to eight layers of cells radiating from the central vein. Structural and metabolic heterogeneity of hepatic parenchymal cells has been demonstrated by a variety of approaches, including histochemical, ultra structural, and ultramicrobiochemical studies. This microheterogeneity is linked to the physiological functions of the liver and its response to injurious substances.
Author : Raymond S. Ochs
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (262 download)
Download or read book Aspects of Regulation of Hepatic Metabolism written by Raymond S. Ochs and published by . This book was released on 1979 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Keith N. Frayn
Publisher : John Wiley & Sons
ISBN 13 : 1119331463
Total Pages : 402 pages
Book Rating : 4.1/5 (193 download)
Download or read book Human Metabolism written by Keith N. Frayn and published by John Wiley & Sons. This book was released on 2019-03-19 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The updated bestselling guide to human metabolism and metabolic regulation The revised and comprehensively updated new edition of Human Metabolism (formerly Metabolic Regulation – A Human Perspective) offers a current and integrated review of metabolism and metabolic regulation. The authors explain difficult concepts in clear and concise terms in order to provide an accessible and essential guide to the topic. This comprehensive text covers a wide range of topics such as energy balance, body weight regulation, exercise, and how the body copes with extreme situations, and illustrates how metabolic regulation allows the human body to adapt to many different conditions. This fourth edition has been revised with a new full colour text design and helpful illustrations that illuminate the regulatory mechanisms by which all cells control the metabolic processes necessary for life. The text includes chapter summaries and additional explanatory text that help to clarify the information presented. In addition, the newly revised edition includes more content on metabolic pathways and metabolic diseases. This important resource: Is a valuable tool for scientists, practitioners and students across a broad range of health sciences including medicine, biochemistry, nutrition, dietetics, sports science and nursing Includes a full colour text filled with illustrations and additional diagrams to aid understanding Offers a companion website with additional learning and teaching resources. Written for students of medicine, biochemistry, nutrition, dietetics, sports science and nursing, Human Metabolism has been revised and updated to provide a comprehensive review of metabolism and metabolic regulation.
Author :
Publisher :
ISBN 13 : 9780124603608
Total Pages : 828 pages
Book Rating : 4.6/5 (36 download)
Download or read book Regulation of Hepatic Metabolism written by and published by . This book was released on 1974 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Åke Nilsson
Publisher : Cambridge Scholars Publishing
ISBN 13 : 152757797X
Total Pages : 267 pages
Book Rating : 4.5/5 (275 download)
Download or read book Metabolic and Clinical Perspectives on the Functions of the Liver written by Åke Nilsson and published by Cambridge Scholars Publishing. This book was released on 2024-02-07 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how the liver executes and coordinates numerous physiological processes including metabolism, innate immunity, blood coagulation, bile secretion, and our symbiotic relation with the gut microbiome. It places the functions in clinical contexts, such as the pathogenesis of alcohol-related liver disease and metabolic (obesity) associated liver disease. It describes how in severe catabolic diseases such as cancer and sepsis, the liver redistributes bodily resources to increase chances of survival and recovery, and how the liver exemplifies many of the effects of diet and physical activity on health and wellbeing, via its regulation of glucose, lipid and cholesterol metabolism, and inflammation. The book is for professionals working in gastroenterology, hepatology, metabolic disorders, and many other medical disciplines, and for scientists and curious students of medicine, nutrition and biosciences.
Author : James M. Ntambi
Publisher : Springer
ISBN 13 : 3319250655
Total Pages : 309 pages
Book Rating : 4.3/5 (192 download)
Download or read book Hepatic De Novo Lipogenesis and Regulation of Metabolism written by James M. Ntambi and published by Springer. This book was released on 2015-12-17 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The liver is the largest solid vital organ in mammals that supports other organ in the body in some facet. This book synthesizes all the primary and relevant metabolic information that one needs to review to understand the complex and diverse role of the liver in metabolism. With the current epidemic of metabolic diseases, it is of immediate importance to understand the contribution of the liver in health and its role in the development of impaired metabolic regulation. This book covers the many studies that have unmasked important roles that proteins expressed in the liver play in the development of or protection from metabolic diseases. One of the major metabolic functions of the liver is to carry out de novo lipogenesis, which is the metabolic pathway that allows the conversion of excess carbohydrates into fatty acids. The process of de novo lipogenesis is covered in depth within this volume. The book is an important contribution to the vast literature and ongoing research on liver function.
Author : Keith N. Frayn
Publisher : John Wiley & Sons
ISBN 13 : 140514761X
Total Pages : 352 pages
Book Rating : 4.4/5 (51 download)
Download or read book Metabolic Regulation written by Keith N. Frayn and published by John Wiley & Sons. This book was released on 2009-02-11 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Regulation looks in detail at how molecules, cells and tissues operate collectively in human health and disease, using an approach that has become known as ‘integrative physiology’. Since the publication of the first edition of this extremely well received book, the understanding of how metabolism is regulated has developed substantially in several ways, for example with the discovery of the hormone leptin, and also in the continuing advances in the understanding of gene expression. Full details of these and other new advances are included in this fully updated edition. Carefully laid out with relevant and clearly explained examples, and containing much new material, this new edition covers in an integrated way: concepts and mechanisms, digestion and intestinal absorption, organs and tissues, endocrine organs and hormones, the integration of carbohydrate, fat and protein metabolism, the nervous system and metabolism, lipoprotein metabolism, diabetes mellitus, energy balance and body weight regulation and how the body copes with some extreme situations. The author, Keith Frayn, who has many years’ experience teaching and researching in this subject, has written a book of great clarity, which is an extremely valuable tool for scientists, practitioners and students working and studying across a broad range of allied health sciences including nutrition, dietetics, sports science and nursing. Students of medicine, physiology, biochemistry and biological sciences will also find much of great use and interest in this book. All libraries in research establishments, universities and medical schools where these subjects are studied and taught should have multiple copies of this excellent book on their shelves. Keith Frayn is Professor of Human Metabolism at the University of Oxford, UK.Reviews of the First Edition ‘This is an excellent textbook’: Trends in Endocrinology and Metabolism ‘The coverage is excellent for students following courses such as nutrition and human biology’:Biologist ‘This book is ideal for medical students’:Australian Society for Biochemistry and Molecular Biology
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Author : Linda Grasfeder
Publisher :
ISBN 13 :
Total Pages : 418 pages
Book Rating : 4.:/5 (318 download)
Download or read book Regulation of Hepatic Metabolism Through PGC-1 [alpha]-mediated Pathways written by Linda Grasfeder and published by . This book was released on 2007 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: PGC-1alpha is a transcriptional coactivator selectively expressed in tissues with high metabolic demands and induced by a variety of metabolic stressors, including cold, exercise, and fasting. When expressed, PGC-1alpha can coactivate a number of transcription factors to coordinately activate metabolic pathways that supply tissues and the body with necessary nutrients. PGC-1alpha has emerged as a master controller of mitochondria and many of the processes focused within them, including oxidative phosphorylation, fatty acid oxidation, the TCA cycle and free radical scavenging. PGC-1alpha also induces gluconeogenesis and expression of glucose transporters, thereby regulating blood glucose levels. Given this integral role in modulating energy homeostasis, understanding how PGC-1alpha functions and what factors regulate its activity could help identify processes and proteins that malfunction in various metabolic disorders.
Author : Alison Jean Marker
Publisher :
ISBN 13 :
Total Pages : 250 pages
Book Rating : 4.:/5 (593 download)
Download or read book Mechanisms of Regulation of Liver Metabolism and Growth written by Alison Jean Marker and published by . This book was released on 1998 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Walter Wahli
Publisher : MDPI
ISBN 13 : 303943635X
Total Pages : 268 pages
Book Rating : 4.0/5 (394 download)
Download or read book Metabolism and Metabolomics of Liver in Health and Disease written by Walter Wahli and published by MDPI. This book was released on 2021-02-19 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.
Author : Maria Yung-chu Wu-Rideout
Publisher :
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.:/5 (89 download)
Download or read book The Regulatory Role of the Fatty Acid Binding Protein in Hepatic Metabolism written by Maria Yung-chu Wu-Rideout and published by . This book was released on 1977 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kevin M. Conricode
Publisher :
ISBN 13 :
Total Pages : 334 pages
Book Rating : 4.:/5 (233 download)
Download or read book Studies on the Hormonal Regulation of Hepatic Metabolism written by Kevin M. Conricode and published by . This book was released on 1990 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lara Bideyan
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)
Download or read book Transcriptional Control of Hepatic Metabolism in Physiology written by Lara Bideyan and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver is a key regulator of systemic metabolism in physiology and pathology. It maintains cholesterol, triglyceride and glucose homeostasis in response to fasting and feeding. Transcription factors responsive to hormones and nutrients coordinate many of these responses. They regulate gene networks relating to lipid, glucose and amino acid metabolism during fasting and feeding, and factors such as sex, circadian rhythms and dietary content interact with these transcriptional programs, as reviewed in chapter 1. Understanding the different players in these processes and how they interact with each other will be key to develop strategies to combat metabolic diseases. Recent advances in probing the transcriptional landscape, coupled with high throughput sequencing approaches such as assay for transposase accessible chromatin (ATAC-Seq), have enabled the identification of transcriptional regulators of these processes and their interrelationships. In chapter 2, I describe results from a screen using ATAC-Seq and RNA-Seq to profile novel transcriptional regulators of the hepatic response to fasting and feeding. We determined GATA4 expression and activity to be upregulated by feeding through insulin. Knocking out Gata4 in adult liver impaired the transcriptional and metabolic response to feeding. Additionally, loss of hepatic GATA4 led to a reduction in HDL cholesterol and to the accumulation of liver triglycerides. These effects were accompanied by the downregulation of genes involved in cholesterol efflux and triglyceride hydrolysis, and the upregulation of genes involved in lipid uptake. Furthermore, hepatic GATA4 colocalized and collaborated with Liver X Receptor (LXR), a key regulator of cholesterol transport. In chapter 3, I investigated the dynamics of hepatic LXRs via ATAC-Seq and RNA-Seq in wild-type and LXR[alpha]/[Beta] knockout liver. Loss of LXRs in liver changed the transcriptional regulatory landscape by reducing accessibility at enhancers and increasing accessibility at promoters. A broad set of transcription factors that bind enhancers, including nuclear receptors, had reduced activity based on their motif accessibility, showing their reliance on LXRs. Moreover, this investigation demonstrated that LXR also functions as a transcriptional repressor of certain genes. Overall, these studies revealed important functions for GATA4 and LXR within hepatic transcriptional networks, extending our understanding of transcriptional regulation of hepatic lipid metabolism.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book Regulation of Hepatic Metabolism written by and published by . This book was released on 1974 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Frank Lundquist
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (181 download)
Download or read book Regulation of Hepatic Metabolism written by Frank Lundquist and published by . This book was released on 1974 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Louis Hue
Publisher : North Holland
ISBN 13 : 9780444803337
Total Pages : 464 pages
Book Rating : 4.8/5 (33 download)
Download or read book Short-term Regulation of Liver Metabolism written by Louis Hue and published by North Holland. This book was released on 1981-01-01 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
